Neuroscience Insights最新文献_第9页

At the Root of 3 "Long" Diseases: Persistent Antigens Inflicting Chronic Damage on the Brain and Other Organs in Gulf War Illness, Long-COVID-19, and Chronic Fatigue Syndrome. 三种“长期”疾病的根源:海湾战争病、长期covid -19和慢性疲劳综合征中对大脑和其他器官造成慢性损伤的持久性抗原

IF 3.6

Neuroscience Insights Pub Date : 2022-07-22 eCollection Date: 2022-01-01 DOI: 10.1177/26331055221114817

Lisa M James, Apostolos P Georgopoulos

{"title":"At the Root of 3 \"Long\" Diseases: Persistent Antigens Inflicting Chronic Damage on the Brain and Other Organs in Gulf War Illness, Long-COVID-19, and Chronic Fatigue Syndrome.","authors":"Lisa M James, Apostolos P Georgopoulos","doi":"10.1177/26331055221114817","DOIUrl":"https://doi.org/10.1177/26331055221114817","url":null,"abstract":"Several foreign antigens such as those derived from viruses and bacteria have been linked to long-term deleterious effects on the brain and other organs; yet, health outcomes subsequent to foreign antigen exposure vary depending in large part on the host's immune system, in general, and on human leukocyte antigen (HLA) composition, in particular. Here we first provide a brief description of 3 conditions characterized by persistent long-term symptoms, namely long-COVID-19, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and Gulf War Illness (GWI), followed by a brief overview of the role of HLA in the immune response to foreign antigens. We then discuss our Persistent Antigen (PA) hypothesis and highlight associations between antigen persistence due to HLA-antigen incongruence and chronic health conditions in general and the 3 \"long\" diseases above in particular. This review is not intended to cover the breadth and depth of symptomatology of those diseases but is specifically focused on the hypothesis that the presence of persistent antigens underlies their pathogenesis.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":" ","pages":"26331055221114817"},"PeriodicalIF":3.6,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/70/1e/10.1177_26331055221114817.PMC9335483.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40572350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

VEGF Paradoxically Reduces Cerebral Blood Flow in Alzheimer's Disease Mice. VEGF矛盾地减少阿尔茨海默病小鼠的脑血流量。

IF 3.6

Neuroscience Insights Pub Date : 2022-07-04 eCollection Date: 2022-01-01 DOI: 10.1177/26331055221109254

Muhammad Ali, Oliver Bracko

引用次数: 7

Sleep Quality of Covid-19 Recovered Patients in India. 印度新冠肺炎康复患者的睡眠质量

IF 3.6

Neuroscience Insights Pub Date : 2022-06-23 eCollection Date: 2022-01-01 DOI: 10.1177/26331055221109174

Raina Chhajer, Sunil Dutt Shukla

{"title":"Sleep Quality of Covid-19 Recovered Patients in India.","authors":"Raina Chhajer, Sunil Dutt Shukla","doi":"10.1177/26331055221109174","DOIUrl":"https://doi.org/10.1177/26331055221109174","url":null,"abstract":"Objective: The second wave of the Covid-19 pandemic in India was widespread and caused psychological distress among the citizens. Hospitals were running at a premium, increasing deaths and trepidation stories were on air by media, this generated sleep disturbances for many. This study aimed to examine the sleep quality of Covid-19 recovered patients in India during the second wave of the pandemic.Methods: Patients who had recently recovered from Covid-19 were invited to participate in this cross-sectional study using various social media platforms. An online survey questionnaire, including socio-demographics, health-related information, Covid-19 related information, and the Pittsburgh Sleep Quality Index (PSQI), was administered in June 2021. Descriptive statistics were used to compare the scores among the mild, moderate, and severe groups. ANOVA was used to find the difference between the groups for global PSQI scores.Results: A total of 311 participants (261 mild, 45 moderate, and 5 severe) provided usable responses. The Global PSQI score for the overall study sample was 8.22 ± 3.79. In the severe group, scores were higher 16.8 ± 2.59, and statistically significant from mild or moderate groups. Sleep quality of Covid-19 recovered patients was found to be statistically significantly different based on their gender (P < .001), annual income (P < .001), employment status (P < .001), and marital status (P < .001).Conclusion: Females, employment in the private sector, annual income below rupees 11 lakh, and unmarried Covid-19 recovered patients reported poor sleep quality. As our findings indicate poor sleep quality among the Covid-19 recovered patients during the second wave in India, designing psychological interventions is recommended to support their wellbeing post-recovery.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":" ","pages":"26331055221109174"},"PeriodicalIF":3.6,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/88/ae/10.1177_26331055221109174.PMC9235310.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40406418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Genetic Toolkit for Simultaneous Generation of LexA- and QF-Expressing Clones in Selected Cell Types in Drosophila. 在果蝇选定细胞类型中同时产生表达LexA和qf的克隆的遗传工具包。

IF 3.6

Neuroscience Insights Pub Date : 2022-01-24 eCollection Date: 2022-01-01 DOI: 10.1177/26331055211069939

Kota Banzai, Ping Shen, Daichi Kamiyama

引用次数: 0

Effects of a 12-Week Periodized Resistance Training Program on Resting Brain Activity and Cerebrovascular Function: A Nonrandomized Pilot Trial. 12周周期抗阻训练计划对静息脑活动和脑血管功能的影响:一项非随机试验。

IF 3.6

Neuroscience Insights Pub Date : 2022-01-01 DOI: 10.1177/26331055221119441

Timothy R Macaulay, Amy Hegarty, Lirong Yan, Dominique Duncan, Judy Pa, Jason J Kutch, Marianna La Rocca, Christianne J Lane, E Todd Schroeder

{"title":"Effects of a 12-Week Periodized Resistance Training Program on Resting Brain Activity and Cerebrovascular Function: A Nonrandomized Pilot Trial.","authors":"Timothy R Macaulay, Amy Hegarty, Lirong Yan, Dominique Duncan, Judy Pa, Jason J Kutch, Marianna La Rocca, Christianne J Lane, E Todd Schroeder","doi":"10.1177/26331055221119441","DOIUrl":"https://doi.org/10.1177/26331055221119441","url":null,"abstract":"Resistance training is a promising strategy to promote healthy cognitive aging; however, the brain mechanisms by which resistance training benefits cognition have yet to be determined. Here, we examined the effects of a 12-week resistance training program on resting brain activity and cerebrovascular function in 20 healthy older adults (14 females, mean age 69.1 years). In this single group clinical trial, multimodal 3 T magnetic resonance imaging was performed at 3 time points: baseline (preceding a 12-week control period), pre-intervention, and post-intervention. Along with significant improvements in fluid cognition (d = 1.27), 4 significant voxelwise clusters were identified for decreases in resting brain activity after the intervention (Cerebellum, Right Middle Temporal Gyrus, Left Inferior Parietal Lobule, and Right Inferior Parietal Lobule), but none were identified for changes in resting cerebral blood flow. Using a separate region of interest approach, we provide estimates for improved cerebral blood flow, compared with declines over the initial control period, in regions associated with cognitive impairment, such as hippocampal blood flow (d = 0.40), and posterior cingulate blood flow (d = 0.61). Finally, resistance training had a small countermeasure effect on the age-related progression of white matter lesion volume (rank-biserial = -0.22), a biomarker of cerebrovascular disease. These proof-of-concept data support larger trials to determine whether resistance training can attenuate or even reverse salient neurodegenerative processes.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"17 ","pages":"26331055221119441"},"PeriodicalIF":3.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/36/10.1177_26331055221119441.PMC9379950.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10608764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing Spinal Interneurons for Spinal Cord Repair. 利用脊髓中间神经元修复脊髓。

IF 3.6

Neuroscience Insights Pub Date : 2022-01-01 DOI: 10.1177/26331055221101607

Lyandysha V Zholudeva, Michael A Lane

引用次数: 1

Brain Networks of Connectionally Unique Basolateral Amygdala Cell Types 连接独特的基底外侧杏仁核细胞类型的脑网络

IF 3.6

Neuroscience Insights Pub Date : 2022-01-01 DOI: 10.1177/26331055221080175

Houri Hintiryan, Hong-wei Dong

引用次数: 2

Protein Network Analysis Reveals a Functional Connectivity of Dysregulated Processes in ALS and SMA 蛋白质网络分析揭示了ALS和SMA失调过程的功能连通性

IF 3.6

Neuroscience Insights Pub Date : 2022-01-01 DOI: 10.1177/26331055221087740

S. Kubinski, P. Claus

{"title":"Protein Network Analysis Reveals a Functional Connectivity of Dysregulated Processes in ALS and SMA","authors":"S. Kubinski, P. Claus","doi":"10.1177/26331055221087740","DOIUrl":"https://doi.org/10.1177/26331055221087740","url":null,"abstract":"Spinal Muscular Atrophy (SMA) and Amyotrophic Lateral Sclerosis (ALS) are neurodegenerative diseases which are characterized by the loss of motoneurons within the central nervous system. SMA is a monogenic disease caused by reduced levels of the Survival of motoneuron protein, whereas ALS is a multi-genic disease with over 50 identified disease-causing genes and involvement of environmental risk factors. Although these diseases have different causes, they partially share identical phenotypes and pathomechanisms. To analyze and identify functional connections and to get a global overview of altered pathways in both diseases, protein network analyses are commonly used. Here, we used an in silico tool to test for functional associations between proteins that are involved in actin cytoskeleton dynamics, fatty acid metabolism, skeletal muscle metabolism, stress granule dynamics as well as SMA or ALS risk factors, respectively. In network biology, interactions are represented by edges which connect proteins (nodes). Our approach showed that only a few edges are necessary to present a complex protein network of different biological processes. Moreover, Superoxide dismutase 1, which is mutated in ALS, and the actin-binding protein profilin1 play a central role in the connectivity of the aforementioned pathways. Our network indicates functional links between altered processes that are described in either ALS or SMA. These links may not have been considered in the past but represent putative targets to restore altered processes and reveal overlapping pathomechanisms in both diseases.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46276512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Commentary: How Do Microglia Regulate Neural Circuit Connectivity and Activity in the Adult Brain? 评论:小胶质细胞如何调节成人大脑中的神经回路连接和活动?

IF 3.6

Neuroscience Insights Pub Date : 2022-01-01 DOI: 10.1177/26331055211071124

Yong-Jun Liu, Kim N Green, Todd C Holmes, Xiangmin Xu

引用次数: 1

A Tailored Music-Motor Therapy and Real-Time Biofeedback Mobile Phone App (‘GotRhythm’) to Promote Rehabilitation Following Stroke: A Pilot Study 定制的音乐-运动疗法和实时生物反馈手机应用程序(“gorhythm”)促进中风后康复:一项试点研究

IF 3.6

Neuroscience Insights Pub Date : 2022-01-01 DOI: 10.1177/26331055221100587

Katherine Hankinson, A. Shaykevich, A. Vallence, J. Rodger, Michael A. Rosenberg, C. Etherton-Beer

{"title":"A Tailored Music-Motor Therapy and Real-Time Biofeedback Mobile Phone App (‘GotRhythm’) to Promote Rehabilitation Following Stroke: A Pilot Study","authors":"Katherine Hankinson, A. Shaykevich, A. Vallence, J. Rodger, Michael A. Rosenberg, C. Etherton-Beer","doi":"10.1177/26331055221100587","DOIUrl":"https://doi.org/10.1177/26331055221100587","url":null,"abstract":"Background: Stroke persists as an important cause of long-term disability world-wide with the need for rehabilitation strategies to facilitate plasticity and improve motor function in stroke survivors. Rhythm-based interventions can improve motor function in clinical populations. This study tested a novel music-motor software application ‘GotRhythm’ on motor function after stroke. Methods: Participants were 22 stroke survivors undergoing inpatient rehabilitation in a subacute stroke ward. Participants were randomised to the GotRhythm intervention (combining individualised music and augmented auditory feedback along with wearable sensors to deliver a personalised rhythmic auditory stimulation training protocol) or usual care. Intervention group participants were offered 6-weeks of the GotRhythm intervention, consisting of a supervised 20-minute music-motor therapy session using GotRhythm conducted 3 times a week for 6 weeks. The primary feasibility outcomes were adherence to the intervention and physical function (change in the Fugl-Meyer Assessment of Motor Recovery score) measured at baseline, after 3-weeks and at end of the intervention period (6-weeks). Results: Three of 10 participants randomised to the intervention did not receive any of the GotRhythym music-motor therapy. Of the remaining 7 intervention group participants, only 5 completed the 3-week mid-intervention assessment and only 2 completed the 6-week post-intervention assessment. Participants who used the intervention completed 5 (IQR 4,7) sessions with total ‘dose’ of the intervention of 70 (40, 201) minutes. Conclusion: Overall, adherence to the intervention was poor, highlighting that application of technology assisted music-based interventions for stroke survivors in clinical environments is challenging along with usual care, recovery, and the additional clinical load.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"17 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44197673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7