Widespread neuronal activity related to bimanual coordination in non-human primates: evidence from Fos-like activation during bimanual versus unimanual motor task.

IF 2.9 Q2 NEUROSCIENCES
Neuroscience Insights Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI:10.1177/26331055251352807
Yu Liu, Eric M Rouiller
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引用次数: 0

Abstract

Electrophysiological data support the notion that spatial and temporal coordination between the forelimbs in primates takes place in a wide network of cortical and subcortical brain structures. However, single neuron electrophysiology is biased towards large, long distance projecting neurons. The aim of the present study was to assess whether the same neural network is involved when small and medium size neurons are considered. To address this issue, neuronal activity with cellular resolution was investigated and quantified using the c-fos mapping technique, targeting small and medium size diameter neurons, in adult non-human primates. Two male macaque monkeysi were trained to perform a reach and grasp drawer task, executed either bimanually (BIM) or unimanually (UNI). Extensive single unit electrophysiological recordings were conducted in these two monkeys over a two-year period, preceding a final terminal c-fos session during which one monkey (Mk-1) performed exclusively the BIM task, while the second monkey (Mk-2) performed the UNI task only (250 trials each). One additional monkey (control Mk-3) did not perform any task. Fos-like immunoreactivity (FLI) was significantly higher in both Mk-1 and Mk-2 in motor brain areas than in the control monkey, demonstrating that motor activity triggered c-fos. Although the overall muscle activity was roughly comparable in both tasks, Mk-1 (BIM) exhibited a clearly stronger FLI than Mk-2 all along the rostrocaudal axis of the primary, supplementary and cingulate motor cortices, as well as the striatum. In contrast, Mk-1 and Mk-2 displayed a comparable FLI in non-motor regions, such as the visual and auditory thalamus. The present study, a very rare c-fos mapping investigation conducted in macaques performing a complex behavioral task, suggests that small and medium size (local) neurons may also contribute to the specific neural activity responsible for precise interlimb coordination, within a network associating motor cortical areas and the basal ganglia.

非人类灵长类动物中与双手协调相关的广泛神经元活动:来自双手与单手运动任务中fos样激活的证据。
电生理学数据支持灵长类动物前肢之间的空间和时间协调发生在皮层和皮层下大脑结构的广泛网络中的观点。然而,单个神经元电生理学倾向于大的、长距离投射的神经元。本研究的目的是评估当考虑到中小型神经元时,是否涉及相同的神经网络。为了解决这一问题,研究人员利用c-fos作图技术,对非人灵长类成年动物中、小直径神经元的细胞分辨率神经元活动进行了研究和量化。两只雄性猕猴被训练去执行一个伸手和抓住抽屉的任务,分别是手动(BIM)和手动(UNI)。这两只猴子在两年的时间里进行了大量的单单元电生理记录,在最后的终端c-fos会议之前,一只猴子(Mk-1)只执行BIM任务,而第二只猴子(Mk-2)只执行UNI任务(每只250次试验)。另外一只猴子(对照组Mk-3)没有执行任何任务。运动脑区的Mk-1和Mk-2的fos样免疫反应性(FLI)明显高于对照组,表明运动活动触发了c-fos。尽管在这两项任务中,整体肌肉活动大致相当,但Mk-1 (BIM)在初级、辅助和扣带运动皮质以及纹状体的背尾轴上表现出明显强于Mk-2的FLI。相比之下,Mk-1和Mk-2在非运动区域(如视觉和听觉丘脑)表现出类似的FLI。本研究是在执行复杂行为任务的猕猴中进行的一项非常罕见的c-fos映射调查,表明在运动皮质区和基底神经节相关的网络中,中小型(局部)神经元也可能参与负责精确肢体间协调的特定神经活动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neuroscience Insights
Neuroscience Insights Neuroscience-Neuroscience (all)
CiteScore
6.10
自引率
0.00%
发文量
24
审稿时长
9 weeks
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