Health Science Reports最新文献

{"title":"The Efficacy and Safety of Negative-Pressure Wound Therapy Combined With Platelet-Rich Plasma in Chronic Refractory Wounds: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","authors":"Ran Hao, Mao Luo, Yanting Xiao, Jing Li, Xinyue Lv, Yumei Peng, Yuxuan Wu, Yan Shen, Wei Jiang","doi":"10.1002/hsr2.70205","DOIUrl":"https://doi.org/10.1002/hsr2.70205","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Chronic refractory wound is a disease that seriously impairs the quality of life of patients. Negative pressure wound therapy and platelet-rich plasma are commonly used to treat various types of wounds. Further research is necessary to explore the efficacy and safety of the combination of negative pressure wound therapy and platelet-rich plasma in treating chronic refractory wounds.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>PubMed, Web of Science, EMBASE, Cochrane, CINAHL, CNKI, Sino Med, and Wanfang Med Online up until March 2024 were searched(PROSPERO No. CRD42024507963). Two investigators screened literature according to inclusion and exclusion criteria, evaluated bias and certainty of evidence using RoB 2.0 and GRADE. Stata 12.0 was used to analyze the data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 35 randomized controlled trials involving 2495 participants were included. 34 studies were assessed as having some concerns, and 1 study as having high risk in the risk of bias assessment. The results of meta-analysis showed that effective rate (RR1.23, 95% CI [1.17, 1.30], <i>p</i> < 0.001; I<sup>2</sup> = 44.7%, <i>p</i> = 0.013), healing time (WMD-9.32, 95% CI [−10.60, −8.03], <i>p</i> < 0.001; I² = 91.00%, <i>p</i> < 0.001), healing rate (RR1.76, 95% CI [1.50, 2.07], <i>p</i> < 0.001; I<sup>2</sup> = 62.6%, <i>p</i> < 0.001), positive rate of bacterial(RR0.25, 95% CI [0.15, 0.40], <i>p</i> < 0.001; I² = 0%, <i>p</i> = 0.841), pain score (WMD-1.43, 95% CI [−2.14, −0.72], <i>p</i> < 0.001; I² = 96.5%, <i>p</i> < 0.001), incidence of complications (RR0.45, 95% CI [0.30, 0.68], <i>p</i> < 0.001; I² = 46.3%, <i>p</i> = 0.098), length of hospital stay (WMD-9.88, 95% CI [−13.42, 6.34], <i>p</i> < 0.001; I<sup>2</sup> = 98.9%, <i>p</i> < 0.001), number of dressing changes (WMD-2.56, 95% CI [−4.28, −0.83], <i>p</i> = 0.004; I² = 98.9%, <i>p</i> < 0.001), white blood cell level (WMD-1.71, 95% CI [−2.00, −1.41], <i>p</i> < 0.001; I² = 33.9%, <i>p</i> = 0.195), c-reactive protein level (WMD-0.68, 95% CI [−1.04, −0.33], <i>p</i> < 0.001; I² = 88.8%, <i>p</i> < 0.001), erythrocyte sedimentation rate (WMD-6.09, 95% CI [−8.05, −4.13], <i>p</i> < 0.001; I² = 13%, <i>p</i> = 0.32), score of vancouver scar scale (WMD-1.78, 95% CI [−1.89, −1.66], <i>p</i> < 0.001; I² = 38.3%, <i>p</i> = 0.166) and preparation time of secondary repair (WMD-4.95, 95% CI [−7.03, −2.87], <i>p</i> < 0.001; I² = 84.7%, <i>p</i> < 0.001) had statistically significant effects. However, hospitalization costs (WMD1423.56, 95% CI [−4588.93, 7436.06], <i>p</i> = 0.643; I","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soft Tissue Sarcoma in Sub-Saharan Africa: Surgical Management Outcomes, Gaps, and Future Prospects: A Narrative Review","authors":"Favour Tope Adebusoye,&nbsp;Sakshi Roy,&nbsp;Hareesha Rishab Bharadwaj,&nbsp;Syed Hasham Ali,&nbsp;Wireko Andrew Awuah,&nbsp;Tomas Ferreira,&nbsp;Joecelyn Kirani Tan,&nbsp;Nicholas Aderinto,&nbsp;Saleha Azeem,&nbsp;Paul Olutosin Salako,&nbsp;Pearl Ohenewaa Tenkorang,&nbsp;Harendra Kumar,&nbsp;Toufik Abdul-Rahman","doi":"10.1002/hsr2.70215","DOIUrl":"https://doi.org/10.1002/hsr2.70215","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>The diagnosis and management of soft tissue sarcoma (STS) in sub-Saharan Africa (SSA) present significant challenges. Positive outcomes in STS treatment include achieving negative margins, improved quality of life, and reduced recurrence rates, while negative outcomes involve incomplete resection, local recurrence, and surgical complications. This review aims to examine the current state of STS management in SSA, identify key challenges, and propose potential solutions to improve patient outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive review of the literature using PubMed/MEDLINE, Google Scholar, and Scopus, focusing on English-language studies examining the management of STS in SSA. Inclusion criteria centered on studies reporting on surgical interventions, outcomes, and healthcare challenges in the region. Articles lacking sufficient data, non-English sources, conference abstracts, and duplicates were excluded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Findings highlight several obstacles in the management of STS in SSA, including limited multidisciplinary teams, inadequate healthcare infrastructure, financial constraints, and lack of standardized treatment protocols. Key themes such as diagnostic capacity and resource allocation were identified as significant barriers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Improving STS outcomes in SSA requires investment in healthcare infrastructure, professional development, enhanced funding, and collaborative research. Addressing these gaps is crucial to achieving better surgical management and improving survival rates for patients with STS in SSA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70215","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Value of Serum Soluble Programmed Death 1 (sPD-1) and Programmed Death Ligand 1 (sPD-L1) in Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis About Cohort Studies","authors":"Qiyao Yu,&nbsp;Jie Li,&nbsp;Wenjie Mao,&nbsp;Zheng Li,&nbsp;Xuan Li,&nbsp;Bin Li","doi":"10.1002/hsr2.70178","DOIUrl":"https://doi.org/10.1002/hsr2.70178","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>There are still no useful biomarkers for the prognosis of esophageal squamous cell carcinoma (ESCC). In the prognosis of some kinds of cancer, soluble programmed death 1 (sPD-1) and programmed death ligand 1 (sPD-L1) have demonstrated statistical significance, but the prognostic value of serum sPD-L1 and sPD-1 remains unclear in ESCC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Here, a meta-analysis was performed to estimate the prognostic value of sPD-L1 and sPD-1 in ESCC. To obtain eligible studies, we searched mainstream databases (PubMed, Cochrane, Embase, Web of Science, Wanfang Data, and CNKI), and the survival data including hazard ratios (HR) and its 95% confidence intervals (95% CI) from included literature were extracted.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Six articles were included, including 645 patients with ESCC. The statistical result of this meta-analysis indicated that serum sPD-1 had no significant correlation with overall survival (OS) of patients with ESCC (<i>p</i> &gt; 0.05). Patients with ESCC with high concentrations of serum sPD-L1 demonstrated a significantly poor prognosis (HR = 1.73, 95% CI: 1.42–2.11, <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Higher levels of serum sPD-L1 may predict poor OS in ESCC patients, which may be a promising and credible prognostic biomarker for esophageal cancer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Preliminary Testing of the Staffordshire Questionnaire for Adolescent Idiopathic Scoliosis (SQ-AIS): Content and Face Validity","authors":"Enza Leone,&nbsp;Nachiappan Chockalingam,&nbsp;Robert Needham,&nbsp;Aoife Healy,&nbsp;Nicola Eddison,&nbsp;Nikola Jevtic,&nbsp;Vinay Jasani","doi":"10.1002/hsr2.70213","DOIUrl":"https://doi.org/10.1002/hsr2.70213","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Adolescent Idiopathic Scoliosis (AIS) is a structural spinal deformity with implications for health-related quality of life (HR-QoL). The Scoliosis Research Society-22 revised (SRS-22r) questionnaire is the standard for HR-QoL assessment. However, studies have identified limitations with the SRS-22r, including content and face validity issues, reliability concerns, and language appropriateness. This study aimed to develop and validate a patient-reported questionnaire, the Staffordshire Questionnaire for Adolescent Idiopathic Scoliosis (SQ-AIS), to assess the impact of AIS on HR-QoL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The SQ-AIS comprises six domains: general health, pain, function/activity, self-image/appearance, mental health, and intervention. Individuals with AIS aged 10–19 years and clinicians from a range of countries with expertise in AIS contributed to the testing process. Face validity and clinical applicability were assessed using Likert scales, while content validity was evaluated through a categorical binary variable (yes/no).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Involving 8 AIS patients and 43 clinicians, face validity scores demonstrated an acceptable level of understanding (≥ 4/5) for both individuals with AIS and clinicians. Most individuals with AIS (85.71%) and clinicians (80.95%) affirmed that the questionnaire sufficiently covers various aspects of scoliosis, indicating a satisfactory level of content validity. Ratings for applicability to clinical practice indicated an acceptable level of practical relevance (≥ 4/5).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion and Conclusion</h3>\u0000 \u0000 <p>The SQ-AIS emerges as a valid and promising tool to overcome existing challenges in AIS-related outcome assessment. Pending further validation studies, the favorable reception from the international community of clinicians suggests its potential as a new benchmark for evaluating AIS impact on HR-QoL and monitoring scoliosis management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142707928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological flexibility as a mediator in the relationship between resilience and academic burnout among Doctor of Physical Therapy students: A structural equation modeling study","authors":"Jason Cherry,&nbsp;Gurpreet Singh,&nbsp;Michael Buck","doi":"10.1002/hsr2.2291","DOIUrl":"https://doi.org/10.1002/hsr2.2291","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Although resilience has been identified as an important factor for mitigating burnout among health profession students, little is known regarding the modifiable factors that should be emphasized to improve resilience in this population. The purpose of this study was to evaluate psychological flexibility as a modifiable mediator of the relationship between resilience and academic burnout among healthcare students.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study was conducted with 369 Doctor of Physical Therapy (DPT) students from universities across the United States. A two-stage structural equation modeling approach, including confirmatory factor analysis and structural path analysis, was used to investigate psychological flexibility as a mediator of the relationship between resilience and academic burnout.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The measurement and structural path models demonstrated a good fit to the data. Resilience had a statistically significant indirect association with less academic burnout through psychological flexibility as the mediator (<i>β</i> = −0.32, 95% confidence interval = [−0.43, −0.08], <i>p</i> &lt; 0.001). The direct relationship between resilience and academic burnout was not statistically significant (<i>β</i> = −0.19, <i>p</i> = 0.10).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These results indicate that the positive effects of resilience on academic burnout occur through modifiable psychological flexibility processes only. These results suggest that psychological flexibility is a modifiable mechanism through which resilience impacts academic burnout. Developing interventions focusing on psychological flexibility may help students build resilience and limit academic burnout, positively impacting the students, their future institutions, and their future patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.2291","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142707664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing the Peri-Wound Intact Skin of Hard-To-Heal Diabetic Foot Ulcers With Topical Red Deer Conditioned Media (PTT-6TM) Skin Conditioner: A Case Series on Clinical Efficacy","authors":"Kimberley Leow,&nbsp;Leon Timothy Charles Alvis,&nbsp;Bradley Edmond Charles Yuen,&nbsp;Leighton Cheng,&nbsp;Shiqi Chiam,&nbsp;Siti Nurfarahdillah Binte Abdul Razak,&nbsp;Gerard Benjamin Evans,&nbsp;Kenneth Koh,&nbsp;Ivor Jiun Lim,&nbsp;Toan Thang Phan,&nbsp;Keng Lin Wong","doi":"10.1002/hsr2.70211","DOIUrl":"https://doi.org/10.1002/hsr2.70211","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>The healing of diabetic foot ulcers (DFUs) can be hindered by the susceptibility of the surrounding intact skin to pro-inflammatory proteases. A conditioned media, known as PTT-6^TM, derived from mesenchymal stem cells found in the lining of red deer umbilical cords, has been formulated to protect the intact peri-wound skin of DFUs. The aim is to evaluate the clinical effectiveness of PTT-6^TM in managing peri-wound intact skin in hard-to-heal DFUs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with DFUs that persisted for over 3 months were divided into two subgroups. The active wound group received standard-of-care treatment protocol followed by PTT-6^TM application around the peri-wound area, while the maintenance wound group applied PTT-6^TM media over the healed wound site.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Forty cases were recorded, of which 22 (55%) were included in the active wound group. The majority were male (75%, <i>n</i> = 30) and vast majority had cardiovascular risk factors, including diabetes mellitus (100%, <i>n</i> = 40), hyperlipidemia (82.5%, <i>n</i> = 33), and hypertension (77.5%, <i>n</i> = 31). Most patients had forefoot wounds (80%, <i>n</i> = 32) on the plantar aspect (82.5%, <i>n</i> = 33). The patients in the active wound group had chronic DFUs for a mean of 218 ± 201 days. Of those treated with PTT-6™ media, 68.4% (<i>n</i> = 13) achieved complete wound healing within a mean duration of 69 ± 50 days. Additionally, most patients in the maintenance wound group remained ulcer-free at 3 months (91.7%, <i>n</i> = 11) and 6 months (66.7%, <i>n</i> = 6).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study results suggest that PTT-6^TM media may serve as an additional treatment modality for enhancing the microenvironment at the peri-wound intact skin site. This could indirectly facilitate wound healing by preserving the integrity of the peri-wound intact skin.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70211","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Multiparametric MRI Protocols for Prostate Cancer Detection: A Comprehensive Assessment Aligned with PI-RADS Guidelines","authors":"Mohammad Hossein Jamshidi,&nbsp;Ali Fatemi,&nbsp;Aida Karami,&nbsp;Sepehr Ghanavati,&nbsp;Durjoy D. Dhruba,&nbsp;Mohammad H. Negarestanian","doi":"10.1002/hsr2.70172","DOIUrl":"https://doi.org/10.1002/hsr2.70172","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>Multiparametric magnetic resonance imaging (mpMRI) is recognized as the most indicative method for diagnosing prostate cancer. The purpose of this narrative review is to provide a comprehensive evaluation aligned with the Prostate Imaging and Reporting Data System (PI-RADS) guidelines, offering an in-depth insight into the various MRI sequences used in a standard mpMRI protocol. Additionally, it outlines the critical technical requirements necessary to perform a standard mpMRI examination of the prostate, as defined by the PI-RADS specifications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>European Society of Urogenital Radiology has released PI-RADS guideline detailing its suggestions aimed at improving the standards of the procedure. The purpose of this guideline is to establish a standard strategy for MRI protocols and image interpretation, aiming to prevent variability in each of the imaging and interpretation stages.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A standard mpMRI protocol comprises morphological sequences and functional sequences. Morphological sequences which encompass T1- and T2-weighted images, and various functional sequences include diffusion-weighted imaging, and dynamic contrast-enhanced MRI. The PI-RADS recommendations assert that having a standard and uniform protocol for all MRI centers is imperative. Furthermore, the existence of a standardized checklist for interpreting MRI images can foster greater consensus in the process of diagnosing and treating patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Standardized protocols and checklists for mpMRI interpretation are essential for achieving greater consensus among radiologists, ultimately leading to improved diagnostic outcomes in prostate cancer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70172","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A State-of-the-Art Review on the Recent Advances in Exosomes in Oncogenic Virus.","authors":"Fatemeh Ebrahimi, Ali Modaresi Movahedi, Mohammad Sabbaghian, Vahdat Poortahmasebi","doi":"10.1002/hsr2.70196","DOIUrl":"10.1002/hsr2.70196","url":null,"abstract":"<p><strong>Background and aims: </strong>Oncogenic viruses are responsible for approximately 12% of human malignancies, influencing various cancer processes through intricate interactions with host cells. Exosomes (EXOs), nanometric-sized microvesicles involved in cell communication, have emerged as critical mediators in these interactions. This review aims to explore the mechanisms by which EXOs produced by cells infected with oncogenic viruses promote cancer growth, enhance viral transmissibility, and act as immunomodulators.</p><p><strong>Methods: </strong>A comprehensive review was conducted, focusing on recent studies highlighting the mechanisms by which EXOs facilitate the oncogenic potential of viruses. The analysis included the characterization of exosomal content, such as microRNAs (miRNAs) and proteins, and their effects on tumor microenvironments and immune responses. A search was performed using databases including PubMed, ScienceDirect, and Google Scholar. MeSH keywords related to EXOs, oncogenic viruses, and cancer were used to retrieve relevant review, systematic, and research articles.</p><p><strong>Results: </strong>Findings indicate that EXOs from oncogenic virus-infected cells carry viral components that facilitate infection and inflammation. These EXOs alter the tumor microenvironment, contributing to the development of virus-associated cancers. Additionally, the review highlights the growing interest among researchers regarding the implications of EXOs in cancer progression and their potential role in enhancing the oncogenicity of viruses.</p><p><strong>Conclusion: </strong>The findings underscore the pivotal role of EXOs in mediating the oncogenic effects of viruses, suggesting that targeting exosomal pathways may provide new therapeutic avenues for managing virus-associated cancers. Further research is needed to fully elucidate the functional mechanisms of EXOs in viral oncogenesis.</p>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":"e70196"},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Determinants of Scabies Among Schoolchildren in Ethiopia: A Systematic Review and Meta-Analysis","authors":"Abayeneh Girma,&nbsp;Indiris Abdu","doi":"10.1002/hsr2.70199","DOIUrl":"https://doi.org/10.1002/hsr2.70199","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>In deprived and poor communities worldwide, scabies remains an overlooked tropical disease. Numerous individual studies have been conducted in Ethiopia on this issue, demonstrating notable disparities and inconclusive findings. This systematic review and meta-analysis aimed to establish Ethiopia's pooled scabies prevalence and determinants among schoolchildren.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Studies were retrieved from PubMed, Scopus, Science Direct, Google Scholar, and African Journals Online through a systematic search. The Joanna Briggs Institute's critical appraisal tool was employed to assess the quality of observational studies (cross-sectional and case-control). The meta-analysis was performed using Stata software version 14 and its metan command. A forest plot was used with a random effects model to calculate the pooled prevalence and its 95% confidence interval (CI). Subgroup and sensitivity analyses were employed to evaluate potential sources of heterogeneity. The funnel plot and Egger's test were used to evaluate publication bias, while heterogeneity was assessed using inverse variance (<i>I</i>²).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In this systematic review and meta-analysis, 14.71% (733/5104) of schoolchildren had scabies, with a 95% CI of 8.90%−20.52%. The highest prevalence is recorded in the Amhara region (17.09%; 95% CI: 2.15–32.04), and the lower prevalence is seen in the Oromia region (12.52%; 95% CI: 10.08–14.95). Children sharing clothes with scabies cases, using common sleeping beds/fomites, having a family history of scabies, and having illiterate parents are significantly associated with scabies among Ethiopian schoolchildren (based on adjusted odds ratios: 7.07; 95% CI: 1.55–12.59, 2.13; 95% CI: 0.04–4.22, 1.45; 95% CI: 0.35–3.94, 1.42; 95% CI: 0.94–0.89).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The current prevalence of scabies ranges from 12.52% to 17.09% and is higher in the Amhara region. The national policymakers and health planners should prioritize implementing prevention and control measures of scabies among schoolchildren through ivermectin-based mass drug administration for three to five rounds annually until the prevalence is less than 2%.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70199","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A State-of-the-Art Review on the Recent Advances in Exosomes in Oncogenic Virus","authors":"Fatemeh Ebrahimi,&nbsp;Ali Modaresi Movahedi,&nbsp;Mohammad Sabbaghian,&nbsp;Vahdat Poortahmasebi","doi":"10.1002/hsr2.70196","DOIUrl":"https://doi.org/10.1002/hsr2.70196","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Oncogenic viruses are responsible for approximately 12% of human malignancies, influencing various cancer processes through intricate interactions with host cells. Exosomes (EXOs), nanometric-sized microvesicles involved in cell communication, have emerged as critical mediators in these interactions. This review aims to explore the mechanisms by which EXOs produced by cells infected with oncogenic viruses promote cancer growth, enhance viral transmissibility, and act as immunomodulators.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive review was conducted, focusing on recent studies highlighting the mechanisms by which EXOs facilitate the oncogenic potential of viruses. The analysis included the characterization of exosomal content, such as microRNAs (miRNAs) and proteins, and their effects on tumor microenvironments and immune responses. A search was performed using databases including PubMed, ScienceDirect, and Google Scholar. MeSH keywords related to EXOs, oncogenic viruses, and cancer were used to retrieve relevant review, systematic, and research articles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Findings indicate that EXOs from oncogenic virus-infected cells carry viral components that facilitate infection and inflammation. These EXOs alter the tumor microenvironment, contributing to the development of virus-associated cancers. Additionally, the review highlights the growing interest among researchers regarding the implications of EXOs in cancer progression and their potential role in enhancing the oncogenicity of viruses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings underscore the pivotal role of EXOs in mediating the oncogenic effects of viruses, suggesting that targeting exosomal pathways may provide new therapeutic avenues for managing virus-associated cancers. Further research is needed to fully elucidate the functional mechanisms of EXOs in viral oncogenesis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70196","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}