Superior effectiveness and acceptability of saliva samples for the detection of SARS-CoV-2 in China

IF 3.5 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Biosafety and Health Pub Date : 2024-04-01 DOI:10.1016/j.bsheal.2024.03.002

Hui Yao , Ying Shen , Zhichao Liang , Xiaoyu Xue , Chenxi Zhao , Xiang Xu , Yuxin Cai , Yonghong Liu , Wei Zhang , Yang Pan , Xiaoli Wang

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引用次数: 0

Abstract

In response to problems of poor sampling quality, low sensitivity, and high demand for medical personnel regarding the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) oropharyngeal (OP) swab sampling used in China, we aimed to evaluate the diagnostic performance and acceptability of saliva-based nucleic acid amplification tests (NAATs) in China. The results showed that, using nasopharyngeal (NP) swab results as the gold standard, the overall sensitivities for saliva specimens and OP swabs were 93.3 % and 85.0 %, the specificities were 92.6 % and 93.8 %, respectively. The results of an acceptability survey showed that the scores for saliva, OP, and NP samples were 9.46 ± 1.69, 8.11 ± 2.42, and 4.58 ± 3.82 out of 10, respectively, with significant differences among the three groups (P < 0.05). With higher sensitivity, comparable specificity, and strong public preference, saliva-based NAATs represent a convenient and effective method for detecting SARS-CoV-2 in future epidemics.

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中国唾液样本检测SARS-CoV-2的优越性和可接受性

针对中国目前采用的严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）口咽拭子采样存在的采样质量差、灵敏度低、对医务人员要求高等问题，我们对中国基于唾液的核酸扩增检测（NAATs）的诊断性能和可接受性进行了评估。结果显示，以鼻咽（NP）拭子结果为金标准，唾液标本和鼻咽（OP）拭子的总体灵敏度分别为 93.3 % 和 85.0 %，特异度分别为 92.6 % 和 93.8 %。可接受性调查结果显示，唾液、OP 和 NP 样本的得分分别为（9.46 ± 1.69）、（8.11 ± 2.42）和（4.58 ± 3.82）（满分 10 分），三组之间差异显著（P < 0.05）。基于唾液的 NAATs 具有较高的灵敏度、相当的特异性和公众的强烈偏好，是未来流行病中检测 SARS-CoV-2 的一种方便有效的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biosafety and Health Medicine-Infectious Diseases

CiteScore

7.60

自引率

0.00%

发文量

116

审稿时长

66 days