Differential expression of CK20, β-catenin, and MUC2/5AC/6 in Lynch syndrome and familial colorectal cancer type X.

Q2 Medicine

BMC Clinical Pathology Pub Date : 2017-08-17 eCollection Date: 2017-01-01 DOI:10.1186/s12907-017-0052-1

Stefan Haraldsson, Louise Klarskov, Mef Nilbert, Inge Bernstein, Jesper Bonde, Susanne Holck

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引用次数: 2

Abstract

Background: Hereditary non-polyposis colorectal cancer comprises Lynch syndrome and familial colorectal cancer type X (FCCTX). Differences in genetics, demographics and histopathology have been extensively studied. The purpose of this study is to characterize their immunoprofile of markers other than MMR proteins.

Methods: We compared the expression patterns of cytokeratins (CK7 and CK20), mucins (MUC2/5 AC/6), CDX2 and β-catenin in Lynch syndrome and FCCTX.

Results: Differences were identified for CK20 and nuclear β-catenin, which were significantly more often expressed in FCCTX than in Lynch syndrome (p < 0.001), whereas MUC2, MUC5AC and MUC6 were overexpressed in Lynch syndrome tumors compared with FCCTX tumors (p = 0.001, < 0.01, and < 0.001, respectively). We observed no differences in the expression patterns of CK7 and CDX2.

Conclusions: In summary, we identified significant differences in the immunoprofiles of colorectal cancers linked to FCCTX and Lynch syndrome with a more sporadic-like profile in the former group and a more distinct profile with frequent MUC6 positivity in the latter group.

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CK20、β-catenin、MUC2/5AC/6在Lynch综合征和家族性结直肠癌X型中的差异表达

背景:遗传性非息肉病性结直肠癌包括Lynch综合征和家族性结直肠癌X型(FCCTX)。遗传学、人口统计学和组织病理学方面的差异已被广泛研究。本研究的目的是表征除MMR蛋白外的其他标志物的免疫谱。方法:比较细胞角蛋白(CK7和CK20)、粘蛋白(MUC2/5 AC/6)、CDX2和β-catenin在Lynch综合征和FCCTX中的表达规律。结果:CK20和细胞核β-catenin在FCCTX中的表达明显高于Lynch综合征(p p = 0.001)。结论:综上所述，我们发现与FCCTX和Lynch综合征相关的结直肠癌的免疫谱存在显著差异，前者具有更散发性的特征，后者具有更明显的MUC6阳性特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Clinical Pathology Medicine-Pathology and Forensic Medicine

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： BMC Clinical Pathology is an open access journal publishing original peer-reviewed research articles in all aspects of histopathology, haematology, clinical biochemistry, and medical microbiology (including virology, parasitology, and infection control). BMC Clinical Pathology (ISSN 1472-6890) is indexed/tracked/covered by PubMed, CAS, EMBASE, Scopus and Google Scholar.