Nanotheranostics最新文献

{"title":"The development of a milk-derived nanovesicle with its potentials for nucleic acid delivery and bioconjugation.","authors":"Bhanubhong Prommalee, Chalermchai Pilapong","doi":"10.7150/ntno.113165","DOIUrl":"10.7150/ntno.113165","url":null,"abstract":"<p><p>To date, nanotechnology facilitating cellular penetration toward specific target sites has widely been adopted in several studies. Some use chemical synthetic approaches for enhancing drug delivery whereas some attempt to select bioresources. Biomaterial substances that are thought to be less toxic to cells are currently in demand since they have been proven to demonstrate drug delivering capability. We thus explored the production of a nanovesicle from bioresource that is supposed to be one of the potential carriers facilitating target delivery. Herein, a breast milk-derived substance was used as a bioresource for producing the milk-derived nanovesicle. The results showed that a small, spherical and negatively charged nanovesicle was successfully prepared by using an extrusion method without the use of any chemical substances and solvents. The nanovesicle showed satisfactory profiles in terms of cytotoxicity without any sustained secretion of cytokines. The nanovesicle also provided delivering potential towards different nucleic acids including single strand DNA, microRNA, and mRNA. Moreover, the nanovesicle was also shown to have bioconjugation capability. These outcomes illustrate the benefits of using breast milk as one of the most vigorous biomaterial substances that can be adopted into a nanovesicle-based drug delivery strategy.</p>","PeriodicalId":36934,"journal":{"name":"Nanotheranostics","volume":"9 3","pages":"280-288"},"PeriodicalIF":0.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-Derived Natural Product-Based Nanoformulations for Healthcare Application.","authors":"Saloni Kakkar, Rajan K Jha, Deeksha Hattila, Abhishek Kumar Singh, Pradeep K Shukla, Shiv Pratap Singh Yadav, Avtar S Meena","doi":"10.7150/ntno.113606","DOIUrl":"10.7150/ntno.113606","url":null,"abstract":"<p><p>Plants produce numerous natural compounds developed into commercial products. These compounds offer medicinal benefits for treating diseases like diabetes, neurological disorders, malaria, and cancer. They also serve as hepatoprotective agents and immunomodulators. These natural products are secondary metabolites that plants produce for their defense and adaptation. Recently, numerous reports have highlighted the effectiveness of natural products in different diseases. However, comprehensive analysis of plant-based products currently used in the clinical setting for various human diseases is insufficient. This review provides extensive information about the application of natural plant products in both clinical and preclinical settings. It highlights their role in developing drugs for human diseases. Additionally, these plant products could serve as diagnostic tools for various diseases. Plant-derived natural products, integrated with advanced nanotechnology-based approaches, could enhance healthcare monitoring without compromising treatment efficacy. Nanotechnology techniques employing both diagnostics and therapeutics, known as nanotheranostics, utilize engineered biocompatible nanomaterials with potential prospects for healthcare management. Nanomaterials like polymeric nanoparticles and liposomes offer diagnostic value by enabling real-time imaging of disease progression and treatment response. Functionalized with contrast agents or dyes, they enhance MRI, CT, PET, and fluorescence imaging, improving diagnosis, patient stratification, and monitoring of drug delivery and efficacy. With the increasing demand for natural dietary supplements, this issue encompasses the identification of various plant-based natural products as potential nanotheranostics with promising potential for chronic disorders such as cancer, neurological pathologies, diabetes, and immunological issues. This review focuses on applications of nanotheranostics utilizing natural products in biomedical applications, outlining the current breakthroughs, supplemented with future potentialities.</p>","PeriodicalId":36934,"journal":{"name":"Nanotheranostics","volume":"9 3","pages":"262-279"},"PeriodicalIF":0.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in SERS: Revolutionizing Biomedical Analysis and Applications.","authors":"Panangattukara Prabhakaran Praveen Kumar, Shivanjali Saxena, Rakesh Joshi","doi":"10.7150/ntno.106396","DOIUrl":"10.7150/ntno.106396","url":null,"abstract":"<p><p>Surface-enhanced Raman scattering (SERS) has emerged as a powerful technique for bioanalysis, offering ultrasensitive molecular detection and identification capabilities. The signal intensity and reproducibility of Raman responses from analytes are primarily influenced by the surface roughness and nanogap architecture of plasmonic materials. Numerous designs, plasmonic nanostructures, and fabrication methods have been explored to optimize these factors. The precise nanogap ranging from 0.5 to 1.0 nm between the metallic nanoparticles and analytes offers significantly higher Raman enhancement, enabling single-molecule detection through SERS. With advancements in nano- and microfabrication techniques, the development of highly efficient SERS substrates has significantly enhanced the analytical performance in various biomedical applications. This review comprehensively examines the latest innovations in nano- and microfabricated SERS sensors, emphasizing their design, fabrication techniques, and functionalization strategies for biomolecular detection, bioimaging, and theranostic applications. Furthermore, we explore the growing role of artificial intelligence (AI) in optimizing SERS-based bioanalysis, from enhancing spectral data processing to developing machine learning models for pattern recognition and diagnostic applications. The integration of AI with SERS technologies holds great promise for revolutionizing point-of-care diagnostics, real-time biomarker monitoring, and personalized medicine.</p>","PeriodicalId":36934,"journal":{"name":"Nanotheranostics","volume":"9 3","pages":"216-261"},"PeriodicalIF":0.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined physical and biological contributions to radiotherapy enhancement by Lu-based nanoscintillators in pancreatic cancer models.","authors":"Sarah Stelse-Masson, Xenie Lytvynenko, Kristel Bedregal-Portugal, Clémentine Aubrun, Matéo Lavaud, Malika Kadri, Thibault Jacquet, Christine Moriscot, Benoit Gallet, Benoit Chovelon, Jean-Luc Coll, Jean-Luc Ravanat, Eva Mihóková, Václav Čuba, Hélène Elleaume, Anne-Laure Bulin","doi":"10.7150/ntno.115120","DOIUrl":"10.7150/ntno.115120","url":null,"abstract":"<p><p><b><i>Rationale:</i></b> Pancreatic cancer has a dismal prognosis and requires better treatments. One promising approach aims at improving radiotherapy using nanoscintillators, which down-convert ionizing radiation into visible light, triggering various radiotherapeutic effects upon X-ray irradiation. One such effect is radiation dose-enhancement, driven by high-Z elements present in the nanoscintillator core. These elements efficiently absorb X-rays, releasing secondary electrons that amplify the radiation dose in the surrounding tissue. <b><i>Methods:</i></b> In this paper, we study the ability of Lu₃Al₅O₁₂:Pr@SiO₂, a lutetium-based nanoscintillator, to exert a radiation dose-enhancement effect in two human pancreatic cancer cell models, namely PANC-1 and MIA PaCa-2. <b><i>Results:</i></b> Lu₃Al₅O₁₂:Pr@SiO₂ nanoparticles showed negligible toxicity up to 1 mg/mL in 2D and 3D models. Using monochromatic synchrotron radiation, we demonstrated that a subtoxic nanoparticle concentration enhances the radiation dose in 3D spheroids in an energy-dependent manner. These results were further supported by Monte Carlo simulations. Beyond this physical contribution, γ-H2AX foci quantification revealed a biological component to the radiosensitization: Lu₃Al₅O₁₂:Pr@SiO₂ nanoparticles not only amplified initial DNA damage, but also impaired its repair. <b><i>Conclusion:</i></b> These findings highlight the dual contribution of Lu₃Al₅O₁₂:Pr@SiO₂ nanoparticles to radiotherapy enhancement, combining both physical dose-enhancement and biological modulation of DNA repair.</p>","PeriodicalId":36934,"journal":{"name":"Nanotheranostics","volume":"9 3","pages":"199-215"},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doxorubicin-NFL-TBS.40-63 peptide Gold Complex Nanovector (DOX IN-NFL@AuNPs): Efficacy Evaluation in a mouse transplantation tumor model induced by PANC-1/ADR human pancreatic cancer resistant strain cells.","authors":"Hui Liu, Qiqian Liu, Xiaowu Li, Abdelkader Boucetta, Joel Eyer, Jolanda Spadavecchia","doi":"10.7150/ntno.109280","DOIUrl":"10.7150/ntno.109280","url":null,"abstract":"<p><p>The key role of the NFL-TBS.40-63 peptide (BIOT-NFL) is to target and destroy glioma cancer cells. Recently we have performed a novel peptide-hybrid-gold nanovector (BIOT-NFL-PEG-AuNPs) capable to destroy microtubule network of pancreatic cancer cells (PDAC) exhibiting a decrease of tumor index with a real anti-angiogenic effect. In order to improve the scientific background of our study, we conceived a chemotherapeutic hybrid nanovector based on gold-doxorubicin (DOX) functionalized with the NFL-TBS.40-63 peptide (BIOT-NFL) as a promising therapeutic in PDAC cancer. Mouse transplantation tumor model induced by PANC-1/ADR human pancreatic cancer resistant strain cells, was used to evaluated the therapeutic efficacy of DOX IN-NFL@AuNPs as chemotherapeutic nano-drug. Our results indicate that DOX IN-NFL@AuNPs have a great impact on the decrease of the tumor growth and decreased the tumor index with a relevant effect on cytokines and ROS levels, thus confirming the impact of DOX IN-NFL@AuNPs to boost the immune system.</p>","PeriodicalId":36934,"journal":{"name":"Nanotheranostics","volume":"9 2","pages":"186-198"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Detection of Pancreatic Cancer Circulating Tumor Cells Using Biomarkers and Magnetic Particle Spectroscopy.","authors":"Ali Dinari, Hafiz Ashfaq Ahmad, Seungjun Oh, Yun-Hee Kim, Jungwon Yoon","doi":"10.7150/ntno.110074","DOIUrl":"10.7150/ntno.110074","url":null,"abstract":"<p><p><b>Background:</b> Pancreatic ductal adenocarcinoma (PDAC) typically develops without symptoms, and its aggressive progression combined with late-stage diagnosis underscores the critical need for improved early detection strategies. Circulating tumor cells (CTCs) in blood are potential biomarkers for PDAC. In this study, the detection of pancreatic cancer-associated CTCs was evaluated using two magnetic-based diagnostic systems in a comparative approach. <b>Methods:</b> Two distinct nanotheranostic platforms were developed: monoclonal antibody-conjugated magnetic nanoparticles (mAbs-MNPs) and magnetized exosomes (termed Magxosomes). Anti-mesothelin and anti-vimentin were used as monoclonal antibodies, while mesenchymal stem cells (MSCs) treated with MNPs served as the source of Magxosomes. Characterization of nano-systems was performed using dynamic light scattering (DLS), inductively coupled plasma mass spectrometry (ICP-MS), nanoparticle tracking analysis (NTA), and transmission electron microscopy (TEM). Blood samples were collected from pancreatic cancer mouse models, treated with nanotheranostic platforms, and analyzed using a homemade magnetic particle spectroscopy (MPS) device. <b>Results:</b> The detection of pancreatic cancer-associated CTCs was investigated using nanotheranostic platforms alongside an MPS instrument. In this context, the mAbs-MNPs systems demonstrated varying efficiencies in the diagnosis of CTCs, with Ant-V-MNPs (anti-vimentin conjugated MNPs) achieving 27.47%, Ant-M-MNPs (anti-mesothelin conjugated MNPs) at 13.59%, and a 50:50 mixture of Ant-M-MNPs: Ant-V-MNPs showing an efficiency of 19.73%. Conversely, the efficiencies of Magxosomes were notably higher. Bone marrow stem cell (BMSC)-derived Magxosomes achieved an average efficiency of 63.39%, while adipose-derived stem cell (ADSC)-derived Magxosomes exhibited an average efficiency of 56.23%. <b>Conclusions:</b> This study introduces a promising method for early pancreatic cancer diagnosis by detecting CTCs in blood. It employs a non-invasive, rapid test using an advanced MPS instrument (1 ng detection limit) and nanotheranostic platforms. Results confirm the system's robustness in identifying pancreatic cancer CTCs. This approach may support future developments in cancer diagnostics and monitoring.</p>","PeriodicalId":36934,"journal":{"name":"Nanotheranostics","volume":"9 2","pages":"171-185"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PACA nanoparticles target and deliver sildenafil to rejuvenate aged mouse liver sinusoidal endothelial cells.","authors":"Tetyana Voloshyna, Christopher Holte, Jakub Pospíšil, Karolina Szafranska, Ole Martin Fuskevåg, Sabina P Strand, Andreas K O Åslund, Yrr Mørch, Sofie Snipstad, Einar Sulheim, Nicholas J Hunt, Victoria C Cogger, David G Le Couteur, Erik Sveberg Dietrichs, Peter A G McCourt","doi":"10.7150/ntno.103000","DOIUrl":"10.7150/ntno.103000","url":null,"abstract":"<p><p>Ageing is established as the most significant risk factor for disease. About 75% of people over 75 years have diabetes or pre-diabetes and/or hyperlipidaemia which are established risk factors for cardiovascular outcomes, and risk factors for age-related conditions such as dementia, sarcopenia, frailty and osteoporosis. Age-related changes in the liver microcirculation, in particular relating to the cells lining the blood vessels, the liver sinusoidal endothelial cells (LSEC), are a potential cause for dyslipidaemia and insulin resistance in old age. There is also loss of LSEC mediated waste clearance functions essential for homeostasis. Finding ways to reverse these age-related changes in the LSEC will fill a significant gap in therapeutic options available for the treatment of ageing disorders. Such therapies may also benefit patients with fibrotic livers, since LSEC changes in this disease resemble those seen in the ageing LSEC in many aspects. Nanoparticles that access systemic circulation frequently accumulate in the liver. This could be utilized as a promising strategy for targeted drug delivery to the liver. The present study assessed if poly(alkyl-cyanoacrylate) nanoparticles (PACA NPs) are a suitable vector for the targeted transport of such therapeutics to LSEC, to reverse age-related changes such as fenestration/porosity loss. Mice were co-injected with PACA NPs and formaldehyde denatured serum albumin (FSA) and their livers were then examined by microscopy. PACA and FSA co-localised to LSEC, including at the sub-cellular level in endocytic vesicles. Isolated LSEC were challenged with Nile Red (NR668) labelled PACA NPs, which were rapidly internalized. HEK293 cells overexpressing stabilin-2 internalized PACA NPs, suggesting that stabilin-2 mediates PACA uptake on LSEC. Cultured LSEC from aged mice were challenged with PACA NPs containing sildenafil and examined with scanning electron microscopy to determine effects on fenestrations. Sildenafil PACA reversed age-related changes LSEC fenestration frequency and porosity at 3-fold lower sildenafil concentrations than sildenafil alone. If sildenafil PACA induces similar changes <i>in vivo</i>, age-related reduction of LSEC porosity could be reversed by the targeted delivery of sildenafil via PACA NPs.</p>","PeriodicalId":36934,"journal":{"name":"Nanotheranostics","volume":"9 2","pages":"155-170"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microemulsion Gels of Tapentadol Hydrochloride: Statistical Analysis of Pharmacokinetics and Skin Irritation Studies.","authors":"Nimmathota Madhavi, Naveen Kumar Ganji, Heera Battu, Beeravelli Sudhakar","doi":"10.7150/ntno.110819","DOIUrl":"10.7150/ntno.110819","url":null,"abstract":"<p><p><b>Background:</b> The present study aimed to overcome the drawbacks of tapentadol through the oral route and to assess the significance of microemulsion gels for transdermal delivery via pharmacokinetic approach. <b>Methods:</b> Microemulsions were prepared via a ternary phase diagram. The optimized microemulsion was converted into gels, and the microemulsion was evaluated for particle size, zeta potential and cumulative <i>in vitro</i> drug release, whereas the gel was characterized for viscosity, spreadability, <i>in vitro</i>, <i>ex vivo</i>, <i>in vivo</i> and skin irritation studies. The prepared ME-gel PKs were tested against MEs, oral solution and plain gel. <b>Results:</b> The PK study revealed that the half-life of the ME gel was 2.2-fold greater than that of the oral solution and 1.65-fold greater than that of the plain gel. The MRT of the ME gel was 6-fold greater than that of the oral solution and 3.3-fold greater than that of the plain gel. The overall mean value of the AUC (0-∞) was 3.16 times greater than that of the oral route. The skin irritation studies found that absence of irritation and damage after application of ME-gel. <b>Conclusion:</b> The PK study revealed that ME-gel was effective in pain management. The level A IVIVC between the <i>in vitro</i> fraction of drug released and the fraction of drug absorbed <i>in vivo</i> was 0.9731.</p>","PeriodicalId":36934,"journal":{"name":"Nanotheranostics","volume":"9 2","pages":"144-154"},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine.","authors":"Vinita Karumuru, Anupam Dhasmana, Narsimha Mamidi, Subhash C Chauhan, Murali M Yallapu","doi":"10.7150/ntno.110966","DOIUrl":"10.7150/ntno.110966","url":null,"abstract":"<p><p>Cancer remains a leading global health challenge, with high mortality rates persisting despite significant advancements in therapeutic interventions. Major obstacles, including systemic toxicity, therapy resistance, metastasis, and relapses, emphasize the urgent need for safer, more effective, and readily accessible treatment strategies. Among emerging alternatives, natural bioactive compounds have gained considerable attention because of their diverse therapeutic potential and lower toxicity profiles. Urolithin A (UA), a metabolite derived from ellagic acid through gut microbiota metabolism, has emerged as a compelling anticancer agent. UA has multiple mechanisms of action, including the regulation of autophagy, enhancement of mitochondrial function, and inhibition of tumor progression and metastatic pathways. Additionally, its chemo-, immuno-, and radio-sensitization properties further increase its therapeutic advantages. Nanotechnology-driven approaches, such as nanoparticle formulations, lipids, and powder formulations, have successfully increased the solubility, stability, bioavailability, precise targeted delivery to cancer tissues, and overall therapeutic benefits of these materials. This review comprehensively explores the anticancer mechanisms of UA, its modulatory role, and advances in nanoformulation strategies, highlighting its potential as a next-generation therapeutic agent for improved cancer treatment and prevention.</p>","PeriodicalId":36934,"journal":{"name":"Nanotheranostics","volume":"9 2","pages":"121-143"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomics for the Identification of Biomarkers in Kidney Diseases.","authors":"Swarnima Pandey","doi":"10.7150/ntno.108320","DOIUrl":"10.7150/ntno.108320","url":null,"abstract":"<p><p>With the apparent rise in lifestyle-related changes, there has been a significant decline in renal health. Metabolomics plays a crucial role in the prognosis, diagnosis, and treatment of various renal conditions, including chronic kidney disease, acute kidney injury, diabetic kidney disease, kidney cancer, and post-transplant complications. Metabolomics has identified novel biomarkers, providing insights into altered pathways and potential therapeutic targets for kidney diseases. Kidney diseases and metabolomics keywords were searched in correspondence with the assigned keywords, including chronic kidney diseases, acute kidney injury, kidney carcinoma, kidney transplant, and diabetic kidney diseases on literature search engines. The applicable studies from this search were extracted and included in the study. This review is focused on the biomarkers identified in different kidney diseases such as chronic kidney diseases, acute kidney injury, diabetic kidney disease, kidney carcinoma and kidney transplant.</p>","PeriodicalId":36934,"journal":{"name":"Nanotheranostics","volume":"9 2","pages":"110-120"},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}