Evaluation of Anxiolytic, Amnesic, and Psychomotor Effects of Nitrous Oxide Inhalation Sedation: An In Vivo Study.

Q3 Dentistry

International Journal of Clinical Pediatric Dentistry Pub Date : 2025-04-01 Epub Date: 2025-05-19 DOI:10.5005/jp-journals-10005-3108

Sunidhi Chaudhary, Shivani Mathur, Sakshi Joshi, Nikita Gulati

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Abstract

Aim: To evaluate the anxiolytic, amnesic, physiological, and psychomotor effects of nitrous oxide (N2O) inhalation sedation in children indicated for dental treatment.

Methods: A total of 44 children indicated for single-sitting pulpectomy were divided into group I (control group) and group II (single-sitting pulpectomy under nitrous oxide inhalation sedation) to evaluate anxiolytic, amnesic, physiological, and psychomotor effects of nitrous oxide inhalation sedation. Physiological, anxiolytic, psychomotor, and amnesic effects were assessed using pulse oximeter, Modified Dental Anxiety Scale (MDAS), salivary cortisol levels, salivary nitric oxide (NO) levels, Bender visual motor Gestalt test, and recalling of images of shapes, respectively.

Results: The results revealed statistically significant difference in pulse rate (PR) intraoperatively under nitrous oxide sedation but no significant difference in oxygen saturation (SpO₂) among the groups. Anxiety had significantly reduced after onset of sedation due to the anxiolytic effect of N₂O. Significant impairment of coordination and psychomotor ability was seen intraoperatively under nitrous oxide sedation. Statistically significant levels of amnesia were observed in nitrous oxide inhalation sedation.

Conclusion: Nitrous oxide sedation caused a significant decrease in anxiety, a significant effect on amnesic and psychomotor abilities of children.

How to cite this article: Chaudhary S, Mathur S, Joshi S, et al. Evaluation of Anxiolytic, Amnesic, and Psychomotor Effects of Nitrous Oxide Inhalation Sedation: An In Vivo Study. Int J Clin Pediatr Dent 2025;18(4):436-443.

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氧化亚氮吸入镇静对焦虑、遗忘和精神运动的影响：一项体内研究。

目的：评价一氧化二氮（N2O）吸入镇静对牙科治疗患儿的抗焦虑、遗忘、生理和精神运动的影响。方法：将44例患儿分为ⅰ组（对照组）和ⅱ组(吸入性氧化亚氮镇静下吸入性氧化亚氮镇静下吸入性氧化亚氮镇静下吸入性氧化亚氮镇静下吸入性氧化亚氮镇静下吸入性氧化亚氮镇静对焦虑、遗忘、生理和精神运动的影响。分别使用脉搏血氧仪、改良牙科焦虑量表（MDAS）、唾液皮质醇水平、唾液一氧化氮（NO）水平、Bender视觉运动格式塔测试和形状图像回忆来评估生理、焦虑、精神运动和遗忘效应。结果：两组患者在氧化亚氮镇静下术中脉搏率（PR）差异有统计学意义，而血氧饱和度（SpO₂）差异无统计学意义。由于N₂O的抗焦虑作用，镇静后焦虑明显减少。术中在氧化亚氮镇静下观察到明显的协调和精神运动能力损害。在氧化亚氮吸入镇静组中观察到有统计学意义的健忘症水平。结论：氧化亚氮镇静能显著降低儿童的焦虑，对儿童的遗忘和精神运动能力有显著影响。如何引用本文：Chaudhary S， Mathur S， Joshi S等。氧化亚氮吸入镇静对焦虑、遗忘和精神运动的影响：一项体内研究。中华临床儿科杂志，2015;18(4):436-443。

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来源期刊

International Journal of Clinical Pediatric Dentistry Dentistry-Periodontics

CiteScore

1.20

自引率

0.00%

发文量

135