Doxorubicin-NFL-TBS.40-63 peptide Gold Complex Nanovector (DOX IN-NFL@AuNPs): Efficacy Evaluation in a mouse transplantation tumor model induced by PANC-1/ADR human pancreatic cancer resistant strain cells.

Q1 Pharmacology, Toxicology and Pharmaceutics

Nanotheranostics Pub Date : 2025-06-19 eCollection Date: 2025-01-01 DOI:10.7150/ntno.109280

Hui Liu, Qiqian Liu, Xiaowu Li, Abdelkader Boucetta, Joel Eyer, Jolanda Spadavecchia

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Abstract

The key role of the NFL-TBS.40-63 peptide (BIOT-NFL) is to target and destroy glioma cancer cells. Recently we have performed a novel peptide-hybrid-gold nanovector (BIOT-NFL-PEG-AuNPs) capable to destroy microtubule network of pancreatic cancer cells (PDAC) exhibiting a decrease of tumor index with a real anti-angiogenic effect. In order to improve the scientific background of our study, we conceived a chemotherapeutic hybrid nanovector based on gold-doxorubicin (DOX) functionalized with the NFL-TBS.40-63 peptide (BIOT-NFL) as a promising therapeutic in PDAC cancer. Mouse transplantation tumor model induced by PANC-1/ADR human pancreatic cancer resistant strain cells, was used to evaluated the therapeutic efficacy of DOX IN-NFL@AuNPs as chemotherapeutic nano-drug. Our results indicate that DOX IN-NFL@AuNPs have a great impact on the decrease of the tumor growth and decreased the tumor index with a relevant effect on cytokines and ROS levels, thus confirming the impact of DOX IN-NFL@AuNPs to boost the immune system.

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Doxorubicin-NFL-TBS。40-63肽金复合物纳米载体（DOX IN-NFL@AuNPs）： PANC-1/ADR人胰腺癌耐药株诱导小鼠移植肿瘤模型的疗效评价

NFL-TBS的关键作用。40-63肽（BIOT-NFL）是一种靶向和破坏胶质瘤癌细胞的肽。最近，我们研究了一种新的肽-混合金纳米载体（BIOT-NFL-PEG-AuNPs），它能够破坏胰腺癌细胞（PDAC）的微管网络，显示出肿瘤指数的降低和真正的抗血管生成作用。为了提高我们研究的科学背景，我们设想了一种基于NFL-TBS功能化的金-阿霉素（DOX）的化疗混合纳米载体。40-63肽（BIOT-NFL）作为一种有前景的治疗PDAC癌症的药物。采用PANC-1/ADR人胰腺癌耐药株诱导小鼠移植肿瘤模型，评价DOX IN-NFL@AuNPs作为纳米化疗药物的治疗效果。我们的研究结果表明，DOX IN-NFL@AuNPs对肿瘤生长的抑制和肿瘤指数的降低有很大的影响，并对细胞因子和ROS水平有相关影响，从而证实了DOX IN-NFL@AuNPs对免疫系统的增强作用。

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