Evaluating human exposure to antibiotic resistance genes

IF 3.5 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Zhenchao Zhou , Hong Chen
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引用次数: 0

Abstract

Antibiotic resistance is an escalating global concern, leading to millions of annual fatalities. Antibiotic resistance genes (ARGs) present in bacteria equip them to withstand the effects of antibiotics. Intra- and interspecific ARGs transmission through horizontal gene transfer further exacerbates resistance dissemination. The presence of ARGs in the environment heightens the probability of human exposure via direct inhalation, ingestion, or contact with polluted air, food, or water, posing substantial biosafety and health hazards. Consequently, ARGs represent a critical focal point in public health and environmental safety and are classified as emerging contaminants. This perspective underscores the necessity to assess ARG exposure within the One Health framework and to accord greater attention to the mitigation strategies and tactics associated with ARGs.

评估人类接触抗生素耐药基因的情况
抗生素耐药性是一个日益严重的全球性问题,每年导致数百万人死亡。细菌中的抗生素耐药性基因(ARGs)使它们能够抵御抗生素的作用。ARGs 通过水平基因转移在种内和种间传播,进一步加剧了抗药性的传播。环境中 ARGs 的存在增加了人类通过直接吸入、摄入或接触受污染的空气、食物或水而接触 ARGs 的几率,从而对生物安全和健康造成严重危害。因此,ARGs 是公共卫生和环境安全的一个关键焦点,被归类为新兴污染物。这一观点强调了在 "一个健康 "框架内评估 ARG 暴露的必要性,以及更加关注与 ARG 相关的缓解战略和策略的必要性。
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来源期刊
Biosafety and Health
Biosafety and Health Medicine-Infectious Diseases
CiteScore
7.60
自引率
0.00%
发文量
116
审稿时长
66 days
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