Neuroscience Insights最新文献_第6页

SARS-CoV-2 and Hypertension: Evidence Supporting Invasion into the Brain Via Baroreflex Circuitry and the Role of Imbalanced Renin-Angiotensin-Aldosterone-System. SARS-CoV-2 与高血压：有证据支持通过巴氏反射回路入侵大脑以及失衡的肾素-血管紧张素-醛固酮系统的作用。

IF 3.6

Neuroscience Insights Pub Date : 2023-02-01 eCollection Date: 2023-01-01 DOI: 10.1177/26331055231151926

Kellysson Bruno Oliveira, Igor Santana de Melo, Bianca Rodrigues Melo da Silva, Keylla Lavínia da Silva Oliveira, Robinson Sabino-Silva, Lucas Anhezini, Pedro Lourenco Katayama, Victor Rodrigues Santos, Ashok K Shetty, Olagide Wagner de Castro

{"title":"SARS-CoV-2 and Hypertension: Evidence Supporting Invasion into the Brain Via Baroreflex Circuitry and the Role of Imbalanced Renin-Angiotensin-Aldosterone-System.","authors":"Kellysson Bruno Oliveira, Igor Santana de Melo, Bianca Rodrigues Melo da Silva, Keylla Lavínia da Silva Oliveira, Robinson Sabino-Silva, Lucas Anhezini, Pedro Lourenco Katayama, Victor Rodrigues Santos, Ashok K Shetty, Olagide Wagner de Castro","doi":"10.1177/26331055231151926","DOIUrl":"10.1177/26331055231151926","url":null,"abstract":"Hypertension is considered one of the most critical risk factors for COVID-19. Evidence suggests that SARS-CoV-2 infection produces intense effects on the cardiovascular system by weakening the wall of large vessels via vasa-vasorum. In this commentary, we propose that SARS-CoV-2 invades carotid and aortic baroreceptors, leading to infection of the nucleus tractus solitari (NTS) and paraventricular hypothalamic nucleus (PVN), and such dysregulation of NTS and PVN following infection causes blood pressure alteration at the central level. We additionally explored the hypothesis that SARS-CoV-2 favors the internalization of membrane ACE2 receptors generating an imbalance of the renin-angiotensin-aldosterone system (RAAS), increasing the activity of angiotensin II (ANG-II), disintegrin, and metalloproteinase 17 domain (ADAM17/TACE), eventually modulating the integration of afferents reaching the NTS from baroreceptors and promoting increased blood pressure. These mechanisms are related to the increased sympathetic activity, which leads to transient or permanent hypertension associated with SARS-CoV-2 invasion, contributing to the high number of deaths by cardiovascular implications.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"18 ","pages":"26331055231151926"},"PeriodicalIF":3.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b7/30/10.1177_26331055231151926.PMC9900164.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10684095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Schizophrenia, Human Leukocyte Antigen (HLA), and Herpes Viruses: Immunogenetic Associations at the Population Level. 精神分裂症、人类白细胞抗原(HLA)和疱疹病毒:群体水平上的免疫遗传关联。

IF 3.6

Neuroscience Insights Pub Date : 2023-01-01 DOI: 10.1177/26331055231166411

Lisa M James, Spyros A Charonis, Apostolos P Georgopoulos

{"title":"Schizophrenia, Human Leukocyte Antigen (HLA), and Herpes Viruses: Immunogenetic Associations at the Population Level.","authors":"Lisa M James, Spyros A Charonis, Apostolos P Georgopoulos","doi":"10.1177/26331055231166411","DOIUrl":"https://doi.org/10.1177/26331055231166411","url":null,"abstract":"Several factors have been implicated in schizophrenia (SZ), including human herpes viruses (HHV) and the adaptive immunity Human Leukocyte Antigen (HLA) genes. Here we investigated these issues in 2 complementary ways. In one analysis, we evaluated SZ-HLA and HHV-HLA associations at the level of a single allele by computing (a) a SZ-HLA protection/susceptibility (P/S) score based on the covariance between SZ and 127 HLA allele prevalences in 14 European countries, (b) estimating in silico HHV-HLA best binding affinities for the 9 HHV strains, and (c) evaluating the dependence of P/S score on HHV-HLA binding affinities. These analyses yielded (a) a set of 127 SZ-HLA P/S scores, varying by >200× (maximum/minimum), which could not be accounted for by chance, (b) a set of 127 alleles × 9 HHV best-estimated affinities, varying by >600×, and (c) a set of correlations between SZ-HLA P/S scores and HHV-HLA binding which indicated a prominent role of HHV1. In a subsequent analysis, we extended these findings to the individual person by taking into account the fact that every individual carries 12 HLA alleles and computed (a) the average SZ-HLA P/S scores of 12 randomly chosen alleles (2 per gene), an indicator of HLA-based SZ P/S for an individual, and (b) the average of the corresponding HHV estimated affinities for those alleles, an indicator of overall effectiveness of HHV-HLA binding. We found (a) that HLA protection for SZ was significantly more prominent than susceptibility, and (b) that protective SZ-HLA scores were associated with higher HHV-HLA binding affinities, indicating that HLA binding and subsequent elimination of several HHV strains may confer protection against schizophrenia.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"18 ","pages":"26331055231166411"},"PeriodicalIF":3.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/5f/10.1177_26331055231166411.PMC10108429.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9385132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Chronic Neurocognitive, Neuropsychological, and Pulmonary Symptoms in Outpatient and Inpatient Cohorts After COVID-19 Infection. COVID-19感染后门诊和住院患者的慢性神经认知、神经心理和肺部症状

IF 3.6

Neuroscience Insights Pub Date : 2023-01-01 DOI: 10.1177/26331055231186998

Samuel F Oliver, Samuel A Lazoff, John Popovich, Kyle B Enfield, Mark Quigg, Eric M Davis, Alexandra Kadl

{"title":"Chronic Neurocognitive, Neuropsychological, and Pulmonary Symptoms in Outpatient and Inpatient Cohorts After COVID-19 Infection.","authors":"Samuel F Oliver, Samuel A Lazoff, John Popovich, Kyle B Enfield, Mark Quigg, Eric M Davis, Alexandra Kadl","doi":"10.1177/26331055231186998","DOIUrl":"https://doi.org/10.1177/26331055231186998","url":null,"abstract":"Neuropsychological symptoms associated with post-COVID-19 conditions may prevent patients from resuming normal activities at home or work. We report a retrospective, cross-sectional evaluation of neuropsychological and cardiopulmonary outcomes in 2 groups of patients: outpatients with mild enough infection to be spared from hospitalization and those who required inpatient admission. We hypothesized a dose-response model of post-COVID symptom severity in which persistent consequences would be more severe in those who experienced worse acute infections. In a dedicated COVID clinic, 321 patients were seen (33% outpatient, 67% inpatient). Outpatients skewed female, White, non-Hispanic, and younger. Outpatients had worse insomnia (measured with insomnia severity index) and were less able to resume their usual activities (EQ-5D-5L usual activities scale), despite inpatients experiencing worse cognition (Montreal Cognitive Assessment), having greater obesity (body mass index), decreased exercise tolerance (6-minute-walk distance), and more exertional oxygen desaturation. In both groups, insomnia worsened while cognition improved significantly with time from infection to testing while controlling for patient age; other variables did not. In logistic regression, female sex, higher MoCA score, EQ-5D-5L \"usual activities\" subscore, less oxygen desaturation with exertion, and longer time from infection remained as significant associations with outpatient status. Our study demonstrated that the functional sequelae of post-COVID-19 conditions in patients with mild acute disease have the potential to be as severe as that in patients who have recovered from severe illness.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"18 ","pages":"26331055231186998"},"PeriodicalIF":3.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/11/8c/10.1177_26331055231186998.PMC10354529.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9850306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Leukocyte Antigen (HLA) Modulates the Dependence on Age of the Variability of Synchronous Neural Interactions. 人类白细胞抗原(HLA)调节同步神经相互作用变异性对年龄的依赖性。

IF 3.6

Neuroscience Insights Pub Date : 2023-01-01 DOI: 10.1177/26331055231159658

Lisa M James, Arthur C Leuthold, Apostolos P Georgopoulos

{"title":"Human Leukocyte Antigen (HLA) Modulates the Dependence on Age of the Variability of Synchronous Neural Interactions.","authors":"Lisa M James, Arthur C Leuthold, Apostolos P Georgopoulos","doi":"10.1177/26331055231159658","DOIUrl":"https://doi.org/10.1177/26331055231159658","url":null,"abstract":"Recent evidence documented a protective effect of Class II human leukocyte antigen (HLA) DRB1*13 on brain health across the lifespan including evidence of reduced neural network variability relative to non-carriers. Here, in an extension of those findings, we evaluated the influence of a large number of Class I and Class II HLA alleles on aging-related changes in neural network variability. Cognitively healthy women (N = 178) ranging in age from 28 to 99 years old underwent a magnetoencephalography scan from which neural network variability was calculated and provided a blood sample from which HLA and apolipoprotein E (ApoE) genotype were determined. The primary analyses assessed the dependence of network variability on age in carriers of a specific HLA allele compared to non-carriers. Effects were considered protective if there was a significant increase of network variability with age in the absence of a given HLA allele but not in its presence, and were considered to confer susceptibility if the converse was documented; HLA alleles that did not influence the dependence of network variability on age in their presence or absence were considered neutral. Of 50 alleles investigated, 22 were found to be protective, 7 were found to confer susceptibility, and 21 were neutral. The frequencies of those 50 alleles were not associated significantly with ApoE genotype. The findings, which document the influence of HLA on age-related brain changes and highlight the role of HLA in healthy brain function, are discussed in terms of the role of HLA in the human immune response to foreign antigens.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"18 ","pages":"26331055231159658"},"PeriodicalIF":3.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/47/cb/10.1177_26331055231159658.PMC10037734.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9561066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Physiological and Molecular Links Between Physical Activity and Brain Health: A Review. 体育活动与大脑健康之间的生理和分子联系:综述。

IF 3.6

Neuroscience Insights Pub Date : 2023-01-01 DOI: 10.1177/26331055231191523

Sarah Schock, Antoine Hakim

引用次数: 0

Thanks to Reviewers. 感谢评论者。

IF 3.6

Neuroscience Insights Pub Date : 2023-01-01 DOI: 10.1177/26331055231153918

引用次数: 0

COVID-19 Vaccine Evolution and Beyond. COVID-19疫苗的演变及其后续。

IF 3.6

Neuroscience Insights Pub Date : 2023-01-01 DOI: 10.1177/26331055231180543

Yardley Brice, Larry Morgan, Maaida Kirmani, Maha Kirmani, Mercy C Udeh

{"title":"COVID-19 Vaccine Evolution and Beyond.","authors":"Yardley Brice, Larry Morgan, Maaida Kirmani, Maha Kirmani, Mercy C Udeh","doi":"10.1177/26331055231180543","DOIUrl":"https://doi.org/10.1177/26331055231180543","url":null,"abstract":"In December 2019, a new severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) was first reported in China. It would quickly spread and emerge as a COVID-19 pandemic. The illness caused by SARS CoV-2 would fall on a clinical spectrum ranging from asymptomatic, mild to severe respiratory symptoms, ARDS, and death. This led to significant morbidity and mortality further impacting at-risk populations with severe complications. Thus, a concerted worldwide effort to meet the challenges of diagnosing, treating, and preventing COVID-19 led to rapid advances in medicine. Some mitigating methods of masking, social distancing, and frequent handwashing, helped to slow the spread of SARS-CoV-2. Effective therapeutics consisting of antivirals and monoclonal antibodies, plus their use for prophylaxis, contributed to the management of COVID-19. The vaccines from various platforms (mRNA, viral vectors, protein base, and inactivated) contributed to decreased incidence, severity, and overall decreased hospitalizations and mortality. This article aims to review the novel mRNA vaccines (Moderna + Pfizer/BioNTech), viral vector (Janssen& Johnson), and protein base (Novavax), their side effects, and their use as boosters.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"18 ","pages":"26331055231180543"},"PeriodicalIF":3.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4d/09/10.1177_26331055231180543.PMC10280118.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10070968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Neuromuscular Disorders Associated With COVID-19. 与COVID-19相关的神经肌肉疾病。

IF 3.6

Neuroscience Insights Pub Date : 2023-01-01 DOI: 10.1177/26331055231176251

Larry Morgan, Mary Hollist, Katherine Au, Lena Ayari, Colton Betts, Batool F Kirmani

引用次数: 0

Neurobiology of Disorganized Attachment: A Review of Primary Studies on Human Beings. 无组织依恋的神经生物学:对人类初步研究的回顾。

IF 3.6

Neuroscience Insights Pub Date : 2023-01-01 DOI: 10.1177/26331055221145681

Marcelo Arancibia, Mariane Lutz, Álvaro Ardiles, Camila Fuentes

{"title":"Neurobiology of Disorganized Attachment: A Review of Primary Studies on Human Beings.","authors":"Marcelo Arancibia, Mariane Lutz, Álvaro Ardiles, Camila Fuentes","doi":"10.1177/26331055221145681","DOIUrl":"https://doi.org/10.1177/26331055221145681","url":null,"abstract":"This article describes and analyzes various aspects related to the neurobiology of disorganized attachment (DA), which is associated with personality, eating, affective, dissociative, and addictive disorders. We included primary studies in humans, published in PubMed from 2000 to 2022. Eight genetic and one epigenetic study were considered. Three molecular studies describe possible roles of oxytocin and cortisol, seven neurophysiological studies investigated functional correlates, and five morphological studies describe anatomical changes. Findings in candidate genes involved in dopaminergic, serotonergic, and oxytonergic systems have not been able to be replicated in large-scale human studies. Alterations in the functioning of cortisol and oxytocin are preliminary. Neurophysiological studies show changes in subcortical structures (mainly in the hippocampus) and occipital, temporal, parietal, and insular cortices. Since there is a lack of robust evidence on the neurobiology of DA in humans, the possible inferences of these studies are preliminary, which restricts their translation to clinical parameters.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"18 ","pages":"26331055221145681"},"PeriodicalIF":3.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/18/08/10.1177_26331055221145681.PMC9947683.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9340857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Drosophila Stat92E Signaling Following Pre-exposure to Ethanol. 预暴露于乙醇后果蝇Stat92E信号传导

IF 3.6

Neuroscience Insights Pub Date : 2023-01-01 DOI: 10.1177/26331055221146755

Alexandria Wilson, Erica M Periandri, Mackenzie Sievers, Emily Petruccelli

{"title":"Drosophila Stat92E Signaling Following Pre-exposure to Ethanol.","authors":"Alexandria Wilson, Erica M Periandri, Mackenzie Sievers, Emily Petruccelli","doi":"10.1177/26331055221146755","DOIUrl":"https://doi.org/10.1177/26331055221146755","url":null,"abstract":"Repeated exposure to alcohol alters neuromolecular signaling that influences acute and long-lasting behaviors underlying Alcohol Use Disorder (AUD). Recent animal model research has implicated changes in the conserved JAK/STAT pathway, a signaling pathway classically associated with development and the innate immune system. How ethanol exposure impacts STAT signaling within neural cells is currently unclear. Here, we investigated the role of Drosophila Stat92E in ethanol-induced locomotion, signaling activity, and downstream transcriptional responses. Findings suggest that expressing Stat92E-RNAi causes enhanced ethanol-induced hyperactivity in flies previously exposed to ethanol. Furthermore, alternative splicing of Stat92E itself was detected after repeated ethanol exposure, although no changes were found in downstream transcriptional activity. This work adds to our growing understanding of altered neuromolecular signaling following ethanol exposure and suggests that STAT signaling may be a relevant target to consider for AUD treatment.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"18 ","pages":"26331055221146755"},"PeriodicalIF":3.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c2/47/10.1177_26331055221146755.PMC9834942.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10589583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0