Cells and Development最新文献_第7页

Prechordal structures act cooperatively in early trabeculae development of gnathostome skull 索前结构在颚骨骨早期小梁发育中起协同作用

IF 3.9 4区生物学

Cells and Development Pub Date : 2023-10-14 DOI: 10.1016/j.cdev.2023.203879

Jaqueline Isoppo da Cunha , Alessandra Maria Duarte Barauna , Ricardo Castilho Garcez

{"title":"Prechordal structures act cooperatively in early trabeculae development of gnathostome skull","authors":"Jaqueline Isoppo da Cunha , Alessandra Maria Duarte Barauna , Ricardo Castilho Garcez","doi":"10.1016/j.cdev.2023.203879","DOIUrl":"10.1016/j.cdev.2023.203879","url":null,"abstract":"<div>The vertebrate skull is formed by mesoderm and neural crest (NC) cells. The mesoderm contributes to the skull chordal domain, with the notochord playing an essential role in this process. The NC contributes to the skull prechordal domain, prompting investigation into the embryonic structures involved in prechordal neurocranium cartilage formation. The trabeculae cartilage, a structure of the prechordal neurocranium, arises at the convergence of prechordal plate (PCP), ventral midline (VM) cells of the diencephalon, and dorsal oral ectoderm. This study examines the molecular participation of these embryonic structures in gnathostome trabeculae development. PCP-secreted SHH induces its expression in VM cells of the diencephalon, initiating a positive feedback loop involving SIX3 and GLI1. SHH secreted by the VM cells of the diencephalon acts on the dorsal oral ectoderm, stimulating condensation of NC cells to form trabeculae. SHH from the prechordal region affects the expression of SOX9 in NC cells. BMP7 and SHH secreted by PCP induce NKX2.1 expression in VM cells of the diencephalon, but this does not impact trabeculae formation. Molecular cooperation between PCP, VM cells of the diencephalon, and dorsal oral ectoderm is crucial for craniofacial development by NC cells in the prechordal domain.</div>","PeriodicalId":36123,"journal":{"name":"Cells and Development","volume":"176 ","pages":"Article 203879"},"PeriodicalIF":3.9,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41239235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developmental roles of natriuretic peptides and their receptors 钠尿肽及其受体的发育作用。

IF 3.9 4区生物学

Cells and Development Pub Date : 2023-09-22 DOI: 10.1016/j.cdev.2023.203878

Hugo Juraver-Geslin , Arun Devotta , Jean-Pierre Saint-Jeannet

引用次数: 0

Corrigendum to “Single-cell RNA sequencing of mouse lower respiratory tract epithelial cells: A meta-analysis” [Cells Dev. 174C (2023) 203847] “小鼠下呼吸道上皮细胞的单细胞RNA测序:meta分析”的勘误表[cells Dev. 174C (2023) 203847]

IF 3.9 4区生物学

Cells and Development Pub Date : 2023-09-10 DOI: 10.1016/j.cdev.2023.203877

Leila R. Martins , Hanno Glimm , Claudia Scholl

引用次数: 0

Human pluripotent stem cell-based models of heart development and disease 基于人类多能干细胞的心脏发育和疾病模型

IF 3.9 4区生物学

Cells and Development Pub Date : 2023-09-01 DOI: 10.1016/j.cdev.2023.203857

Gabriel Velichkova , Gergana Dobreva

引用次数: 0

Inflammation and oxidative stress impair preimplantation embryonic morphogenesis in allergic asthma model 炎症和氧化应激对过敏性哮喘模型着床前胚胎形态发生的影响

IF 3.9 4区生物学

Cells and Development Pub Date : 2023-09-01 DOI: 10.1016/j.cdev.2023.203864

Che Ismail Wafriy , Yuhaniza Shafinie Kamsani , Mohamed Noor Khan Nor-Ashikin

{"title":"Inflammation and oxidative stress impair preimplantation embryonic morphogenesis in allergic asthma model","authors":"Che Ismail Wafriy , Yuhaniza Shafinie Kamsani , Mohamed Noor Khan Nor-Ashikin","doi":"10.1016/j.cdev.2023.203864","DOIUrl":"10.1016/j.cdev.2023.203864","url":null,"abstract":"<div>The incidence of allergic asthma has been increasing worldwide in recent decades. Also, an increasing number of women are suffering from poor pregnancy outcome. However, the causal relationship between allergic asthma and embryonic growth in terms of cell morphogenesis has not been well elucidated. Here, we investigated the impact of allergic asthma on the morphogenesis of preimplantation embryos. Twenty-four female BALB/c were randomly divided into control (PBS), 50-μg (OVA1), 100-μg (OVA2) and 150-μg (OVA3). On Days-0 and -14, mice were induced intraperitoneally (i.p) with ovalbumin (OVA). On Days-21 until −23, mice were challenged with OVA via intranasal instillation (i.n). Control animals were sensitized and challenged with PBS. At the end of treatment (Day-25), 2-cell embryos were retrieved and cultured in vitro until the blastocysts hatched. Results showed reduced number of preimplantation embryos at all developing stages in all treated groups (p ≤ 0.0001). Uneven blastomere size, partial compaction- and cavitation-activity, low formation of trophectoderm (TE), as well as cell fragmentation were noted in all the treated groups. Maternal serum interleukin (IL)-4, immunoglobulin (Ig)-E and 8-hydroxydeoxyguanosine (8-OHdG) were notably high (p ≤ 0.0001, p ≤ 0.01) in contrast with low total antioxidant capacity (TAOC) (p ≤ 0.0001). Our findings indicated that OVA-induced allergic asthma had compromised cell morphogenesis through reduced blastomere cleavage division, partial compaction and cavitation-activity, impairment of TE production, and cell fragmentation leading to embryonic cell death via OS mechanism.</div>","PeriodicalId":36123,"journal":{"name":"Cells and Development","volume":"175 ","pages":"Article 203864"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9854274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differentiation tracing identifies hematopoietic regeneration from multipotent progenitors but not stem cells 分化追踪发现造血再生来自多能祖细胞，而不是干细胞

IF 3.9 4区生物学

Cells and Development Pub Date : 2023-09-01 DOI: 10.1016/j.cdev.2023.203861

Tamar Nizharadze , Katrin Busch , Ann-Kathrin Fanti , Hans-Reimer Rodewald , Thomas Höfer

{"title":"Differentiation tracing identifies hematopoietic regeneration from multipotent progenitors but not stem cells","authors":"Tamar Nizharadze , Katrin Busch , Ann-Kathrin Fanti , Hans-Reimer Rodewald , Thomas Höfer","doi":"10.1016/j.cdev.2023.203861","DOIUrl":"10.1016/j.cdev.2023.203861","url":null,"abstract":"<div>Hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) generate the immune system in development, and contribute to its maintenance under steady-state conditions. How stem and progenitor cells respond to increased demand for mature cells upon injury is a fundamental question of stem cell biology. Several studies of murine hematopoiesis have reported increased proliferation of HSCs in situ when exposed to inflammatory stimuli, which has been taken as a proxy for increased HSC differentiation. Such surplus generation of HSC may fuel enhanced HSC differentiation or, alternatively, maintain HSC cellularity in the face of increased cell death without enhanced HSC differentiation. This key question calls for direct measurements of HSC differentiation in their natural niches in vivo. Here, we review work that quantifies native HSC differentiation by fate mapping and mathematical inference. Recent differentiation tracing studies show that HSC do not increase their differentiation rate upon a wide range of challenges, including systemic bacterial infection (sepsis), blood loss, and transient or persistent ablation of specific mature immune cells. By contrast, MPPs differentiate more rapidly in response to systemic infection to accelerate the production of myeloid cells. These new in vivo data identify MPPs as a major source of hematopoietic regeneration; HSCs might not contribute to regeneration while remaining protected.</div>","PeriodicalId":36123,"journal":{"name":"Cells and Development","volume":"175 ","pages":"Article 203861"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10172648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The molecular evolution of mammalian spermatogenesis 哺乳动物精子发生的分子进化

IF 3.9 4区生物学

Cells and Development Pub Date : 2023-09-01 DOI: 10.1016/j.cdev.2023.203865

Nils Trost , Noe Mbengue , Henrik Kaessmann

引用次数: 0

Intestinal stem cells and their niches in homeostasis and disease 肠道干细胞及其生态位在体内平衡和疾病中的作用

IF 3.9 4区生物学

Cells and Development Pub Date : 2023-09-01 DOI: 10.1016/j.cdev.2023.203862

Jun Zhou , Michael Boutros

{"title":"Intestinal stem cells and their niches in homeostasis and disease","authors":"Jun Zhou , Michael Boutros","doi":"10.1016/j.cdev.2023.203862","DOIUrl":"10.1016/j.cdev.2023.203862","url":null,"abstract":"<div>Tissues such as the intestine harbor stem cells that have remarkable functional plasticity in response to a dynamic environment. To adapt to the environment, stem cells constantly receive information from their surrounding microenvironment (also called the ‘niche’) that instructs them how to adapt to changes. The Drosophila midgut shows morphological and functional similarities to the mammalian small intestine and has been a useful model system to study signaling events in stem cells and tissue homeostasis. In this review, we summarize the current understanding of the Drosophila midgut regarding how stem cells communicate with microenvironmental niches including enteroblasts, enterocytes, enteroendocrine cells and visceral muscles to coordinate tissue regeneration and homeostasis. In addition, distant cells such as hemocytes or tracheal cells have been shown to interact with stem cells and influence the development of intestinal diseases. We discuss the contribution of stem cell niches in driving or counteracting disease progression, and review conceptual advances derived from the Drosophila intestine as a model for stem cell biology.</div>","PeriodicalId":36123,"journal":{"name":"Cells and Development","volume":"175 ","pages":"Article 203862"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9795319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Bub3 and Nup75 in the Drosophila male germline lineage 果蝇雄性种系中Bub3和Nup75的分析

IF 3.9 4区生物学

Cells and Development Pub Date : 2023-09-01 DOI: 10.1016/j.cdev.2023.203863

Kerem Yildirim , Patrick van Nierop y Sanchez , Ingrid Lohmann

{"title":"Analysis of Bub3 and Nup75 in the Drosophila male germline lineage","authors":"Kerem Yildirim , Patrick van Nierop y Sanchez , Ingrid Lohmann","doi":"10.1016/j.cdev.2023.203863","DOIUrl":"10.1016/j.cdev.2023.203863","url":null,"abstract":"<div>Extensive communication at the stem cell-niche interface and asymmetric stem cell division is key for the homeostasis of the Drosophila male germline stem cell system. To improve our understanding of these processes, we analysed the function of the mitotic checkpoint complex (MCC) component Bub3 and the nucleoporin Nup75, a component of the nuclear pore complex realizing the transport of signalling effector molecules to the nucleus, in the Drosophila testis. By lineage-specific interference, we found that the two genes control germline development and maintenance. Bub3 is continuously required in the germline, as its loss results in the beginning in an over-proliferation of early germ cells and later on in loss of the germline. The absence of the germline lineage in such testes has dramatic cell non-autonomous consequences, as cells co-expressing markers of hub and somatic cyst cell fates accumulate and populate in extreme cases the whole testis. Our analysis of Nups showed that some of them are critical for lineage maintenance, as their depletion results in the loss of the affected lineage. In contrast, Nup75 plays a role in controlling proliferation of early germ cells but not differentiating spermatogonia and seems to be involved in keeping hub cells quiescent. In sum, our analysis shows that Bub3 and Nup75 are required for male germline development and maintenance.</div>","PeriodicalId":36123,"journal":{"name":"Cells and Development","volume":"175 ","pages":"Article 203863"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10172652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D imaging reveals apical stem cell responses to ambient temperature 三维成像显示顶端干细胞对环境温度的反应

IF 3.9 4区生物学

Cells and Development Pub Date : 2023-09-01 DOI: 10.1016/j.cdev.2023.203850

Christian Wenzl, Jan U. Lohmann

{"title":"3D imaging reveals apical stem cell responses to ambient temperature","authors":"Christian Wenzl, Jan U. Lohmann","doi":"10.1016/j.cdev.2023.203850","DOIUrl":"10.1016/j.cdev.2023.203850","url":null,"abstract":"<div>Plant growth is driven by apical meristems at the shoot and root growth points, which comprise continuously active stem cell populations. While many of the key factors involved in homeostasis of the shoot apical meristem (SAM) have been extensively studied under artificial constant growth conditions, only little is known how variations in the environment affect the underlying regulatory network. To shed light on the responses of the SAM to ambient temperature, we combined 3D live imaging of fluorescent reporter lines that allowed us to monitor the activity of two key regulators of stem cell homeostasis in the SAM namely CLAVATA3 (CLV3) and WUSCHEL (WUS), with computational image analysis to derive morphological and cellular parameters of the SAM. Whereas CLV3 expression marks the stem cell population, WUS promoter activity is confined to the organizing center (OC), the niche cells adjacent to the stem cells, hence allowing us to record on the two central cell populations of the SAM. Applying an integrated computational analysis of our data we found that variations in ambient temperature not only led to specific changes in spatial expression patterns of key regulators of SAM homeostasis, but also correlated with modifications in overall cellular organization and shoot meristem morphology.</div>","PeriodicalId":36123,"journal":{"name":"Cells and Development","volume":"175 ","pages":"Article 203850"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9790246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0