肠道病毒轴:揭示病毒对炎症性肠病肠道菌群失调和转化医学的贡献

Q2 Medicine
Naziya Akhtar, Chirag Jain, Shikha Baghel Chauhan, Indu Singh
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引用次数: 0

摘要

肠道微生物群和免疫系统受到人类肠道病毒轴的显著影响,该轴主要由噬菌体和真核病毒组成。通过影响微生物平衡、免疫反应和肠屏障完整性的机制,最近的研究强调了其在炎症性肠病(IBD)的发生和进展中的作用。本文综述了肠道病毒——尤其是噬菌体——通过生物膜发育、转导和细菌多样性调节来促进生态失调的途径。我们还会讨论病毒如何影响慢性炎症和宿主免疫信号。由于宏基因组学和病毒组学技术的发展,现在可以彻底分析IBD患者的病毒组,这些技术已经确定了可以用作治疗靶点或诊断生物标志物的独特变化。将病毒组研究整合到肠道微生物群的更大框架中,为IBD的病理生理学提供了一个新的视角,并有可能推进精准医学技术和基于病毒的治疗,尽管事实上该主题仍未得到充分研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gut virus axis: Unravelling viral contribution to gut microbiota dysbiosis and translational medicine in inflammatory bowel disease
The gut microbiota and immune system are significantly influenced by the human gut-virus axis, which is mostly composed of bacteriophages and eukaryotic viruses. Through mechanisms affecting microbial balance, immunological responses, and intestinal barrier integrity, recent research emphasizes its role in the onset and progression of inflammatory bowel disease (IBD). This review examines the ways in which gut viruses—bacteriophages in particular—contribute to dysbiosis through biofilm development, transduction, and bacterial diversity modulation. We also go over how the virome affects chronic inflammation and host immunological signaling. The virome in IBD patients can now be thoroughly profiled thanks to developments in metagenomic and viromic technologies, which have identified unique changes that could be used as therapeutic targets or diagnostic biomarkers. Integrating virome research into the larger framework of the gut microbiota offers a fresh viewpoint on the pathophysiology of IBD and has the potential to advance precision medicine techniques and virus-based treatments, despite the fact that the topic is still understudied.
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来源期刊
Medicine in Microecology
Medicine in Microecology Medicine-Gastroenterology
CiteScore
5.60
自引率
0.00%
发文量
16
审稿时长
76 days
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