Neuroscience Insights最新文献_第8页

Traumatic Brain Injury and Posttraumatic Stress Disorder: Comorbid Consequences of War. 创伤性脑损伤和创伤后应激障碍:战争的共病后果。

IF 3.6

Neuroscience Insights Pub Date : 2019-12-31 eCollection Date: 2019-01-01 DOI: 10.1177/1179069519892933

John Ni Dieter, Scot D Engel

{"title":"Traumatic Brain Injury and Posttraumatic Stress Disorder: Comorbid Consequences of War.","authors":"John Ni Dieter, Scot D Engel","doi":"10.1177/1179069519892933","DOIUrl":"https://doi.org/10.1177/1179069519892933","url":null,"abstract":"Scientific literature is reviewed supporting a “consequence of war syndrome (CWS)” in Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn soldiers. CWS constituents include chronic pain and insomnia, other physical complaints, posttraumatic stress disorder (PTSD), anxiety, depression, and neuropsychological deficits. The foundation of CWS lies with the chronic stressors inherent to deployment and the cascade of biological events mediated and maintained by hypothalamic-pituitary-adrenal (HPA) axis dysregulation. Such dysregulation is modified by the individual’s specific experiences at war, difficulty reintegrating to post-deployment life, and the onset or exacerbation of the chronic and comorbid physical, emotional, and cognitive disorders. The circuit network between the prefrontal cortex (PFC), amygdala, and hippocampus is particularly sensitive to the consequences of war. The review’s specific conclusions are as follows: HPA axis dysregulation contributes to the chronic insomnia and hyperarousal seen in soldiers. There is considerable symptom overlap between PTSD and blast-related head injury, and it is difficult to determine the relative contributions of the two disorders to abnormal imaging studies. In some cases, traumatic brain injury (TBI) may directly precipitate PTSD symptoms. While not intuitive, the relationship between TBI and postconcussion syndrome appears indirect and mediated through PTSD. Blast-related or conventional head injury may have little long-term impact on neuropsychological functioning; contrarily, PTSD particularly accounts for current cognitive deficits. The psychological experience of CWS includes a “war-within” where soldiers continue to battle an internalized enemy. Successful treatment of CWS entails transdisciplinary care that addresses each of the constituent disorders.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"14 ","pages":"1179069519892933"},"PeriodicalIF":3.6,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179069519892933","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37897308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Older Adults Show Less Flexible Spatial Cue Use When Navigating in a Virtual Reality Environment Compared With Younger Adults. 与年轻人相比，老年人在虚拟现实环境中导航时空间线索使用的灵活性较低。

IF 3.6

Neuroscience Insights Pub Date : 2019-12-31 eCollection Date: 2019-01-01 DOI: 10.1177/2633105519896803

Kazushige Kimura, James F Reichert, Debbie M Kelly, Zahra Moussavi

引用次数: 6

Meningeal Lymphatics: A Review and Future Directions From a Clinical Perspective. 脑膜淋巴管:从临床角度回顾和未来发展方向。

IF 3.6

Neuroscience Insights Pub Date : 2019-12-31 eCollection Date: 2019-01-01 DOI: 10.1177/1179069519889027

Korri S Hershenhouse, Orr Shauly, Daniel J Gould, Ketan M Patel

{"title":"Meningeal Lymphatics: A Review and Future Directions From a Clinical Perspective.","authors":"Korri S Hershenhouse, Orr Shauly, Daniel J Gould, Ketan M Patel","doi":"10.1177/1179069519889027","DOIUrl":"https://doi.org/10.1177/1179069519889027","url":null,"abstract":"<p><p>The recent discovery of lymphatic vessels in the meningeal layers calls into question the known mechanisms of fluid and macromolecule homeostasis and immunoregulation within the central nervous system. These meningeal lymphatic vessels and their potential role in the pathophysiology of neurological disease have become a rapidly expanding area of research, with the hopes that they may provide a novel therapeutic target in the treatment of many devastating conditions. This article reviews the current state of knowledge surrounding the anatomical structure of the vessels, their functions in fluid and solute transport and immune surveillance, as well as their studied developmental biology, relationship with the novel hypothesized \"glymphatic\" system, and implications in neurodegenerative disease in animal models. Furthermore, this review summarizes findings from the human studies conducted thus far regarding the presence, anatomy, and drainage patterns of meningeal lymphatic vessels and discusses, from a clinical perspective, advancements in both imaging technologies and interventional methodologies used to access ultrafine peripheral lymphatic vessels.</p>","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"14 ","pages":"1179069519889027"},"PeriodicalIF":3.6,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179069519889027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37895924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Thanks to Reviewers 感谢审稿人

IF 3.6

Neuroscience Insights Pub Date : 2012-03-01 DOI: 10.1093/mmy/myz019

K. Clemons

引用次数: 0

Thanks to Reviewers 感谢审稿人

IF 3.6

Neuroscience Insights Pub Date : 2007-07-01 DOI: 10.1080/13545700701464588

Siyu Røskaft, Eivin Ruppert, Kirstie Sabadini Carvalho

引用次数: 0