牙龈卟啉单胞菌调节e -钙粘蛋白表达:可能涉及机制的迷你回顾

Q2 Medicine
Zahra Khorshidi Asl , Mahtab Mottaghi , Fatemeh Farshad , Faezeh Azmoudeh
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引用次数: 0

摘要

背景牙龈卟啉单胞菌(P. gingivalis)是导致牙周炎致病性变化的细菌菌株,可显著破坏上皮完整性,导致其作为病原体保护屏障的功能失效。e -钙粘蛋白是一种已知的细胞间黏附蛋白,可受牙龈假单胞菌的影响。目的综述了该细菌对e -钙粘蛋白的影响、可能的机制以及该蛋白在牙周炎相关全体性疾病中的作用。方法于2024年9月,利用PubMed、Scopus、Web of Science、b谷歌Scholar进行综合检索。搜索的重点是最近五年发表的文章。综述和非英文文章被排除在外。从数据库中找到的83条记录中,选择了10条记录用于本研究。结果和结论最近的研究一致表明,E-cadherin在牙龈卟啉卟啉感染的细胞和组织中下调。然而,仍有必要阐明细菌感染和e -钙粘蛋白下调在牙周炎相关的全身性疾病中的作用,如癌症发展中的上皮-间质转化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Porphyromonas gingivalis modulates E-cadherin expression: a mini-review of possible involved mechanisms

Background

Porphyromonas gingivalis (P. gingivalis), the bacterial strain responsible for pathogenic changes in periodontitis, can significantly deteriorate epithelial integrity, leading to its malfunction as a protective barrier against pathogens. As one of the known intercellular adhesive proteins, E-cadherin can be affected by P. gingivalis.

Objectives

This review summarizes the most recent research on the effect of this bacterium on E-cadherin, the suggested involved mechanisms, and the contribution of this protein deterioration in the systemic disease associated with periodontitis.

Methods

In September 2024, a comprehensive search was conducted using PubMed, Scopus, Web of Science, and Google Scholar. The search focused on articles published within the last five years. Review and non-English articles were excluded. Out of 83 records found in databases, 10 records were selected for this study.

Results and conclusion

Most recent studies have consistently demonstrated the downregulation of E-cadherin in P. gingivalis-infected cells and tissues. However, there remains a need to elucidate the contribution of the bacterial infection and E-cadherin downregulation that occur during systemic diseases related to periodontitis, such as Epithelial-Mesenchymal Transition in cancer development.
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来源期刊
Medicine in Microecology
Medicine in Microecology Medicine-Gastroenterology
CiteScore
5.60
自引率
0.00%
发文量
16
审稿时长
76 days
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