Health Science Reports最新文献

{"title":"A Comparative Study of Pancreatic Acinar Cell Carcinoma: A Case–Control Study","authors":"Bor-Shiuan Shyr,&nbsp;Ting-Chung Chen,&nbsp;Shin-E. Wang,&nbsp;Shih-Chin Chen,&nbsp;Yi-Ming Shyr,&nbsp;Bor-Uei Shyr","doi":"10.1002/hsr2.70633","DOIUrl":"https://doi.org/10.1002/hsr2.70633","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Pancreatic acinar cell carcinoma (PACC) is rare. This study aims to elucidate its clinical features and survival outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients diagnosed with PACC were enrolled. A comparison between PACC and pancreatic ductal adenocarcinoma (PDAC) patients was conducted following propensity score matching (PSM).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were 11 resectable and nine unresectable PACC. The majority (60%) of PACC cases were located in the pancreatic head, with a median tumor size of 5.9 cm. Elevated serum lipase level was observed in 64.3% of cases. Regional lymph node involvement was found in 65.0%. The median survival was 20.0 months for resectable PACC patients compared to 6.7 months for unresectable cases. The 1-, 3-, and 5-year survival rates were 100%, 49.1%, and 32.0%, respectively, for resectable PACC patients, while for unresectable cases, they were 33.3%, 0%, and 0%. Resectable PACC patients exhibited lower rates of lymph node involvement (36.4% vs. 66.1%), lymphovascular invasion (LVI), 36.4% versus 72.8%, and perineural invasion (PNI), 45.5% versus 86.0%, compared to PDAC. Following PSM, there was no significant difference in survival between resectable PACC and PDAC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PACC is associated with lower rates of lymph node involvement, LVI, and PNI, which might attribute to superior outcome when compared with PDAC reported in the literature. However, there is no survival difference between resecrable PACC and PDAC after PSM.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70633","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying the Relationships Between Health Sector Strategic Planning Practices and Health Sector Results in Tanzania: A Cross-Sectional Study","authors":"Mwandu Kini Jiyenze,&nbsp;Henry Mollel,&nbsp;Charles Tundui","doi":"10.1002/hsr2.70637","DOIUrl":"https://doi.org/10.1002/hsr2.70637","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>There is still limited evidence on the relationships between strategic planning practices and strategic results in the health sector. The study aimed to examine and quantify these relationships in Tanzania.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study involving 290 council health managers from 23 councils was conducted. We used a questionnaire to collect data on health sector strategic planning practices and health sector results related to health sector strategic plan IV (HSSP). We analyze the data using descriptive methods analysis, factor analysis, and multiple regression analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our findings showed separately that HSSP formulation practices had a positive, weak, and significant relationship with perceived health sector results; HSSP implementation practices had a positive, moderate, and significant relationship with perceived health sector results; HSSP monitoring and evaluation had a positive, strong, and significant relation with perceived health sector results. Furthermore, jointly, all the practices of HSSP formulation, implementation, and monitoring and evaluation were positively related to perceived strategic health sector results, and findings indicated that only HSSP implementation and monitoring and evaluation practices were significantly and positively related to the health sector results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study provides additional evidence to the ongoing debate on the relationships between strategic planning practices and strategic results in the health sector and the public sector. Overall, our evidence suggests that only the HSSP implementation and HSSP monitoring and evaluation practices are significantly and positively related to strategic health sector results. We recommend that the council health managers continue to engage in the implementation, monitoring, and evaluation practices to enhance their chances of achieving the strategic results set out in the health sector strategic plans. We encourage future studies using longitudinal study design, objective and in other settings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70637","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Distraction on Pain Management in Children Aged 5 to 12 Years Old With Acute Leukemia Undergoing Bone Marrow Aspiration","authors":"Soodabeh Razmi,&nbsp;Mehrdad Karajizadeh,&nbsp;Soheila Zarei Fard,&nbsp;Saeideh Pourahmad,&nbsp;Pooria Fazeli,&nbsp;Najmeh Bordbar","doi":"10.1002/hsr2.70634","DOIUrl":"https://doi.org/10.1002/hsr2.70634","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Acute leukemia is considered the most common form of cancer in children. Different painful diagnostic approaches may be applied to diagnose acute lymphoblastic leukemia (ALL) in children suspected of having the disease, such as blood tests and bone marrow aspiration (BMA). Several studies reported that distraction strategies could alleviate pain severity in children. Therefore, the current study aimed to investigate the effectiveness of distraction in pain management in children aged 5−12 years old with acute leukemia undergoing BMA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In a quasi-experimental study involving 60 participants, using convenience sampling, they were assigned to control (<i>n</i> = 30) and distraction (<i>n</i> = 30) groups. Children in the distraction group watched TV cartoons during BMA, while children in the control group didn't. The children's level of acute pain was measured using Oucher's scale before, 30, and 60 min after the intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean pain severity score immediately before the intervention between the intervention and control groups was markedly different (2.33 ± 1.21 vs. 3.60 ± 1.56, <i>p</i> = 0.005). Also, the mean severity score after 30 min of the second BMA illustrated a significant difference between the intervention and control groups (4.20 ± 1.84 vs. 6.6 ± 2.16, <i>p</i> &lt; 0.001). We observed a considerable difference between the intervention and control groups regarding the mean severity score after 60 min of the second BMA (2.06 ± 0.82 vs. 4.8 ± 2.34, <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The design and implementation of well-developed pain management regularly involving sustained and organized distraction can effectively manage the severity of pain in acute leukemia children undergoing BMA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70634","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Practice, and Associated Factors of Insulin Self-Administration in Patients With Diabetes at Dessie City Governmental Hospital Follow Up Clinic, Amhara Region, North East Ethiopia: Cross-Sectional Study","authors":"Wasihun Melaku Feleke,&nbsp;Caridad Sanchez Olis,&nbsp;Adem Hussien Endris,&nbsp;Seid Legesse Hassen,&nbsp;Yimer Seid Ali,&nbsp;Dessale Abate Beyene","doi":"10.1002/hsr2.70631","DOIUrl":"https://doi.org/10.1002/hsr2.70631","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Diabetes mellitus is an increasingly prevalent medical condition. The primary method of treating high blood sugar levels is subcutaneous insulin therapy. However, insufficient knowledge and poor practice related to insulin can negatively impact its effectiveness and adherence. Diabetic patients who are unaware of proper insulin self-administration can experience severe complications. Hence, the aim of this study was to assess knowledge, practices, and associated factors related to the self-administration of insulin among diabetic patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An institutional cross-sectional study used interviewer-administered questionnaires from April 1, 2022, to June 30, 2022. Descriptive statistics were used to summarize sociodemographic data. Univariate and multivariate regression analyses were performed to measure the associations between the dependent and independent variables. A <i>p</i> value of less than 0.05 was generally considered statistically significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In this study, 69.3% of participants had good knowledge and 63.9% had good practice. In multiple logistic regressions, patients' occupation, type of diabetes, membership in the Ethiopian Diabetic Association, and the source of information about diabetes (from health professionals or media) were associated with knowledge of self-administration of insulin. On the other hand, younger age (18–24 years) and duration of insulin therapy &gt; 9 years were associated with good practice of self-administration of insulin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study found that patients had suboptimal knowledge and practice regarding insulin self-administration. Patients must receive adequate education to address these knowledge gaps and improve insulin therapy outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70631","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iranian Healthcare System Response to Hospital and Intensive Care Bed Requirements During the COVID-19 Pandemic: A Cross-Sectional Study","authors":"Fazeleh Hemmati,&nbsp;Kasra Jafari,&nbsp;Majid Mirmohammadkhani","doi":"10.1002/hsr2.70639","DOIUrl":"https://doi.org/10.1002/hsr2.70639","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>The COVID-19 pandemic posed significant challenges to healthcare systems worldwide, including Iran. This article examines the Iranian healthcare system's response to hospital and intensive care unit (ICU) bed requirements during the pandemic. Objectives were to describe the number of total, general, and ICU beds and their change before and during the COVID-19 outbreak in Iran and to describe the change variations among provinces and in pandemic and post-pandemic periods.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study design was used to analyze data from the Statistical Centre of Iran. The data set included information on total, general, and ICU beds across different types of healthcare facilities for pre- and post-pandemic periods. We assessed changes in bed counts (both in crude numbers and population-standardized rates) in the two mentioned periods from March 2015 to 2022.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study revealed that during the pandemic, there was a notable increase in total, general, and ICU bed counts in Iran. However, when comparing the pre- and post-pandemic periods, ICU beds showed a significantly higher increase (+34.01%) and general beds increased less (+7.47%). The variations in bed count changes among provinces underscored the importance of considering local impacts and resource availability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings demonstrate the adaptability of the Iranian healthcare system to the pandemic. While the system successfully increased ICU bed capacity, there was a shift in resource allocation priorities, with a lesser emphasis on general beds. International comparisons highlight similar strategies employed globally, emphasizing the need for scalable resources during a crisis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70639","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitude, and Practice of Medication Use During Pregnancy: A Cross-Sectional Study in Western Uganda","authors":"Musiime Brian,&nbsp;Narayana Goruntla,&nbsp;Bhavana Reddy Bommireddy,&nbsp;Bhavani Mopuri,&nbsp;Easwaran Vigneshwaran,&nbsp;Mohammad Jaffar Sadiq Mantargi,&nbsp;Vishnuvandana Bandaru,&nbsp;Joseph Obiezu Chukwujekwu Ezeonwumelu,&nbsp;Sarad Pawar Naik Bukke,&nbsp;Tadele Mekuriya Yadesa,&nbsp;Ebere Emilia Ayogu","doi":"10.1002/hsr2.70644","DOIUrl":"https://doi.org/10.1002/hsr2.70644","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Medication use (MU) during pregnancy can increase the risk of maternal and fetal health consequences. Women's knowledge, attitude, and practice (KAP) regarding safe MU can influence pregnancy outcomes. The study aimed to assess and explore women's KAP regarding safe MU during pregnancy and identify possible determinants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional analytical, interview-based survey was conducted among pregnant women attending antenatal care (ANC) visits in the obstetrics and gynaecology department of Kyegegwa General Hospital, Kyegegwa district, Western Uganda. A 24-item pre-designed, validated structured questionnaire was used to assess the KAP of MU among pregnant women. Binary and multiple logistic regression analyses were used to identify factors associated with KAP about MU.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 415 pregnant women with a mean (SD) age of 26.51 (5.15) years were included. Most of the women have a positive attitude (78.60%) towards safe MU, but less than half only hold adequate knowledge (42.60%), and rational practice (34.50%). Factors such as secondary education level or less (AOR = 0.15; 95% CI = 0.01–0.38), urban residence (AOR = 1.54; 95% CI = 2.68–4.49), profession (AOR = 1.94; 95% CI = 2.36–10.59), regular ANC visits (AOR = 1.22; 95% CI = 1.06–3.48), GP visit during pregnancy (AOR = 2.54; 95% CI = 1.09–5.91), and using at least one medication (AOR = 9.00; 95% CI = 2.78–6.43) were significantly associated with adequate knowledge regarding MU. The practice domain revealed that age less than 30 years (AOR = 0.53; 95% CI = 0.28–0.98), profession (AOR = 2.56; 95% CI = 1.86–7.59), regular ANC visits (AOR = 1.79; 95% CI = 1.05–3.74), and GP visit during pregnancy (AOR = 1.73; 95% CI = 1.02–3.25) were significantly associated with rational practice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study concludes that three-fourths of the pregnant women have a positive attitude regarding safe MU, still there is an extensive gap in transforming this positive attitude into rational practice due to lack of adequate knowledge. So, to address the gap identified in the knowledge and practice domain, hospital-based educational interventions on safe MU can be initiated by targeting young age, lower or no education, rural residents, and participants working in non-healthcare profession.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70644","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing the Dual Threat of Dengue and Influenza in Bangladesh: A Perspective on the Prevention and Preparedness Strategies","authors":"Taslima Jamal Urmi,&nbsp;Syed Masudur Rahman Dewan,&nbsp;Md. Rabiul Islam","doi":"10.1002/hsr2.70656","DOIUrl":"https://doi.org/10.1002/hsr2.70656","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>In Bangladesh, dengue fever and influenza pose serious public health risks due to their high rates of morbidity and fatality. Frequent outbreaks have been caused by dengue, a virus spread by mosquitoes that causes flu-like symptoms, particularly during the monsoon season. Another infectious respiratory illness that varies every year is influenza. Both illnesses frequently co-circulate in tropical areas like Bangladesh, raising the possibility of co-infection and putting vulnerable groups at higher risk. The purpose of the article is to explore the effects of dengue and influenza co-infection in Bangladesh, looking at present issues and possible solutions to this dual health burden.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methodology</h3>\u0000 \u0000 <p>This perspective piece gathers data from authoritative sources, including PubMed, the World Health Organization, Directorate General of Health Services, Ministry of Health and Family Welfare, Bangladesh, and the European Center for Disease Prevention and Control. Relevant literature on dengue and influenza incidence, control measures, and co-infection dynamics was reviewed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>In Bangladesh, dengue incidence are still on the rise, while influenza infections have climbed, especially during the winter. The country's healthcare system may be overburdened by the simultaneous spread of both diseases, particularly if dengue rates keep rising and influenza cases rise. To lessen the effects of these illnesses, effective community awareness campaigns, vector control initiatives, and early diagnosis techniques are crucial.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Bangladesh must emphasize increased preventative and preparation measures, such as better monitoring, public health communication, and vaccine development research, given the twin danger posed by dengue and influenza. To lower the likelihood of co-infection and avert future public health emergencies, coordinated actions are essential.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70656","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Significance of Serum Ferritin and Hepcidin as Complementary Biomarkers for Prostate Disease: A Prospective Case–Control Study in a Mission Hospital, Ghana","authors":"Samuel Kwasi Appiah,&nbsp;Bosomtwi Boateng,&nbsp;Charles Nkansah,&nbsp;Bismark Nantomah,&nbsp;Sibiri Ballu,&nbsp;Gabriel Abbam,&nbsp;Samira Daud,&nbsp;Gifty Yambor Yenpiini,&nbsp;Ethel Akabawon Abagulum,&nbsp;Felix Osei-Boakye,&nbsp;Christopher Nkrumah,&nbsp;Michael Asamoah Gyamfi,&nbsp;Eric Antwi Osei Kwadwo,&nbsp;Yussif Adams,&nbsp;Simon Bannison Bani,&nbsp;Moses Banyeh,&nbsp;Adams Abubakari Sadick,&nbsp;Haajaratu Zama Alhassan,&nbsp;Solomon Yeboah,&nbsp;Charles A. Derigubah,&nbsp;Ejike Felix Chukwurah","doi":"10.1002/hsr2.70642","DOIUrl":"https://doi.org/10.1002/hsr2.70642","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>Currently, available evidence suggests prostate-specific antigen (PSA) is highly sensitive but poorly specific for prostate cancer detection in symptomatic patients and those with lower urinary tract symptoms. Serum ferritin and hepcidin, which are implicated in the pathogenesis of prostate cancers, may complement the diagnostic value of PSA. This study explored the correlation of serum PSA with ferritin and hepcidin as new and complementary diagnostic biomarkers for prostate disease.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This hospital-based case–control study was conducted at Methodist Hospital, Wenchi, with 90 participants. Venous blood sample was taken for complete blood count, PSA, ferritin, and hepcidin measurements using Mindray automated hematology analyzer and ELISA, respectively. Data were analyzed with SPSS version 27, and <i>p</i> &lt; 0.05 was considered statistically significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Serum PSA levels were significantly higher among the Prostate Cancer patients compared to BPE patients [32.1 (18.2–47.6) vs. 18.3 (12.2–0.6), <i>p</i> &lt; 0.001]. Levels of serum ferritin and hepcidin were found to be significantly higher in PCa patients compared to BPE and controls <i>(p</i> &lt; 0.001). Serum PSA of prostate disease patients showed a strong positive correlation with levels of ferritin (<i>r</i> = 0.739, <i>p</i> &lt; 0.001) but moderately correlated with serum hepcidin levels (<i>r</i> = 0.670, <i>p</i> &lt; 0.001). Serum ferritin was found to be an excellent diagnostic marker for prostate cancer (AUC = 0.972, <i>p</i> &lt; 0.001) and BPE (AUC = 0.900, <i>p</i> &lt; 0.001). Serum hepcidin was a better marker for PCa (AUC = 0.911) but a poor BPE (AUC = 0.664, <i>p</i> = 0.023). Significant reduction in the levels of Hb, RBC, MCHC, and HCT but higher counts of TWBC and RDW-CV were observed in patients with prostate cancers compared to those with BPE and the normal control group <i>(p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>High levels of serum ferritin and hepcidin significantly correlated directly with increased serum total PSA levels and could play a valuable role to complement the noninvasive total PSA to improve diagnostic accuracy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70642","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Malignancy on the Risk of Venous Thromboembolism in Pregnant Women: A Systematic Review","authors":"Ali Vaezi,&nbsp;Seyyed Kiarash Sadat Rafiei,&nbsp;Bita Amiri,&nbsp;Ali Rezvanimehr,&nbsp;Maryam Naji abhary,&nbsp;Pariya Mahdavi,&nbsp;Mohammad Abbasalizadeh,&nbsp;Ghazale Yavari,&nbsp;Mahsa Shirforoush Sattari,&nbsp;Ali Kheirandish,&nbsp;Gisou Erabi,&nbsp;Foad Vakili Zadeh,&nbsp;Fatemeh Rasekh,&nbsp;Asiyeh Pormehr-yabandeh,&nbsp;Seyede Zohreh Mohagheghi,&nbsp;Hoda Zaraj,&nbsp;Amir Abdi,&nbsp;Parisa alsadat Dadkhah,&nbsp;Niloofar Deravi","doi":"10.1002/hsr2.70456","DOIUrl":"https://doi.org/10.1002/hsr2.70456","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Venous thromboembolism (VTE) is a distinct malignancy complication that raises the risk of demise in cancer patients by up to thrice. However, pregnant females have a 4–5 times greater chance of getting VTE than nonpregnant women. The current systematic review aimed to elucidate the impact of malignancy on the risk of VTE in pregnant females.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We carried out a systematic search in multiple databases, including PubMed (Medline), Google Scholar, and Scopus, up to January 2023. Finally, 441 related articles were extracted from the databases. After screening the title, abstract, and full text, seven articles were included in the study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seven studies (six cohorts and one cross-sectional) with 58,854,195 pregnant females (22,396 cancer patients) were included. These studies were done in the United States of America, Canada, Brazil, and Denmark. All of the studies except one study demonstrated that cancer in pregnant patients increased the risk of deep vein thrombosis (DVT). The risk of VTE prevalence in pregnant females with a record of malignancy was significantly higher than in free cancer groups, and the highest aOR was correlated to myeloid leukemia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Evidence in this systematic review showed that pregnant women with malignancy are more susceptible to VTE and other coagulation disorders. Physicians and health policymakers should be of high vigilance to pregnancy-associated VTE, especially in women who have cancer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70456","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous Pulmonary Valve Implantation In Native Right Ventricular Outflow Tract Using Myval™ Without Pre-Stenting","authors":"João Luiz Langer Manica,&nbsp;Raul Ivo Rossi Filho,&nbsp;Carlos Augusto Cardoso Pedra,&nbsp;Fabio Vieira Caovilla,&nbsp;Francisco Chamié,&nbsp;Carlo Benatti Pilla,&nbsp;Pablo Thomé,&nbsp;Vinicius Fraga,&nbsp;Marcelo Ribeiro,&nbsp;Germana Cerqueira Coimbra,&nbsp;João Henrique Aramayo Rossi,&nbsp;Ênio Guerios,&nbsp;João Vitor Slaviero,&nbsp;Santiago Raul Arrieta","doi":"10.1002/hsr2.70598","DOIUrl":"https://doi.org/10.1002/hsr2.70598","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Percutaneous pulmonary valve implantation was introduced two decades ago as a low-risk alternative for patients previously operated with conduits presenting RVOT dysfunction. Recently, Sapien valve was approved for use in the pulmonary position but this valve cannot be used for RVOT larger than 29 mm. Self-expanding valves can be used for large native RVOT, however, there are some cases not suitable for this technique. The advent of 30.5 and 32 mm Myval™ balloon expandable heart valves provided the possibility to treat these patients percutaneously. The objective of this study is to describe immediate results of 30.5 and 32 mm MyVal™ valves implantation in native and large RVOT without pre-stenting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seventeen patients underwent to percutaneous pulmonary valve implantation to treat large and native dysfunctional RVOT. The mean patient age was 26.2 ± 13.0 years, and the mean patient weight was 64.8 ± 14.8 kg. All patients had been previously submitted to at least one surgical procedure. The implantation was directly performed without pre-stenting in all patients. The mean basal RVOT diameter was 27.6 ± 2.1 mm. Five patients underwent to 30.5 mm and 12 patients underwent to 32 mm pulmonary valve implantation. All patients had satisfactory valve function immediately after valve implantation. The average hospital stay was 3.2 days.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In conclusion, the 30.5 and 32 mm MyVal™ valves have significant potential for treating patients with large native RVOTs, providing a safe and effective alternative to traditional surgical approaches and existing percutaneous options.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70598","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}