Neuroscience Insights最新文献_第7页

Pleiotrophin Signals Through ALK Receptor to Enhance the Growth of Neurons in the Presence of Inhibitory Chondroitin Sulfate Proteoglycans. 抑制性硫酸软骨素蛋白聚糖存在下通过ALK受体的多营养信号促进神经元生长。

IF 3.6

Neuroscience Insights Pub Date : 2023-01-01 DOI: 10.1177/26331055231186993

Somnath J Gupta, Matthew A Churchward, Kathryn G Todd, Ian R Winship

{"title":"Pleiotrophin Signals Through ALK Receptor to Enhance the Growth of Neurons in the Presence of Inhibitory Chondroitin Sulfate Proteoglycans.","authors":"Somnath J Gupta, Matthew A Churchward, Kathryn G Todd, Ian R Winship","doi":"10.1177/26331055231186993","DOIUrl":"https://doi.org/10.1177/26331055231186993","url":null,"abstract":"Chondroitin sulfate proteoglycans (CSPGs), one of the major extracellular matrix components of the glial scar that surrounds central nervous system (CNS) injuries, are known to inhibit the regeneration of neurons. This study investigated whether pleiotrophin (PTN), a growth factor upregulated during early CNS development, can overcome the inhibition mediated by CSPGs and promote the neurite outgrowth of neurons in vitro. The data showed that a CSPG matrix inhibited the outgrowth of neurites in primary cortical neuron cultures compared to a control matrix. PTN elicited a dose-dependent increase in the neurite outgrowth even in the presence of the growth inhibitory CSPG matrix, with optimal growth at 15 ng mL-1 of PTN (114.8% of neuronal outgrowth relative to laminin control). The growth-promoting effect of PTN was blocked by inhibition of the receptor anaplastic lymphoma kinase (ALK) by alectinib in a dose-dependent manner. Neurite outgrowth in the presence of this CSPG matrix was induced by activation of the protein kinase B (AKT) pathway, a key downstream mediator of ALK activation. This study identified PTN as a dose-dependent regulator of neurite outgrowth in primary cortical neurons cultured in the presence of a CSPG matrix and identified ALK activation as a key driver of PTN-induced growth.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"18 ","pages":"26331055231186993"},"PeriodicalIF":3.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/03/79/10.1177_26331055231186993.PMC10350765.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10665326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possible Gender Differences in Classical Music, Flamenco and Fado. 古典音乐、弗拉门戈和法多中可能存在的性别差异。

IF 3.6

Neuroscience Insights Pub Date : 2023-01-01 DOI: 10.1177/26331055221147009

Alicia Garcia-Falgueras

{"title":"Possible Gender Differences in Classical Music, Flamenco and Fado.","authors":"Alicia Garcia-Falgueras","doi":"10.1177/26331055221147009","DOIUrl":"https://doi.org/10.1177/26331055221147009","url":null,"abstract":"Music is an art form and cultural activity whose language, the sounds and silences, is organized in time with logic and sensitivity. Music as a whole is the result of an ancestral nonverbal and international mode of human expression and communication. The primitive and former mother-child bonding might be highly influenced and modulated by the music and singing with their babies. Musicality and music imply two different sides of the same coin, where the former is based on the human capacity to produce the latter. Some theories about evolution suggest music might have an adaptive advantage for humans in society. Historical examples of different styles in music point out that if any allusion or reminder about gender in music might happen most probably occurs in folk non always written pagan or secular music with lyrics or voice. This genre of music usually tells about traditional gender differences in jobs, habits, lifestyles, etc., and has a clear preference for male musicians, while on the contrary, classical music usually does not have a clear gender difference in meaning, and instruments are played by both. In this text, I explore and empirically describe, neuroanatomically or functionally, some examples of different genres of music and brain differences, related to music and dance. Three different genres of music (Classical music, Fado and Flamenco) are explored in an attempt to elucidate some reasons for possible gender differences.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"18 ","pages":"26331055221147009"},"PeriodicalIF":3.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ca/2a/10.1177_26331055221147009.PMC9813978.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10513876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Circulating Aβ Seeds in the Progression of Cerebral Amyloidosis. 循环Aβ种子在脑淀粉样变性进展中的作用。

IF 2.9

Neuroscience Insights Pub Date : 2022-09-15 eCollection Date: 2022-01-01 DOI: 10.1177/26331055221123072

Nazaret Gamez, Rodrigo Morales

引用次数: 0

Effects of a 12-Week Periodized Resistance Training Program on Resting Brain Activity and Cerebrovascular Function: A Nonrandomized Pilot Trial. 12周周期抗阻训练计划对静息脑活动和脑血管功能的影响:一项非随机试验。

IF 3.6

Neuroscience Insights Pub Date : 2022-01-01 DOI: 10.1177/26331055221119441

Timothy R Macaulay, Amy Hegarty, Lirong Yan, Dominique Duncan, Judy Pa, Jason J Kutch, Marianna La Rocca, Christianne J Lane, E Todd Schroeder

{"title":"Effects of a 12-Week Periodized Resistance Training Program on Resting Brain Activity and Cerebrovascular Function: A Nonrandomized Pilot Trial.","authors":"Timothy R Macaulay, Amy Hegarty, Lirong Yan, Dominique Duncan, Judy Pa, Jason J Kutch, Marianna La Rocca, Christianne J Lane, E Todd Schroeder","doi":"10.1177/26331055221119441","DOIUrl":"https://doi.org/10.1177/26331055221119441","url":null,"abstract":"Resistance training is a promising strategy to promote healthy cognitive aging; however, the brain mechanisms by which resistance training benefits cognition have yet to be determined. Here, we examined the effects of a 12-week resistance training program on resting brain activity and cerebrovascular function in 20 healthy older adults (14 females, mean age 69.1 years). In this single group clinical trial, multimodal 3 T magnetic resonance imaging was performed at 3 time points: baseline (preceding a 12-week control period), pre-intervention, and post-intervention. Along with significant improvements in fluid cognition (d = 1.27), 4 significant voxelwise clusters were identified for decreases in resting brain activity after the intervention (Cerebellum, Right Middle Temporal Gyrus, Left Inferior Parietal Lobule, and Right Inferior Parietal Lobule), but none were identified for changes in resting cerebral blood flow. Using a separate region of interest approach, we provide estimates for improved cerebral blood flow, compared with declines over the initial control period, in regions associated with cognitive impairment, such as hippocampal blood flow (d = 0.40), and posterior cingulate blood flow (d = 0.61). Finally, resistance training had a small countermeasure effect on the age-related progression of white matter lesion volume (rank-biserial = -0.22), a biomarker of cerebrovascular disease. These proof-of-concept data support larger trials to determine whether resistance training can attenuate or even reverse salient neurodegenerative processes.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"17 ","pages":"26331055221119441"},"PeriodicalIF":3.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/36/10.1177_26331055221119441.PMC9379950.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10608764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing Spinal Interneurons for Spinal Cord Repair. 利用脊髓中间神经元修复脊髓。

IF 3.6

Neuroscience Insights Pub Date : 2022-01-01 DOI: 10.1177/26331055221101607

Lyandysha V Zholudeva, Michael A Lane

引用次数: 1

Brain Networks of Connectionally Unique Basolateral Amygdala Cell Types 连接独特的基底外侧杏仁核细胞类型的脑网络

IF 3.6

Neuroscience Insights Pub Date : 2022-01-01 DOI: 10.1177/26331055221080175

Houri Hintiryan, Hong-wei Dong

引用次数: 2

Protein Network Analysis Reveals a Functional Connectivity of Dysregulated Processes in ALS and SMA 蛋白质网络分析揭示了ALS和SMA失调过程的功能连通性

IF 3.6

Neuroscience Insights Pub Date : 2022-01-01 DOI: 10.1177/26331055221087740

S. Kubinski, P. Claus

{"title":"Protein Network Analysis Reveals a Functional Connectivity of Dysregulated Processes in ALS and SMA","authors":"S. Kubinski, P. Claus","doi":"10.1177/26331055221087740","DOIUrl":"https://doi.org/10.1177/26331055221087740","url":null,"abstract":"Spinal Muscular Atrophy (SMA) and Amyotrophic Lateral Sclerosis (ALS) are neurodegenerative diseases which are characterized by the loss of motoneurons within the central nervous system. SMA is a monogenic disease caused by reduced levels of the Survival of motoneuron protein, whereas ALS is a multi-genic disease with over 50 identified disease-causing genes and involvement of environmental risk factors. Although these diseases have different causes, they partially share identical phenotypes and pathomechanisms. To analyze and identify functional connections and to get a global overview of altered pathways in both diseases, protein network analyses are commonly used. Here, we used an in silico tool to test for functional associations between proteins that are involved in actin cytoskeleton dynamics, fatty acid metabolism, skeletal muscle metabolism, stress granule dynamics as well as SMA or ALS risk factors, respectively. In network biology, interactions are represented by edges which connect proteins (nodes). Our approach showed that only a few edges are necessary to present a complex protein network of different biological processes. Moreover, Superoxide dismutase 1, which is mutated in ALS, and the actin-binding protein profilin1 play a central role in the connectivity of the aforementioned pathways. Our network indicates functional links between altered processes that are described in either ALS or SMA. These links may not have been considered in the past but represent putative targets to restore altered processes and reveal overlapping pathomechanisms in both diseases.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46276512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Commentary: How Do Microglia Regulate Neural Circuit Connectivity and Activity in the Adult Brain? 评论:小胶质细胞如何调节成人大脑中的神经回路连接和活动?

IF 3.6

Neuroscience Insights Pub Date : 2022-01-01 DOI: 10.1177/26331055211071124

Yong-Jun Liu, Kim N Green, Todd C Holmes, Xiangmin Xu

引用次数: 1

Test-Retest Reliability and Agreement of Single Pulse Transcranial Magnetic Stimulation (TMS) for Measuring Activity in Motor Cortex in Patients With Acute Ischemic Stroke. 单脉冲经颅磁刺激(TMS)测量急性缺血性脑卒中患者运动皮质活动的重测信度和一致性。

IF 3.6

Neuroscience Insights Pub Date : 2022-01-01 DOI: 10.1177/26331055221145002

Busk Henriette, Nilsen Marianne, Pedersen Julie Rønne, Kristensen Malene Glavin, Kjær Troels Wesenberg, Skou Søren Thorgaard, Wienecke Troels

{"title":"Test-Retest Reliability and Agreement of Single Pulse Transcranial Magnetic Stimulation (TMS) for Measuring Activity in Motor Cortex in Patients With Acute Ischemic Stroke.","authors":"Busk Henriette, Nilsen Marianne, Pedersen Julie Rønne, Kristensen Malene Glavin, Kjær Troels Wesenberg, Skou Søren Thorgaard, Wienecke Troels","doi":"10.1177/26331055221145002","DOIUrl":"https://doi.org/10.1177/26331055221145002","url":null,"abstract":"Background: Transcranial magnetic stimulation (TMS) is often used to examine neurophysiology. We aimed to investigate the inter-rater reliability and agreement of single pulse TMS in hospitalised acute ischemic stroke patients.Methods: Thirty-one patients with first-time acute ischemic stroke (median age 72 (IQR 64-75), 35% females) underwent TMS motor threshold (MT) assessment in 4 muscles bilaterally, conducted by 1 of 2 physiotherapists. Test-retest reliability was evaluated using a two-way random effects model (2,1) absolute agreement-type Interclass Correlation Coefficient (ICC). Standard Error of Measurement (SEM) and Smallest Detectable Change (SDC) were used to evaluate agreement.Results: Reliability, SEM, and SDC of TMS was found to be moderate in right opponens pollicis (0.78 [CI 95% 0.55-0.89], SEM: 4.51, SDC: 12.51), good in right vastus medialis and tibial anterior (0.88 [CI 95% 0.72-0.96], SEM: 2.89, SDC: 8.01 and 0.88 [CI 95% 0.76-0.94], SEM: 2.88, SDC: 7.98 respectively), and excellent in right and left biceps brachii (0.98 [CI 95% 0.96-0.99], SEM: 1.79 SDC: 4.96, and 0.94 [CI 95% 0.89-0.97], SEM: 2.17 SDC: 6.01), opponens pollicis (0.92 [CI 95% 0.83-0.96], SEM: 2.68 SDC: 8.26, vastus medialis (0.92 [CI 95% 0.84-0.96], SEM: 2.87 SDC: 7.95), and tibial anterior (0.93 [CI 95% 0.86-0.96], SEM: 2.51 SDC: 6.95).Conclusion: The TMS demonstrated moderate to excellent inter-rater reliability confirming the ability of these measures to reliably discriminate between individuals in the current study sample. Improvements of less than 4.96 to 12.51 could be a result of measurement error and may therefore not be considered a true change.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"17 ","pages":"26331055221145002"},"PeriodicalIF":3.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/78/b0/10.1177_26331055221145002.PMC9791285.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9260458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Tailored Music-Motor Therapy and Real-Time Biofeedback Mobile Phone App (‘GotRhythm’) to Promote Rehabilitation Following Stroke: A Pilot Study 定制的音乐-运动疗法和实时生物反馈手机应用程序(“gorhythm”)促进中风后康复:一项试点研究

IF 3.6

Neuroscience Insights Pub Date : 2022-01-01 DOI: 10.1177/26331055221100587

Katherine Hankinson, A. Shaykevich, A. Vallence, J. Rodger, Michael A. Rosenberg, C. Etherton-Beer

{"title":"A Tailored Music-Motor Therapy and Real-Time Biofeedback Mobile Phone App (‘GotRhythm’) to Promote Rehabilitation Following Stroke: A Pilot Study","authors":"Katherine Hankinson, A. Shaykevich, A. Vallence, J. Rodger, Michael A. Rosenberg, C. Etherton-Beer","doi":"10.1177/26331055221100587","DOIUrl":"https://doi.org/10.1177/26331055221100587","url":null,"abstract":"Background: Stroke persists as an important cause of long-term disability world-wide with the need for rehabilitation strategies to facilitate plasticity and improve motor function in stroke survivors. Rhythm-based interventions can improve motor function in clinical populations. This study tested a novel music-motor software application ‘GotRhythm’ on motor function after stroke. Methods: Participants were 22 stroke survivors undergoing inpatient rehabilitation in a subacute stroke ward. Participants were randomised to the GotRhythm intervention (combining individualised music and augmented auditory feedback along with wearable sensors to deliver a personalised rhythmic auditory stimulation training protocol) or usual care. Intervention group participants were offered 6-weeks of the GotRhythm intervention, consisting of a supervised 20-minute music-motor therapy session using GotRhythm conducted 3 times a week for 6 weeks. The primary feasibility outcomes were adherence to the intervention and physical function (change in the Fugl-Meyer Assessment of Motor Recovery score) measured at baseline, after 3-weeks and at end of the intervention period (6-weeks). Results: Three of 10 participants randomised to the intervention did not receive any of the GotRhythym music-motor therapy. Of the remaining 7 intervention group participants, only 5 completed the 3-week mid-intervention assessment and only 2 completed the 6-week post-intervention assessment. Participants who used the intervention completed 5 (IQR 4,7) sessions with total ‘dose’ of the intervention of 70 (40, 201) minutes. Conclusion: Overall, adherence to the intervention was poor, highlighting that application of technology assisted music-based interventions for stroke survivors in clinical environments is challenging along with usual care, recovery, and the additional clinical load.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"17 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44197673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7