Medicine in Microecology最新文献

{"title":"Gut microbiota composition of stunted children in Banyumas Regency, Indonesia: A 16S rRNA microbiome profiling analysis","authors":"Rizqi Yanuar Pauzi ,&nbsp;Suci Ihtiaringtyas ,&nbsp;Novia Yunika ,&nbsp;Glory Aprilia Kusumawardani","doi":"10.1016/j.medmic.2026.100174","DOIUrl":"10.1016/j.medmic.2026.100174","url":null,"abstract":"<div><div>Stunting remains a major public health challenge in Indonesia and is increasingly associated with gut microbiota dysbiosis. This study examined 36 children aged 2–5 years through anthropometry, dietary assessment, and pooled fecal sampling. Full-length 16S rRNA sequencing using Oxford Nanopore Technologies revealed notable microbial alterations in the stunted group. Stunted children exhibited reduced alpha diversity and lower microbial richness, indicating a simplified gut ecosystem. Although both groups were dominated by Bacillota (&gt;96%), stunted children showed higher proportions of Clostridia affiliated orders, including Eubacteriales, Peptostreptococcales, and Erysipelotrichaceae, along with enrichment of fermentative and dysbiosis associated genera such as Blautia, Romboutsia, and Terrisporobacter. Beneficial fiber degrading taxa, including Lachnospiraceae, were proportionally higher in normal children. Functional predictions using PICRUSt2 revealed greater microbial metabolic activity in the stunting group, particularly in carbohydrate, amino acid, and nucleotide metabolism, with elevated pathways such as starch and sucrose metabolism, glycolysis, porphyrin, and pyrimidine metabolism. Dietary assessment showed significantly lower intake of energy, protein, fat, and multiple micronutrients among stunted children, consistent with observed microbial and functional alterations. These findings indicate a distinct fermentative dysbiosis in Banyumas stunted children and highlight the need for integrated nutritional and microbiota targeted interventions.</div></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"28 ","pages":"Article 100174"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147802833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered gut microbiome in fibromyalgia: Systematic review of genomic and metabolomic bacterial findings","authors":"Gladys Helena Sánchez-Martínez ,&nbsp;Dora Cardona Rivas ,&nbsp;Mariana Sofía Candamil-Cortes","doi":"10.1016/j.medmic.2026.100166","DOIUrl":"10.1016/j.medmic.2026.100166","url":null,"abstract":"<div><div>Disruption of the gut microbiome has been implicated in several human disorders, including fibromyalgia, a musculoskeletal disorder characterized by widespread chronic pain and significant impairment of quality of life. Although it has been extensively studied, the results have been inconclusive. This systematic review aimed to analyze the available clinical evidence on the relationship between the altered gut bacterial microbiome and fibromyalgia, considering the microbiota gut brain axis and the use of omics. We searched Medline (Ovid), Scopus, Embase, Web of Science and Google Scholar, including observational studies in adults diagnosed with fibromyalgia, applying molecular, genetic, genomic and metabolomic techniques. The methodological quality was evaluated with tools from the Joanna Briggs Institute and the results were integrated into a narrative synthesis.</div><div>Of the 732 studies initially identified, 11 fit the inclusion criteria, including a total of 455 patients with fibromyalgia and 385 controls, aged between 30 and 60 years. The overall certainty of the evidence is low to moderate, with greater strength for β-diversity, SCFAs, and the clinical manifestations of pain, fatigue, mood disturbances, and cognitive dysfunction supported by high-resolution techniques. Findings based solely on 16S have low certainty, supporting plausible associations between bacterial gut dysbiosis and fibromyalgia. Challenges such as methodological standardization and control of confounding factors, multi-omics, interdisciplinary and collaborative research are necessary to overcome the gaps in basic research and move towards translational research.</div></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"27 ","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146188979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot study of Raman-deep learning integration for rapid detection of antibiotic-resistant Escherichia coli: A proof-of-concept analysis","authors":"Xinkui Chang ,&nbsp;Bo Zhou ,&nbsp;Limei Yu ,&nbsp;Liying Sun ,&nbsp;Haixia Li ,&nbsp;Anpei Ye","doi":"10.1016/j.medmic.2025.100162","DOIUrl":"10.1016/j.medmic.2025.100162","url":null,"abstract":"<div><div>In recent years, the accelerating emergence of antibiotic-resistant bacterial pathogens has posed profound challenges to the therapeutic management, prophylactic strategies, and epidemiological control of infectious diseases caused by these microorganisms. Consequently, identifying resistant bacteria is essential for therapeutic decisions and epidemiological studies. However, conventional approaches for the detection of antibiotic resistance are frequently constrained by lengthy protocols, substantial costs, and operational intricacies, thereby impeding the rapid and precise identification of resistance phenotypes. Raman optical tweezers have proven useful for classifying different bacterial species and isolates. This study establishes a fast, reliable, and cost-effective method to differentiate between <em>Escherichia coli</em> strains with <strong>antibiotic resistance (extended spectrum β-lactam resistant, ESBL)</strong> and susceptible strains using Raman optical tweezers and deep learning techniques. High-quality single-cell Raman spectra were collected from antibiotic-resistant and susceptible strains without exposure to antibiotics, revealing a higher nucleic acid/protein ratio in resistant strains. We propose a new network, RamanU-Net, for the accurate classification of these Raman spectra. The model achieved 99.5 % average accuracy in identifying antibiotic-resistant and sensitive strains of <em>Escherichia coli</em>. Our results demonstrate that combining Raman optical tweezers with deep learning models can enable rapid identification of bacterial antibiotic resistance while significantly reducing the associated time, cost, and workload.</div></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"27 ","pages":"Article 100162"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145885217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-silico analysis, molecular docking and dynamic simulation of anti-cancer metabolites derived from Bacillus velezensis","authors":"Zabin K. Bagewadi ,&nbsp;Deepak A. Yaraguppi ,&nbsp;Sikandar I. Mulla ,&nbsp;Vishal S. Patil ,&nbsp;Muskan M. Naik","doi":"10.1016/j.medmic.2026.100165","DOIUrl":"10.1016/j.medmic.2026.100165","url":null,"abstract":"<div><div>The complex nature of cancer poses significant challenges in deciphering its underlying molecular mechanisms. To facilitate advancements in biological research and therapeutic development, computational models have emerged as powerful tools for elucidating cancer biology. In the present study, <em>in-silico</em> approaches were employed to identify metabolites from <em>Bacillus velezensis</em> strain with anticancer potential by targeting protein molecules associated with malignancies. Genome mining revealed biosynthetic potential of the strain, and target prediction was conducted using BindingDB (p ≥ 0.7). Pathway enrichment analysis was performed using STRING and KEGG databases, which showed involvement of compounds in modulation of multiple pathways involved in cancer. Molecular docking simulations showed that fengycin, a secondary metabolite derived from <em>B. velezensis</em>, exhibited strongest binding affinity toward MAPK9, with a docking energy of −17.1 kcal/mol. This interaction was validated through Molecular Dynamics (MD) simulation. The mean RMSD values for the APO and MAPK9 complexes were 0.29 ± 0.03 nm and 0.32 ± 0.03 nm, respectively, confirming structural stability throughout the simulation. The mean radius of gyration (Rg) values were 2.33 ± 0.02 nm for APO and 2.35 ± 0.02 nm for MAPK9, indicating compactness of the protein-ligand complex. RMSF values were recorded as 0.15 ± 0.09 nm for APO and 0.14 ± 0.07 nm for MAPK9, reflecting minimal residue-level fluctuations. Solvent Accessible Surface Area (SASA) remained stable at 177.63 ± 5.8 nm² for APO and 179.67 ± 3.4 nm² for MAPK9, suggesting no significant conformational alterations. Additionally, MAPK9 displayed a van der Waals energy of −493.903 ± 17.608 kJ/mol, electrostatic energy of −118.975 ± 26.098 kJ/mol, polar solvation energy of 480.496 ± 21.551 kJ/mol, and a final binding energy of −189.266 ± 33.873 kJ/mol, indicating a strong and stable interaction with the drug candidate. Overall, metabolites derived from <em>B. velezensis</em>, particularly fengycin, demonstrated potential anticancer attributes and warrant further experimental validation.</div></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"27 ","pages":"Article 100165"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytomolecule and microbiota-modulation based therapeutic strategies for MDR-Tuberculosis: Mechanistic interplay and translational perspectives","authors":"Sobhanjan Bhunia ,&nbsp;Nilanjan Adhikari ,&nbsp;Biplab Kumar Chakra ,&nbsp;Suman Ghosh ,&nbsp;Sajal Kumar Jha ,&nbsp;Ishita Debnath ,&nbsp;Mithun Bhowmik ,&nbsp;Sonia Mallick ,&nbsp;Piyali Basak ,&nbsp;Rajarshi Das ,&nbsp;Sourav pal ,&nbsp;Tamalika Chakraborty","doi":"10.1016/j.medmic.2025.100163","DOIUrl":"10.1016/j.medmic.2025.100163","url":null,"abstract":"<div><div>Multidrug-resistant tuberculosis (MDR-TB) continues to represent a critical global health challenge due to resistance against first- and second-line anti-TB drugs. Emerging evidence highlights the pivotal role of the human microbiota in TB pathogenesis, immune regulation, and drug response. This review systematically explores the microbiota–MDR-TB axis, with a focus on phytomolecule-based therapeutic interventions. A comprehensive literature search was conducted in PubMed, Scopus, Web of Science, Google Scholar, and Elsevier ScienceDirect following PRISMA guidelines, covering studies from January 2004 to August 2025. Included studies encompassed in vitro, <em>in vivo</em>, and clinical investigations elucidating microbiota alterations during TB infection and therapy, mechanistic insights into microbiota-derived metabolites (short-chain fatty acids, indoles), and their regulation of host immunity through AMPK–mTOR signaling, autophagy, and Treg/Th1 cell balance. Our analysis reveals that TB-associated gut and lung dysbiosis leads to SCFA depletion, epithelial barrier disruption, and systemic inflammation, weakening granuloma integrity and favoring <em>M.tb</em> persistence. Phytomolecules such as curcumin, emodin, resveratrol, and berberine exhibit dual actions by exerting direct antimycobacterial effects while simultaneously restoring the microbiota. These effects help reprogram immune responses through PRR, AHR, and AMPK pathways. Additionally, microbiota-sparing drug formulations, including ridinilazole, cadazolid, and lolamicin, along with probiotics, prebiotics, and synbiotics, demonstrate potential as adjunctive strategies to mitigate dysbiosis and enhance treatment outcomes. This review provides a mechanistic and translational framework for integrating phytomolecules and microbiome-modulating approaches into precision therapy, supporting the development of microbiota-informed host-directed therapies for MDR-TB.</div></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"27 ","pages":"Article 100163"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145885122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial potential of Aspergillus oryzae secondary metabolites against carbapenem-resistant Klebsiella pneumoniae","authors":"Lailia Nur Rachma ,&nbsp;Zulvikar Syambani Ulhaq","doi":"10.1016/j.medmic.2025.100161","DOIUrl":"10.1016/j.medmic.2025.100161","url":null,"abstract":"<div><div>The antibacterial potential of <em>Aspergillus oryzae</em> (<em>A. oryzae</em>) EO product (AOEP) extract against <em>Klebsiella pneumoniae</em> (<em>K. pneumoniae</em>) strains BAA-1706 and BAA-1705 was investigated through minimal inhibitory concentration (MIC), biofilm inhibition assays, electron microscopy, and gene expression analysis. AOEP extract exhibited inhibitory activity with MIC₅₀ values ranging from 3.1 % to 50 % for both strains. Notably, AOEP suppressed biofilm formation at low concentrations (3.1 %–12.5 %), outperforming the positive control, kanamycin, at 6.25 %. Morphological examination revealed significant alterations upon AOEP treatment, including reduced colony size and fragmented cells, distinct from kanamycin-induced changes. qRT-PCR demonstrated that AOEP significantly downregulated key virulence genes <em>ompA</em>, <em>lppA</em>, and <em>mrkA</em> in strain BAA-1706, and <em>ompA</em> and <em>lppA</em> in strain BAA-1705, while <em>pal</em> and <em>wzi</em> expression remained unaffected. LC-MS/MS profiling identified several lactone-related secondary metabolites, including acyl homoserine lactone (AHL) analogs and butyrolactone I analogs, suggesting possible quorum sensing interference as a mechanism of action. These findings highlight AOEP extract as a promising multifunctional antibacterial agent that disrupts <em>K. pneumoniae</em> growth, biofilm formation, and virulence, with potential applications in combating antibiotic-resistant infections.</div></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"27 ","pages":"Article 100161"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotic Bacillus subtilis attenuates cisplatin-induced multi-organ toxicity via redox modulation and anti-apoptotic mechanisms: Evidence from a preclinical probiotic intervention study","authors":"Kusuma Kandati ,&nbsp;Viswanath Buddolla ,&nbsp;John Sushma Nannepaga","doi":"10.1016/j.medmic.2025.100160","DOIUrl":"10.1016/j.medmic.2025.100160","url":null,"abstract":"<div><h3>Background</h3><div>Cisplatin, a widely used chemotherapeutic agent, is limited by dose-dependent multi-organ toxicity. Probiotic interventions have recently emerged as promising strategies to alleviate such adverse effects through antioxidative and cytoprotective mechanisms.</div></div><div><h3>Methods</h3><div>This preclinical study evaluated the protective effects of the spore-forming probiotic <em>Bacillus subtilis</em> against cisplatin-induced toxicity in female Wistar rats. Animals were assigned to control, cisplatin-only, probiotic-only, and cisplatin + probiotic groups. Biochemical indices, antioxidant enzyme activities, oxidative stress markers, and histopathological changes were systematically evaluated to determine the therapeutic efficacy of <em>B. subtilis</em>.</div></div><div><h3>Results</h3><div>Cisplatin disrupted hematological indices, altered carbohydrate and lipid metabolism, elevated oxidative stress markers (ROS, MDA), and increased DNA damage (8-OHdG) and apoptosis (caspase-3). <em>B. subtilis</em> supplementation restored antioxidant enzyme activities (CAT, SOD, GPx), reduced oxidative and apoptotic damage, and preserved tissue structure. These protective effects are consistent with modulation of the Nrf2/Keap1 and NF-κB pathways, suggesting enhancement of endogenous antioxidant defenses and suppression of pro-apoptotic signaling.</div></div><div><h3>Conclusions</h3><div><em>B. subtilis</em> demonstrates potential as a safe, gut-resilient probiotic adjunct to chemotherapy, capable of mitigating systemic toxicity through redox regulation and cytoprotective mechanisms. These findings support further mechanistic and translational studies to validate probiotic-based microecological strategies in oncology care.</div></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"27 ","pages":"Article 100160"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal immunization with recombinant Omp34 and its derivative engineered construct, rOmp34L3×5, against Acinetobacter baumannii pulmonary infection","authors":"Zahra Abbasi Fashami ,&nbsp;Abolfazl Jahangiri ,&nbsp;Mohammadreza Jalali Nadoushan ,&nbsp;Saeede Masoomkhani ,&nbsp;Iraj Rasooli","doi":"10.1016/j.medmic.2025.100164","DOIUrl":"10.1016/j.medmic.2025.100164","url":null,"abstract":"<div><div>The emergence of extreme and pan-drug-resistant strains of <em>Acinetobacter baumannii</em> has intensified the need for effective prevention strategies, including developing vaccines. This study evaluates the immunogenicity and protective efficacy of the outer membrane protein Omp34 and its engineered construct, rOmp34L3 × 5, as potential vaccine candidates against <em>A. baumannii</em> pulmonary infections. The recombinant proteins were expressed and purified using Ni-NTA columns. The clinical colistin-resistant strain of <em>A. baumannii</em> Ab/TU/ColR was used in the murine pneumonia challenge experiments. Mice were immunized intranasally with the recombinant proteins. IgG, IgA titers, and their reactivity were assessed. Bacterial challenges and survival analysis were performed. Post-challenge, bacterial burdens in organs and histopathology of the lungs were evaluated. The results demonstrated that both vaccine candidates elicited strong immune responses, particularly with significant IgA and IgG antibody production. However, immunization with rOmp34L3 × 5 showed relatively stable IgG levels over 22 weeks, whereas rOmp34 alone induced higher IgG titers. Lung, spleen, and liver cultures confirmed the effectiveness of the specific antibodies in clearing bacterial loads, with histological analysis revealing normal lung tissue in immunized mice, contrasting with severe inflammation in controls. These findings suggest that rOmp34 and rOmp34L3 × 5 have the potential to serve as effective immunogens in preventing <em>A. baumannii</em> infections. Nonetheless, the variability in immune response depending on the clinical strain underscores the need for further studies to optimize vaccine efficacy across diverse <em>A. baumannii</em> isolates.</div></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"27 ","pages":"Article 100164"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology targeting ESKAPE pathogens: Eco-friendly produced nanomaterials as an innovative antibiofilm approach","authors":"Arunagiri Ragu Prasath ,&nbsp;Chinnasamy Ragavendran ,&nbsp;Paramasivam Deepak ,&nbsp;Nathiya Thiyagarajulu","doi":"10.1016/j.medmic.2025.100149","DOIUrl":"10.1016/j.medmic.2025.100149","url":null,"abstract":"<div><div>The prevalence of antibiotic resistance has made ESKAPE pathogens a severe global health hazard, owing to the limits and regular failures of conventional treatment methods. The ESKAPE pathogens (<em>Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa</em>, and <em>Enterobacter species</em>) are the most common causes of nosocomial diseases worldwide. Most of them are multidrug-resistant isolates, which pose one of the most significant difficulties in clinical treatment. The rising incidence of multidrug-resistant (MDR) advantageous infections in intensive care units (ICUs) is particularly concerning, as it poses a danger to public health and significantly impacts morbidity and death rates. MDR ESKAPE bacteria make up the great bulk of these opportunistic infections. Among these issues, nanotechnology appears as a potential area in the battle against biofilms. Considering their distinct characteristics at the nanoscale, provide novel antimicrobial techniques that are not present in standard defence mechanisms. Green-synthesized nanoparticles and their <em>anti</em>-biofilm qualities are highlighted in this in-depth examination of nanotechnology's possibility to combat biofilms. The prevalence of resistant microorganisms and antibiotics environmental residues need immediate worldwide encounter to avoid antimicrobial resistance (AMR). These natural medications may also be improved by adding silver nanoparticles and mixing them with current antibiotics. By focusing on ESKAPE organisms, the AMR problem may be tackled considerably more effectively.</div></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"26 ","pages":"Article 100149"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The gut microbiota and breast cancer: A comprehensive review of emerging links and therapeutic implications","authors":"Haja Abdul Nazeer ,&nbsp;Suganya Kannan ,&nbsp;Jeyakumar Balakrishanan ,&nbsp;Vijaya Kumar Nair ,&nbsp;Y. Kavitha ,&nbsp;Namrata K. Bhosale","doi":"10.1016/j.medmic.2025.100155","DOIUrl":"10.1016/j.medmic.2025.100155","url":null,"abstract":"<div><div>Breast cancer remains a major global health concern, with persistent challenges in recurrence, treatment resistance, and therapy-related toxicity. Parallel to advancements in oncology, recent research has uncovered a compelling connection between the gut microbiota and breast cancer pathogenesis, progression, and therapeutic response. This comprehensive review synthesizes current evidence linking microbial dysbiosis to breast cancer through key mechanisms such as chronic systemic inflammation, estrogen metabolism via the estrobolome, genotoxin production, immune system modulation, and epigenetic alterations. The emerging concept of the gut-mammary axis illustrates a systemic interplay whereby gut-derived microbial metabolites and immune signals directly influence breast tissue and tumor biology. Additionally, specific microbial profiles have been shown to impact the efficacy and toxicity of chemotherapy and immune checkpoint inhibitors, opening new avenues for microbiome-targeted interventions. With growing interest in personalized nutrition, probiotics, and fecal microbiota transplantation, the gut microbiota is poised to become an integral component of precision oncology. This review highlights the translational potential of microbiome science in breast cancer prevention, prognosis, and therapy, while calling for rigorous interdisciplinary research and large-scale clinical trials to validate and integrate these findings into standard care.</div></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"26 ","pages":"Article 100155"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145424435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}