Neuroscience Insights最新文献

{"title":"Neuronal Regulation and Locomotion in Rats Following Spinal Cord Injury: Reconciling Behavioral Scales With Neuroelectrophysiology.","authors":"Angelo H All","doi":"10.1177/26331055261480926","DOIUrl":"10.1177/26331055261480926","url":null,"abstract":"<p><p>Progress in translating spinal cord injury (SCI) therapies from bench to bedside remains bottlenecked by a critical paradox in preclinical phenotyping: the frequent divergence between behavioral recovery metrics and objective neurophysiological outcomes. For decades, the Basso, Beattie, and Bresnahan (BBB) open-field locomotor scale has served as the standard subjective metric for assessing hindlimb function in rodent models. However, while behavioral scales often capture substantial endogenous recovery and central pattern generator (CPG) autonomy, they frequently fail to correlate with objective neuro-electrophysiological metrics, such as motor and somatosensory evoked potentials (MEPs/SSEPs), particularly during the acute and sub-acute phases of injury. This perspective evaluates the neuroanatomical and pathophysiological mechanisms underlying this discrepancy. We dissect how the spatial distribution of contusive forces, the demyelination of anatomically spared fibers, and transient spinal shock alter early electrophysiological signaling without permanently arresting long-term behavioral plasticity. Furthermore, we highlight key neuroanatomical differences-specifically the dorsal preservation of the corticospinal tract in rodents versus the lateral architecture in humans-that complicate cross-species translation. Ultimately, we argue that relying solely on locomotor scales overestimates functional tract integrity, and we advocate for a paradigm shift toward integrating synchronized behavioral and electrophysiological profiling to improve the predictive validity of preclinical SCI trials.</p>","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"21 ","pages":"26331055261480926"},"PeriodicalIF":3.5,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroscience Insights: Publishing Rigorous Work Through Fair Review Process.","authors":"Michel Cayouette","doi":"10.1177/26331055261481948","DOIUrl":"10.1177/26331055261481948","url":null,"abstract":"<p><p>This editorial marks the beginning of my tenure as Editor-in-Chief of <i>Neuroscience Insights</i>. The journal's founding aims of publishing rigorous, mechanistically grounded research spanning the nervous system from molecule to behavior remain unchanged. But as the incoming Editor-in-Chief, I am committed to changing how we support authors in reaching publication: a peer-review process built to distinguish genuinely necessary revisions from optional ones. We also intend to strengthen our presence in cellular and molecular neuroscience.</p>","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"21 ","pages":"26331055261481948"},"PeriodicalIF":3.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurocognitive Mechanism of Perceptual Errors in Radiologists: Results of Pilot Studies.","authors":"Michael A Bruno, Elizabeth A Krupinski, Scott C Bunce, Grayson L Baird, Caitlin Mills, Prasanna R Karunanayaka, Howard Egeth, Ryan Chang, Ross Cottrill, Samuel Jump, Krishnankutty Sathian, Timothy J Mosher","doi":"10.1177/26331055261470384","DOIUrl":"10.1177/26331055261470384","url":null,"abstract":"<p><strong>Background: </strong>The most prevalent type of radiologist error is failing to detect abnormalities on images, the so-called \"perceptual error.\" The prevalence of this type of false-negative (FN) error remains essentially unchanged since it was first described in 1949. Reducing this error rate would be highly beneficial for patients who often depend on radiological observations for a timely diagnosis.</p><p><strong>Purpose: </strong>To identify a potential neurocognitive mechanism contributing to radiologists' perceptual errors, in order to inform intervention strategies to reduce such errors in practice. These experiments evaluated the relationship between brain network activation states and radiologists' perceptual errors on two distinct visual tasks utilizing functional MRI (fMRI) and functional Near Infrared Spectroscopy (fNIRS).</p><p><strong>Materials and methods: </strong>A prospective, pilot study was carried out on a small number of radiologist participants utilizing two distinct types of visual tasks while monitoring activity in two targeted brain networks, the default mode network (DMN) and the \"executive\" frontoparietal network (FPN), to test the hypothesis that simultaneous co-activation of these networks produces an error-prone neurocognitive state (EPS). A third experiment using fNIRS alone was an observational study of subjects' neurocognitive states during their usual practice to determine the baseline prevalence of the EPS in the clinical setting.</p><p><strong>Results: </strong>An approximately threefold increased risk of FN perceptual errors (misses) on the visual tasks was observed in the presence of simultaneous co-activation of elements of the Default Mode Network (DMN) and Frontoparietal Network (FPN), which supports the \"error-prone state\" (EPS) hypothesis. EPS prevalence declined with participant age.</p><p><strong>Conclusion: </strong>Our results suggest that dynamic interactions between the Default Mode Network (DMN) and Frontoparietal Network (FPN) create a unique error-prone state (EPS), associated with an approximately threefold increased risk of perceptual error in radiologists. These results suggest potential intervention strategies for perceptual error, the largest class of radiologist errors in practice.</p>","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"21 ","pages":"26331055261470384"},"PeriodicalIF":3.5,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13389148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Geometric Signatures of Brain State Transitions: Recursive Informational Curvature Reveals Hidden Dynamics in Primate Cortex.","authors":"Mahsa Asadi Anar, Seyed Kiarash Sadat Rafiei, Soroosh Najafi, Parham Mahmoudi, Hossein Gharedaghi, Sasan Ghazanafar Ahari, Maryam Rafiei, Pouya Asgari, Zahra Narimani, Mohammad Saeed Soleimani Meigoli","doi":"10.1177/26331055261460858","DOIUrl":"10.1177/26331055261460858","url":null,"abstract":"<p><strong>Objective: </strong>Recursive Informational Curvature (RIC) was recently introduced as an information-geometric framework for describing the balance between recursive structure and entropy change in dynamical systems. Here, we present the first empirical implementation and benchmark evaluation of its scalar curvature term, <math><mrow><mi>K</mi></mrow> </math> in high-density macaque electrocorticography (ECoG).</p><p><strong>Methods: </strong>We analyzed 2 open-access datasets: a 128-channel eyes-open versus eyes-closed benchmark derived from the George anesthesia-and-sleep recording package, and a 64-channel food-tracking dataset with synchronized motion capture. Following standardized preprocessing and symbolic discretization, we extracted Shannon entropy, recursive gain, and empirical curvature for each channel and epoch. We then evaluated these features using single-feature, multichannel, and combined-feature models, together with ablation and sensitivity analyses across symbolic bin counts, epoch lengths, and classifier families.</p><p><strong>Results: </strong>In the primary eyes-open versus eyes-closed benchmark, multichannel curvature features supported near-perfect state discrimination. In the food-tracking task, the strongest performance was obtained from combined curvature and amplitude features. Across analyses, entropy alone was weak, whereas recursive gain and curvature showed closely matched performance profiles, indicating that in the present implementation much of the discriminative structure captured by curvature is concentrated in the recursive term.</p><p><strong>Conclusion: </strong>These findings establish the empirical RIC curvature term as an interpretable and state-sensitive descriptor of neural dynamics in ECoG, provide a reproducible benchmark for future refinement of the framework, and clarify both the promise and the current limits of curvature-based analysis in neural states.</p>","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"21 ","pages":"26331055261460858"},"PeriodicalIF":3.5,"publicationDate":"2026-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13311254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromodulation of Working Memory: Mechanisms, Targets, and Behavioral Outcomes.","authors":"Seyed Kiarash Sadat Rafiei, Fatemeh Ghorbani, Janan Rezaei, Ana Saremi, Maryam Rafiei, Shadi Hajizamani, Mahsa Asadi Anar, Mehrab Samiei","doi":"10.1177/26331055261458642","DOIUrl":"10.1177/26331055261458642","url":null,"abstract":"<p><p>Working memory (WM) is a capacity-limited control system that maintains and updates task-relevant representations for goal-directed cognition. Because WM declines with aging and is disrupted across neuropsychiatric and neurodegenerative disorders, neuromodulation has emerged as both a causal probe of circuit function and a potential therapeutic adjunct. This mechanistic narrative review evaluates evidence across transcranial direct current stimulation, transcranial magnetic stimulation/theta-burst stimulation, transcranial alternating current stimulation, transcranial random noise stimulation, and deep brain stimulation. Rather than asking whether neuromodulation uniformly enhances WM, we examine when different modalities alter distinct WM subprocesses. Across modalities, effects are generally modest and heterogeneous, but the literature increasingly suggests that stimulation acts less by adding \"capacity\" than by biasing gain, timing, and plasticity-related control variables that shape WM trajectories. More precise dosing, targeting, and computation-aligned outcomes are needed to establish reproducible and mechanistically interpretable effects.</p>","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"21 ","pages":"26331055261458642"},"PeriodicalIF":3.5,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13276230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148296734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Sex, Estradiol, and Acute Stress on Spontaneous Recovery of a Conditioned Touchscreen Response in Rats.","authors":"Olga Lipatova, Matthew M Campolattaro, Emery W Harlan, Srinidhi Gopal, Brisa B Rasmussen","doi":"10.1177/26331055261446788","DOIUrl":"10.1177/26331055261446788","url":null,"abstract":"<p><p>The present study examined sex differences and the effects of estradiol on acquisition and extinction using an appetitive reinforcement schedule in operant touchscreen chambers. Additionally, it aimed to clarify how acute stress influences response inhibition, as assessed by the spontaneous recovery of operant responses following extinction, in males, females, and ovariectomized females with and without estradiol treatment. In Experiment 1, male and female rats exhibited equal rates of acquisition. While male and female rats extinguished their response also at similar rates, female rats showed transient but significantly greater extinction compared to male rats during the first day of extinction. Acute stress administered immediately prior to the extinction retention test, conducted 21 days following extinction phase, enhanced spontaneous recovery of the learned response in both male and female rats, but also led to a more rapid decline in response rates across the re-extinction session. In Experiment 2, ovariectomized female rats receiving chronic estradiol or cholesterol (control) treatment showed no significant differences in acquisition or extinction learning. Unlike Experiment 1, both estradiol-treated and non-treated ovariectomized stressed rats exhibited lower spontaneous recovery throughout the extinction retention test, indicating that naturally cycling female hormones may modulate stress effects on response recovery. Additionally, non-stressed rats treated with estradiol demonstrated reduced responding in the early stages of the extinction retention test compared to controls. These findings suggest that acute stress enhances response recovery in intact, cycling female and male rats. However, in ovariectomized female rats, acute stress attenuates the spontaneous recovery of an extinguished response in a manner partially dependent on estradiol treatment. These results provide insight into how acute stress influences response inhibition in an appetitive learning paradigm and highlight the role of sex and gonadal hormone status in learning, memory, and response inhibition, with implications for stress-related disorders and addiction behavior.</p>","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"21 ","pages":"26331055261446788"},"PeriodicalIF":3.5,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13167318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147943043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activity and State-Dependent Modulation of Salt Taste Behavior Via Pharyngeal Neurons in <i>Drosophila melanogaster</i>.","authors":"Shivam Kaushik, Kartik Singh, Rahul Kumar, Sachin Kumar, Srishti Sanghi, Teiichi Tanimura, Diego E Rincon-Limas, Pinky Kain","doi":"10.1177/26331055261440786","DOIUrl":"10.1177/26331055261440786","url":null,"abstract":"<p><p>Sodium, which is present in NaCl (Sodium Chloride), is a vital nutrient required for numerous physiological processes. In animals, including <i>Drosophila</i>, low-salt concentrations induce attraction and high-salt concentrations trigger aversive behavior. Although the analysis of low and high salt concentrations in <i>Drosophila</i> has been described at the cellular level, the mechanisms governing high salt consumption and taste modulation remain unclear. Our study examined the neural basis of high NaCl consumption in adult <i>Drosophila</i>, focusing on how dietary adaptation influences salt acceptance. Our findings suggest that prolonged exposure to high salt alters the taste sensitivity of the pharyngeal labral sense organ (LSO) neurons, promoting increased salt intake, particularly under starvation conditions. This modulation requires active LSO neurons, as genetic suppression of their activity in high-salt-fed flies prevents excessive salt consumption under starvation or dopamine-supplemented feeding. Furthermore, multiple independent taste receptor neurons and pathways within the LSO contribute to this response. Silencing any one of these LSO neuron types can prevent excessive salt intake. In conclusion, our study suggests that <i>Drosophila</i> undergoes dietary salt adaptation over time, revealing a key mechanism for resetting salt appetite and related neural circuits.</p>","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"21 ","pages":"26331055261440786"},"PeriodicalIF":3.5,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mature Schwann Cells Derived From Human Induced Pluripotent Stem Cells Promote Peripheral Nerve Regeneration In Vivo.","authors":"Kazuaki Fujita, Ryosuke Ikeguchi, Tomoki Aoyama, Takashi Noguchi, Koichi Yoshimoto, Daichi Sakamoto, Terunobu Iwai, Tetsuya Miyamoto, Yuta Takeuchi, Momoko Nagai-Tanima, Daiki Nohara, Norie Tooi, Koichi Igura, Takayuki Kiboku, Rio Okama, Hiroyuki Ogasawara, Shuichi Matsuda","doi":"10.1177/26331055261443172","DOIUrl":"10.1177/26331055261443172","url":null,"abstract":"<p><p>Peripheral nerve injuries (PNIs) often cause persistent sensory and motor deficits that impair quality of life. To improve outcomes, cell-based therapies have been explored, and Schwann cells (SCs) are considered a promising option because of their essential roles in myelination and neurotrophic support. However, the clinical use of autologous SCs is limited by donor site morbidity and challenges in large-scale expansion, leading to growing interest in human induced pluripotent stem cell (iPSC)-derived SCs. This study aimed to verify the therapeutic effects of iPSC-derived SCs in vivo and to determine whether the differentiation stage of the SCs influences their efficacy. We generated dibutyryl-cAMP-treated mature SCs and untreated immature SCs from iPSCs and transplanted them into a rat sciatic nerve crush injury model. Morphometric analysis showed that myelinated fiber density (fibers/mm²) was significantly higher in the mature SC group than in the control group (12 602 ± 1419 vs 10 105 ± 1673). Myelinated axon diameter (µm) was also significantly greater in the mature SC group (4.73 ± 0.25) compared with the immature SC (4.06 ± 0.28) and control (3.86 ± 0.15) groups. Electrophysiological testing demonstrated that compound muscle action potentials in the pedal adductor muscle were detected only in the mature SC group within 28 days after surgery. Western blot analysis of the tibialis anterior muscle showed significantly higher myosin heavy chain 1 (MYH1) expression in the mature SC group than in the control group. Quantitative reverse transcription-polymerase chain reaction revealed higher expression of <i>bNGF</i>, <i>CCL2</i>, and <i>LAMA2</i> in mature SCs than in immature SCs. Pathological analysis suggested accelerated Wallerian degeneration in the mature SC group. These results demonstrate that mature iPSC-derived Schwann cells, rather than immature ones, most effectively promote nerve regeneration both histologically and functionally in vivo, highlighting the critical importance of the SC differentiation stage for therapeutic efficacy.</p>","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"21 ","pages":"26331055261443172"},"PeriodicalIF":3.5,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-Examination and Extension of Manual Dexterity Behavioral Data in M1 Lesioned Adult Macaque Monkeys: A Survey of Therapies Induced Enhancement of Functional Recovery.","authors":"Eric M Rouiller","doi":"10.1177/26331055261421348","DOIUrl":"10.1177/26331055261421348","url":null,"abstract":"<p><p>The present report offers a survey, with re-examination and extension of data, of previously published intermediate papers on the functional recovery of manual dexterity in non-human primates following primary motor cortex (M1) lesion, either spontaneous or enhanced with 2 distinct therapies. For each monkey, the M1 lesion volume was derived from histological sections. As a result of data extension, spontaneous recovery is represented here by individual data points derived from 14 monkeys, while data points from 8 monkeys represent therapy enhanced recovery. One therapy consisted of the administration immediately post-lesion of an anti-Nogo-A antibody (n = 4); the other treatment was a delayed autologous cellular therapy (ANCE; n = 4). The manual dexterity performance was longitudinally assessed during several years with the modified Brinkman Board task, testing the ability to grasp small food pellets from horizontal or vertical slots, using the precision grip. After M1 lesion, the grasping score dropped to zero, followed by a spontaneous, incomplete recovery in untreated monkeys, characterized by a unique plateau of recovery. In the majority of treated monkeys (n = 6), there was an additional second plateau of recovery, reflecting the effect of the treatment. Statistical non-parametric comparisons between the 14 untreated versus the 8 treated data points showed a statistically significant difference between the 2 subpopulations, based both on univariate statistics and bivariate statistics taking into account the lesion volume. This was true for recovery expressed as a degree of recuperation expressed in percent (post-lesion score/pre-lesion score × 100) as well as for the post-lesion scores only. The difference between the 2 subpopulations was more pronounced for the most difficult horizontal slots than for the less challenging vertical slots. In conclusion, the treatments appear to be efficient to promote functional motor recovery, even when considering post-lesion behavioral readouts only, as this would be the case in clinical trials.</p>","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"21 ","pages":"26331055261421348"},"PeriodicalIF":3.5,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulsatility index: Insights into post-stroke haemodynamics.","authors":"Christina Shen-Zhuang Yde, Vladimir V Matchkov","doi":"10.1177/26331055261427992","DOIUrl":"10.1177/26331055261427992","url":null,"abstract":"<p><p>Acute ischaemic stroke is a leading cause of acquired disability globally, with millions of patients afflicted each year. Fast and efficient recanalization therapies have revolutionized long-term patient outcomes. However, a substantial fraction of patients does not regain complete functional independence, despite undergoing timely and successful recanalization. Although various alterations in cerebral haemodynamics have been reported in both animal and clinical studies, the underlying mechanisms are complex and remain to be fully elucidated. In this mini-review, we summarize the current understanding of pulsatile haemodynamics in occlusion-reperfusion and emphasize the potential value of pulsatility assessment as a biomarker with prognostic and diagnostic value in the clinic.</p>","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"21 ","pages":"26331055261427992"},"PeriodicalIF":3.5,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}