Biosafety and Health最新文献_第10页

Simultaneous detection of enterovirus-D68 and vaccine-related poliovirus 3 in the stool samples of a 5-month hospitalized child with acute respiratory disease: A case report 急性呼吸道疾病住院5个月儿童粪便样本中同时检测肠道病毒- d68和疫苗相关脊髓灰质炎病毒3:1例报告

Biosafety and Health Pub Date : 2023-08-01 DOI: 10.1016/j.bsheal.2023.07.002

Wenzhe Su , Qing Zeng , Jinmei Geng , Jingwen Liu , Huaping Xie , Kuibiao Li , Pengzhe Qin , Chaojun Xie , Biao Di

{"title":"Simultaneous detection of enterovirus-D68 and vaccine-related poliovirus 3 in the stool samples of a 5-month hospitalized child with acute respiratory disease: A case report","authors":"Wenzhe Su , Qing Zeng , Jinmei Geng , Jingwen Liu , Huaping Xie , Kuibiao Li , Pengzhe Qin , Chaojun Xie , Biao Di","doi":"10.1016/j.bsheal.2023.07.002","DOIUrl":"10.1016/j.bsheal.2023.07.002","url":null,"abstract":"<div><p>Human enterovirus (EV) infections can lead to various manifestations, with variable correlations between genotypes and symptoms. Human enterovirus D68 (EV-D68) was considered to be associated with acute respiratory disease and acute flaccid myelitis. In this short report, both EV-D68 and poliovirus 3 were detected in the stool of a hospitalized 5-month child who presented with acute respiratory symptoms and who was recently vaccinated with oral polio vaccine (OPV), using a metatranscriptomic high-throughput sequencing method. The nearly full-length genome sequences with complete open reading frames of EV-D68 and poliovirus 3 were assembled. One previously-reported neurovirulence-related amino acid substitution (T860N) in the EV-D68 VP1 region was observed, but the patient showed no neurological symptoms. More attention should be paid to EV-D68, and continuous multiple syndrome-based surveillance on non-polio enterovirus is called for.</p></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"5 4","pages":"Pages 250-253"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41381250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the distribution characteristics of enterovirus types based on environmental surveillance from 2013 to 2021 in Fujian Province, China 基于2013 - 2021年福建省环境监测的肠道病毒类型分布特征分析

Biosafety and Health Pub Date : 2023-08-01 DOI: 10.1016/j.bsheal.2023.05.003

Xiuhui Yang , Shaojian Cai , Xiaoqian Wu , Yong Zhang , Dong Li , Yahong Chen , Qianjing Chen , Shuangli Zhu , Dongmei Yan , Wenbo Xu , Hairong Zhang , Zhifei Chen , Suhan Zhang , Yong Zhou , Mengping Zhang , Ningxuan Zheng , Na You

{"title":"Analysis of the distribution characteristics of enterovirus types based on environmental surveillance from 2013 to 2021 in Fujian Province, China","authors":"Xiuhui Yang , Shaojian Cai , Xiaoqian Wu , Yong Zhang , Dong Li , Yahong Chen , Qianjing Chen , Shuangli Zhu , Dongmei Yan , Wenbo Xu , Hairong Zhang , Zhifei Chen , Suhan Zhang , Yong Zhou , Mengping Zhang , Ningxuan Zheng , Na You","doi":"10.1016/j.bsheal.2023.05.003","DOIUrl":"10.1016/j.bsheal.2023.05.003","url":null,"abstract":"<div><p>Environmental surveillance (ES) is a useful approach for monitoring circulating viruses, including polioviruses (PVs) and non-polio enteroviruses (NPEVs). In this study, the results of nine years of ES from 2013 to 2021 at six sampling sites in three cities in Fujian Province, China, were summarized. It showed that the sewage samples contained abundant viruses, but the positive rate was affected by different sampling sites. From the 520 samples, 431 PVs, 1,713 NPEVs, and 281 human adenoviruses (HAdVs) were isolated. PV isolates had been markedly affected following the adjustment of the immunization strategy. All but one PV isolate were Sabin-like strains without wild PVs. One isolate was vaccine-derived PV type 3 with 10 variation points in the <em>VP1</em> region. After May 2016, PV type 2 was no longer detected, and PV type 3 became a superior serotype. Of 1,713 NPEVs, 24 serotypes were identified, including echovirus11 (E11), E6, coxsackievirus B3 (CVB3), CVB5, E7, and E3 were the predominant serotypes (37.65%, 20.96%, 11.50%, 8.87%, 8.23%, and 7.06%, respectively). The temporal dynamic of the six common serotypes was inconsistent. E3 was frequently isolated, but the number of isolates was low, with no obvious peaks. E6, E7, and CVB3 exhibited periodic changes with a high peak every three to four years, and E11 only had one high peak lasting four years. Summer-fall peaks of the echoviruses and spring-winter peaks of CVB were observed in the monthly distribution of virus isolation. The infectious isolates of various serotypes of different species identified from the sewage samples showed that ES is an essential part of pathogen surveillance.</p></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"5 4","pages":"Pages 240-249"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44723474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Forecast the potential SARS-CoV-2 variants in the future and predict their biological properties and social impacts from bioinformatics and public health perspectives 预测未来潜在的严重急性呼吸系统综合征冠状病毒2型变异株，并从生物信息学和公共卫生角度预测其生物学特性和社会影响

Biosafety and Health Pub Date : 2023-08-01 DOI: 10.1016/j.bsheal.2023.07.005

Yixue Li , Yuming Guo , Tao Huang

引用次数: 0

On the collection and integration of SARS-CoV-2 genome data 关于严重急性呼吸系统综合征冠状病毒2型基因组数据的收集和整合

Biosafety and Health Pub Date : 2023-08-01 DOI: 10.1016/j.bsheal.2023.07.004

Lina Ma , Wei Zhao , Tianhao Huang , Enhui Jin , Gangao Wu , Wenming Zhao , Yiming Bao

{"title":"On the collection and integration of SARS-CoV-2 genome data","authors":"Lina Ma , Wei Zhao , Tianhao Huang , Enhui Jin , Gangao Wu , Wenming Zhao , Yiming Bao","doi":"10.1016/j.bsheal.2023.07.004","DOIUrl":"10.1016/j.bsheal.2023.07.004","url":null,"abstract":"<div><p>Genome data of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for virus diagnosis, vaccine development, and variant surveillance. To archive and integrate worldwide SARS-CoV-2 genome data, a series of resources have been constructed, serving as a fundamental infrastructure for SARS-CoV-2 research, pandemic prevention and control, and coronavirus disease 2019 (COVID-19) therapy. Here we present an overview of extant SARS-CoV-2 resources that are devoted to genome data deposition and integration. We review deposition resources in data accessibility, metadata standardization, data curation and annotation; review integrative resources in data source, de-redundancy processing, data curation and quality assessment, and variant annotation. Moreover, we address issues that impede SARS-CoV-2 genome data integration, including low-complexity, inconsistency and absence of isolate name, sequence inconsistency, asynchronous update of genome data, and mismatched metadata. We finally provide insights into data standardization consensus and data submission guidelines, to promote SARS-CoV-2 genome data sharing and integration.</p></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"5 4","pages":"Pages 204-210"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45326889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Pathogenesis of enterovirus infection in central nervous system 肠病毒感染中枢神经系统的发病机制

Biosafety and Health Pub Date : 2023-08-01 DOI: 10.1016/j.bsheal.2023.06.001

Congcong Wang , Jichen Li , Ying Liu , Qiang Sun , Zhijun Liu

{"title":"Pathogenesis of enterovirus infection in central nervous system","authors":"Congcong Wang , Jichen Li , Ying Liu , Qiang Sun , Zhijun Liu","doi":"10.1016/j.bsheal.2023.06.001","DOIUrl":"https://doi.org/10.1016/j.bsheal.2023.06.001","url":null,"abstract":"<div><p>Enteroviruses (EVs) are classified into 15 species according to their sequence diversity. They include four human EV (A, B, C, and D) and three rhinoviruses (A, B, and C), and cause diseases in millions of people worldwide. Generally, individuals with enteroviral infections have mild clinical symptoms, including respiratory illness, vomiting, diarrhea, dizziness, and fever. More importantly, some members of the human EV family are neurotropic pathogens that may cause a wide range of clinical diseases, such as aseptic meningitis and encephalitis. Previously, the EV that caused the most severe neurotropic symptoms was poliovirus (PV), a member of the EV C group. Poliovirus has been eliminated in most countries through a global vaccination campaign. Non-PV EVs infect the central nervous system (CNS) and are the major EVs causing neurological diseases. These human non-PV EVs include EV A (e.g., EV-A71, CVA6, and CVA16), B (e.g., CVA9 and CVB3, CVB5, echovirus 11 [E11], E30, and E7), C (e.g., CVA24), and D (e.g., EV-D68). Here, we review the relationship between EV infection and CNS diseases and advance in the use of cellular receptors and host immune responses during viral infection.</p></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"5 4","pages":"Pages 233-239"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49731663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology and control measures of an outbreak of neonatal echovirus 11 infections in Guangdong, China: A retrospective analysis 广东省一起新生儿埃可病毒11型感染暴发的流行病学及控制措施:回顾性分析

Biosafety and Health Pub Date : 2023-08-01 DOI: 10.1016/j.bsheal.2023.07.006

Chunxiao Fang , Xiaoming Zhang , Xuemin Huang , Fengqin Xu , Danyang Zhao

{"title":"Epidemiology and control measures of an outbreak of neonatal echovirus 11 infections in Guangdong, China: A retrospective analysis","authors":"Chunxiao Fang , Xiaoming Zhang , Xuemin Huang , Fengqin Xu , Danyang Zhao","doi":"10.1016/j.bsheal.2023.07.006","DOIUrl":"https://doi.org/10.1016/j.bsheal.2023.07.006","url":null,"abstract":"<div><p>The objective of this study was to investigate the outbreak of echovirus 11 (ECHO 11) infection in newborns at a hospital in Guangdong Province, China, and to study the effectiveness of prevention and control measures to infer the epidemiological characteristics of ECHO 11 and explore the effective measures for its prevention and control. We performed retrospective analyses of hospital records and laboratory test data. In this outbreak, ten cases of ECHO 11 infection were identified, of which nine cases were nosocomial infections. Most of the cases (90%) were severe, and three died. The onset time interval of 10 patients was 1–4 days, most of which occur in 1–2 days. There were eight (80%) males and two females (20%). The gestational age of the patients was 31 to 40 weeks (mean, 35<sup>+4</sup> weeks; median, 35<sup>+4</sup> weeks). The onset time was 3–26 days (average 9 days; median 8 days). The birth weights of the patients ranged from 1,650 g to 3,450 g (mean 2,385 g; median 2,250 g). We concluded that neonatal infection with ECHO 11 will lead to serious symptoms and high mortality, and is prone to outbreaks of nosocomial infection. We speculate that ECHO 11 is most likely to spread via contact transmission; however, we do not rule out the possibility of droplet transmission. Prevention and control measures can effectively prevent and control hospital enteroviral infections.</p></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"5 4","pages":"Pages 227-232"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49708276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The first local case of mpox caused by an imported case in the Chinese mainland 中国大陆首例输入性病例引起的猴痘本土病例

Biosafety and Health Pub Date : 2023-08-01 DOI: 10.1016/j.bsheal.2023.07.003

Daitao Zhang , Xiao Qi , Fu Li , Yanhui Chu , Ke Wu , Jia Li , Xin Meng , Xiangfeng Dou , Zhenyong Ren , Haoyuan Jin , Shuang Li , Yulan Sun , Yanwei Chen , Renqing Li , Dan Li , Weihong Li , Yang Yang , Yang Pan , Wenjie Tan , Quanyi Wang

{"title":"The first local case of mpox caused by an imported case in the Chinese mainland","authors":"Daitao Zhang , Xiao Qi , Fu Li , Yanhui Chu , Ke Wu , Jia Li , Xin Meng , Xiangfeng Dou , Zhenyong Ren , Haoyuan Jin , Shuang Li , Yulan Sun , Yanwei Chen , Renqing Li , Dan Li , Weihong Li , Yang Yang , Yang Pan , Wenjie Tan , Quanyi Wang","doi":"10.1016/j.bsheal.2023.07.003","DOIUrl":"10.1016/j.bsheal.2023.07.003","url":null,"abstract":"<div><p>Monkeypox (mpox) is a zoonotic disease caused by the mpox virus (MPXV) that has been primarily limited to Central and West African nations since its discovery. The recent spread of the West African lineage of MPXV in historically unaffected countries has raised concerns for global public health. Despite a significant decrease in global mpox cases, there is still a risk of a global resurgence. This study reports the first local case of mpox caused by an imported case in the Chinese mainland. Polymerase chain reaction (PCR) diagnosed the two cases, and the viral genomes were obtained by next-generation sequencing. Genomic analysis revealed that the two strains shared an identical genome sequence and belonged to the B.1.3 branch of the West African lineage, which is the first local case of mpox caused by an imported case in the Chinese mainland, highlighting the potential threat of mpox in China and the immediate need for adequate surveillance measures.</p></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"5 4","pages":"Pages 187-190"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48082998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Epidemiology and control measures of an outbreak of neonatal echovirus 11 infection in Guangdong, China: A retrospective analysis 广东省一起新生儿埃可病毒11型暴发流行病学及控制措施的回顾性分析

Biosafety and Health Pub Date : 2023-07-01 DOI: 10.1016/j.bsheal.2023.07.006

Chun-xiao Fang, Xiaoming Zhang, Xuemin Huang, Fengqin Xu, Danyang Zhao

引用次数: 0

The recombinant truncated envelope protein of West Nile virus adjuvanted with Alum/CpG induces potent humoral and T cell immunity in mice. Alum/CpG修饰的西尼罗河病毒截短包膜蛋白诱导小鼠产生强大的体液免疫和T细胞免疫

IF 3.5

Biosafety and Health Pub Date : 2023-06-27 eCollection Date: 2023-10-01 DOI: 10.1016/j.bsheal.2023.06.003

Yongping Du, Yao Deng, Ying Zhan, Ren Yang, Jiao Ren, Wen Wang, Baoying Huang, Wenjie Tan

{"title":"The recombinant truncated envelope protein of West Nile virus adjuvanted with Alum/CpG induces potent humoral and T cell immunity in mice.","authors":"Yongping Du, Yao Deng, Ying Zhan, Ren Yang, Jiao Ren, Wen Wang, Baoying Huang, Wenjie Tan","doi":"10.1016/j.bsheal.2023.06.003","DOIUrl":"10.1016/j.bsheal.2023.06.003","url":null,"abstract":"<p><p>West Nile virus (WNV) is a mosquito-transmitted flavivirus distributed globally for decades and can cause disease in humans and animals. So far, no WNV vaccine has been licensed for human use. Therefore, the development of novel candidate vaccines and the improvement of vaccination strategies is imperative. As the WNV envelope (E) glycoprotein plays an important role in mediating viral binding to cellular receptors and virus-cell membrane fusion, it is a critical target for the host humoral response. Here, we prepared a recombinant truncated envelope protein of WNV (rWNV-80E) and developed a WNV subunit vaccine formulation with a combination of aluminum hydroxide (alum) and a synthetic oligonucleotide CpG as adjuvants. C57BL/6 mice were immunized twice intramuscularly at 28-day intervals with 5 µg purified rWNV-80E adjuvanted with Alum/CpG. WNV E-specific IgG was detected by enzyme-linked immunosorbent assay and neutralizing antibodies (nAbs) was detected using single-round infectious particles of WNV. Furthermore, T cell immunity was detected by enzyme-linked immunospot assay and intracellular cytokine staining assay. Notably, rWNV-80E was highly immunogenic and elicited potent humoral and cell immunity, as evidenced by significant levels of IFN-γ and TNF-α secretion in the T cells of mice. In summary, the Alum/CpG-adjuvanted rWNV-80E subunit vaccine elicited potent and balanced B- and T-cell immunity in mice, and therefore it is a promising candidate vaccine that warrants further investigation for use in human or veterinary applications.</p>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":" ","pages":"300-307"},"PeriodicalIF":3.5,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47552457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathogenesis of enterovirus infection in central nervous system. 肠病毒感染中枢神经系统的发病机制

IF 3.5

Biosafety and Health Pub Date : 2023-06-14 eCollection Date: 2023-08-01 DOI: 10.1016/j.bsheal.2023.06.001

Congcong Wang, Jichen Li, Ying Liu, Qiang Sun, Zhijun Liu

{"title":"Pathogenesis of enterovirus infection in central nervous system.","authors":"Congcong Wang, Jichen Li, Ying Liu, Qiang Sun, Zhijun Liu","doi":"10.1016/j.bsheal.2023.06.001","DOIUrl":"10.1016/j.bsheal.2023.06.001","url":null,"abstract":"<p><p>Enteroviruses (EVs) are classified into 15 species according to their sequence diversity. They include four human EV (A, B, C, and D) and three rhinoviruses (A, B, and C), and cause diseases in millions of people worldwide. Generally, individuals with enteroviral infections have mild clinical symptoms, including respiratory illness, vomiting, diarrhea, dizziness, and fever. More importantly, some members of the human EV family are neurotropic pathogens that may cause a wide range of clinical diseases, such as aseptic meningitis and encephalitis. Previously, the EV that caused the most severe neurotropic symptoms was poliovirus (PV), a member of the EV C group. Poliovirus has been eliminated in most countries through a global vaccination campaign. Non-PV EVs infect the central nervous system (CNS) and are the major EVs causing neurological diseases. These human non-PV EVs include EV A (e.g., EV-A71, CVA6, and CVA16), B (e.g., CVA9 and CVB3, CVB5, echovirus 11 [E11], E30, and E7), C (e.g., CVA24), and D (e.g., EV-D68). Here, we review the relationship between EV infection and CNS diseases and advance in the use of cellular receptors and host immune responses during viral infection.</p>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":" ","pages":"233-239"},"PeriodicalIF":3.5,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42943062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0