Biosafety and Health最新文献

{"title":"Analysis of the distribution characteristics of enterovirus types based on environmental surveillance from 2013 to 2021 in Fujian Province, China","authors":"Xiuhui Yang ,&nbsp;Shaojian Cai ,&nbsp;Xiaoqian Wu ,&nbsp;Yong Zhang ,&nbsp;Dong Li ,&nbsp;Yahong Chen ,&nbsp;Qianjing Chen ,&nbsp;Shuangli Zhu ,&nbsp;Dongmei Yan ,&nbsp;Wenbo Xu ,&nbsp;Hairong Zhang ,&nbsp;Zhifei Chen ,&nbsp;Suhan Zhang ,&nbsp;Yong Zhou ,&nbsp;Mengping Zhang ,&nbsp;Ningxuan Zheng ,&nbsp;Na You","doi":"10.1016/j.bsheal.2023.05.003","DOIUrl":"10.1016/j.bsheal.2023.05.003","url":null,"abstract":"<div><p>Environmental surveillance (ES) is a useful approach for monitoring circulating viruses, including polioviruses (PVs) and non-polio enteroviruses (NPEVs). In this study, the results of nine years of ES from 2013 to 2021 at six sampling sites in three cities in Fujian Province, China, were summarized. It showed that the sewage samples contained abundant viruses, but the positive rate was affected by different sampling sites. From the 520 samples, 431 PVs, 1,713 NPEVs, and 281 human adenoviruses (HAdVs) were isolated. PV isolates had been markedly affected following the adjustment of the immunization strategy. All but one PV isolate were Sabin-like strains without wild PVs. One isolate was vaccine-derived PV type 3 with 10 variation points in the <em>VP1</em> region. After May 2016, PV type 2 was no longer detected, and PV type 3 became a superior serotype. Of 1,713 NPEVs, 24 serotypes were identified, including echovirus11 (E11), E6, coxsackievirus B3 (CVB3), CVB5, E7, and E3 were the predominant serotypes (37.65%, 20.96%, 11.50%, 8.87%, 8.23%, and 7.06%, respectively). The temporal dynamic of the six common serotypes was inconsistent. E3 was frequently isolated, but the number of isolates was low, with no obvious peaks. E6, E7, and CVB3 exhibited periodic changes with a high peak every three to four years, and E11 only had one high peak lasting four years. Summer-fall peaks of the echoviruses and spring-winter peaks of CVB were observed in the monthly distribution of virus isolation. The infectious isolates of various serotypes of different species identified from the sewage samples showed that ES is an essential part of pathogen surveillance.</p></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"5 4","pages":"Pages 240-249"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44723474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forecast the potential SARS-CoV-2 variants in the future and predict their biological properties and social impacts from bioinformatics and public health perspectives","authors":"Yixue Li ,&nbsp;Yuming Guo ,&nbsp;Tao Huang","doi":"10.1016/j.bsheal.2023.07.005","DOIUrl":"10.1016/j.bsheal.2023.07.005","url":null,"abstract":"","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"5 4","pages":"Pages 191-192"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45281759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the collection and integration of SARS-CoV-2 genome data","authors":"Lina Ma ,&nbsp;Wei Zhao ,&nbsp;Tianhao Huang ,&nbsp;Enhui Jin ,&nbsp;Gangao Wu ,&nbsp;Wenming Zhao ,&nbsp;Yiming Bao","doi":"10.1016/j.bsheal.2023.07.004","DOIUrl":"10.1016/j.bsheal.2023.07.004","url":null,"abstract":"<div><p>Genome data of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for virus diagnosis, vaccine development, and variant surveillance. To archive and integrate worldwide SARS-CoV-2 genome data, a series of resources have been constructed, serving as a fundamental infrastructure for SARS-CoV-2 research, pandemic prevention and control, and coronavirus disease 2019 (COVID-19) therapy. Here we present an overview of extant SARS-CoV-2 resources that are devoted to genome data deposition and integration. We review deposition resources in data accessibility, metadata standardization, data curation and annotation; review integrative resources in data source, de-redundancy processing, data curation and quality assessment, and variant annotation. Moreover, we address issues that impede SARS-CoV-2 genome data integration, including low-complexity, inconsistency and absence of isolate name, sequence inconsistency, asynchronous update of genome data, and mismatched metadata. We finally provide insights into data standardization consensus and data submission guidelines, to promote SARS-CoV-2 genome data sharing and integration.</p></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"5 4","pages":"Pages 204-210"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45326889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenesis of enterovirus infection in central nervous system","authors":"Congcong Wang ,&nbsp;Jichen Li ,&nbsp;Ying Liu ,&nbsp;Qiang Sun ,&nbsp;Zhijun Liu","doi":"10.1016/j.bsheal.2023.06.001","DOIUrl":"https://doi.org/10.1016/j.bsheal.2023.06.001","url":null,"abstract":"<div><p>Enteroviruses (EVs) are classified into 15 species according to their sequence diversity. They include four human EV (A, B, C, and D) and three rhinoviruses (A, B, and C), and cause diseases in millions of people worldwide. Generally, individuals with enteroviral infections have mild clinical symptoms, including respiratory illness, vomiting, diarrhea, dizziness, and fever. More importantly, some members of the human EV family are neurotropic pathogens that may cause a wide range of clinical diseases, such as aseptic meningitis and encephalitis. Previously, the EV that caused the most severe neurotropic symptoms was poliovirus (PV), a member of the EV C group. Poliovirus has been eliminated in most countries through a global vaccination campaign. Non-PV EVs infect the central nervous system (CNS) and are the major EVs causing neurological diseases. These human non-PV EVs include EV A (e.g., EV-A71, CVA6, and CVA16), B (e.g., CVA9 and CVB3, CVB5, echovirus 11 [E11], E30, and E7), C (e.g., CVA24), and D (e.g., EV-D68). Here, we review the relationship between EV infection and CNS diseases and advance in the use of cellular receptors and host immune responses during viral infection.</p></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"5 4","pages":"Pages 233-239"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49731663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and control measures of an outbreak of neonatal echovirus 11 infections in Guangdong, China: A retrospective analysis","authors":"Chunxiao Fang ,&nbsp;Xiaoming Zhang ,&nbsp;Xuemin Huang ,&nbsp;Fengqin Xu ,&nbsp;Danyang Zhao","doi":"10.1016/j.bsheal.2023.07.006","DOIUrl":"https://doi.org/10.1016/j.bsheal.2023.07.006","url":null,"abstract":"<div><p>The objective of this study was to investigate the outbreak of echovirus 11 (ECHO 11) infection in newborns at a hospital in Guangdong Province, China, and to study the effectiveness of prevention and control measures to infer the epidemiological characteristics of ECHO 11 and explore the effective measures for its prevention and control. We performed retrospective analyses of hospital records and laboratory test data. In this outbreak, ten cases of ECHO 11 infection were identified, of which nine cases were nosocomial infections. Most of the cases (90%) were severe, and three died. The onset time interval of 10 patients was 1–4 days, most of which occur in 1–2 days. There were eight (80%) males and two females (20%). The gestational age of the patients was 31 to 40 weeks (mean, 35⁺⁴ weeks; median, 35⁺⁴ weeks). The onset time was 3–26 days (average 9 days; median 8 days). The birth weights of the patients ranged from 1,650 g to 3,450 g (mean 2,385 g; median 2,250 g). We concluded that neonatal infection with ECHO 11 will lead to serious symptoms and high mortality, and is prone to outbreaks of nosocomial infection. We speculate that ECHO 11 is most likely to spread via contact transmission; however, we do not rule out the possibility of droplet transmission. Prevention and control measures can effectively prevent and control hospital enteroviral infections.</p></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"5 4","pages":"Pages 227-232"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49708276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The first local case of mpox caused by an imported case in the Chinese mainland","authors":"Daitao Zhang ,&nbsp;Xiao Qi ,&nbsp;Fu Li ,&nbsp;Yanhui Chu ,&nbsp;Ke Wu ,&nbsp;Jia Li ,&nbsp;Xin Meng ,&nbsp;Xiangfeng Dou ,&nbsp;Zhenyong Ren ,&nbsp;Haoyuan Jin ,&nbsp;Shuang Li ,&nbsp;Yulan Sun ,&nbsp;Yanwei Chen ,&nbsp;Renqing Li ,&nbsp;Dan Li ,&nbsp;Weihong Li ,&nbsp;Yang Yang ,&nbsp;Yang Pan ,&nbsp;Wenjie Tan ,&nbsp;Quanyi Wang","doi":"10.1016/j.bsheal.2023.07.003","DOIUrl":"10.1016/j.bsheal.2023.07.003","url":null,"abstract":"<div><p>Monkeypox (mpox) is a zoonotic disease caused by the mpox virus (MPXV) that has been primarily limited to Central and West African nations since its discovery. The recent spread of the West African lineage of MPXV in historically unaffected countries has raised concerns for global public health. Despite a significant decrease in global mpox cases, there is still a risk of a global resurgence. This study reports the first local case of mpox caused by an imported case in the Chinese mainland. Polymerase chain reaction (PCR) diagnosed the two cases, and the viral genomes were obtained by next-generation sequencing. Genomic analysis revealed that the two strains shared an identical genome sequence and belonged to the B.1.3 branch of the West African lineage, which is the first local case of mpox caused by an imported case in the Chinese mainland, highlighting the potential threat of mpox in China and the immediate need for adequate surveillance measures.</p></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"5 4","pages":"Pages 187-190"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48082998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and control measures of an outbreak of neonatal echovirus 11 infection in Guangdong, China: A retrospective analysis","authors":"Chun-xiao Fang, Xiaoming Zhang, Xuemin Huang, Fengqin Xu, Danyang Zhao","doi":"10.1016/j.bsheal.2023.07.006","DOIUrl":"https://doi.org/10.1016/j.bsheal.2023.07.006","url":null,"abstract":"","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42420037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenesis of enteroviruses infection in central nervous system","authors":"Congcong Wang, Jichen Li, Y. Liu, Q. Sun, Zhijun Liu","doi":"10.1016/j.bsheal.2023.06.001","DOIUrl":"https://doi.org/10.1016/j.bsheal.2023.06.001","url":null,"abstract":"","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42943062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study on environmental surveillance of enterovirus: Using a two-phase separation method and a filtration method with a mixed cellulose ester (MCE) membrane","authors":"Ling Fang ,&nbsp;Meizhong Chen ,&nbsp;Shuangli Zhu ,&nbsp;Wei Zhang ,&nbsp;Dongmei Yan ,&nbsp;Xiaolei Li ,&nbsp;Shufen Huang ,&nbsp;Caixia Li ,&nbsp;Xue Guo ,&nbsp;Hanri Zeng ,&nbsp;Bixia Ke ,&nbsp;Hui Li ,&nbsp;Wenbo Xu ,&nbsp;Changwen Ke ,&nbsp;Xiaoling Deng ,&nbsp;Yong Zhang ,&nbsp;Huanying Zheng","doi":"10.1016/j.bsheal.2023.04.001","DOIUrl":"10.1016/j.bsheal.2023.04.001","url":null,"abstract":"<div><p>This study aimed to compare the sensitivity of two-phase separation and the filtration method using a mixed cellulose ester (MCE) membrane to detect enteroviruses in sewage samples. From December 2015 to July 2016, four domestic sewage samples (1 L/sample) were collected monthly from the Guangzhou Liede Sewage Treatment Plant, and each sewage sample was divided into two aliquots (500 mL). The sewage sample was concentrated using the two-phase separation and the filtration method using an MCE membrane, and the treated solutions were inoculated into cells for enterovirus isolation. Polymerase chain reaction amplification, <em>VP1</em> sequencing, and enterovirus molecular typing were performed on the positive isolates. The detection rates of poliovirus (PV) and non-polio enterovirus (NPEV) obtained using the filtration method using an MCE membrane were higher than those using the two-phase separation method. McNemar's test showed that the detection rates of PV, NPEV, type 1 Sabin-like (SL1), type 2 Sabin-like (SL2), and type 3 Sabin-like (SL3) strain were not statistically significant (<em>P</em> &gt; 0.05). In Guangdong Province, China, the detection rates for PV and NPEV were 53.13% and 62.50% (20/32), respectively. Twenty-seven PVs were isolated, three highly variable strains of the type 1 vaccine, with seven nucleotide substitutions in the <em>VP1</em> region, compared with the type 1 Sabin strains. Eighty-seven strains of NPEV were isolated and nine serotypes were identified, among which coxsackievirus B3 (CVB3), echovirus 6(E6), and echovirus 11(E11) were the dominant strains. The filtration method using an MCE membrane is more sensitive than two-phase separation and can be used as a robust, sensitive, and cost-effective method to isolate enteroviruses from sewage.</p></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"5 3","pages":"Pages 174-180"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41791956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recombinant truncated envelope protein of West Nile virus adjuvanted with Alum/CpG induces potent humoral and T cell immunity in mice","authors":"Yongping Du, Yao Deng, Ying Zhan, Ren Yang, Jiao Ren, Wen Wang, Baoying Huang, W. Tan","doi":"10.1016/j.bsheal.2023.06.003","DOIUrl":"https://doi.org/10.1016/j.bsheal.2023.06.003","url":null,"abstract":"","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47552457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}