European Journal of Obstetrics and Gynecology and Reproductive Biology: X最新文献

{"title":"Perinatal outcomes after increased fetal movement as counted by a fetal movement acceleration measurement recorder","authors":"Eiji Ryo,&nbsp;Hideo Kamata,&nbsp;Keita Yatsuki,&nbsp;Takashi Kosaka,&nbsp;Kazunori Nagasaka","doi":"10.1016/j.eurox.2025.100428","DOIUrl":"10.1016/j.eurox.2025.100428","url":null,"abstract":"<div><h3>Introduction</h3><div>There is no consensus in perinatal medicine about what increased fetal movement means.</div></div><div><h3>Objective</h3><div>Our purpose was to study the relationship between perinatal outcomes and an increase in gross fetal movement as counted by an objective method.</div></div><div><h3>Methods</h3><div>This was a prospective cohort study. A total of 471 pregnant women recorded fetal movement with a fetal movement acceleration measurement recorder at night weekly after 28 weeks. The ratio of 10-second epochs with fetal movement to all epochs was calculated as a fetal movement parameter when movement could be recorded for more than 4 h on one night. If the parameter was above the 90th percentile on the previously made reference curve, it was defined as increased movement. Women who showed the increased fetal movement at least once were classified into a study group, and the other women were classified into a control group. Perinatal abnormalities between the two groups were compared with the Chi-square test or Fisher’s exact test.</div></div><div><h3>Results</h3><div>A total of 13,931 h were recorded from 390 women, including 74 and 316 women, respectively, in the study and control groups. There were fewer preterm births (1.4 %), non-cephalic presentations at delivery (0 %), and Cesarean deliveries (25.7 %) in the study group than in the control group (15.5 %, 6.0 %, and 39.9 %; p = 0.0003, 0.031, and 0.024, respectively). There were no significant differences in the other perinatal outcomes.</div></div><div><h3>Conclusion</h3><div>An increase in long-term gross fetal movement has a protective effect against preterm birth, non-cephalic presentation at birth, and Cesarean delivery.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"28 ","pages":"Article 100428"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroendocrine carcinoma of the cervix (NECC): A retrospective study of 175 Chinese patients","authors":"Ning Su ,&nbsp;Xiao Li ,&nbsp;Dian Wang ,&nbsp;Min Wang ,&nbsp;Shuping Yan ,&nbsp;Haifeng Qiu","doi":"10.1016/j.eurox.2025.100434","DOIUrl":"10.1016/j.eurox.2025.100434","url":null,"abstract":"<div><h3>Purpose</h3><div>Neuroendocrine carcinoma of the cervix (NECC) is rare and aggressive. We analyzed a dual-center Chinese cohort to describe clinicopathologic features, outcomes, and treatment patterns, and to identify prognostic factors.</div></div><div><h3>Methods</h3><div>We retrospectively included patients with pathologically confirmed NECC treated from June 2012 to June 2021. Variables included age at diagnosis, symptoms, high-risk human papillomavirus (hrHPV), FIGO 2009/2018 stage, tumor histology, tumor diameter, depth of stromal invasion (DOI), lymphovascular space invasion (LVSI), lymph-node metastasis (LNM), and treatments. Follow-up followed NCCN guidance. Survival was assessed using Kaplan–Meier and Cox regression.</div></div><div><h3>Results</h3><div>We analyzed 175 patients. hrHPV was positive in 54.3 % (95/175); 84.0 % (147/175) presented with abnormal vaginal bleeding. By FIGO 2018, 39.4 % (69/175) had stage IIB–IVB disease. On univariable Cox regression analysis, younger age, higher FIGO stage (2009 and 2018), pure NECC histology, deeper DOI, larger tumor diameter, and positive LNM were associated with worse survival. In contrast, multivariable Cox regression analysis revealed that FIGO 2009 stage and DOI were independent predictors of both progression-free survival (PFS) and overall survival (OS); tumor histology was independently associated with OS. Survival did not differ between abdominal and laparoscopic radical hysterectomy. Among surgically treated patients, adjuvant radiotherapy did not improve PFS or OS across early-stage, locally advanced, or late-stage subgroups.</div></div><div><h3>Conclusions</h3><div>In this cohort, primary-tumor factors—especially DOI—and FIGO 2009 stage were independent prognostic factors, whereas surgical route and postoperative radiotherapy showed no survival benefit; these findings can inform staging considerations and treatment decisions for NECC.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"28 ","pages":"Article 100434"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to evidence-based intrapartum care practices and influencing factors among obstetric care providers in Ethiopia: A systematic review and meta-analysis","authors":"Gemeda Wakgari Kitil ,&nbsp;Abiy Tasew Dubale","doi":"10.1016/j.eurox.2025.100431","DOIUrl":"10.1016/j.eurox.2025.100431","url":null,"abstract":"<div><h3>Background</h3><div>Globally standardized evidence-based intrapartum care practices are essential for enhancing health outcomes for mothers and newborns. Despite recent advancements, Ethiopia grapples with significant challenges in maternal healthcare, with the implementation of evidence-based intrapartum practices falling below recognized standards. To address this gap, our systematic review and meta-analysis investigate existing literature to unveil the current state of evidence-based intrapartum care practices and identify contributing factors in Ethiopia.</div></div><div><h3>Methods</h3><div>This study focused on Ethiopian research and adhered to the PRISMA checklist. Thirteen relevant studies were identified through databases such as Google Scholar, Web of Science, PubMed, and Scopus. Using STATA version 14, we systematically extracted data employing a checklist. Heterogeneity was evaluated using I2 tests and the Cochrane Q test statistic. To assess publication bias, a funnel plot, Begg's test, and Egger's weighted regression were employed.</div></div><div><h3>Results</h3><div>In this systematic review and meta-analysis, 1770 research articles were identified, with thirteen studies meeting eligibility criteria for analysis. The pooled prevalence of evidence-based intrapartum care practices was 49.50 % (95 % CI: 39.02–59.98). Factors significantly associated with these practices included good knowledge (OR = 2.64, 95 % CI: 2.04–3.41), in-service training related to intrapartum practice (OR = 2.38, 95 % CI: 1.55–3.64), positive attitudes towards intrapartum care practice (OR = 2.68, 95 % CI: 1.78–4.03), a higher number of obstetric care providers per shift (OR = 2.54, 95 % CI: 1.27–5.10), and educational attainment at the level of Master's degree and above (OR = 4.92, 95 % CI: 2.45–9.91).</div></div><div><h3>Conclusion</h3><div>This study reveals that despite recognizing the importance of evidence-based intrapartum practices, only half of the observed obstetric care providers apply them. Factors influencing their application include knowledge, in-service training, attitudes, staffing, and education. Recommendations include continuous knowledge enhancement, reinforced in-service training, and psychological support. Optimizing staffing and creating pathways for advanced degrees are also proposed to improve evidence-based intrapartum care practices.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"28 ","pages":"Article 100431"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous regression rate of high-grade cervical lesions in women under 35 at Dijon University Hospital: Incidence and predictive factors","authors":"TRONCHE Perrine,&nbsp;BOUIT Camille,&nbsp;AHO Serge,&nbsp;DOUVIER Serge,&nbsp;KADHEL Philippe","doi":"10.1016/j.eurox.2025.100436","DOIUrl":"10.1016/j.eurox.2025.100436","url":null,"abstract":"<div><h3>Introduction</h3><div>According to current guidelines, women with CIN 2/3 should undergo a conization procedure. However, for young patients with small lesions, it is possible to consider therapeutic abstention with close monitoring while awaiting potential spontaneous regression. The objectives of this study were to evaluate the regression rate of CIN 2/3 lesions over 24 months of follow-up in women under the age of 35 and to identify predictive factors for spontaneous healing.</div></div><div><h3>Methods</h3><div>This was a retrospective observational study based on data from patients diagnosed with CIN 2 or CIN 3 who underwent close monitoring every 6 months via colposcopy, for a maximum follow-up period of 24 months between May 2008 and May 2024. The primary endpoint was the rate of spontaneous regression of high-grade lesions.</div></div><div><h3>Results</h3><div>104 patients, with a mean age of 27.8 years, were included. Cervical intraepithelial neoplasia spontaneously regressed in 37 patients (35.6 %, <em>95 % CI: 26.4 % – 45.5 %</em>) after a median follow-up of 25.22 months. In multivariate analysis, patients with a lesion limited to a single quadrant were more likely to experience spontaneous healing (<em>OR = 2.98 [1.21–7.34], p = 0.017</em>). No other presumed predictive factors were found to significantly influence spontaneous regression. 2 patients had an in-situ cancer at conization, performed after surveillance and no cases of invasive cancer were described.</div></div><div><h3>Conclusion</h3><div>The results of the study are consistent with the literature and support the possibility of 24-month surveillance of patients with a high-grade lesion, especially given the low risk of progression to more severe disease within two years.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"28 ","pages":"Article 100436"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert transvaginal ultrasound is determinant for diagnosing pelvic conditions after recurrent implantation failure in IVF","authors":"Aikaterini Selntigia ,&nbsp;Consuelo Russo ,&nbsp;Daniele Farsetti ,&nbsp;Giulia Monaco ,&nbsp;Elvira Nocita ,&nbsp;Sara Valeriani ,&nbsp;Federica Iacobini ,&nbsp;Caterina Exacoustos","doi":"10.1016/j.eurox.2025.100438","DOIUrl":"10.1016/j.eurox.2025.100438","url":null,"abstract":"<div><h3>Objective</h3><div>Recurrent implantation failure (RIF) is a clinical phenomenon characterized by a lack of implantation after several embryo-transfers. The aim of this study was to evaluate missing pelvic pathologies in patients with RIF, following at least two embryo-transfers of good-quality blastocyst, using a dedicated transvaginal ultrasound (TVS) performed by experienced specialists.</div></div><div><h3>Methods</h3><div>This retrospective study included patients with RIF who were admitted to the Gynecological Ultrasound Unit of the University of Rome 'Tor Vergata' between 2020 and 2024 for a second-opinion ultrasound. Only patients with transfers of euploid blastocysts and/or blastocysts from oocytes donation were included. All patients underwent 2D, 3D and Power-Doppler transvaginal examination to evaluate all possible pelvic pathologies.</div></div><div><h3>Results</h3><div>The study included 152 patients who met the inclusion criteria. Pathological pelvic findings were identified in 45 of 152 women during the initial TVS scans performed at the IVF centres before ET, whereas expert TVS evaluation at our center after RIF diagnosed pelvic pathology in 129 of 152 cases (p &lt; 0.0001). Significant differences were observed for all pathological ultrasound findings between the initial IVF center scan and the expert TVS, except for isthmocele. In particular, the lowest overall agreement (OA), Cohen’s Kappa (K) and positive percent agreement (PPA) was described regarding the diagnosis of adenomyosis, uterine malformations, hydrosalpinx and deep infiltrated endometriosis.</div></div><div><h3>Conclusion</h3><div>Our study revealed a significant discrepancy in the diagnosis of ultrasound-detectable pelvic pathologies between IVF centres and our expert gynecological ultrasound unit. This difference highlights the potential underdiagnosis of critical pelvic conditions when ultrasound is performed by not expert sonographers in IVF centres.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"28 ","pages":"Article 100438"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145680825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin, a bioactive supplement for premenstrual syndrome and dysmenorrhea: A systematic review of randomised clinical trials","authors":"Oadi N. Shrateh ,&nbsp;Areesha Jawed ,&nbsp;Muhammad Hamza Shuja ,&nbsp;Kanwal Ashok Kumar ,&nbsp;Syeda Tayyaba Rehan ,&nbsp;Sondos Abdelrhman ,&nbsp;Mashhour Naasan ,&nbsp;Nor Azlia Abdul Wahab","doi":"10.1016/j.eurox.2025.100432","DOIUrl":"10.1016/j.eurox.2025.100432","url":null,"abstract":"<div><h3>Introduction</h3><div>The anti-inflammatory nature of curcumin suggests its potential to modulate the body's inflammatory processes, offering a novel avenue for mitigating heightened inflammatory responses often observed in conditions like PMS and dysmenorrhea.</div></div><div><h3>Methods</h3><div>MEDLINE, Cochrane Central, ScienceDirect, Web of Science, CINAHL, ClinicalTrials.gov, and Google Scholar from their inception to November 12, 2023. The review was conducted according to the Cochrane Handbook for Systematic Reviews of Interventions. The outcomes of interest encompassed evaluating the severity of PMS symptoms and dysmenorrhea, including physical symptoms, behavioral symptoms, mood symptoms. Additionally, the study focused on assessing inflammatory biomarkers, Iron profile and Vitamin D status as other outcomes.</div></div><div><h3>Results</h3><div>Ten randomized controlled trials have evaluated the effectiveness of curcumin in reducing premenstrual syndrome and dysmenorrhea symptoms in women. These studies used various scales such as the Premenstrual Syndrome Screening Tool (PSST) and visual analog scale. Out of ten trials, six of them reported a significant decrease in PMS and dysmenorrhea symptoms. Additionally, six studies evaluated curcumin's association with inflammatory markers, hematological parameters, iron profile, Vitamin D, and sleep patterns. This demonstrated significant association between curcumin and inflammatory markers (nitric oxide metabolites, BDNF, IgE, Il-10, IL-12, hs-CRP), and vitamin D status.</div></div><div><h3>Conclusion</h3><div>The findings of this systematic review suggest that curcumin holds promise in the management of PMS and dysmenorrhea. However, further research is needed to establish optimal dosages and treatment durations, considering potential interactions with iron metabolism. The results encourage the exploration of curcumin as a complementary approach in enhancing the overall well-being of individuals affected by these menstrual conditions.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"28 ","pages":"Article 100432"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of curcumin capsule on the severity and duration of primary dysmenorrhea among students: A triple-blind randomized controlled trial in the West of Iran","authors":"Sara Abdoli ,&nbsp;Salman Khazaei ,&nbsp;Maryam Mehrpooya ,&nbsp;Farideh kazemi ,&nbsp;Ensiyeh jenabi ,&nbsp;Reyhane Yazdaniroshan","doi":"10.1016/j.eurox.2025.100427","DOIUrl":"10.1016/j.eurox.2025.100427","url":null,"abstract":"<div><h3>Background</h3><div>The present study was conducted to evaluate the efficacy of curcumin capsules on the severity and duration of primary dysmenorrhea.</div></div><div><h3>Methods</h3><div>A randomized controlled trial conducted among female students at Hamadan University of Medical Sciences who met predetermined inclusion criteria in 2024 at 34 participants per group. In the intervention group, participants received curcumin capsules containing 500 mg of curcumin. These capsules were ingested once daily over the course of two menstrual cycles. The control group was administered placebo capsules, which contained 500 mg of starch, with the method of administration mirroring that of the intervention group. Data collection tools were including demographic characteristics questionnaire, visual pain ruler, pain duration and multidimensional verbal scale.</div></div><div><h3>Results</h3><div>after the intervention, a significant difference emerged (P &lt; 0.001). In the intervention group, dysmenorrhea severity decreased significantly from a mean of 6.5–4.53 in the first menstrual cycle and further reduced to 3.44 in the second cycle. In contrast, the control group showed no significant change. The intervention group's improvement was consistent across both cycles, highlighting the effectiveness of the intervention in reducing dysmenorrhea severity (P &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>curcumin capsules can be used as an effective and low-risk complementary treatment for reducing the severity and duration of primary dysmenorrhea.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"28 ","pages":"Article 100427"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of postoperative outcomes following hysterectomy versus sacrocolpopexy: Insights from global federated health research network","authors":"Muhammed A.M. Hammad,&nbsp;MacKinnly T. Knoerzer,&nbsp;Gamal M. Ghoniem","doi":"10.1016/j.eurox.2025.100433","DOIUrl":"10.1016/j.eurox.2025.100433","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the risk of opioid use, antimicrobial utilization, and postoperative complications, including paralytic ileus, between patients undergoing abdominal hysterectomy and sacrocolpopexy.</div></div><div><h3>Methods</h3><div>Using a global federated health research network, we performed a retrospective cohort analysis. After 1:1 propensity score matching for age, BMI, race, ethnicity, diabetes, and hypertension, 993 patients were included per group. Kaplan-Meier survival analysis assessed antimicrobial and opioid use, resistance, and opioid abuse or dependence.</div></div><div><h3>Results</h3><div>Mean follow-up was significantly longer in the sacrocolpopexy group (7.67 ± 4.66 years) than in the hysterectomy group (3.13 ± 4.23 years). Hysterectomy patients experienced a higher mean number of postoperative complications although these results were not statistically significant (p = 0.0688). Postoperative antimicrobial use was significantly higher in the hysterectomy group (25.9 %) than sacrocolpopexy (14.1 %) (HR 3.84, 95 % CI: 2.99–4.93; p &lt; 0.0001). Opioid use was also more frequent in hysterectomy patients (44.4 % vs. 15.6 %; HR 5.68, 95 % CI: 4.69–6.88; p &lt; 0.0001), with a higher incidence of abuse/dependence (6.04 % vs. 2.02 %; HR 6.91, 95 % CI: 4.07–11.73). No significant difference was observed in antimicrobial resistance (p = 0.4409). Paralytic ileus was rare and not significantly different between groups.</div></div><div><h3>Conclusion</h3><div>Hysterectomy was associated with greater risk of postoperative opioid use, opioid abuse/dependence, and antimicrobial use. These findings support individualized surgical planning and proactive postoperative management.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"28 ","pages":"Article 100433"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Guidance Paper VVOG: Pharmacological treatment of endometriosis-related pain","authors":"Ellen Remans ,&nbsp;Celine Bafort ,&nbsp;Celine Blank ,&nbsp;Alex Bongima ,&nbsp;Brecht Geysenbergh ,&nbsp;Tjalina Hamerlynck ,&nbsp;Geert Page ,&nbsp;Jasper Verguts ,&nbsp;Carla Tomassetti","doi":"10.1016/j.eurox.2025.100403","DOIUrl":"10.1016/j.eurox.2025.100403","url":null,"abstract":"","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"27 ","pages":"Article 100403"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of clinical usability and reproducibility of the American Society for Reproductive Medicine Müllerian Anomalies Classification","authors":"Julia Lastinger ,&nbsp;Natalia Palasz ,&nbsp;Peter Oppelt ,&nbsp;Galymzhan Toktarbekov ,&nbsp;Milan Terzic ,&nbsp;Raimund Stein ,&nbsp;Katharina Rall ,&nbsp;Helga Wagner ,&nbsp;Philipp Hermann ,&nbsp;Stephanie Kiblboeck","doi":"10.1016/j.eurox.2025.100425","DOIUrl":"10.1016/j.eurox.2025.100425","url":null,"abstract":"<div><h3>Objective</h3><div>To study the usability, reproducibility and practicality of the revised American Society for Reproductive Medicine Müllerian Anomalies Classification (ASRM MAC2021) compared to the formerly used American Fertility Society (AFS) classification. The main focus of this paper is to present clinicians’ assessment when using these classification systems and to explore possible benefits and disadvantages of the transformation of the AFS into the more recently published ASRM classification. To incorporate all commonly used classification systems, all cases were additionally classified using the ESHRE/ESGE and the VCUAM classification.</div></div><div><h3>Methods</h3><div>An observational study using a questionnaire and opinion survey was conducted with the goal of comparing clinicians’ subjective usability and reproducibility of the AFS classification with the newly presented ASRM MAC2021 classification. Cases of female genital malformations encompassed a wide range of various anomalies, including vaginal, cervical and adnexal conditions and associated malformations.</div></div><div><h3>Results</h3><div>The study investigators rated the ASRM MAC2021 classification better in relation to usability and reproducibility compared to the AFS classification. It significantly improved diagnostic precision for vaginal and cervical anomalies and expanded recognition of adnexal malformations. However, challenges remain in addressing associated malformations. Clinicians ranked the ASRM MAC2021 higher than the AFS classification. However, investigators rated the ESHRE/ESGE and VCUAM classifications better in the overall assessment of female genital malformations.</div></div><div><h3>Conclusion</h3><div>The ASRM MAC2021 classification offers substantial improvements in diagnosing and managing female genital malformations, addressing limitations of the AFS system. With better usability and subjective reproducibility, further refinements are needed to fully address complex associated anomalies — emphasizing the importance of evolving classification systems.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"27 ","pages":"Article 100425"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}