Simultaneous detection of enterovirus-D68 and vaccine-related poliovirus 3 in the stool samples of a 5-month hospitalized child with acute respiratory disease: A case report

IF 3.5 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Biosafety and Health Pub Date : 2023-08-01 DOI:10.1016/j.bsheal.2023.07.002

Wenzhe Su , Qing Zeng , Jinmei Geng , Jingwen Liu , Huaping Xie , Kuibiao Li , Pengzhe Qin , Chaojun Xie , Biao Di

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Abstract

Human enterovirus (EV) infections can lead to various manifestations, with variable correlations between genotypes and symptoms. Human enterovirus D68 (EV-D68) was considered to be associated with acute respiratory disease and acute flaccid myelitis. In this short report, both EV-D68 and poliovirus 3 were detected in the stool of a hospitalized 5-month child who presented with acute respiratory symptoms and who was recently vaccinated with oral polio vaccine (OPV), using a metatranscriptomic high-throughput sequencing method. The nearly full-length genome sequences with complete open reading frames of EV-D68 and poliovirus 3 were assembled. One previously-reported neurovirulence-related amino acid substitution (T860N) in the EV-D68 VP1 region was observed, but the patient showed no neurological symptoms. More attention should be paid to EV-D68, and continuous multiple syndrome-based surveillance on non-polio enterovirus is called for.

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急性呼吸道疾病住院5个月儿童粪便样本中同时检测肠道病毒- d68和疫苗相关脊髓灰质炎病毒3:1例报告

人类肠道病毒(EV)感染可导致各种表现，基因型与症状之间具有可变相关性。人类肠道病毒D68 (EV-D68)被认为与急性呼吸道疾病和急性弛缓性脊髓炎有关。在这篇简短的报告中，使用超转录组学高通量测序方法，在一名出现急性呼吸道症状并最近接种了口服脊髓灰质炎疫苗(OPV)的住院5个月儿童的粪便中检测到EV-D68和脊髓灰质炎病毒3。组装了EV-D68和脊髓灰质炎病毒3型近全长的基因组序列，并具有完整的开放阅读框。在EV-D68 VP1区观察到一种先前报道的神经毒力相关氨基酸替代(T860N)，但患者未出现神经系统症状。应更多地关注EV-D68，并要求对非脊髓灰质炎肠道病毒进行持续的多综合征监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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