Medicina Clinica Practica最新文献

Neumonitis inducida por ibrutinib 伊布鲁替尼引起的肺炎

Medicina Clinica Practica Pub Date : 2025-09-25 DOI: 10.1016/j.mcpsp.2025.100518

Carmen Gil Barroso, Juan Nicolás Rodríguez Rodríguez

引用次数: 0

The impact of sevelamer in aluminum phosphide poisoning: a preliminary study on mortality sevelamer对磷化铝中毒的影响：对死亡率的初步研究

Medicina Clinica Practica Pub Date : 2025-09-23 DOI: 10.1016/j.mcpsp.2025.100520

Kiandokht Khorshidi , Maral Ramezani , Mitra Rahimi , Shahin Shadnia , Babak Mostafazadeh , Peyman Erfan Talab Evini

{"title":"The impact of sevelamer in aluminum phosphide poisoning: a preliminary study on mortality","authors":"Kiandokht Khorshidi , Maral Ramezani , Mitra Rahimi , Shahin Shadnia , Babak Mostafazadeh , Peyman Erfan Talab Evini","doi":"10.1016/j.mcpsp.2025.100520","DOIUrl":"10.1016/j.mcpsp.2025.100520","url":null,"abstract":"<div><h3>Background</h3><div>Aluminum phosphide (ALP) poisoning, commonly referred to as rice tablet poisoning, is among the deadliest forms of poisoning. Treatment for aluminum phosphide poisoning is limited to supportive care, as no specific antidote is currently available. Sevelamer is being repurposed as an antidote for phosphine gas poisoning. This study seeks to assess the impact of sevelamer treatment on patients’ outcomes and overall prognosis.</div></div><div><h3>Method</h3><div>This single-blind trial was conducted on patients suffering from aluminum phosphide poisoning (Oct 2023–Dec 2024). Participants were split into two groups: the control group received standard treatment, while the intervention group received standard treatment plus 2.4 g sevelamer carbonate initially, followed by 800 mg tablets every 8 hours. Data were collected using a study-specific checklist covering demographics, clinical symptoms, lab findings, patient outcomes, hospital stay duration, disease history, and secondary complications.</div></div><div><h3>Results</h3><div>The control group comprised 19 males (63.3%) and 11 females (36.7%). The sevelamer group, 26 males (81.25%) and 6 females (18.75%). This study demonstrated that sevelamer decreased mortality rates (56.25% compared to 86.7%) and enhanced ejection fraction (from 35.8% to 47.5% post-treatment). On the first day, it significantly raised blood PH (7.13 vs 7.23) and PO2 levels (34 vs 53.67).</div></div><div><h3>Conclusion</h3><div>This study suggests that sevelamer may serve as an effective antidote for treating aluminum phosphide poisoning. Further research is necessary to confirm its efficacy, determine optimal dosing strategies, and assess potential side effects in clinical settings.</div></div>","PeriodicalId":36921,"journal":{"name":"Medicina Clinica Practica","volume":"8 4","pages":"Article 100520"},"PeriodicalIF":0.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exantema y mucositis inducida por mycoplasma pneumonia (MIRM): presentación de un caso y revisión de la literatura 肺炎支原体（MIRM）引起的皮疹和粘膜炎：案例介绍和文献综述

Medicina Clinica Practica Pub Date : 2025-09-23 DOI: 10.1016/j.mcpsp.2025.100521

Christian Alberto Vargas Machuca-Carranza, Luis Ángel Rodríguez-Chávez, Melissa Ysabel Romero-Diaz, José Miguel Sáenz Lázaro, Víctor Alexander Lozano Araujo, José Guillermo Cabanillas López

引用次数: 0

Tumor de colisión pancreático entre adenocarcinoma bien diferenciado y carcinoma indiferenciado de células gigantes tipo osteoclasto: descripción de un caso y revisión de la literatura 分化良好的腺癌和未分化的巨细胞型骨裂体之间的胰腺碰撞肿瘤：病例描述和文献综述

Medicina Clinica Practica Pub Date : 2025-09-12 DOI: 10.1016/j.mcpsp.2025.100517

Pablo del Val-Ruiz, Beatriz Carrasco-Aguilera, Laura Castro-Diez, Pablo Granero-Castro

引用次数: 0

Estimulación en el área de la rama izquierda del haz de His mediante acceso venoso derecho en un paciente con persistencia de vena cava superior izquierda 左上腔静脉持续性患者右静脉通路刺激His束左支区

Medicina Clinica Practica Pub Date : 2025-09-02 DOI: 10.1016/j.mcpsp.2025.100514

Christopher Torres-Bogarín , Carlos de la Fuente Macip , Juan Carlos Pérez-Alva

引用次数: 0

The outcome of complete coronary artery surgical revascularization on left ventricular function 完全冠状动脉手术重建术对左心室功能的影响

Medicina Clinica Practica Pub Date : 2025-07-28 DOI: 10.1016/j.mcpsp.2025.100515

Zaid Mohammed Abdulwahhab Al-Noori , Laith Saleh Al-Kaaby , Heba Khaled Hatem

{"title":"The outcome of complete coronary artery surgical revascularization on left ventricular function","authors":"Zaid Mohammed Abdulwahhab Al-Noori , Laith Saleh Al-Kaaby , Heba Khaled Hatem","doi":"10.1016/j.mcpsp.2025.100515","DOIUrl":"10.1016/j.mcpsp.2025.100515","url":null,"abstract":"<div><div>Coronary artery disease (CAD) is the leading cause of myocardial ischemia, contributing significantly to global cardiovascular mortality. Coronary artery bypass grafting (CABG) remains a cornerstone in the management of multivessel CAD.</div><div>Our objective was to evaluate the effects of complete coronary artery surgical revascularization on left ventricular function in patients with ischemic heart disease.</div><div>This prospective cross-sectional study was conducted at the Iraqi Center for Cardiac Diseases, Baghdad, from July to December 2019. Fifty patients who underwent CABG were included. Preoperative, early postoperative (2 weeks), and late postoperative (1 year) echocardiographic evaluations were performed. Echocardiographic data were obtained using the biplane modified Simpson’s method. Variables analyzed included left ventricular ejection fraction (LVEF), left ventricular internal diameters, and wall thicknesses.</div><div>No significant changes in LVEF or ventricular dimensions were observed within two weeks post-surgery. However, at one-year follow-up, patients with preoperative EF <50% (n=15) demonstrated a 10% increase in LVEF. Mild changes in left atrial diameter, septal wall thickness, and ventricular dimensions were also observed.</div><div>In conclusion, Patients with impaired preoperative systolic function showed significant improvement in LVEF following complete surgical revascularization. The absence of preoperative myocardial viability assessment and incomplete adherence to guideline-directed therapy were noted limitations.</div></div>","PeriodicalId":36921,"journal":{"name":"Medicina Clinica Practica","volume":"8 4","pages":"Article 100515"},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Valoración de la importancia de la confidencialidad y del manejo adecuado de la historia clínica en el servicio de urgencias hospitalarias 评估医院急诊部门保密和妥善管理病史的重要性

Medicina Clinica Practica Pub Date : 2025-07-15 DOI: 10.1016/j.mcpsp.2025.100510

Amparo Ruiz Carbonell , Florencia Laffont Oscoz , Begoña Navarro Lluesma , Alexander Sammel , Ginés Gómez Úbeda , Miguel Ángel García García

{"title":"Valoración de la importancia de la confidencialidad y del manejo adecuado de la historia clínica en el servicio de urgencias hospitalarias","authors":"Amparo Ruiz Carbonell , Florencia Laffont Oscoz , Begoña Navarro Lluesma , Alexander Sammel , Ginés Gómez Úbeda , Miguel Ángel García García","doi":"10.1016/j.mcpsp.2025.100510","DOIUrl":"10.1016/j.mcpsp.2025.100510","url":null,"abstract":"<div><h3>Objective</h3><div>Healthcare professionals sometimes forget their obligations regarding professional secrecy and confidentiality. Violating them is punishable by law. We carried out a study to evaluate the degree of knowledge about the use of secrecy and confidentiality of patients' medical information in the care practice of the professionals of the Hospital Emergency Service of a second level hospital.</div></div><div><h3>Methods</h3><div>An anonymous survey was designed with questions about daily activity in the Emergency Department related to confidentiality. They tried to evaluate, by all the professional groups involved in the care of patients in the Emergency Department, 4 aspects: the degree of workers' perception of confidentiality; knowledge in confidentiality and the desire to obtain that knowledge; the perception of unauthorized exchange or search for information; and the perception of physical means to safeguard privacy. The statistical tests chi-square, t-Student and ANOVA were used, with a level of statistical significance of <em>p</em> < 0.05.</div></div><div><h3>Results</h3><div>100 workers from all professional groups responded to the survey. Knowledge of confidentiality was adequate (69.25% of positive responses), and the perception of unauthorized information exchange and physical means to safeguard privacy were less good (55 and 55.9% of positive responses).</div></div><div><h3>Conclusions</h3><div>The management of confidentiality in the emergency department of our hospital has a large room for improvement.</div></div>","PeriodicalId":36921,"journal":{"name":"Medicina Clinica Practica","volume":"8 4","pages":"Article 100510"},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of mortality in individuals infected with dengue: An Indian case study 登革热感染个体死亡率的预测因素：一个印度案例研究

Medicina Clinica Practica Pub Date : 2025-06-20 DOI: 10.1016/j.mcpsp.2025.100511

Parthraj Shenoy, Ashok Kumar Pannu, Atul Saroch, Sourabh S. Sharda, Mandeep Bhatia, Deba Parsad Dhibar

{"title":"Predictors of mortality in individuals infected with dengue: An Indian case study","authors":"Parthraj Shenoy, Ashok Kumar Pannu, Atul Saroch, Sourabh S. Sharda, Mandeep Bhatia, Deba Parsad Dhibar","doi":"10.1016/j.mcpsp.2025.100511","DOIUrl":"10.1016/j.mcpsp.2025.100511","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Dengue infection and its associated complication contributes to a significant number of deaths as per World Health Organization (WHO) statistics. The aim of the study is to identify Predictors associated with mortality in Dengue infection.</div></div><div><h3>Materials and methods</h3><div>In this prospective observational study conducted at the tertiary care hospitals of north India from August 2023 to December 2024, confirmed cases of dengue fever with a duration of less than seven days were recruited. Patients classified into Survivors or non-survivors, variables that were found to have statistically significant associations on univariate analysis were subjected to multivariate analysis by logistic regression by enter method for predictors of dengue mortality.</div></div><div><h3>Results</h3><div>A total of 158 dengue patients were recruited of which 18 (11.4%) died from the disease. Altered mental status, dyspnea at rest, and decreased urine output were significantly more frequent among non-survivors. Regarding laboratory parameters, non-survivor group exhibited significantly elevated levels of total leukocyte count, urea, creatinine, liver enzymes and International normalized ratio. Application of logistic regression using 3 factors-qSOFA (quick sequential organ failure assessment), creatinine and ferritin were performed which showed a statistically significant association with creatinine and ferritin. Odd Ratio (OR) for creatinine 1.449 indicates that for every unit increase in creatinine, the odds of mortality increase by 44.9%. Although the OR is exactly 1, the tight CI around 1 suggests that elevated ferritin is associated with mortality, but with a small effect size (p – 0.047).</div></div><div><h3>Conclusions</h3><div>The presence of raised creatinine and elevated serum ferritin were predictors associated with a higher risk of mortality.</div></div>","PeriodicalId":36921,"journal":{"name":"Medicina Clinica Practica","volume":"8 3","pages":"Article 100511"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary embolism presenting with syncope, complicated by fatal delayed acute subdural hemorrhage 肺栓塞表现为晕厥，并发致命的迟发性急性硬膜下出血

Medicina Clinica Practica Pub Date : 2025-06-18 DOI: 10.1016/j.mcpsp.2025.100512

Guo Li , Mingming Yang , Bo Cheng , Peng Wang

引用次数: 0

Linfangiectasia intestinal primaria y síndrome de uñas amarillas 原发性肠道淋巴管扩张和黄指甲综合征

Medicina Clinica Practica Pub Date : 2025-06-02 DOI: 10.1016/j.mcpsp.2025.100509

Laura López Allúe , Alejandra Romano Medina , Estibaliz Obregón Martínez , María de África Juárez Martin

引用次数: 0