International Journal of Clinical Pediatric Dentistry最新文献

{"title":"Impact of Novel Pit and Fissure Sealant Infused with Silver Nanoparticles in Comparison with Conventional Pit and Fissure Sealant in both Primary and Permanent Teeth: An SEM and Stereomicroscope Study.","authors":"Taranum Bhambri, Meenu Bhola, Nitika Bajaj, Manpreet Kaur, Samarpreet Kaur, Anu Rani","doi":"10.5005/jp-journals-10005-3231","DOIUrl":"10.5005/jp-journals-10005-3231","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate and compare the qualitative and quantitative microleakage analysis using stereomicroscope and scanning electron microscope (SEM) of the conventional pit and fissure sealant with silver nanoparticles infused pit and fissure sealant in primary and permanent teeth.</p><p><strong>Materials and methods: </strong>Sixty extracted over-retained primary molars and sixty premolars extracted for orthodontic purposes were collected and then randomly and equally divided into groups, i.e., group I (primary teeth) and group II (permanent teeth), and further into subgroups, i.e., subgroup IA-primary molars on which conventional pit and fissure sealant was applied, subgroup IB-primary molars on which silver nanoparticles infused pit and fissure sealant was applied, subgroup IIA-premolars on which conventional pit and fissure sealant was applied, and subgroup IIB-premolars on which silver nanoparticles infused pit and fissure sealant was applied. Occlusal surfaces of all teeth were cleaned, etched, and water rinsed, followed by the application of pit and fissure sealant according to the groups allocated. All the samples were then subjected to thermocycling, immersed in 5% methylene blue dye, sectioned, and analyzed for qualitative and quantitative analysis of microleakage under stereomicroscope and SEM.</p><p><strong>Results: </strong>The results were tabulated and statistically analyzed using χ² and <i>post hoc</i> tests. No statistically significant difference was seen in qualitative and quantitative microleakage of silver nanoparticles infused pit and fissure sealant when compared to conventional pit and fissure sealant.</p><p><strong>Conclusion: </strong>Infusion of silver nanoparticles into pit and fissure sealant does not affect the microleakage in primary and permanent teeth.</p><p><strong>Clinical significance: </strong>Addition of silver nanoparticles to pit and fissure sealant gives an added advantage of silver without affecting the physical properties of the pit and fissure sealant.</p><p><strong>How to cite this article: </strong>Bhambri T, Bhola M, Bajaj N, <i>et al</i>. Impact of Novel Pit and Fissure Sealant Infused with Silver Nanoparticles in Comparison with Conventional Pit and Fissure Sealant in both Primary and Permanent Teeth: An SEM and Stereomicroscope Study. Int J Clin Pediatr Dent 2025;18(8):964-970.</p>","PeriodicalId":36045,"journal":{"name":"International Journal of Clinical Pediatric Dentistry","volume":"18 8","pages":"964-970"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Munchausen Syndrome: The First Reported Case of Painted Blood.","authors":"Harsh U Manerkar, Paul Chalakkal, Siya G Dukle, Rashmi Naik, Ramya Ramanathan","doi":"10.5005/jp-journals-10005-3241","DOIUrl":"10.5005/jp-journals-10005-3241","url":null,"abstract":"<p><strong>Aim and background: </strong>Munchausen syndrome (MS) or Munchausen syndrome by proxy (MSP) in relation to the oral cavity is rarely reported. This article highlights the first ever reported case of painted blood in the oral cavity, arm, nose, chest, and abdomen of an 11-year-old female child, made to resemble real blood.</p><p><strong>Case description: </strong>The complaints were backed by images of bleeding that were sent to the pedodontist from the parents; however, no signs of bleeding were found on physical examination. Various blood tests were carried out by the parents for their child in this regard, although none were conclusive of any bleeding disorder.</p><p><strong>Conclusion: </strong>The parents had never reported during a bleeding episode, and neither did they answer a video call that was made to them to assess the bleeding. Moreover, the blood on all the pictures resembled paint since they appeared pinkish-red in color. These factors helped us conclude it to be a case of MS.</p><p><strong>Clinical significance: </strong>This is the first ever reported case of intraoral MS where paint had been used to mimic blood.</p><p><strong>How to cite this article: </strong>Manerkar HU, Chalakkal P, Dukle SG, <i>et al</i>. Munchausen Syndrome: The First Reported Case of Painted Blood. Int J Clin Pediatr Dent 2025;18(8):1011-1013.</p>","PeriodicalId":36045,"journal":{"name":"International Journal of Clinical Pediatric Dentistry","volume":"18 8","pages":"1011-1013"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Clinical Performance of Strip Crown Restorations with Composite Resin vs Glass Hybrid Restorative System for Primary Anterior Teeth of Children with Early Childhood Caries: A Double-blind Parallel Group Randomized Controlled Trial.","authors":"Nidhi Malik, Rashmi Nayak, Shashidhar Acharya","doi":"10.5005/jp-journals-10005-3188","DOIUrl":"10.5005/jp-journals-10005-3188","url":null,"abstract":"<p><strong>Background: </strong>Composite resin strip crowns (CRSC) are a popular choice for the restoration of primary incisors affected by early childhood caries (ECC). The inherent disadvantage of composite resins necessitates a search for more biological materials to be used for restorations in this high-caries-risk scenario.</p><p><strong>Aims and objective: </strong>This <i>in vivo</i> study aimed to compare the clinical effectiveness and parental satisfaction with strip crown restorations placed using a glass hybrid restorative system (GC Equia Forte HT) and CRSC (GC G-aenial anterior composite) in primary maxillary incisors.</p><p><strong>Materials and methods: </strong>A total of 32 teeth from 16 children aged 3-6 years with ECC requiring multisurface restorations in their primary maxillary incisors were included and randomly assigned to the test group (GC Equia Forte) or the control group (GC G-aenial composite resin). Clinical assessment was done using Fédération Dentaire Internationale (FDI) criteria, and parental satisfaction was evaluated using a five-point Likert scale over 3 months. The Chi-squared test and Mann-Whitney <i>U</i> test were used for inferential and intergroup analysis, respectively, and intragroup analysis was done using the Wilcoxon signed-rank test.</p><p><strong>Results: </strong>GC Equia Forte outperformed GC G-aenial composite resin in terms of esthetic parameters, that is, color match and translucency (<i>p</i> < 0.005). In terms of functional and biological aspects, the performance of both restorations was comparable. Parental satisfaction did not differ between the study groups.</p><p><strong>Conclusion: </strong>The results suggest that GC Equia Forte HT is a suitable and viable alternative to composite resin for strip crown restorations in pediatric patients with ECC.</p><p><strong>Clinical significance: </strong>GC Equia Forte HT proves to be esthetically superior and functionally and biologically comparable to composite resin for strip crown restoration of carious primary incisors in precooperative-aged children with ECC.</p><p><strong>How to cite this article: </strong>Malik N, Nayak R, Acharya S. Evaluation of the Clinical Performance of Strip Crown Restorations with Composite Resin vs Glass Hybrid Restorative System for Primary Anterior Teeth of Children with Early Childhood Caries: A Double-blind Parallel Group Randomized Controlled Trial. Int J Clin Pediatr Dent 2025;18(8):922-929.</p>","PeriodicalId":36045,"journal":{"name":"International Journal of Clinical Pediatric Dentistry","volume":"18 8","pages":"922-929"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Combination of Biomimetic Materials Enhances the Functional Differentiation of Stem Cells Exfoliated from Human Deciduous Teeth.","authors":"Prasanna T Dahake, Shruti Bhamare, Yogesh Jagannath Kale, Mahesh V Dadpe, Shrikant Bhujangrao Kendre, Dilip Duryodhan Ghadage, Vijay M Kumbar","doi":"10.5005/jp-journals-10005-3192","DOIUrl":"10.5005/jp-journals-10005-3192","url":null,"abstract":"<p><strong>Introduction: </strong>Stem cell therapy has been used in a variety of clinical procedures. When introduced into a specific part of the body, these cells differentiate into a target cell type and help replace damaged tissue and improve function. This experimental study was conducted to evaluate the effect of combining various natural biomimetic materials on stem cells from human exfoliated deciduous teeth (SHED).</p><p><strong>Materials and methods: </strong>After isolation and culturing of SHED to the fifth passage, cells were treated with a regular culture medium (Group I-negative control), osteoinduction medium (Group II-positive control), a combination of mineral trioxide aggregate plus coral (MC, group III), and a combination of Biodentine plus coral (BC, group IV). Viability was assessed using MTT assay on the 7th, 14th, and 21st days. Mineralization was evaluated by Alizarin Red S staining to detect calcium deposits at the same intervals. The anti-inflammatory potential for expression of MMP-9 and MMP-2 was analyzed using gelatin zymography. One-way ANOVA followed by <i>post hoc</i> Bonferroni test was applied for statistical comparison (<i>p</i> < 0.05).</p><p><strong>Results: </strong>MC showed better cell viability than BC on the 14th and 21st days. However, BC demonstrated significantly better cytodifferentiation potential (<i>p</i> < 0.001) and anti-inflammatory effect (<i>p</i> < 0.001) than MC.</p><p><strong>Conclusion: </strong>With the addition of coral, the properties of both commercially available biomimetic materials were enhanced, resulting in improved osteoinductive properties of mineral trioxide aggregate and Biodentine. The MC combination showed better cell viability and proliferation, while BC showed superior cytodifferentiation and anti-inflammatory properties. Coral, as a natural material, enhanced both formulations significantly.</p><p><strong>How to cite this article: </strong>Dahake PT, Bhamare S, Kale YJ, <i>et al</i>. The Combination of Biomimetic Materials Enhances the Functional Differentiation of Stem Cells Exfoliated from Human Deciduous Teeth. Int J Clin Pediatr Dent 2025;18(8):946-955.</p>","PeriodicalId":36045,"journal":{"name":"International Journal of Clinical Pediatric Dentistry","volume":"18 8","pages":"946-955"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Undergraduate Training in Pulpectomy Using Model Teeth and Extracted Natural Teeth.","authors":"Ranjana Venkatraj, Deepa Gurunathan","doi":"10.5005/jp-journals-10005-3197","DOIUrl":"10.5005/jp-journals-10005-3197","url":null,"abstract":"<p><strong>Aims and background: </strong>Pulpectomy is a procedure that is done by removing the entire coronal and radicular pulp of primary teeth. To achieve an optimal outcome in dental treatment, a combination of scientific knowledge and technical skills is required. Sufficient simulated practice is needed for dental students before performing treatment on patients as they get better hand-eye-foot coordination. The main aim of the study is to assess undergraduate training in pulpectomy using the typodont model and extracted natural teeth.</p><p><strong>Materials and methods: </strong>The study included 100 final-year Bachelor of Dental Surgery (BDS) students, with 50 practicing pulpectomy on typodont teeth and 50 on extracted natural teeth. All students then performed pulpectomy on pediatric teeth. Clinical performance was assessed based on access cavity preparation, biomechanical preparation (BMP), obturation, and procedural efficiency. Data were analyzed using Statistical Package for the Social Sciences (SPSS) to compare the effectiveness of training on model vs natural teeth.</p><p><strong>Results: </strong>Regarding obturation, students trained with extracted teeth showed better results, with an optimal obturation (91 vs 96%). Group II (extracted natural teeth) outperformed group I (artificial teeth) in BMP. Canal cleaning adequacy was higher (91 vs 87%), and shaping accuracy improved (93 vs 87%), likely due to the realistic anatomical challenges of natural teeth. Errors in over- or underpreparation were also fewer in group II (6 vs 18%), indicating enhanced judgment in canal preparation.</p><p><strong>Conclusion: </strong>In conclusion, the study demonstrated that training with extracted natural teeth resulted in superior performance in key pulpectomy procedures, such as access cavity preparation, BMP, and obturation, compared to training with model teeth.</p><p><strong>Clinical significance: </strong>This study evaluates the effectiveness of model and natural teeth training in enhancing student competency for pediatric pulpectomy, aiding improvements in dental education and clinical outcomes.</p><p><strong>How to cite this article: </strong>Venkatraj R, Gurunathan D. Assessment of Undergraduate Training in Pulpectomy Using Model Teeth and Extracted Natural Teeth. Int J Clin Pediatr Dent 2025;18(8):977-981.</p>","PeriodicalId":36045,"journal":{"name":"International Journal of Clinical Pediatric Dentistry","volume":"18 8","pages":"977-981"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency and Obturation Quality Outcomes between Kedo-S Rotary Files and Kedo-SH Manual Files Instrumentation during Pulpectomy in Primary Molars.","authors":"Bharati Dewangan, Ankita Ukey, Pratik Surana, Balasubramanyam Vasant, Kanika Singh Dhull, Brahmananda Dutta","doi":"10.5005/jp-journals-10005-3198","DOIUrl":"10.5005/jp-journals-10005-3198","url":null,"abstract":"<p><strong>Background: </strong>Enduring research in pediatric endodontics has resulted in the development of many file systems with increased efficacy and advantages. The rotary system was created to improve treatment quality and reduce manual dexterity, resulting in a better treatment protocol.</p><p><strong>Aim: </strong>The purpose of the research involves the evaluation and comparison of efficiency as well as subsequent obturation quality of the Kedo-S and Kedo-SH files during pulp canal therapy in deciduous molars.</p><p><strong>Materials and methods: </strong>Children of 4-8 years requiring pulpectomy in forty deciduous lower molars were randomly divided into two different groups: Kedo-SH file (Group I) and Kedo-S file (Group II). A stopwatch was utilized for documentation of instrumentation time, and Coll and Sadrian criteria were utilized for observation of obturation quality. Statistical analysis of the obtained data was analyzed using the independent <i>t</i>-test and Chi-square test.</p><p><strong>Results: </strong>Mean instrumentation time in group I was 207.2 seconds, which was far more than group II (150.8 seconds), with <i>p</i>-value < 0.0001. No statistically significant variance was observed in obturation quality.</p><p><strong>Conclusion: </strong>Kedo-S group resulted in less instrumentation time when compared to Kedo-SH with better obturation quality.</p><p><strong>How to cite this article: </strong>Dewangan B, Ukey A, Surana P, <i>et al</i>. Efficiency and Obturation Quality Outcomes between Kedo-S Rotary Files and Kedo-SH Manual Files Instrumentation during Pulpectomy in Primary Molars. Int J Clin Pediatr Dent 2025;18(8):982-985.</p>","PeriodicalId":36045,"journal":{"name":"International Journal of Clinical Pediatric Dentistry","volume":"18 8","pages":"982-985"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Artificial Intelligence-generated Image Exposure before the Treatment Reduce Dental Anxiety in Children Aged 6-12 Years: An Observational Study.","authors":"Shital Kiran Davangere Padmanabh, Shrushti Tusharkumar Dagli, Seema Bargale","doi":"10.5005/jp-journals-10005-3199","DOIUrl":"10.5005/jp-journals-10005-3199","url":null,"abstract":"<p><strong>Introduction: </strong>Children commonly feel dental anxiety, and the efficacy of treatment is contingent upon the dentist's skill and capacity to establish a productive rapport with the patient.</p><p><strong>Aim: </strong>To evaluate the effect of anxiety before the extraction procedure by showing artificial intelligence (AI)-generated images and similar non-AI-generated images.</p><p><strong>Materials and methods: </strong>This observational study, conducted over a 2-month period, involved 30 children between 6 and 12 years of age. The children were divided into two groups, one exposed to non-AI-generated images and the other to AI-generated images, for 4 minutes in the waiting area, who required the extraction. Anxiety levels were measured before and after the image exposure using a pulse oximeter and the Raghvendra, Madhuri, and Sujata digital anxiety scale (RMS-DAS scale).</p><p><strong>Results: </strong>The pulse rate between the non-AI and AI groups was insignificant; however, RMS-DAS scores were significant (<i>p</i> = 0.001). Intergroup comparison between groups for pulse rate was insignificant, whereas a significant difference was noted in RMS-DAS scores (<i>p</i> = 0.013). Non-AI positively correlated with pulse rate after the procedure and negatively correlated with RMS-DAS after showing AI images.</p><p><strong>Conclusion: </strong>Both AI and non-AI images demonstrated efficacy in relieving dental anxiety before the dental extraction; however, artificial intelligence images exhibited more reduction in dental anxiety.</p><p><strong>How to cite this article: </strong>Davangere Padmanabh SK, Dagli ST, Bargale S. Does Artificial Intelligence-generated Image Exposure before the Treatment Reduce Dental Anxiety in Children Aged 6-12 Years: An Observational Study. Int J Clin Pediatr Dent 2025;18(8):986-991.</p>","PeriodicalId":36045,"journal":{"name":"International Journal of Clinical Pediatric Dentistry","volume":"18 8","pages":"986-991"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Treatment Modality Using Miniplates for Skeletal Class II Malocclusion with Anterior Open Bite: A Case Report.","authors":"S Shreya, Rajmohan Shetty, Vabitha Shetty, Isha Gore, Trupti B Bhosale","doi":"10.5005/jp-journals-10005-3195","DOIUrl":"10.5005/jp-journals-10005-3195","url":null,"abstract":"<p><strong>Aims and background: </strong>Skeletal class II malocclusion is a challenge to treat when the patient presents in the adolescent stage of growth with a vertical growth pattern along with an anterior open bite (AOB). The usage of traditional myofunctional modalities in such conditions has not provided favorable outcomes.</p><p><strong>Case description: </strong>An 11.5-year-old male patient reported with a chief complaint of spacing between the upper and lower teeth. A detailed examination was done, following which the patient was diagnosed with skeletal class II malocclusion with an AOB. We present a unique case of combining twin block therapy with miniplates for treating the aforementioned diagnosis.</p><p><strong>Conclusion: </strong>The treatment modality resulted in an esthetic profile along with correction of the open bite.</p><p><strong>Clinical significance: </strong>This novel treatment modality could be an effective approach in treating skeletal class II malocclusion in conjunction with an AOB and a hyperdivergent facial growth pattern.</p><p><strong>How to cite this article: </strong>Shreya S, Shetty R, Shetty V, <i>et al</i>. A Novel Treatment Modality Using Miniplates for Skeletal Class II Malocclusion with Anterior Open Bite: A Case Report. Int J Clin Pediatr Dent 2025;18(8):1014-1017.</p>","PeriodicalId":36045,"journal":{"name":"International Journal of Clinical Pediatric Dentistry","volume":"18 8","pages":"1014-1017"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The New Era of Holistic and Precision Dentistry with Integration of Digital Twin Technology: A Scoping Review.","authors":"Lakshmi Thribhuvanan, M S Saravanakumar, Priyanka Panikkar, Preethi Durairaj","doi":"10.5005/jp-journals-10005-3234","DOIUrl":"10.5005/jp-journals-10005-3234","url":null,"abstract":"<p><p>Technology has embraced all sectors of mankind with its trailblazers extending to exponential growth and development at an infinite arena of futuristic advancements. The education system has also undergone a progressive reformation and hyper-realistic transformations by incorporating these technological innovations, thereby creating the concept of education at your pace, possible in the most acceptable manner. However, in developing countries like India, where health care continues to be a booming sector with augmented growth and developments, the inclusion of these technological advancements still remains as an interest of concern and viability. The lack of financial investments, inability to obtain individual patient data and screening records from both urban and rural medical care settings, lack of connectivity with cities and villages within the country, and providential glitches of communication all continue to barrel as a hindrance in incorporating technological progression within one of the highly anticipated sectors of the nation. Digital twin technology is also expected to cater both the health care professionals as well as the patients with an extremely well-defined treatment plan, schedules, and a multitude of options incorporating highly efficient consultants from across the country in a speck of second. Hence, this article will discuss in detail the strategic and sequential advancements that will forefront on the application of the concept of digital twin technology into the Indian health care system, thereby creating a more simplified treatment environment with highly effective disease diagnosis and treatment strategies.</p><p><strong>How to cite this article: </strong>Thribhuvanan L, Saravanakumar M, Panikkar P, <i>et al</i>. The New Era of Holistic and Precision Dentistry with Integration of Digital Twin Technology: A Scoping Review. Int J Clin Pediatr Dent 2025;18(8):1046-1050.</p>","PeriodicalId":36045,"journal":{"name":"International Journal of Clinical Pediatric Dentistry","volume":"18 8","pages":"1046-1050"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Cytotoxicity of a Novel Obturating Material with Metapex for Pulpectomy in Primary Teeth Using 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Bromide Assay: An <i>In Vitro</i> Study.","authors":"Manisha Bala Rathy Rajadurai, Lavanya Govindaraju","doi":"10.5005/jp-journals-10005-3167","DOIUrl":"10.5005/jp-journals-10005-3167","url":null,"abstract":"<p><strong>Introduction: </strong>Pulpectomy is a critical procedure for managing pulpally infected primary teeth. The choice of obturating material is important for the treatment's success. Metapex, a commonly used material, has several disadvantages such as rapid resorption and resistance issues against certain microorganisms. To overcome these disadvantages, a novel obturating material combining zinc oxide, calcium hydroxide, and metronidazole was developed. The aim of the study is to compare cytotoxic effects of the novel obturating material with Metapex using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.</p><p><strong>Materials and methods: </strong>An <i>in vitro</i> study was conducted using 3T3 mouse fibroblast cells. The cells were treated with different concentrations (2.5, 5, 10, 20, 40, 60 µg/mL) of the novel obturating material and Metapex. Cell viability was assessed using the MTT assay, where formazan crystals were dissolved in DMSO and absorbance was measured at 570 nm. Independent <i>t</i>-tests were used to compare cell viability between the groups, while repeated measures analysis of variance (ANOVA) with Bonferroni <i>post hoc</i> tests analyzed intragroup differences.</p><p><strong>Results: </strong>Both materials demonstrated minimal cytotoxicity at lower concentrations (2.5-10 µg/mL) and progressively higher cytotoxicity at increased concentrations (20-60 µg/mL). In the novel material group, significant differences were observed between 2.5 and 5 µg/mL (<i>p</i> = 0.015). However, independent <i>t</i>-tests revealed no significant differences between the two materials across various concentrations (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>The novel obturating material showed acceptable cytotoxicity at lower concentrations but exhibited higher cytotoxicity at increased levels. Further research is needed to optimize its composition for safe clinical use, particularly in pediatric patients.</p><p><strong>How to cite this article: </strong>Rajadurai MBR, Govindaraju L. Comparison of the Cytotoxicity of a Novel Obturating Material with Metapex for Pulpectomy in Primary Teeth Using 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Bromide Assay: An <i>In Vitro</i> Study. Int J Clin Pediatr Dent 2025;18(8):917-921.</p>","PeriodicalId":36045,"journal":{"name":"International Journal of Clinical Pediatric Dentistry","volume":"18 8","pages":"917-921"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}