BMC Clinical Pathology最新文献

{"title":"Primary breast angiosarcoma: a rare presentation of rare tumor - case report.","authors":"Fayçal Abbad,&nbsp;Najat Cherif Idrissi,&nbsp;Btissam Fatih,&nbsp;Bouchra Fakhir,&nbsp;Jamal Drissi,&nbsp;Mouna Khouchani,&nbsp;Hanane Rais","doi":"10.1186/s12907-017-0055-y","DOIUrl":"https://doi.org/10.1186/s12907-017-0055-y","url":null,"abstract":"<p><strong>Background: </strong>Primary breast angiosarcoma is defined as malignant proliferation showing endothelial differentiation. It is a very rare tumour (0.05% of primary mammary cancers), whose diagnosis can be difficult.</p><p><strong>Case presentation: </strong>We report the observation of a patient with no previous history, aged 27 years. The clinical examination finds a right breast discreetly increased in volume. The trucut biopsy was in favour of a lactating tubular adenoma. However, an immunohistochemical complement was requested. An absence of pancytokeratin labelling contrasted with strong expression of CD31, CD34 (endothelial markers) are described. The proliferation index (Ki67) was estimated at 30%. This led to the conclusion that the phenotypic aspect is related to a vascular proliferation that evokes an angiosarcoma. After a multidisciplinary assessment, the patient benefited from an enlarged excision of the tumour. The histopathological examination of the surgical specimen found an infiltrating mesenchymal proliferation made of vessels of variable sizes anastomosed to vascular slits with lesional limits. The immunohistochemical examination on the surgical specimen showed to the same phenotypic profile on biopsy. The final diagnosis was a high-grade mammary angiosarcoma of incomplete excision. The patient refused any additional surgical management; external radiotherapy and close supervision were prescribed. After eight months of evolution, no local or remote recurrence was reported.</p><p><strong>Conclusion: </strong>Primary breast angiosarcoma is a mesenchymal malignant tumour of rare vascular origin. Our observation is peculiar by the absence of any prior radiotherapy, its clinical presentation, its morpho-phenotypic characteristics, its management and its evolutive aspects.</p>","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12907-017-0055-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35312138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of cervical cytology: comparison of diagnoses of 100 Pap smears read by four pathologists at three hospitals in Norway.","authors":"Sveinung Wergeland Sørbye,&nbsp;Pål Suhrke,&nbsp;Berit Wallem Revå,&nbsp;Jannicke Berland,&nbsp;Ramona Johansen Maurseth,&nbsp;Khalid Al-Shibli","doi":"10.1186/s12907-017-0058-8","DOIUrl":"https://doi.org/10.1186/s12907-017-0058-8","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer can be prevented by early detection and treatment for precancerous lesions. Since 1995, there has been a national cervical cancer screening program in Norway, where women aged 25-69 years are recommended to take Pap smears every three years. There are 17 cytology laboratories covering a population of 5 million people. The detection rate of cervical abnormalities varies from laboratory to laboratory. We wanted to investigate the accuracy of cytology diagnoses by four different pathologists at three different hospitals in Norway.</p><p><strong>Methods: </strong>One hundred Pap smears (20 Normal, 20 ASC-US, 20 LSIL, 20 ASC-H and 20 HSIL) screened at UNN in 2015 were evaluated by four pathologists at three hospitals in Norway. All patients were followed up through December 2016. Histologically confirmed high-grade dysplasia (CIN2+) was considered as study endpoint.</p><p><strong>Results: </strong>The number of Pap smears evaluated as abnormal (ASC-US+) by the four pathologists varied from 61 to 85. The number of high-grade cytology (ASC-H+) varied from 26 to 50. There was moderate agreement (weighted kappa 0.45-0.58) between the observers. There were 32 women with high-grade histology (CIN2+) in the follow-up, including 19 CIN2, 12 CIN3 and one squamous cell carcinoma (SCC). Using high-grade cytology (ASC-H+) as cut-off, the sensitivity for CIN2+ varied from 68.8% to 93.8% (mean 77.4%) and specificity from 70.6% to 95.6% (mean 81.3%). The pathologist with the highest sensitivity for CIN2+ had the highest false positive rate and the lowest specificity (<i>p</i><0.05). The accuracy for CIN2+ varied from 74.1% to 83.8% (mean 79.4%). The Pap smear from the woman with cervical cancer was diagnosed as high-grade (ASC-H+) by one of the four pathologists.</p><p><strong>Conclusions: </strong>Cervical cancer screening based on cytology has limited accuracy. The study revealed a moderate agreement between the observers, along with a trade-off between sensitivity and specificity. This might indicate that hospitals with high detection rates of cervical cytology have higher sensitivity for CIN2+ but lower specificity.</p>","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12907-017-0058-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35316708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary ovarian angiosarcoma in a 12- year -old girl: a case report of an exceptional localization in a context of limited resources country.","authors":"Tchin Darré,&nbsp;Abdoul-Samadou Aboubakari,&nbsp;Bingo K N'Bortche,&nbsp;Akila Bassowa,&nbsp;Solange Adani-Ifé,&nbsp;Gado Napo-Koura","doi":"10.1186/s12907-017-0056-x","DOIUrl":"https://doi.org/10.1186/s12907-017-0056-x","url":null,"abstract":"<p><strong>Background: </strong>Ovarian sarcomas represent less than 1% of all ovary cancers and usually are frequent in adults. Primary angiosarcomas are exceptional in the ovaries within children.</p><p><strong>Case presentation: </strong>We reported a case of primary ovarian angiosarcoma in a 12-year-old girl in a resource-constrained context. Immunohistochemistry study showed the positivity of CD34, CD31, factor VIII, while S100 was negative. The diagnosis of primary non-metastatic angiosarcoma was retained. She was unable to undergo the CWS-2002P chemotherapy since her parents could not afford it.</p><p><strong>Conclusion: </strong>This case report described a rare type of a primary ovarian angiosarcoma within a child, diagnosed in a low-income country in a laboratory with limited resources.</p>","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12907-017-0056-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35356699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrospinal fluid pleocytosis level as a diagnostic predictor? A cross-sectional study.","authors":"Anne Ahrens Østergaard,&nbsp;Thomas Vognbjerg Sydenham,&nbsp;Mads Nybo,&nbsp;Åse Bengård Andersen","doi":"10.1186/s12907-017-0053-0","DOIUrl":"https://doi.org/10.1186/s12907-017-0053-0","url":null,"abstract":"<p><strong>Background: </strong>Lumbar puncture with quantification of leukocytes and differential count of cellular subsets in the cerebrospinal fluid is a standard procedure in cases of suspected neuroinfectious conditions. However, a number of non-infectious causes may result in a low leukocyte number (0-1000 cells/ml). We wanted to assess the diagnostic diversity of unselected adult patients with pleocytosis in the cerebrospinal fluid.</p><p><strong>Methods: </strong>The study is based on data from cerebrospinal fluid (CSF) analyses of all adult patients (15 years or older) admitted to a large university hospital in Denmark during a two-year period (2008-2009). Data from the local patient administrative system supplied with data from patient charts were combined with laboratory data.</p><p><strong>Results: </strong>A total of 5390 cerebrospinal fluid samples from 3290 patients were included. Pleocytosis >5 leucocytes/μl was found in samples from 262 patients of which 106 (40.5%) were caused by infection of the central nervous system (CNS), 20 (7.6%) by infection outside CNS, 79 (30.2%) due to non-infectious neurological diseases, 23 (8.8%) by malignancy, and 34 (13.0%) caused by other conditions. Significantly higher mean CSF leukocytes was found in patients suffering from CNS infection (mean 1135 cells/μl, <i>p</i>-value <0.0001).</p><p><strong>Conclusions: </strong>CNS infection, non-infectious neurological disease, malignancy, and infection outside CNS can cause pleocytosis of the cerebrospinal fluid. Leukocyte counts above 100/μl is mainly caused by CNS infection, whereas the number of differential diagnoses is higher if the CSF leukocyte counts is below 50/μl. These conditions are most commonly caused by non-infectious neurological diseases including seizures.</p>","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12907-017-0053-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35312137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of dielectric blood coagulometry in the evaluation of coagulability in patients with peripheral arterial disease.","authors":"Kimihiro Igari,&nbsp;Toshifumi Kudo,&nbsp;Takahiro Toyofuku,&nbsp;Yoshinori Inoue","doi":"10.1186/s12907-017-0054-z","DOIUrl":"https://doi.org/10.1186/s12907-017-0054-z","url":null,"abstract":"<p><strong>Background: </strong>Platelets and coagulation proteins contribute to the development of peripheral arterial disease, especially atherosclerotic disease. Several experimental studies have proven a significant correlation between hypercoagulability and atherosclerosis. We used dielectric blood coagulometry, which was initially designed to evaluate the coagulable status, to examine the coagulability of peripheral arterial disease patients, and investigated the factors that were significantly correlated with the results.</p><p><strong>Methods: </strong>We performed dielectric blood coagulometry in 49 peripheral arterial disease patients. In addition, we recorded the patients' demographic information, including the presence of comorbidities, hemodynamic status, and laboratory findings. To investigate coagulability, we calculated the T_max value, which indicates the time from recalcification to maximum normalized permittivity.</p><p><strong>Results: </strong>The T_max values of diabetes mellitus patients were significantly lower than those of non-diabetic patients (1 MHz, <i>P</i> = 0.010; 10 MHz, 0.011). Furthermore, the T_max value was statistically correlated with the activated partial thromboplastin time (1 MHz, ρ = 0.286, <i>P</i> = 0.048; 10 MHz, ρ = 0.301, <i>P</i> = 0.037).</p><p><strong>Conclusions: </strong>Dielectric blood coagulometry detected the hypercoagulable status in diabetes mellitus patients, and reflected their level of coagulability, which was also evaluated by the activated partial thromboplastin time.</p>","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12907-017-0054-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35356698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignant Deciduoid Mesothelioma: case presentation of an exceptional variant and review of the literature.","authors":"Mouna Khmou, Soumiya Echcharif, Rachad Kabbaj, Basma El Khannoussi","doi":"10.1186/s12907-017-0051-2","DOIUrl":"10.1186/s12907-017-0051-2","url":null,"abstract":"<p><strong>Background: </strong>Malignant Deciduoid Mesothelioma (MDM) is an extremely rare variant of epithelioid mesothelioma. It was first described in young females, in the peritoneum, and its relation with asbestos was not well defined. Later reports, have shown that this variant may also occur in the pleura, the pericardium and the tunica vaginalis of elderly people, who had been exposed to asbestos.</p><p><strong>Case presentation: </strong>We report a case of malignant deciduoid mesothelioma that occurred in the peritoneal cavity, and the omentum of a 35-year-old woman. The patient had never been exposed to asbestos.</p><p><strong>Conclusions: </strong>Through this observation, we describe clinical, histopathological, and immunohistochemical findings of deciduoid mesothelioma, and review the literature reports.</p>","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12907-017-0051-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35429743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential expression of CK20, β-catenin, and MUC2/5AC/6 in Lynch syndrome and familial colorectal cancer type X.","authors":"Stefan Haraldsson,&nbsp;Louise Klarskov,&nbsp;Mef Nilbert,&nbsp;Inge Bernstein,&nbsp;Jesper Bonde,&nbsp;Susanne Holck","doi":"10.1186/s12907-017-0052-1","DOIUrl":"https://doi.org/10.1186/s12907-017-0052-1","url":null,"abstract":"<p><strong>Background: </strong>Hereditary non-polyposis colorectal cancer comprises Lynch syndrome and familial colorectal cancer type X (FCCTX). Differences in genetics, demographics and histopathology have been extensively studied. The purpose of this study is to characterize their immunoprofile of markers other than MMR proteins.</p><p><strong>Methods: </strong>We compared the expression patterns of cytokeratins (CK7 and CK20), mucins (MUC2/5 AC/6), CDX2 and β-catenin in Lynch syndrome and FCCTX.</p><p><strong>Results: </strong>Differences were identified for CK20 and nuclear β-catenin, which were significantly more often expressed in FCCTX than in Lynch syndrome (<i>p</i> < 0.001), whereas MUC2, MUC5AC and MUC6 were overexpressed in Lynch syndrome tumors compared with FCCTX tumors (<i>p</i> = 0.001, < 0.01, and < 0.001, respectively). We observed no differences in the expression patterns of CK7 and CDX2.</p><p><strong>Conclusions: </strong>In summary, we identified significant differences in the immunoprofiles of colorectal cancers linked to FCCTX and Lynch syndrome with a more sporadic-like profile in the former group and a more distinct profile with frequent MUC6 positivity in the latter group.</p>","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12907-017-0052-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35333653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory myofibroblastic tumor of the lacrimal gland: case report of an exceptional location.","authors":"Adil Boudhas,&nbsp;Mohamed Allaoui,&nbsp;Fouad El Asri,&nbsp;Issam Rharrassi,&nbsp;Mohamed Reda El Ochi,&nbsp;Mohamed Tbouda,&nbsp;Hafsa Chahdi,&nbsp;Abderrahmane Al Bouzidi,&nbsp;Mohamed Oukabli","doi":"10.1186/s12907-017-0050-3","DOIUrl":"https://doi.org/10.1186/s12907-017-0050-3","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory myofibroblastic tumour (IMT) is a mesenchymal neoplasm of intermediate biological potential that may affect a wide range of anatomic sites but has a particular predilection for the lung and intra-abdominal soft tissues.</p><p><strong>Case presentation: </strong>We report here an exceptional case of inflammatory myofibroblastic tumor arising in the lacrimal gland and presenting as an orbital mass in a 24-year-old male.</p><p><strong>Conclusion: </strong>This report aims to discuss the importance of histopathological and immunohistochemical findings in arriving at the diagnosis, which helps dictate the management, treatment and prognosis of the patient.</p>","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12907-017-0050-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35333654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traceability and distribution of <i>Neisseria meningitidis</i> DNA in archived post mortem tissue samples from patients with systemic meningococcal disease.","authors":"Berit Sletbakk Brusletto, Bernt Christian Hellerud, Else Marit Løberg, Ingeborg Løstegaard Goverud, Åshild Vege, Jens Petter Berg, Petter Brandtzaeg, Reidun Øvstebø","doi":"10.1186/s12907-017-0049-9","DOIUrl":"10.1186/s12907-017-0049-9","url":null,"abstract":"<p><strong>Background: </strong>The pathophysiology and outcome of meningococcal septic shock is closely associated with the plasma level of <i>N. meningitidis</i> lipopolysaccharides (LPS, endotoxin) and the circulating level of meningococcal DNA. The aim of the present study was to quantify the number of <i>N. meningitidis</i> in different formalin-fixed, paraffin-embedded (FFPE) tissue samples and fresh frozen (FF) tissue samples from patients with systemic meningococcal disease (SMD), to explore the distribution of <i>N. meningitidis</i> in the body.</p><p><strong>Methods: </strong>DNA in FFPE and FF tissue samples from heart, lungs, liver, kidneys, spleen and brain from patients with meningococcal shock and controls (lethal pneumococcal infection) stored at variable times, were isolated. The bacterial load of <i>N. meningitidis</i> DNA was analyzed using quantitative real-time PCR (qPCR) and primers for the capsule transport A (ctrA) gene (1 copy per <i>N. meningitidis</i> DNA). The human beta-hemoglobin (HBB) gene was quantified to evaluate effect of the storage times (2-28 years) and storage method in archived tissue.</p><p><strong>Results: </strong><i>N. meningitidis</i> DNA was detected in FFPE and FF tissue samples from heart, lung, liver, kidney, and spleen in all patients with severe shock. In FFPE brain, <i>N. meningitidis</i> DNA was only detected in the patient with the highest concentration of LPS in the blood at admission to hospital. The highest levels of <i>N. meningitidis</i> DNA were found in heart tissue (median value 3.6 × 10⁷ copies <i>N. meningitidis</i> DNA/μg human DNA) and lung tissue (median value 3.1 × 10⁷ copies <i>N. meningitidis</i> DNA/μg human DNA) in all five patients. <i>N. meningitidis</i> DNA was not detectable in any of the tissue samples from two patients with clinical meningitis and the controls (pneumococcal infection). The quantity of HBB declined over time in FFPE tissue stored at room temperature, suggesting degradation of DNA.</p><p><strong>Conclusions: </strong>High levels of <i>N. meningitidis</i> DNA were detected in the different tissue samples from meningococcal shock patients, particularly in the heart and lungs suggesting seeding and major proliferation of meningococci in these organs during the development of shock, probably contributing to the multiple organ failure. The age of archived tissue samples appear to have an impact on the amount of quantifiable <i>N. meningitidis</i> DNA.</p>","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12907-017-0049-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35333652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of poorly differentiated thyroid carcinoma probably arising from a nodular goiter.","authors":"Hironao Yasuoka,&nbsp;Yasushi Nakamura,&nbsp;Mitsuyoshi Hirokawa,&nbsp;Ken-Ichi Yoshida,&nbsp;Kana Anno,&nbsp;Masayuki Tori,&nbsp;Masahiko Tsujimoto","doi":"10.1186/s12907-017-0048-x","DOIUrl":"https://doi.org/10.1186/s12907-017-0048-x","url":null,"abstract":"<p><strong>Background: </strong>Some poorly differentiated thyroid carcinomas (PDTC) arise from pre-existing, well-differentiated carcinomas of follicular cell origin; however, others most likely arise de novo<i>.</i> The case of a PDTC adjacent to a pre-existing nodular goiter is very rare.</p><p><strong>Case presentation: </strong>A patient had a PDTC, a widely invasive, cellular tumor with cells that lacked the nuclear features of a papillary thyroid carcinoma. Carcinoma cells were arranged in trabecular, solid, and microfollicular histological patterns and displayed high mitotic activity. A nodule partially encapsulated in a thick fibrous capsule was found adjacent to the PDTC. The nodule was composed of small or dilated follicles, without papillary carcinoma-like nuclear features, that were consistent with a nodular goiter. The PDTC showed a high Ki-67 labeling index and an <i>NRAS</i> gene mutation (codon 61, Q61K).</p><p><strong>Conclusion: </strong>These results support our diagnosis of a PDTC, probably arising from a nodular goiter.</p>","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12907-017-0048-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35065720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}