A rare case of poorly differentiated thyroid carcinoma probably arising from a nodular goiter.

Q2 Medicine

BMC Clinical Pathology Pub Date : 2017-06-02 eCollection Date: 2017-01-01 DOI:10.1186/s12907-017-0048-x

Hironao Yasuoka, Yasushi Nakamura, Mitsuyoshi Hirokawa, Ken-Ichi Yoshida, Kana Anno, Masayuki Tori, Masahiko Tsujimoto

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引用次数: 5

Abstract

Background: Some poorly differentiated thyroid carcinomas (PDTC) arise from pre-existing, well-differentiated carcinomas of follicular cell origin; however, others most likely arise de novo. The case of a PDTC adjacent to a pre-existing nodular goiter is very rare.

Case presentation: A patient had a PDTC, a widely invasive, cellular tumor with cells that lacked the nuclear features of a papillary thyroid carcinoma. Carcinoma cells were arranged in trabecular, solid, and microfollicular histological patterns and displayed high mitotic activity. A nodule partially encapsulated in a thick fibrous capsule was found adjacent to the PDTC. The nodule was composed of small or dilated follicles, without papillary carcinoma-like nuclear features, that were consistent with a nodular goiter. The PDTC showed a high Ki-67 labeling index and an NRAS gene mutation (codon 61, Q61K).

Conclusion: These results support our diagnosis of a PDTC, probably arising from a nodular goiter.

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一例罕见的低分化甲状腺癌，可能由结节性甲状腺肿引起。

背景:一些低分化甲状腺癌(PDTC)起源于先前存在的滤泡细胞来源的高分化癌;然而，其他的很可能是从头开始的。PDTC与已存在的结节性甲状腺肿相邻是非常罕见的。病例介绍:1例患者患甲状腺乳头状癌(PDTC)，这是一种广泛浸润的细胞肿瘤，其细胞缺乏甲状腺乳头状癌的核特征。癌细胞呈小梁状、实体状和微滤泡状排列，有丝分裂活性高。在PDTC附近发现部分包被厚纤维囊的结节。结节由小的或扩张的卵泡组成，无乳头状癌样核征，符合结节性甲状腺肿。PDTC具有较高的Ki-67标记指数和NRAS基因突变(密码子61,Q61K)。结论:这些结果支持我们的诊断PDTC，可能由结节性甲状腺肿引起。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Clinical Pathology Medicine-Pathology and Forensic Medicine

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： BMC Clinical Pathology is an open access journal publishing original peer-reviewed research articles in all aspects of histopathology, haematology, clinical biochemistry, and medical microbiology (including virology, parasitology, and infection control). BMC Clinical Pathology (ISSN 1472-6890) is indexed/tracked/covered by PubMed, CAS, EMBASE, Scopus and Google Scholar.