Sudebno-Meditsinskaya Ekspertisa最新文献_第2页

[Features of lung damage in baclofen poisoning]. [巴氯芬中毒肺损伤的特征]。

Sudebno-Meditsinskaya Ekspertisa Pub Date : 2024-01-01 DOI: 10.17116/sudmed20246701129

O L Romanova, M L Blagonravov, P G Djuvalyakov, E Kh Barinov, A V Ershov, M A Kislov

{"title":"[Features of lung damage in baclofen poisoning].","authors":"O L Romanova, M L Blagonravov, P G Djuvalyakov, E Kh Barinov, A V Ershov, M A Kislov","doi":"10.17116/sudmed20246701129","DOIUrl":"10.17116/sudmed20246701129","url":null,"abstract":"Objective: To reveal pathological lung changes in baclofen poisoning and to assess their dynamics.Material and methods: The experiment included 20 mature (at age 20 weeks) male rats of Wistar line weighing 290-350 gr. The animals were divided into 3 study groups (5 rats in each) depending on experiment's duration after 85 mg/kg baclofen administration: 3, 4.5 and 24 h in the 1st, 2nd and 3rd groups, respectively. Control group consisted of 5 animals without baclofen administration.Results: A number of pathological reactions, including circulatory disorder (venular and capillary congestion, hemorrhage in interalveolar septa, alveoli, sludge) and the appearance of emphysema loci (interalveolar septa at emphysema loci are thinned), alternating with atelectases and dystelectases. The area taken up by vessels after 4.5 h. baclofen administration was statistically significantly higher than in control group, and after 24 h. - statistically significantly higher than in 4.5 h. The area with white blood cells and WBC/IAP ratio after 4.5 h of baclofen administration were statistically significantly higher than in control group after 3 and 24 h of administration. The number of white blood cells, giving PAS positive reaction, increases during baclofen administration. The complex of pathological lung changes, revealed by ourselves, has a certain dynamics.Conclusion: The data on morphological lung changes combined with results of chemical examination can be used to diagnose baclofen poisoning and to determine the time elapsed since this medicine administration.","PeriodicalId":35704,"journal":{"name":"Sudebno-Meditsinskaya Ekspertisa","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139730667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Personalized character of toxic effects through mass nonlethal poisoning by phenazepam and other psychoactive substances]. [通过苯西泮和其他精神活性物质造成的大规模非致命中毒，个性化地确定毒性效应的特征]。

Sudebno-Meditsinskaya Ekspertisa Pub Date : 2024-01-01 DOI: 10.17116/sudmed20246701147

V D Akimova, S S Barsegyan, T V Pleteneva

{"title":"[Personalized character of toxic effects through mass nonlethal poisoning by phenazepam and other psychoactive substances].","authors":"V D Akimova, S S Barsegyan, T V Pleteneva","doi":"10.17116/sudmed20246701147","DOIUrl":"10.17116/sudmed20246701147","url":null,"abstract":"Over several months, 14 people were admitted in 6 hospitals with severe symptoms of intoxication with psychoactive substances as a result of mass poisoning. All symptoms occurred after taking a drink that contained crushed phenazepam tablets. Samples of blood (n=10) and urine (n=6) taken from 14 sufferers for forensic, chemical and toxicological examination were analyzed using the HPLC-MS/MS method. Phenazepam was detected in the biomaterial of all 14 patients. Other psychoactive substances (baclofen, pregabalin, chlorprothixene, chlorpromazine, phenibut, tramadol, diazepam), narcotic substances and ethanol were also found in the sufferers. The phenazepam concentration in the blood was in the range of 109.75-786.50 ng/ml, in the urine - 8.97-101.28 ng/ml. The pharmacokinetic and toxicokinetic characteristics of toxicants as well as additional factors characterizing the phenotype of the sufferer in addition to drug's content in the biological material must be taken into account to determine the toxicity level of phenazepam against the background of combined action with other psychoactive substances.","PeriodicalId":35704,"journal":{"name":"Sudebno-Meditsinskaya Ekspertisa","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139730669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Qualitative and quantitative characteristics of structures of cerebral cortex structure in young people under conditions of chronic alcohol intoxication]. [慢性酒精中毒条件下青少年大脑皮层结构的定性和定量特征]。

Sudebno-Meditsinskaya Ekspertisa Pub Date : 2024-01-01 DOI: 10.17116/sudmed20246701110

A O Saushkina, N S Averkin

{"title":"[Qualitative and quantitative characteristics of structures of cerebral cortex structure in young people under conditions of chronic alcohol intoxication].","authors":"A O Saushkina, N S Averkin","doi":"10.17116/sudmed20246701110","DOIUrl":"10.17116/sudmed20246701110","url":null,"abstract":"Objective: To study morphological changes of cerebral cortex in young people under the conditions of chronic alcohol intoxication (CAI).Material and methods: Morphometric examination of cerebral cortex fragments obtained from 28 persons who died with a CAI diagnosis (average age was 38 years), and 25 subjects who died from other causes, which are not associated with alcohol consumption (average age was 39 years), was carried out.Results: It was shown that neurons of pathological shapes, including hypo- and hyperchromic, pyknotic and «shadow-like», were dominant in group of CAI. There was an increase in the glial index and a greater intensity of perivascular and pericellular edema compared to the control group.Conclusion: Morphological changes of cerebral cortex under the conditions of CAI are non-specific and largely similar to neurodegenerative alterations in other pathological conditions, senile dementia. Clearer histological criteria for alcoholic encephalopathy are needed, including with the use of immunohistochemical methods.","PeriodicalId":35704,"journal":{"name":"Sudebno-Meditsinskaya Ekspertisa","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139730671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Innovations in forensic medicine: accuracy, evidence and effectiveness of expertises in emergencies in case of mass fatality]. [法医学的创新：在发生大规模死亡事件的紧急情况下专家的准确性、证据和有效性]。

Sudebno-Meditsinskaya Ekspertisa Pub Date : 2024-01-01 DOI: 10.17116/sudmed20246704122

Yu I Pigolkin, O I Kosukhina, E E Fomina, S V Leonov, V Yu Turbachkin, E N Leonova

引用次数: 0

[Possibilities of using results of head computed tomography in victims with traumatic brain injuries]. [在脑外伤患者中使用头部计算机断层扫描结果的可能性]。

Sudebno-Meditsinskaya Ekspertisa Pub Date : 2024-01-01 DOI: 10.17116/sudmed20246703124

E V Egorova, E M Kildyushov, D V Burenchev

引用次数: 0

[Thermometrical determination of the postmortem interval by non-linear optimization method]. [用非线性优化方法确定死后间隔的温度计]。

Sudebno-Meditsinskaya Ekspertisa Pub Date : 2024-01-01 DOI: 10.17116/sudmed20246705119

V G Nedugov, G V Nedugov

{"title":"[Thermometrical determination of the postmortem interval by non-linear optimization method].","authors":"V G Nedugov, G V Nedugov","doi":"10.17116/sudmed20246705119","DOIUrl":"https://doi.org/10.17116/sudmed20246705119","url":null,"abstract":"Objective: To develop and implement an online application for the numerical method of determination of the postmortem interval and its limiting faults, caused by errors of measurement processes, based on the Marshall-Hoare law of cooling and dual thermometry of the corpse's core.Material and methods: The numerical search for a minimum of two variables' target function, obtained from the system of non-linear Marshall-Hoare equations, reflecting the dual thermometry of the corpse's core was performed. The code of online program was written in Python 3 programming language.Results: The method for determination of the postmortem interval, based on iterative algorithm of non-linear optimization, allowing by dual thermometry of the corpse to consider the uniqueness of its cooling conditions, as well as to calculate the degree of uncertainty of computational estimations, caused by the impact of measurement errors, has been developed. The method is implemented in the format of the Warm Bodies Z online application.Conclusions: The developed numerical method and its online application are recommended for determining of the postmortem interval.","PeriodicalId":35704,"journal":{"name":"Sudebno-Meditsinskaya Ekspertisa","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Analysis of defects in health care delivery for children based on the data of commission forensic medical examinations performed in the Republic of Uzbekistan]. [根据乌兹别克斯坦共和国委托进行的法医检查数据，分析儿童保健服务的缺陷]。

Sudebno-Meditsinskaya Ekspertisa Pub Date : 2024-01-01 DOI: 10.17116/sudmed20246705115

Z A Giyasov, I I Bakhriev, O V Sokolova, M A Dehkkonov, S A Khakimov

{"title":"[Analysis of defects in health care delivery for children based on the data of commission forensic medical examinations performed in the Republic of Uzbekistan].","authors":"Z A Giyasov, I I Bakhriev, O V Sokolova, M A Dehkkonov, S A Khakimov","doi":"10.17116/sudmed20246705115","DOIUrl":"https://doi.org/10.17116/sudmed20246705115","url":null,"abstract":"Objective: To perform a retrospective analysis of the commission forensic medical examinations' data of pediatric profile with identification of defects in health care delivery and establishment of their connection with unfavorable outcome.Material and methods: The data of 3854 commission forensic medical examinations performed in the period from 2012 to 2021 regarding the evaluation of quality of health care delivery for children with the establishment of nature and type of defects in health care delivery, determination of disease (injury) outcome, identification of cause-effect relationship between the defect in health care delivery and negative disease (injury) outcome.Results and conclusions: Defects in health care delivery were equal 9% in the studied commission forensic medical examinations. Studied data included all types of defects in health care delivery: defects of diagnosis, treatment and health care delivery. The structure of defects in various age groups differed: diagnosis defects prevailed in the age group of children aged from 29 days to 1 year; treatment defects were most frequent in children group of neonatal period and in children group aged 1-17 years. Child disability and death were negative consequences in all age groups. A direct cause-effect relationship was established between the defect in health care delivery and the negative outcome in all cases. The pathogenetically expectable correlation between the defect in health care delivery and negative outcome, represented by disability or death of a child, was considered to be the medical equivalent of this relationship.","PeriodicalId":35704,"journal":{"name":"Sudebno-Meditsinskaya Ekspertisa","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Professional activity of medical staff and attendant risks]. [医务人员的职业活动和随之而来的风险]。

Sudebno-Meditsinskaya Ekspertisa Pub Date : 2024-01-01 DOI: 10.17116/sudmed2024670515

M Sh Mukashev, A E Turganbaev, B A Asanov, B Toktosun Uulu, A B Ibraimov, G M Kalybekova

引用次数: 0

[Fatal radiation-induced injury resulting from the deliberate use of ionizing radiation source for illegal purposes]. [为非法目的蓄意使用电离辐射源造成的致命辐射伤害]。

Sudebno-Meditsinskaya Ekspertisa Pub Date : 2024-01-01 DOI: 10.17116/sudmed20246702139

Yu E Kvacheva, A V Kovalev, Yu P Gribunov, I N Shestakova

引用次数: 0

[Development of a carbamazepine determination method based on high-performance liquid chromatography with diode array]. [基于二极管阵列高效液相色谱法的卡马西平测定方法的开发]。

Sudebno-Meditsinskaya Ekspertisa Pub Date : 2024-01-01 DOI: 10.17116/sudmed20246701125

N A Khabieva, E N Lyust, M I Timerzyanov

引用次数: 0