Medicine in Microecology最新文献_第10页

Human microbiota: A crucial gatekeeper in lung cancer initiation, progression, and treatment 人类微生物群:肺癌发生、发展和治疗的关键把关人

Medicine in Microecology Pub Date : 2022-09-01 DOI: 10.1016/j.medmic.2022.100055

Yuqing Zhou , Tingtao Chen

{"title":"Human microbiota: A crucial gatekeeper in lung cancer initiation, progression, and treatment","authors":"Yuqing Zhou , Tingtao Chen","doi":"10.1016/j.medmic.2022.100055","DOIUrl":"10.1016/j.medmic.2022.100055","url":null,"abstract":"<div><p>Lung cancer is becoming one of the most detrimental cancers with the highest morbidity and mortality rate of all cancers, posing a significant burden for the global health system. Nonetheless, the therapeutic efficacy of traditional lung cancer therapies still remains relatively unsatisfying with varied responsiveness and unexpected adverse effects. Fortunately, studies have reported that an intimate relationship might exist between microbiota and lung carcinoma. Notably, microbial dysbiosis might result in changes in the metabolism, induction of immunosuppression, and recruitment of inflammatory factors, thereby driving lung carcinogenesis. Certain microbial strains were identified to be specifically enriched in the lung tumor beds, indicating their predictive role in lung cancer. Furthermore, the particular microbial composition was also proved to potentiate the outcomes of lung cancer therapies, suggesting that lung and gut microbiome were promising to be clinically applied for lung cancer therapy. In this review, we will comprehensively summarize the recent findings on how microbes mediate the initiation, progression, and treatment of lung cancer, illustrating the potential mechanisms and probing into the putative manipulation of microbiota to facilitate lung cancer treatments.</p></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"13 ","pages":"Article 100055"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590097822000052/pdfft?md5=a27d8fd9d3b75e2c50e8b3a7d21b930c&pid=1-s2.0-S2590097822000052-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46644951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Development of colorectal cancer detection and prediction based on gut microbiome big-data 基于肠道微生物组大数据的结直肠癌检测与预测研究进展

Medicine in Microecology Pub Date : 2022-06-01 DOI: 10.1016/j.medmic.2022.100053

Yangyang Sun , Xiaoqian Fan , Jin Zhao

引用次数: 1

Moving beyond the gut microbiome: Combining systems biology and multi-site microbiome analyses to combat non-communicable diseases 超越肠道微生物组:结合系统生物学和多位点微生物组分析来对抗非传染性疾病

Medicine in Microecology Pub Date : 2022-06-01 DOI: 10.1016/j.medmic.2022.100052

Caitlin A. Selway , Jaya Sudarpa , Laura S. Weyrich

引用次数: 2

The effect of intrinsic factors and mechanisms in shaping human gut microbiota 内在因素和机制在塑造人类肠道微生物群中的作用

Medicine in Microecology Pub Date : 2022-06-01 DOI: 10.1016/j.medmic.2022.100054

Huidi Wang , Jie Li , Guangyan Wu , Feng Zhang , Jia Yin , Yan He

引用次数: 0

The interplay between microbiota, metabolites, immunity during BV 细菌性脑膜炎期间微生物群、代谢物和免疫之间的相互作用

Medicine in Microecology Pub Date : 2022-03-01 DOI: 10.1016/j.medmic.2021.100049

Qiong-qiong Zhang , Rui Chen , Meng Li , Zhen Zeng , Lei Zhang , Qin-ping Liao

{"title":"The interplay between microbiota, metabolites, immunity during BV","authors":"Qiong-qiong Zhang , Rui Chen , Meng Li , Zhen Zeng , Lei Zhang , Qin-ping Liao","doi":"10.1016/j.medmic.2021.100049","DOIUrl":"10.1016/j.medmic.2021.100049","url":null,"abstract":"<div><p>The surface of the female lower genital tract is covered with squamous epithelium, and some bacteria and fungi reside in the cavity. Among them, the dominant <em>Lactobacillus</em> maintain the acidic environment of the vagina. The acidic environment, squamous epithelium barrier, mucus and innate immune response together resist the invasion of pathogens and local homeostasis. Bacterial vaginosis (BV) is a disorder of the vaginal microbiota, which is characterized by a shift in the vaginal flora from the dominant <em>Lactobacillus</em> to a polymicrobial anaerobic flora accompanied by an increase in pH > 4.5. Its high recurrence rate, obvious clinical symptoms, and possible adverse pregnancy outcome seriously disturb women's healthy life. However, its pathogenesis is still elusive. The vaginal microenvironment includes not only microbiota, but also microbially and host-produced metabolites, and vaginal local immunity. Given the inseparable relationship between the microbiota and its metabolites and the immune response, it is important to study how these interactions regulate vaginal local immunity to resist pathogens. In this review, we will discuss the main theories of BV etiology, which eventually involves the interaction between BV-related pathogens, small molecular metabolites, and host immune responses in the vagina.</p></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"11 ","pages":"Article 100049"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590097821000173/pdfft?md5=27897a9f5c20d30acf9a607fd8d89187&pid=1-s2.0-S2590097821000173-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42322076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Biochemical indicators and vaginal microecological abnormalities indicate the occurrence of intrauterine adhesions 生化指标及阴道微生态异常提示发生宫内粘连

Medicine in Microecology Pub Date : 2022-03-01 DOI: 10.1016/j.medmic.2021.100050

Xiaoqing Li , Fang Xu , Xiaoli Sha, Xianyan Chen, Qiong hui Pan, Xuefen He, Hongping Zhang, Yuanyuan Zheng

{"title":"Biochemical indicators and vaginal microecological abnormalities indicate the occurrence of intrauterine adhesions","authors":"Xiaoqing Li , Fang Xu , Xiaoli Sha, Xianyan Chen, Qiong hui Pan, Xuefen He, Hongping Zhang, Yuanyuan Zheng","doi":"10.1016/j.medmic.2021.100050","DOIUrl":"https://doi.org/10.1016/j.medmic.2021.100050","url":null,"abstract":"<div><p>Intrauterine adhesions (IUAs) are important causes of female infertility, mainly but not always caused by iatrogenic endometrial injury. The microbiome of the female reproductive tract, including the vagina and uterine cavity, plays an important role in health and disease. Immune regulation imbalance caused by reproductive tract microecological disorders can act in the formation mechanism of IUAs. Here we collected clinical laboratory indicators, the vaginal secretions and uterine secretions of 6 women with and 8 women without IUAs, with a history of curettage. Vaginal and uterine cavity microbes were detected by high-throughput sequencing technology. Compared with the women without IUAs, the proportion of <em>Lactobacillus</em> in vaginal microbes was decreased and the proportion of <em>Bacteroides</em> was increased in the IUAs. The α-diversity index in the vaginal microbiome was significantly positively correlated with the hematocrit and erythrocyte count (<em>P</em> ＜0.05). These clinical and microbiological indicators could be used to indicate the occurrence of IUAs, so this study has clinical guiding significance for detecting and preventing them.</p></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"11 ","pages":"Article 100050"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590097821000185/pdfft?md5=a1bf9fc3a779d830757dbe414fb22f00&pid=1-s2.0-S2590097821000185-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91778761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Search-based health status detection and disease classification using species-level profiles of metagenomes 基于搜索的健康状况检测和疾病分类，使用物种水平的宏基因组图谱

Medicine in Microecology Pub Date : 2022-03-01 DOI: 10.1016/j.medmic.2021.100048

Yuzhu Chen, Xiaoquan Su

{"title":"Search-based health status detection and disease classification using species-level profiles of metagenomes","authors":"Yuzhu Chen, Xiaoquan Su","doi":"10.1016/j.medmic.2021.100048","DOIUrl":"https://doi.org/10.1016/j.medmic.2021.100048","url":null,"abstract":"<div><p>Microbiome biomarker-based modeling has been widely used in classifying health states. However, many diseases do not have explicit biomarkers, or exhibit shortages in detection accuracy using specific species. Based on microbiome big data and cutting-edge computing engine, here we report the search-based strategy of health status detection for shotgun metagenomes. Comparing the species-level profiles against large-scale metagenomes, outlier samples are screened out as unhealthy, and their detailed disease types can be identified by top matches. Benchmarking on a multi-cohort dataset with over 3,000 metagenomes, the search-based approach achieved a promising overall accuracy that was superior to marker-based models constructed by random forest (RF), supporting vector machine (SVM) and extreme gradient boosting (XGBoost). More importantly, the search-based method also featured a balanced performance on different diseases. Hence, this case study further demonstrates the potential and capability of metagenome big data in human health, as well as moves one-step forward of search-based approach in microbiome research and application.</p></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"11 ","pages":"Article 100048"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590097821000161/pdfft?md5=f305f77b53e2e473ac639d169582e601&pid=1-s2.0-S2590097821000161-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91778762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Microbiome typing in uveal melanoma is associated with plaque radiotherapy 葡萄膜黑色素瘤的微生物组分型与斑块放疗相关

Medicine in Microecology Pub Date : 2022-02-18 DOI: 10.21203/rs.3.rs-1366478/v1

Yu-Ning Chen, Jieying Luo, Haowen Li, R. Fang, Ruiheng Zhang, Yue-ming Liu, Yang Li, Wenbin Wei, J. Xiu

{"title":"Microbiome typing in uveal melanoma is associated with plaque radiotherapy","authors":"Yu-Ning Chen, Jieying Luo, Haowen Li, R. Fang, Ruiheng Zhang, Yue-ming Liu, Yang Li, Wenbin Wei, J. Xiu","doi":"10.21203/rs.3.rs-1366478/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-1366478/v1","url":null,"abstract":"\u0000 Background: Microbiomes have been identified in various tumor types and could affect tumor progression and treatment. As the most prevalent primary malignant eyetumor in adults, uveal melanoma (UM) has not been explored regarding its endogenous microbiome. Plaque radiotherapy (PRT) is the gold standard for the treatment of UM. Hereby, we recruited 71 UM patients, sequenced the 16S rRNA gene of their tumor tissues, and analyzed the association between UM microbiome and disease phenotypes.Results: Clear bacterial signals were observed in UM tissues by using in situ fluorescence hybridization. 523 bacterial species passed strict decontamination against 58 environmental control samples in 16S rRNA gene analysis, and these species formed three distinct types by unsupervised clustering. The UM microbiome types were significantly associated with PRT. A biomarker analysis showed that Pseudomonas and Sphingomonas were significantly enriched in the radiation group (RG) compared to the non-radiation group (NRG). A kind of radiation-resistant bacteria had a significantly higher positive rate in tumor tissues that underwent radiotherapy. We found that radioresistant bacteria Deinococcus was associated with larger tumor and later tumor stage, while Pedobacter, Bradyrhizobium, Variovorax, Pseudomonas and Stenotrophomonas were associated with later metastasis. Conclusion: There was an endogenous microbiome in UM tissues, and the distribution of microbiota was correlated with PRT and clinical features.","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45550017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota dysbiosis in patients with preeclampsia: A systematic review 子痫前期患者肠道菌群失调:一项系统综述

Medicine in Microecology Pub Date : 2021-12-01 DOI: 10.1016/j.medmic.2021.100047

Wei Qing, Yiya Shi, Hongwei Zhou, Muxuan Chen

{"title":"Gut microbiota dysbiosis in patients with preeclampsia: A systematic review","authors":"Wei Qing, Yiya Shi, Hongwei Zhou, Muxuan Chen","doi":"10.1016/j.medmic.2021.100047","DOIUrl":"10.1016/j.medmic.2021.100047","url":null,"abstract":"<div><p>Currently, the etiology of preeclampsia (PE) has not been comprehensively clarified. Accumulating evidence indicated that gut microbiota is associated with the onset of PE. Herein, a systematic review was conducted to explore the dysbiosis of gut microbiota in PE patients compared with healthy controls (HCs). Publications were retrieved from Medline, EMBASE, Web of Science and Scopus. Studies comparing the gut microbiota in PE patients to HCs using culture-independent methods were included. Independent quality assessment and data extraction was performed according to PRISMA statement and Newcastle-Ottawa Scale (NOS). In total, six studies with an overall sample size of 416 PE patients and 704 HCs were included. In terms of alpha- and beta-diversity, consistent results reflecting the alteration of gut microbiota in PE patients. Furthermore, <em>Fusobacterium</em> and <em>Ruminococcus</em> enriched, while <em>Lachnospira</em>, <em>Akkermansia</em>, <em>Faecalibacterium</em>, <em>Bifidobacterium</em> and <em>Alistipes</em> were depleted in PE. This systematic review demonstrates significant dysbiosis of gut microbiota in PE patients and confirms that that the possible correlations between gut microbiota dysbiosis and PE onset. However, heterogeneity in results was also identified, alluding more well-designed studies are warranted. Above all, these evidence demonstrates that the gut microbiota may be a potential treatment and prevention target for PE.</p></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"10 ","pages":"Article 100047"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S259009782100015X/pdfft?md5=0d201c282bbad5a6f8ed2fd95341db40&pid=1-s2.0-S259009782100015X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44092366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Search-based health status detection and disease classification using species-level profiles of shotgun metagenomes 基于搜索的健康状况检测和疾病分类，使用鸟枪元基因组的物种水平谱

Medicine in Microecology Pub Date : 2021-12-01 DOI: 10.1016/j.medmic.2021.100048

Yuzhu Chen, Xiaoquan Su

引用次数: 1