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Development of an identity test for COVID-19 mRNA vaccines using SARS-CoV-2 NAT standard 基于SARS-CoV-2 NAT标准的COVID-19 mRNA疫苗鉴定试验的建立
IF 3
Biosafety and Health Pub Date : 2025-08-01 DOI: 10.1016/j.bsheal.2025.07.007
Miran Jo , Eunjo Lee , Ho Jung Oh , Jin Tae Hong , Kyung Hee Sohn
{"title":"Development of an identity test for COVID-19 mRNA vaccines using SARS-CoV-2 NAT standard","authors":"Miran Jo ,&nbsp;Eunjo Lee ,&nbsp;Ho Jung Oh ,&nbsp;Jin Tae Hong ,&nbsp;Kyung Hee Sohn","doi":"10.1016/j.bsheal.2025.07.007","DOIUrl":"10.1016/j.bsheal.2025.07.007","url":null,"abstract":"<div><div>Despite the development of messenger ribonucleic acid (mRNA) vaccines for the infectious novel coronavirus 2 (SARS-CoV-2), further research on test methods is required to ensure their quality as well as rapid and effective approval for release to the market. During the current national lot release testing, identity tests cannot be conducted on other products using primers, probes, and in-house reference materials provided by the manufacturer and specific to one vaccine, because their sequences do not match. When key reagents and reference materials are dependent on the manufacturer in this way, difficulties in national lot release approval—which serves as an additional step for the government to verify product quality—arise if the manufacturer does not provide them. In this study, we aimed to develop a quantitative polymerase chain reaction (qPCR) assay by using commercially available nucleic acid amplification test (NAT) reference material and a dye instead of a probe along with primers that were newly designed in this study. It can be applied to both vaccines. This study suggests a test method that can be applied when the in-house reference standard for the identity test, a major step to confirm the quality of vaccines, is not secured.</div></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"7 4","pages":"Pages 224-227"},"PeriodicalIF":3.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A metagenomic approach for microbial risk assessment and source attribution in high-risk ports of entry environments 高风险入境口岸环境中微生物风险评估和来源归因的宏基因组方法
IF 3
Biosafety and Health Pub Date : 2025-08-01 DOI: 10.1016/j.bsheal.2025.07.001
Xiaozhou He , Ran Zhang , Jie Dong , Wei Zhen , Li Zhu , Junkai Ren , Xuejun Ma , Feng Wang , Shuang Zhang , Ke Xu , Feng Qiu , Qiudong Su , Jian’an He , Weimin Zhou , Guizhen Wu
{"title":"A metagenomic approach for microbial risk assessment and source attribution in high-risk ports of entry environments","authors":"Xiaozhou He ,&nbsp;Ran Zhang ,&nbsp;Jie Dong ,&nbsp;Wei Zhen ,&nbsp;Li Zhu ,&nbsp;Junkai Ren ,&nbsp;Xuejun Ma ,&nbsp;Feng Wang ,&nbsp;Shuang Zhang ,&nbsp;Ke Xu ,&nbsp;Feng Qiu ,&nbsp;Qiudong Su ,&nbsp;Jian’an He ,&nbsp;Weimin Zhou ,&nbsp;Guizhen Wu","doi":"10.1016/j.bsheal.2025.07.001","DOIUrl":"10.1016/j.bsheal.2025.07.001","url":null,"abstract":"<div><div>The epidemiological characteristics of emerging infectious disease outbreaks in recent years have underscored the critical importance of controlling imported infectious diseases. In this study, we implemented dynamic tracking of microbial invasions by monitoring environmental microbes at the customs and ports. From July to September 2024, a total of 126 environmental samples were collected from three ports of entry in Shenzhen, China. Metagenomic analysis detected 55 non-viral microbial communities and 12 viral taxa. Among these, 26.8 % of the bacteria, 100 % of the fungi, 71.4 % of the protists, and none of the archaea exhibited potential pathogenic properties. Viruses were the most prevalent, including bacteriophages (100 %), unclassified viruses (96.8 %), giant viruses (27.8 %), fungal viruses (4.8 %), and vertebrate viruses (1.6 %). No statistical differences were observed in viral distribution across areas (<em>χ<sup>2</sup></em> = 18.70, <em>P</em> = 0.541), sites (<em>χ<sup>2</sup></em> = 14.02, <em>P</em> = 0.597), or ports of entry (<em>χ<sup>2</sup></em> = 10.27, <em>P</em> = 0.247). However, viral distribution varied significantly across three sampling months (<em>χ<sup>2</sup></em> = 21.06, <em>P</em> = 0.002), with a higher proportion of giant viruses detected in July. Thirty-nine and forty microorganisms were identified across the six areas and five sites, respectively, with relatively few area/site-specific microorganisms. Four distinct disinfection level zones were categorized: relatively safe zone, less safe zone, general disinfection zone and key disinfection zone. Two strains of viruses with potential pathogenicity were identified: pigeon circovirus and Influenza A virus (H4N2). This study established a metagenomics-based surveillance framework for microbial risk assessment in high-risk port environments and proposed a four-tier disinfection strategy to prioritize high-contact zones. Our findings highlighted environmental metagenomics as a critical complement to traveler screening and provided early warning signals for the prevention and control of imported infectious diseases.</div></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"7 4","pages":"Pages 228-237"},"PeriodicalIF":3.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inactivation of BSL-2 and BSL-3 human pathogens using FATHHOME’s Trinion Disinfector: A rapid and eco-friendly ozone-based dry disinfection approach 使用FATHHOME的Trinion消毒器灭活BSL-2和BSL-3人类病原体:一种快速和环保的臭氧干消毒方法
IF 3
Biosafety and Health Pub Date : 2025-08-01 DOI: 10.1016/j.bsheal.2025.07.006
Kabita Adhikari , Elizabeth Zhou , Majid Khan , Shubhasish Goswami , Amir Khazaieli , Blake A. Simmons , Deepika Awasthi , Subhash C. Verma
{"title":"Inactivation of BSL-2 and BSL-3 human pathogens using FATHHOME’s Trinion Disinfector: A rapid and eco-friendly ozone-based dry disinfection approach","authors":"Kabita Adhikari ,&nbsp;Elizabeth Zhou ,&nbsp;Majid Khan ,&nbsp;Shubhasish Goswami ,&nbsp;Amir Khazaieli ,&nbsp;Blake A. Simmons ,&nbsp;Deepika Awasthi ,&nbsp;Subhash C. Verma","doi":"10.1016/j.bsheal.2025.07.006","DOIUrl":"10.1016/j.bsheal.2025.07.006","url":null,"abstract":"<div><div>The role of personal protective equipment (PPE) in protecting against exposure to infectious agents and toxic chemicals is well-established. However, the global surge in PPE demand during the pandemic exposed challenges, including shortages and environmental impacts from disposable waste. Developing effective, scalable, and sustainable decontamination methods for the reuse of PPE is essential. Ozone has emerged as a promising, eco-friendly disinfectant due to its strong oxidative properties, rapid action, and residue-free breakdown into oxygen. This study evaluates the effectiveness of the FATHHOME Trinion Disinfector, an innovative ozone-based dry sterilization device, for inactivating pathogens on PPE materials, such as not resistant to oil 95 (N95) masks and face shields. The device’s bactericidal performance was tested against <em>Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhimurium, Enterococcus durans, Enterococcus faecalis</em>, and <em>Saccharomyces cerevisiae</em>, achieving a 1- to 2-log reduction in these bacterial and fungal pathogens. A 30-minute ozone exposure cycle was found to attain maximum sterilization efficiency. We also demonstrated the disinfector’s efficacy against viral pathogens, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), adeno-associated virus (AAV), herpes simplex virus type 1 (HSV-1), and hepatitis B virus (HBV) on PPE surfaces. SARS-CoV-2 contamination on face shields and N95 masks decreased by 99.9 %, and AAV infectivity was nearly eliminated. Similar reductions were observed for HSV-1 and HBV. Overall, the findings confirm that ozone-based disinfection offers a rapid, scalable, and sustainable method for decontaminating PPE. These results support the establishment of standardized ozone disinfection protocols to enhance infection control, address PPE shortages, and minimize environmental waste.</div></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"7 4","pages":"Pages 245-256"},"PeriodicalIF":3.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Random forest-based predictor selection and pneumonia risk probability assessment in acute respiratory infections: A cross-sectional study in Chongqing, China, 2023–2024 基于随机森林的急性呼吸道感染预测因子选择和肺炎风险概率评估:中国重庆2023-2024年的横断面研究
IF 3
Biosafety and Health Pub Date : 2025-08-01 DOI: 10.1016/j.bsheal.2025.07.004
Yunshao Xu , Yuping Duan , Jule Yang , Mingyue Jiang , Yanxia Sun , Yanlin Cao , Li Qi , Zeni Wu , Luzhao Feng
{"title":"Random forest-based predictor selection and pneumonia risk probability assessment in acute respiratory infections: A cross-sectional study in Chongqing, China, 2023–2024","authors":"Yunshao Xu ,&nbsp;Yuping Duan ,&nbsp;Jule Yang ,&nbsp;Mingyue Jiang ,&nbsp;Yanxia Sun ,&nbsp;Yanlin Cao ,&nbsp;Li Qi ,&nbsp;Zeni Wu ,&nbsp;Luzhao Feng","doi":"10.1016/j.bsheal.2025.07.004","DOIUrl":"10.1016/j.bsheal.2025.07.004","url":null,"abstract":"<div><div>Progression of acute respiratory infection (ARI) to pneumonia increases severity and healthcare burden. Limited evidence exists on using machine learning to identify predictors from demographics, clinical, and pathogen detection data. This study aimed to identify pneumonia predictors in ARI patients using machine learning methods. This observational study was conducted in Chongqing, China, from September 2023 to April 2024. Outpatients and inpatients with ARI were recruited weekly. A random forest algorithm was used for predictor selection, followed by a logistic regression-based nomogram to analyze the probability of pneumonia. Among the 1,638 patients with ARI, those with pneumonia had higher rates of influenza A virus (IFV-A) (49.2 % vs. 39.6 %), influenza B virus (26.3 % vs. 18.6 %), and respiratory syncytial virus (6.1 % vs. 1.9 %) infection than those without pneumonia. In the subgroup of 79 patients with comprehensive blood tests, pneumonia was positively associated with hemoglobin (130.00 g/L vs. 124.00 g/L), blood urea nitrogen (5.73 mmol/L vs. 4.85 mmol/L), C-reactive protein (36.10 mg/L vs. 25.25 mg/L), procalcitonin (0.11 μg/L vs. 0.07 μg/L), and D-dimer (0.95  μg/L vs. 0.80 μg/L) levels, whereas pneumonia was inversely associated with neutrophils (4.20 × 10<sup>9</sup>/L vs. 4.76 × 10<sup>9</sup>/L), aspartate aminotransferase (22.50 U/L vs. 24.00 U/L), and uric acid (280.90 μmol/L vs. 330.00 μmol/L) levels. Elevated D-dimer levels (adjusted odds ratio [aOR] = 1.002, 95 % confidence interval [CI]: 1.001–1.004) and IFV-A infection (aOR = 9.308, 95 % CI: 2.433–35.606) were significantly associated with increased pneumonia probability. In future clinical practice, particular attention should be given to ARI patients with elevated D-dimer levels and IFV-A infections.</div></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"7 4","pages":"Pages 238-244"},"PeriodicalIF":3.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DeepHVI: A multimodal deep learning framework for predicting human-virus protein-protein interactions using protein language models DeepHVI:一个多模态深度学习框架,用于使用蛋白质语言模型预测人-病毒蛋白质-蛋白质相互作用
IF 3
Biosafety and Health Pub Date : 2025-08-01 DOI: 10.1016/j.bsheal.2025.07.005
Xindi Wang , Junyu Luo , Xiyang Cai , Ruibin Liu , Yixue Li , Chitin Hon
{"title":"DeepHVI: A multimodal deep learning framework for predicting human-virus protein-protein interactions using protein language models","authors":"Xindi Wang ,&nbsp;Junyu Luo ,&nbsp;Xiyang Cai ,&nbsp;Ruibin Liu ,&nbsp;Yixue Li ,&nbsp;Chitin Hon","doi":"10.1016/j.bsheal.2025.07.005","DOIUrl":"10.1016/j.bsheal.2025.07.005","url":null,"abstract":"<div><div>Understanding human-virus protein-protein interactions is critical for studying molecular mechanisms driving viral infection, immune evasion, and propagation, thereby informing strategies for public health. Here, we introduce a novel multimodal deep learning framework that integrates high-confidence experimental datasets to systematically predict putative interactions between human and viral proteins. Our approach incorporates two complementary tasks: binary classification for interaction prediction and conditional sequence generation to identify interacting protein partners. By leveraging protein language models and multimodal fusion, the framework demonstrates improved accuracy in identifying biologically relevant interactions. For empirical validation, we applied this method to predict severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-human interactions, identifying candidate proteins absent from training data, several of which were corroborated by independent studies. These predictions offer critical insights into potential therapeutic targets, facilitating the design of antiviral drugs and vaccines. By enabling rapid, cost-effective discovery pipelines, our study contributes to pandemic preparedness and public health interventions, underscoring its value in combating emerging infectious diseases.</div></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"7 4","pages":"Pages 257-266"},"PeriodicalIF":3.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiota of critical areas prior to reopening in an oncology center: Potential uncommon nosocomial pathogens for vulnerable populations 肿瘤中心重新开业前关键区域的微生物群:易感人群潜在的罕见医院病原体
IF 3
Biosafety and Health Pub Date : 2025-08-01 DOI: 10.1016/j.bsheal.2025.07.002
Freddy Villanueva-Cotrina , Fiorella Quiroz , Kathya L. Mimbela , Katia Quispe
{"title":"Microbiota of critical areas prior to reopening in an oncology center: Potential uncommon nosocomial pathogens for vulnerable populations","authors":"Freddy Villanueva-Cotrina ,&nbsp;Fiorella Quiroz ,&nbsp;Kathya L. Mimbela ,&nbsp;Katia Quispe","doi":"10.1016/j.bsheal.2025.07.002","DOIUrl":"10.1016/j.bsheal.2025.07.002","url":null,"abstract":"<div><div>Healthcare-associated infections are linked with the contamination of inanimate surfaces and the air in occupied hospital areas by recognized pathogens. However, there is limited information about the presence of these microorganisms or other potential pathogens in critical areas prior to their clinical operation. Here, we determined the microbial community in critical areas prior to their validation for hospital care and reviewed the background for the potential pathogenic role of this microbiota for populations susceptible to opportunistic infections. We evaluated environmental samples from operating theatres (OTs) and bone marrow transplant rooms (BMTRs) at the Peruvian National Cancer Center. A total of 164 samples (58 air samples and 106 surface samples) were collected for bacterial and fungal culture. In the OTs, the air conditioning sample yielded the highest microbial isolation from air, with a predominance of the genera <em>Bacillus</em> (5/12 isolates; 41.7%) and <em>Aspergillus</em> (5/8 isolates; 62.5%), including <em>Nigri</em> (2/5) and <em>Flavi</em> (2/5) sections and <em>Aspergillus</em> sp. (1/5). Meanwhile, the surface sample with the highest bacterial isolation came from the shelf in the stock area, where there was a predominance of non-glucose-fermenting Gram-negative bacilli (NF-GNB) (8/15 isolates; 53.3%), including the genera <em>Pseudomonas</em> (4/8), <em>Acinetobacter</em> (2/8) and <em>Stenotrophomonas</em> (2/8). In BMTRs, the only microorganisms isolated from the air were coagulase-negative <em>Staphylococcus</em> species and <em>Penicillium</em> sp. In conclusion, the microbial community composition of the critical areas prior to their reopening was consistent with their unoccupied status, consisting of nosocomial saprophytic microorganisms. Furthermore, the predominant species of the basal microbiota included uncommon hospital pathogens for people susceptible to opportunistic infections, such as cancer patients.</div></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"7 4","pages":"Pages 218-223"},"PeriodicalIF":3.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biosafety concept: Origins, Evolution, and Prospects 生物安全概念:起源、演变与展望
IF 3
Biosafety and Health Pub Date : 2025-08-01 DOI: 10.1016/j.bsheal.2025.07.003
Wanying Gao , Zongzhen Wu , Kunlan Zuo , Qiangyu Xiang , Xiaoya Chen , Lu Zhang , Huan Liu
{"title":"Biosafety concept: Origins, Evolution, and Prospects","authors":"Wanying Gao ,&nbsp;Zongzhen Wu ,&nbsp;Kunlan Zuo ,&nbsp;Qiangyu Xiang ,&nbsp;Xiaoya Chen ,&nbsp;Lu Zhang ,&nbsp;Huan Liu","doi":"10.1016/j.bsheal.2025.07.003","DOIUrl":"10.1016/j.bsheal.2025.07.003","url":null,"abstract":"<div><div>Biosafety is essential to ensuring the safe and effective conduct of biological research by minimizing risks associated with laboratory work and biological materials. This paper traces the historical and conceptual development of biosafety, from its origins in pathogen containment to its expansion into broader domains. In the modern context, biosafety also involves the regulation of genetically modified organisms and the strengthening of laboratory oversight mechanisms. Biosafety and biosecurity are closely related in origin. Biosafety focuses on biological risks within laboratory environments, ​​while biosecurity addresses biological risks associated with non-laboratory environments. The article summarizes the development of biosafety, extracting the evolution of its conceptual framework from a historical perspective, condenses and compares its scientific characteristics with those of biosecurity, and applies the methodology of science history to define its conceptual framework​​.</div></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"7 4","pages":"Pages 209-217"},"PeriodicalIF":3.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatiotemporal patterns and influencing factors of genotypic resistance testing utilization among people living with HIV: A 10-year retrospective analysis at a tertiary care hospital in Beijing, China (2014–2023) 2014-2023年北京市某三级医院HIV感染者基因型耐药检测使用时空格局及影响因素分析
IF 3.5
Biosafety and Health Pub Date : 2025-06-01 DOI: 10.1016/j.bsheal.2025.05.001
Defu Yuan , Fei Zhao , Shanshan Liu , Li Li , Hongxia Yan , Lifeng Liu , Tong Zhang , Christiane Moog , Bei Wang , Bin Su
{"title":"Spatiotemporal patterns and influencing factors of genotypic resistance testing utilization among people living with HIV: A 10-year retrospective analysis at a tertiary care hospital in Beijing, China (2014–2023)","authors":"Defu Yuan ,&nbsp;Fei Zhao ,&nbsp;Shanshan Liu ,&nbsp;Li Li ,&nbsp;Hongxia Yan ,&nbsp;Lifeng Liu ,&nbsp;Tong Zhang ,&nbsp;Christiane Moog ,&nbsp;Bei Wang ,&nbsp;Bin Su","doi":"10.1016/j.bsheal.2025.05.001","DOIUrl":"10.1016/j.bsheal.2025.05.001","url":null,"abstract":"<div><div>Prior research indicated low genotypic resistance testing (GRT) for human immunodeficiency virus (HIV) utilization in China due to partial cost coverage under national antiretroviral therapy policies, limited testing accessibility, and financial barriers. Temporal and spatial data on GRT trends were also scarce. We analyzed GRT patterns among 6,895 untreated individuals at a tertiary hospital using Joinpoint regression, multivariable logistic modeling, and spatial analysis (GeoDa/SatScan). GRT rates showed a significant two-phase upward trend, increasing from 5.36 % in 2014 to 74.17 % in 2023, with an average annual percentage change of 31.30 % (<em>P</em> &lt; 0.001). Beijing residency (adjusted odds ratio [aOR] = 2.596, 95 % confidence interval [CI]: 2.307–2.921) and older age were associated with higher GRT uptake. Specifically, ages 35–44 years (aOR = 1.207, 95 % CI: 1.026–1.420), 45–54 years (aOR = 1.335, 95 % CI: 1.104–1.613), and ≥ 55 years (aOR = 1.424, 95 % CI: 1.126–1.802) had significantly higher odds of testing. Lower testing rates were observed in individuals with lower education attainment (high school or technical secondary: aOR = 0.827; junior high school: aOR = 0.835; primary school: aOR = 0.695), unknown sexually transmitted diseases (STDs) history (aOR = 0.415), and non-heterosexual transmission routes (homosexual: aOR = 0.834). Spatial analysis identified GRT clustering across Beijing until 2021, with two space–time clusters identified in 2019–2023 and 2018–2022. This study demonstrates substantial increase in GRT uptake achieving more balanced district-level distribution since 2021. Age, educational attainment, STDs history, and transmission route influence GRT utilization. Improving access, reducing costs, and implementing targeted interventions are critical for optimizing testing and guiding antiretroviral therapy decisions.</div></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"7 3","pages":"Pages 192-198"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The holistic rehabilitation from acute severe fever with thrombocytopenia syndrome virus infection to 10 years after recovery: A cross-sectional study 急性高热伴血小板减少综合征病毒感染10年后的整体康复:一项横断面研究
IF 3.5
Biosafety and Health Pub Date : 2025-06-01 DOI: 10.1016/j.bsheal.2025.05.007
Min Li , Yalan Wang , Peiwen Qiao , Yaxin Guo , Peipei Guo , Tian Ma , Shaobo Dong , Jianbo Zhan , Jun Liu , Guizhen Wu
{"title":"The holistic rehabilitation from acute severe fever with thrombocytopenia syndrome virus infection to 10 years after recovery: A cross-sectional study","authors":"Min Li ,&nbsp;Yalan Wang ,&nbsp;Peiwen Qiao ,&nbsp;Yaxin Guo ,&nbsp;Peipei Guo ,&nbsp;Tian Ma ,&nbsp;Shaobo Dong ,&nbsp;Jianbo Zhan ,&nbsp;Jun Liu ,&nbsp;Guizhen Wu","doi":"10.1016/j.bsheal.2025.05.007","DOIUrl":"10.1016/j.bsheal.2025.05.007","url":null,"abstract":"<div><div>Acute viral infections may lead to long-term adverse health effects. Investigating the hematological and biochemical profiles during recovery can provide valuable insights into the prognosis of severe fever with thrombocytopenia syndrome (SFTS) virus infection. Herein, we performed a cross-sectional analysis of 24 hematological parameters and 12 liver and kidney function-related indicators in 143 naturally infected SFTS patients from the acute phase to 10 years post-recovery. Statistical analyses were performed using the Chi-square test (<em>χ<sup>2</sup></em>), Fisher’s exact test, or the ANOVA with Bonferroni correction to assess group differences. Most indicators gradually recovered over time during the recovery period. The decrease in platelet (PLT), white blood cell, neutrophil (NEU), and lymphocyte counts in the acute phase showed a gradual recovery trend from 1–8 months to 6–10 years post-recovery. PLT count levels positively correlated significantly with recovery duration (<em>P</em> = 0.0149). NEU % and thrombocytocrit continued to improve with the recovery time. In addition, some indicators, including platelet distribution width, mean platelet volume, and mean corpuscular hemoglobin concentration, continued to show abnormalities in a certain proportion (12.9 %–69.8 %) of individuals post-recovery. For liver and kidney function-related indicators, acute-phase elevations in aspartate aminotransferase and alanine aminotransferase resolved progressively. Direct bilirubin showed a gradual upward trend over time. Additionally, persistent reductions in total protein and albumin were observed in a subset of recovered individuals. These findings highlight the need for long-term monitoring of SFTS survivors and inform clinical management strategies.</div></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"7 3","pages":"Pages 183-191"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biosafety considerations triggered by genome-editing technologies 基因组编辑技术引发的生物安全问题
IF 3.5
Biosafety and Health Pub Date : 2025-06-01 DOI: 10.1016/j.bsheal.2025.05.003
Xinxin Li , Yuanjiao Gao , Ziyu Zhang , Wen Deng , Weihua Cao , Xin Wei , Zixuan Gao , Linmei Yao , Shuojie Wang , Yao Xie , Minghui Li
{"title":"Biosafety considerations triggered by genome-editing technologies","authors":"Xinxin Li ,&nbsp;Yuanjiao Gao ,&nbsp;Ziyu Zhang ,&nbsp;Wen Deng ,&nbsp;Weihua Cao ,&nbsp;Xin Wei ,&nbsp;Zixuan Gao ,&nbsp;Linmei Yao ,&nbsp;Shuojie Wang ,&nbsp;Yao Xie ,&nbsp;Minghui Li","doi":"10.1016/j.bsheal.2025.05.003","DOIUrl":"10.1016/j.bsheal.2025.05.003","url":null,"abstract":"<div><div>Since the discovery of the double helix structure of deoxyribonucleic acid (DNA), significant progress has been made in engineering technologies such as gene analysis and editing, greatly promoting the development of biomedical research and clinical applications. In recent years, the rapid development of genome-editing technologies, especially the clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR-Cas9) system, have brought unprecedented opportunities for biomedical research and clinical applications. However, with the widespread application of genome-editing technologies, biosafety issues have gradually attracted the attention of the scientific community and the public. Potential risks such as off-target effects, genomic instability, and ethical and legal issues need to be taken seriously, and their safety and effectiveness in clinical applications still require further verification. This review summarizes the current status and potential risks of gene editing technologies in the medical field and discusses how to ensure its safe application through policies, regulations, and technical means. Through in-depth exploration of these issues, we hope to provide a comprehensive perspective for the scientific community, policy makers, and the public to promote the safe and responsible application of genome-editing technologies.</div></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"7 3","pages":"Pages 141-151"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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