Health Science Reports最新文献

{"title":"Designing the Essential Informational Needs of a Smartphone Application for Self-Management of Patients With Inflammatory Bowel Disease","authors":"Farkhondeh Asadi,&nbsp;Azamossadat Hosseini,&nbsp;Amir Hossein Daeechini","doi":"10.1002/hsr2.70186","DOIUrl":"https://doi.org/10.1002/hsr2.70186","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Inflammatory bowel disease (IBD) is a chronic digestive disease that has a detrimental effect on the quality of life of IBD patients. This study aims to identify the informational needs and design the essential informational needs for a smartphone application for the self-management of IBD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study was conducted in two stages and the informational needs of the patients were extracted in a questionnaire designed in three separate sections and given to 120 patients with UC and 60 patients with CD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After a literature review and analysis of patient responses, it was found that Knowledge of the disease, Medication, Educational information, Complications, Diet &amp; Nutrition, and Lifestyle habits are among the most important domains of informational needs of inflammatory bowel disease patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Patients with IBD have many informational needs, and in this study, identifying these needs, can help improve the quality of life of these patients and be of interest to healthcare providers, designers, and developers of applications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing the Essential Informational Needs of a Smartphone Application for Self-Management of Patients With Inflammatory Bowel Disease.","authors":"Farkhondeh Asadi, Azamossadat Hosseini, Amir Hossein Daeechini","doi":"10.1002/hsr2.70186","DOIUrl":"10.1002/hsr2.70186","url":null,"abstract":"<p><strong>Background and aims: </strong>Inflammatory bowel disease (IBD) is a chronic digestive disease that has a detrimental effect on the quality of life of IBD patients. This study aims to identify the informational needs and design the essential informational needs for a smartphone application for the self-management of IBD.</p><p><strong>Methods: </strong>This study was conducted in two stages and the informational needs of the patients were extracted in a questionnaire designed in three separate sections and given to 120 patients with UC and 60 patients with CD.</p><p><strong>Results: </strong>After a literature review and analysis of patient responses, it was found that Knowledge of the disease, Medication, Educational information, Complications, Diet & Nutrition, and Lifestyle habits are among the most important domains of informational needs of inflammatory bowel disease patients.</p><p><strong>Conclusion: </strong>Patients with IBD have many informational needs, and in this study, identifying these needs, can help improve the quality of life of these patients and be of interest to healthcare providers, designers, and developers of applications.</p>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":"e70186"},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Personalized Stenosing Tenosynovitis Brace Therapy Based on 3D Printing Technology: A Prospective Cohort Study.","authors":"Guantong Sun, Xiaodong Li, Jingjing Dai","doi":"10.1002/hsr2.70156","DOIUrl":"10.1002/hsr2.70156","url":null,"abstract":"<p><strong>Objective: </strong>To explore the clinical effect of personalized brace based on 3D printing technology in the treatment of stenosing tenosynovitis.</p><p><strong>Methods: </strong>From September 2021 to June 2023, 20 patients with stenosing tenosynovitis were collected and randomly divided into the experimental group and the control group, with 10 cases in each group, and each patient signed an informed consent. The experimental group was treated with personalized brace combined with External Diclofenac Diethalamine Emulgel, and the control group was treated with External Diclofenac Diethalamine Emulgel, and the clinical efficacy and pain scores of the two groups were compared.</p><p><strong>Results: </strong>After 8 weeks of treatment, the degree of pain relief, metacarpophalangeal joint mobility and proximal interphalangeal joint mobility of the experimental group were significantly higher than those of the control group. The activity pain scores of both groups were reduced, but the experimental group was significantly lower than the control group (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>For the treatment of patients with stenosing tenosynovitis, it is recommended to use personalized stenosing tenosynovitis brace therapy based on 3D printing technology combined with External Diclofenac Diethalamine Emulgel at the first visit, which can significantly reduce finger pain and improve hand function.</p>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":"e70156"},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Personalized Stenosing Tenosynovitis Brace Therapy Based on 3D Printing Technology: A Prospective Cohort Study","authors":"Guantong Sun,&nbsp;Xiaodong Li,&nbsp;Jingjing Dai","doi":"10.1002/hsr2.70156","DOIUrl":"https://doi.org/10.1002/hsr2.70156","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To explore the clinical effect of personalized brace based on 3D printing technology in the treatment of stenosing tenosynovitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>From September 2021 to June 2023, 20 patients with stenosing tenosynovitis were collected and randomly divided into the experimental group and the control group, with 10 cases in each group, and each patient signed an informed consent. The experimental group was treated with personalized brace combined with External Diclofenac Diethalamine Emulgel, and the control group was treated with External Diclofenac Diethalamine Emulgel, and the clinical efficacy and pain scores of the two groups were compared.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After 8 weeks of treatment, the degree of pain relief, metacarpophalangeal joint mobility and proximal interphalangeal joint mobility of the experimental group were significantly higher than those of the control group. The activity pain scores of both groups were reduced, but the experimental group was significantly lower than the control group (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>For the treatment of patients with stenosing tenosynovitis, it is recommended to use personalized stenosing tenosynovitis brace therapy based on 3D printing technology combined with External Diclofenac Diethalamine Emulgel at the first visit, which can significantly reduce finger pain and improve hand function.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weighted Vest Combined With Vibrotactile Stimulations Decrease the Sympathetic Activity: A Repeated Measures Study","authors":"Mohamad Izzur Maula,&nbsp;Muhammad Imam Ammarullah,&nbsp;Chandra Maulana Nugwita,&nbsp;Muhammad Sultan Faisal,&nbsp;Ilham Yustar Afif,&nbsp;Farhan Ali Husaini,&nbsp;M. Danny Pratama Lamura,&nbsp;Jamari Jamari,&nbsp;Tri Indah Winarni","doi":"10.1002/hsr2.70194","DOIUrl":"10.1002/hsr2.70194","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Mental and neurological disorders are a growing global concern, further intensified by the COVID-19 pandemic. Stress management techniques, such as deep pressure therapy, have gained attention, with weighted vests commonly used for anxiety relief. However, there is limited scientific evidence supporting their efficacy. This study aimed to rigorously assess the effectiveness of a weighted vest incorporating vibrotactile stimulation in reducing anxiety by measuring physiological indicators—pulse rate and skin conductance (SC)—as well as subjective comfort ratings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 30 final-semester college students participated in the study. Participants wore a vibrotactile-weighted vest, and both pulse rate and skin conductance (SC) were measured to gauge anxiety levels. Additionally, participants rated their comfort using a Comfort Rating Scale (CRS). Changes in pulse rate and SC were statistically analyzed, and effect sizes (Cohen's <i>d</i>) were calculated to assess the magnitude of the intervention's impact.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The weighted vest with vibrotactile stimulation resulted in a significant reduction in both pulse rate (dpulse = 0.23–0.62) and SC (dsc = 0.32–0.66), indicating a small to medium effect size in anxiety reduction. Subjective evaluations of the vest using the CRS revealed low scores on discomfort-related items, with participants rating unfavorable statements between 1.5/10 and 4.6/10, suggesting overall comfort during use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study provides compelling evidence that vibrotactile-weighted vests effectively reduce anxiety, as indicated by both physiological measures and subjective comfort ratings. The findings support the potential of this intervention as a formal therapeutic tool for stress and anxiety reduction. Further research may explore long-term effects and broader applications in clinical settings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Maternal Toxoplasma Gondii Molecular and Serological Positivity With Child's Gross-Motor Development and Behavior in Tribal Regions of Gujarat, India: A Prospective Study","authors":"Aarthi Sundararajan,&nbsp;Kranti Vora,&nbsp;Shahin Saiyed,&nbsp;Senthilkumar Natesan,&nbsp;Vidhi Vaidya","doi":"10.1002/hsr2.70183","DOIUrl":"10.1002/hsr2.70183","url":null,"abstract":"&lt;p&gt;&lt;i&gt;Toxoplasma gondii&lt;/i&gt; is a protozoan parasite causing toxoplasmosis in humans, with lifelong presence in brain and muscular tissues [&lt;span&gt;1, 2&lt;/span&gt;]. Disease is mostly asymptomatic with infection largely correlating with changes in human personality [&lt;span&gt;3, 4&lt;/span&gt;]. &lt;i&gt;T. gondii&lt;/i&gt; infection can be acquired from environment and during pregnancy when the parasite can be transmitted to the fetus through the placenta resulting in congenital toxoplasmosis. National and international studies including our previous community study have assessed &lt;i&gt;Toxoplasma&lt;/i&gt; prevalence in pregnant women through molecular and serological methods [&lt;span&gt;5-8&lt;/span&gt;]. Follow-up studies have explored severe or more apparent outcomes among children born to &lt;i&gt;Toxoplasma-&lt;/i&gt;positive mothers, such as hearing-vision deficiencies including chorioretinitis [&lt;span&gt;9, 10&lt;/span&gt;]. Longer pregnancy, slower fetal development, and slower post-natal gross-motor development have been associated with children born to &lt;i&gt;Toxoplasma-&lt;/i&gt;positive mothers [&lt;span&gt;11, 12&lt;/span&gt;]. However, similar profiling of development characteristics in a developing country like India is lacking. In addition, temperament characteristics among children born to &lt;i&gt;Toxoplasma-&lt;/i&gt;positive mothers are unclear.&lt;/p&gt;&lt;p&gt;Therefore, the objective of this small-scale, exploratory study was to explore the association of maternal &lt;i&gt;Toxoplasma&lt;/i&gt; positivity with child's gross-motor development and temperament through structured, well-established, parent-reported questionnaires. This is a nested investigation involving mothers from a previously completed prospective pregnancy cohort study [&lt;span&gt;6&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;There were no significant differences in the prevalence of any of the household-associated infection risk factors among the categories of children born to &lt;i&gt;Toxoplasma-&lt;/i&gt;positive mothers (IgG+, PCR+IgG+, PCR−IgG+) and &lt;i&gt;Toxoplasma-&lt;/i&gt;negative mothers (PCR−IgG−) (Supporting Information: Table S1). Comparing children born to &lt;i&gt;Toxoplasma&lt;/i&gt;-positive and &lt;i&gt;Toxoplasma-&lt;/i&gt;negative groups, there were no significant differences in bio-parameters such as age, low birth weight status, weight, and height (Table 1). Adjustment for confounders such as gender, low birth weight status, and age did not result in any significant association of mothers' &lt;i&gt;Toxoplasma&lt;/i&gt; positivity with the child's weight or height.&lt;/p&gt;&lt;p&gt;In contrast to another study [&lt;span&gt;12&lt;/span&gt;], gross motor skill development did not show significant differences between categories of children born to &lt;i&gt;Toxoplasma-&lt;/i&gt;positive and &lt;i&gt;Toxoplasma-&lt;/i&gt;negative mothers (Table 1). Ages of achieving indicated milestones are within the age cut-offs for normal development as per the Indian Academy of Pediatrics Guidelines [&lt;span&gt;15&lt;/span&gt;], except for the median age of holding head which is delayed by a month from the cut-off in all the groups. None of the children had vision and hearing deficiencies.&lt;/p&gt;&lt;p&gt;IBQ-R-VS responses collected f","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Profile and Risk Factors for Complication of Type 2 Diabetes Mellitus at the National Referral Hospital, Bhutan: A Descriptive Cross-Sectional Study","authors":"Tshering Norbu,&nbsp;Yeshey Dorjey,&nbsp;Sangay Tshering,&nbsp;Namkha Dorji,&nbsp;Guru Prasad Dhakal","doi":"10.1002/hsr2.70202","DOIUrl":"10.1002/hsr2.70202","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>Globally, diabetes mellitus is a major public health concern affecting 10.5% of the population. Nearly 90% of these people have Type 2 diabetes mellitus (T2DM). In Bhutan, T2DM is prevalent in 5.6% of the population, and around 60% are unaware of their diagnosis of diabetes. There is no baseline information on the rate and the risk factors for complications of diabetes in Bhutan. The study assessed the clinical profile and the risk factors for complications of T2DM at the Jigme Dorji Wangchuk (JDW) National Referral Hospital, Bhutan.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A descriptive cross-sectional study was conducted at the JDW National Referral Hospital, Bhutan, from January to December 2019. Patients with T2DM attending diabetic clinics were included in the study. Demographic variables and metabolic profiles were recorded using a standard pro forma. Descriptive statistics were used to express the results. The association of clinical profiles with the microvascular complication was assessed using multivariate logistic analysis with statistical significance at <i>p</i> &lt; 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were 292 patients with T2DM during the study period. The rate of microvascular complication is around 25% in T2DM. Among the complications, diabetic retinopathy occurred in over 51%, followed by neuropathy (29.7%) and nephropathy (18.9%). Over 1/3rd of patients had a duration of diabetes over 10 years with a mean duration of 6.3 (5.4) years, and around 44% (127/292) of them had poor glycemic control (HbA1C ≥ 7%). The age ≥ 60 years and the duration of diabetes ≥ 10 years were independent risk factors for microvascular complications in T2DM patients. Regular exercise prevents retinopathy (OR 0.4, 95%CI 0.2–0.9, <i>p</i> = 0.026).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>There is a microvascular complication in 1 in 4 of type 2 diabetic patients. Age over 60 years and a duration of diabetes of more than 10 years are independent risk factors for microvascular complications, and regular exercise is preventive for microvascular complications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tele-Medical Nutrition Therapy to Promote Healthy Eating and Nutrition Adherence of Chronic Patients in the COVID-19 Pandemic: A Pragmatically Before-After Trial","authors":"Somaye Norouzi,&nbsp;Fateme Arefi Majd,&nbsp;Somaye Rostami,&nbsp;Moghadameh Mirzaee,&nbsp;Samane Sistani,&nbsp;Leila Ahmadian","doi":"10.1002/hsr2.70193","DOIUrl":"10.1002/hsr2.70193","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Patients find it difficult, during the pandemic, to receive appropriate nutrition services because of the limited access to health services. This study assessed the effectiveness of a tele-consulting nutrition intervention on the nutrition adherence of patients with diabetes and hypertension.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A tele-medical nutrition therapy (MNT) intervention was conducted as a one-group before-after trial. The estimated sample size was 314. Of these, 183 patients were selected from Hefdah-e-Shahrivar and 131 from Farabi Hospital. Patients were asked to complete an adapted version of the nutrition adherence self-reported instrument to compare nutrition adherence when they received face-to-face therapy versus tele MNT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 166 completed all phases of the study. The results showed that the nutrition adherence score significantly increased compared to before the intervention. Hedges's <i>g</i> effect size also confirmed the high efficacy of telenutrition therapy. The magnitude of differences was within a high range (effect size 3.76 [CI: 3.40–4.12]).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The present findings showed that providing teleconsulting nutrition services to diabetic and hypertensive patients can positively affect their nutrition adherence. Telenutrition to promote a healthy diet can contribute to effectively controlling diseases in chronic patients during/after the pandemic with no gaps or failures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>This study was a tele-nutrition intervention. In this study, we provided consultation on regular food consumption and did not order any chemical substances or nutritional supplements. Furthermore, we did not perform any treatment or invasive intervention, we assumed that a registration number was unnecessary, so we did not apply for clinical trial registration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the Efficacy of Empirical Anti-Infective Therapy and Follow-Up Observation for Newly Diagnosed Pulmonary Ground-Glass Nodules With Suspected Inflammatory Etiology: A Multicenter Prospective Observational Study Protocol","authors":"Wenhong Feng,&nbsp;Tao He,&nbsp;Yuanqiang Zhang,&nbsp;Yunfei Mu,&nbsp;Yang Pu,&nbsp;Ying Liu,&nbsp;Zhangning Ouyang,&nbsp;Hangao Song,&nbsp;Yiming Zhong,&nbsp;Hong Lu,&nbsp;Yanglin Zhou,&nbsp;Ping Zou,&nbsp;Gang Yang,&nbsp;Honggang Tian,&nbsp;Jianglin Jin,&nbsp;Gaoyu Liang,&nbsp;Lin Yang,&nbsp;Laian Zhang,&nbsp;Yangjun Liu,&nbsp;Wei Dai,&nbsp;Haomiao Qing,&nbsp;Jingyu Zhang,&nbsp;Qiuling Shi,&nbsp;Qiang Li,&nbsp;Ding Yang,&nbsp;Rui Zhang,&nbsp;Xing Wei","doi":"10.1002/hsr2.70201","DOIUrl":"10.1002/hsr2.70201","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>The optimal management strategy for newly diagnosed pulmonary ground-glass nodules (GGNs) with suspected inflammatory etiology remains controversial in clinical practice. Empirical anti-inflammatory therapy is commonly used, but its efficacy compared with that of follow-up observation lacks high-quality evidence. Therefore, this study aims to compare the effectiveness of empirical anti-infective therapy and follow-up observation for pulmonary GGNs in real-world settings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study intends to include 254 participants with newly discovered pulmonary ground-glass opacities (GGOs) suspected to be related to inflammation but without current radiographic features suggestive of malignancy. Antibiotics will be recommended when the doctor considers the GGOs may be infection-related. Upon enrollment, all participants will be assessed with the Self-Rating Anxiety Scale (SAS) and divided into either the intervention or observation group. A repeat CT scan and SAS assessment will be conducted with all participants after 1 month ( ± 2 weeks) following the initial discovery of the GGOs. The primary outcome is the participants' response rate at the first follow-up CT. The secondary outcome is the GGO response rate and total scores of SAS at 1 month after enrollment. A non-inferiority test will be conducted to compare the outcomes between the two groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>To date, the efficacy and necessity of using antibiotics for GGOs suspected to be inflammatory upon primary CT screening remain controversial. This protocol describes the rationale and methodology to address this unmet clinical need using real-world data, aiming to bridge the gap between clinical guidelines and real-world practice.</p>\u0000 \u0000 <p><b>Trial Registration:</b> ChiCTR2200056975.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvements in Hemodynamics and Right Heart Remodeling Following Balloon Pulmonary Angioplasty Treatment in Patients With Chronic Thromboembolic Pulmonary Hypertension: A Retrospective Study","authors":"Qi-Le Shen,&nbsp;Qin-Hua Zhao,&nbsp;Hui-Ting Li,&nbsp;Jie Deng,&nbsp;Jing He,&nbsp;Lan Wang,&nbsp;Su-Gang Gong,&nbsp;Jin-Ming Liu","doi":"10.1002/hsr2.70159","DOIUrl":"10.1002/hsr2.70159","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>This study aimed to evaluate the hemodynamic alterations and right heart remodeling dynamics in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) undergoing treatment with balloon pulmonary angioplasty (BPA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study involved a cohort of 31 patients with a confirmed diagnosis of CTEPH. Comprehensive clinical evaluations were systematically performed before BPA, and at 3 and 6 months following the procedure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant clinical progress was evidenced by the uplift in the percentage of patients achieving WHO-FC II, escalating from 19.35% at baseline to 51.61% at 6 months after BPA (<i>p</i> = 0.003). NT-proBNP levels significantly dropped from a median of 614.6 to 69.9 pg/mL (<i>p</i> &lt; 0.001). Hemodynamic assessments showed significant decreases in mean PAP from 45.53 ± 11.19 to 22.56 ± 5.81 mmHg (<i>p</i> &lt; 0.001) and PVR from 8.33 to 2.86 WU (<i>p</i> &lt; 0.001). Echocardiographic analysis revealed substantial reductions in the right atrial area (RAA, from 20.29 ± 7.55 to 16.79 ± 4.82 cm², <i>p</i> &lt; 0.001) and right ventricular internal diameter (RVID, from 4.13 ± 0.79 to 3.68 ± 0.59 cm, <i>p</i> = 0.001) at the 3-month interval post-BPA. These improvements were sustained or even enhanced by the 6-month mark, with RAA and RVID further diminishing (to 14.46 ± 3.78 cm² and 3.29 ± 0.54 cm, respectively; both <i>p</i> &lt; 0.01). The TAPSE/PASP ratios showed progressive improvement from baseline (0.32 ± 0.13) to 3 months (0.42 ± 0.13) and continued to improve at 6 months following BPA (0.50 ± 0.11, <i>p</i> = 0.04 compared to 3 months post-BPA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>BPA has significantly ameliorated clinical conditions, hemodynamic profiles, and initiated a continued reversal in right heart remodeling in patients with CTEPH.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"7 11","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}