Lúcia Ribeiro-Dias , Joana Fernandes , António Braga , Tatiana Vieira , António Madureira , Vencelau Hespanhol , Isabel Coimbra , José Artur Paiva , Lurdes Santos , André Silva-Pinto
{"title":"Long-Term Sequelae of severe COVID-19: Outpatient assessment of radiological and pulmonary function tests","authors":"Lúcia Ribeiro-Dias , Joana Fernandes , António Braga , Tatiana Vieira , António Madureira , Vencelau Hespanhol , Isabel Coimbra , José Artur Paiva , Lurdes Santos , André Silva-Pinto","doi":"10.1016/j.mcpsp.2023.100373","DOIUrl":"10.1016/j.mcpsp.2023.100373","url":null,"abstract":"<div><h3>Objective</h3><p>Identify lung sequelae of COVID-19 through radiological and pulmonary function assessment.</p></div><div><h3>Design</h3><p>Prospective, longitudinal, cohort study from March 2020 to March 2021.</p></div><div><h3>Setting</h3><p>Intensive Care Units (ICU) in a tertiary hospital in Portugal.</p></div><div><h3>Patients</h3><p>254 patients with COVID-19 admitted to ICU due to respiratory illness.</p></div><div><h3>Interventions</h3><p>A chest computed tomography (CT) scan and pulmonary function tests (PFT) were performed at 3 to 6 months.</p></div><div><h3>Main variables of interest</h3><p>CT-scan; PFT; decreased diffusion capacity of carbon monoxide (DLCO).</p></div><div><h3>Results</h3><p>All CT scans revealed improvement in the follow-up, with 72% of patients still showing abnormalities, 58% with ground glass opacities and 62% with evidence of fibrosis. PFT had abnormalities in 94 patients (46%): thirteen patients (7%) had an obstructive pattern, 35 (18%) had a restrictive pattern, and 58 (30%) had decreased DLCO. There was a statistically significant association between abnormalities in the follow-up CT scan and older age, more extended hospital and ICU stay, higher SAPS II and APACHE scores and invasive ventilation. Mechanical ventilation, especially with no lung protective parameters, was associated with abnormalities in PFT. Multivariate regression showed more abnormalities in lung function with more extended ICU hospitalization, chronic obstructive pulmonary disease (COPD), chronic kidney disease, invasive mechanical ventilation, and ventilation with higher plateau pressure, and more abnormalities in CT-scan with older age, more extended ICU stay, organ solid transplants and ventilation with higher positive end-expiratory pressure (PEEP).</p></div><div><h3>Conclusions</h3><p>Most patients with severe COVID-19 still exhibit abnormalities in CT scans or lung function tests three to six months after discharge.</p></div>","PeriodicalId":36921,"journal":{"name":"Medicina Clinica Practica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45458408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Renal artery stenosis in a single kidney patient: A case report","authors":"Zahra Poshtchaman, Farzaneh Futuhi, Zohreh Sarchahi, Alemeh Dehnabi","doi":"10.1016/j.mcpsp.2022.100362","DOIUrl":"https://doi.org/10.1016/j.mcpsp.2022.100362","url":null,"abstract":"","PeriodicalId":36921,"journal":{"name":"Medicina Clinica Practica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54780160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inestabilidad de la marcha como forma de presentación de la tuberculosis diseminada","authors":"Julián Tejero Cobos, Cristián Hernández Pérez, Javier Medina Almazán, Sergio Tizón González","doi":"10.1016/j.mcpsp.2023.100394","DOIUrl":"10.1016/j.mcpsp.2023.100394","url":null,"abstract":"","PeriodicalId":36921,"journal":{"name":"Medicina Clinica Practica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46834484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of three prognostic and predictive scores in 10 patients with COVID-19 pneumonia caused by nosocomial infection","authors":"Yu Kijima , Tomokazu Shimizu , Hiroshi Toma , Shoichi Iida , Masashi Inui , Toshio Takagi","doi":"10.1016/j.mcpsp.2023.100376","DOIUrl":"10.1016/j.mcpsp.2023.100376","url":null,"abstract":"<div><h3>Introduction</h3><p>A nosocomial outbreak of coronavirus disease (COVID-19) occurred in the Toda Chuo General Hospital in Toda City, Saitama Prefecture, Japan in December 2020. The purpose of this study was to compare the accuracy of three prognostic indices for predicting the outcome of COVID-19 in patents with COVID-19 pneumonia.</p></div><div><h3>Patients and methods</h3><p>Patients in the Department of Urology and Transplant Surgery at Toda Chuo General Hospital with nosocomially acquired COVID-19 confirmed by a positive polymerase chain reaction test were included in the study. We used the COVID-GRAM, International Severe Acute Respiratory and Emerging Infections Consortium’s World Health Organization 4C Mortality Score, and COVID-19 Registry Japan to independently predict the prognoses of 10 patients and identify common prognostic factors. All three indices include age, dyspnea, and comorbidities as prognostic factors.</p></div><div><h3>Results</h3><p>Ten patients were included in the study, of which two patients died. According to the COVID-GRAM both patients were “high risk,” whereas the 4C Mortality Score predicted “high risk” and “very high risk.”</p></div><div><h3>Conclusion</h3><p>The prognostic scores of all three indices were useful for predicting illness severity.</p></div>","PeriodicalId":36921,"journal":{"name":"Medicina Clinica Practica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41844090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A survey of demographic properties of patients who died in intensive care units and their association with the death hour","authors":"Siamak Soltani , Azadeh Memarian , Kamran Aghakhani , Leyla Abdolkarimi , Mehran Kouchek","doi":"10.1016/j.mcpsp.2023.100379","DOIUrl":"10.1016/j.mcpsp.2023.100379","url":null,"abstract":"<div><h3>Introduction</h3><p>Poor sleep hygiene and the hour of changing shifts are among the most important factors which affect the quality of services in the intensive care unit. The present study aimed to investigate the demographic properties of patients who died in the intensive care unit and their association with their death hour.</p></div><div><h3>Materials and methods</h3><p>As a cross-sectional study, this study was performed by referring to the Statistics Center of Hazrat Rasool Akram Hospital and collecting the demographic information of dead patients at 12 intensive care units in this hospital. This information includes age, sex, the cause of death, and the exact time of death of these patients.</p></div><div><h3>Results</h3><p>In this study, the rate of mortality in intensive care units was assessed as follows; from 12 pm to 2 am (14.48%), from 2 am to 4 (5.49%), from 4 to 6 am (8.99%), from 6 to 8 am (11.32%), from 8 to 10 am (6.79%), from 10 am to 12 noon (8.03%), from 12 to 14 (6.04%), from 14 to 16 (6.93%), from 16 to 18 (7.41%), from 18 to 20 (9.47%), from 20 to 22 (8.1%), and from 22 to 24 hours (6.93%). The highest rate of mortality was between 12–2 AM and then 6–8 AM. In this study, a significant rate of deaths occurred during the night and the lowest rate was during normal work hours and in fact during the morning hours of visiting patients.</p></div><div><h3>Conclusion</h3><p>Since the highest rate of mortality was during night hours, during the hours of changing shifts, and at the beginning of midnight, the mortality rate could be decreased with the decrement in staff's working hours and paying more attention to patients during these hours, the overall mortality rate of patients could be decreased in ICU units.</p></div>","PeriodicalId":36921,"journal":{"name":"Medicina Clinica Practica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49457078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}