O L Romanova, M L Blagonravov, P G Dzhuvalyakov, V I Torshin, E Kh Barinov, E A Lukyanova, M A Kislov
{"title":"[Evaluation of VEGF-A, SP-D and MUC-1 expression in poisoning with baclofen and its combination with ethanol].","authors":"O L Romanova, M L Blagonravov, P G Dzhuvalyakov, V I Torshin, E Kh Barinov, E A Lukyanova, M A Kislov","doi":"10.17116/sudmed20256802145","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To detect MUC-1, VEGF-A, SP-D expression in lungs of rats at different times after the administration of baclofen and its combination with ethanol.</p><p><strong>Results: </strong>An increased MUC-1 expression has been noted in presence of the administration of baclofen and its combination with ethanol. MUC-1 caused an enhancement of VEGF-A expression under hypoxia, that has been also observed in all experimental groups. SP-D expression was increased in all experimental groups.</p><p><strong>Conclusions: </strong>Understanding of the processes that occur in lungs of animals in administration of baclofen and its combination with ethanol is necessary to develop effective treatment measures for cases of non-fatal poisoning in human by this substance, and it will be useful in determining the immediate cause of death in the case of fatal poisoning.</p>","PeriodicalId":35704,"journal":{"name":"Sudebno-Meditsinskaya Ekspertisa","volume":"68 2","pages":"45-49"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sudebno-Meditsinskaya Ekspertisa","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17116/sudmed20256802145","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To detect MUC-1, VEGF-A, SP-D expression in lungs of rats at different times after the administration of baclofen and its combination with ethanol.
Results: An increased MUC-1 expression has been noted in presence of the administration of baclofen and its combination with ethanol. MUC-1 caused an enhancement of VEGF-A expression under hypoxia, that has been also observed in all experimental groups. SP-D expression was increased in all experimental groups.
Conclusions: Understanding of the processes that occur in lungs of animals in administration of baclofen and its combination with ethanol is necessary to develop effective treatment measures for cases of non-fatal poisoning in human by this substance, and it will be useful in determining the immediate cause of death in the case of fatal poisoning.
期刊介绍：
The journal is concerned with the theory and practice of forensic medicine - the problems of thanatology, traumatology, toxicology, serology, forensic obstetrics, forensic dentistry, forensic psychiatry, forensic chemistry, physicotechnical methods of investigation, history of forensic medicine and some problems of criminology and legal laws related to forensic medicine. It publishes original studies by Russian authors, casuistry surveys, abstracts and reviews of Russian and foreign literature, scientific information, reports on scientific conferences.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
