Journal of Basic and Clinical Reproductive Sciences最新文献_第8页

Chorangioma of placenta with high risk pregnancy: A case series 高危妊娠胎盘脉管瘤:一个病例系列

Journal of Basic and Clinical Reproductive Sciences Pub Date : 1900-01-01 DOI: 10.4103/2278-960X.129291

Uma S Andola, Shabnam Karangadan, S. Andola, Rajashekhar Jewargikar

{"title":"Chorangioma of placenta with high risk pregnancy: A case series","authors":"Uma S Andola, Shabnam Karangadan, S. Andola, Rajashekhar Jewargikar","doi":"10.4103/2278-960X.129291","DOIUrl":"https://doi.org/10.4103/2278-960X.129291","url":null,"abstract":"Chorangioma is the most common benign tumor of placenta, with an incidence of approximately 1%. Tumors larger than 5 cm are associated with maternal and fetal complications. We report four cases of chorangioma that were identified in mostly primigravida (75%) with a mean gestational age of 33 wks (Range 28-33 wks). All except one case, complete placenta was received with mean weight of 550 g (Range 400-800 g) and tumor size of 9.4 cm (Range 0.5-23 cm). Microscopy showed capillary proliferation resembling fetal vessels in enlarged villi covered by trophoblastic epithelium. Three cases had preterm delivery. One also presented with abruptio placenta and intrauterine fetal death. Because of limited documentation of cases and dismal prognosis of these pregnancies, especially with large chorangiomas, it’s of utmost importance to correctly diagnose them with the aid of color Doppler flow. In this series, 75% of cases (3/4), babies survived probably due to small size of tumor and attainment of fetal maturity. Keywords : Chorangioma, placenta, placental tumor, vascular tumor Key Messages : Even though chorangioma is the most common tumor of placenta, tumors arising from placenta are rare. Because of dismal prognosis of these pregnancies with large lesions, it’s important to correctly diagnose them with the aid of color Doppler flow. This case series demonstrates the need for awareness of such lesions.","PeriodicalId":356195,"journal":{"name":"Journal of Basic and Clinical Reproductive Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130950984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Salivary Versus Serum Approaches in Assessment of Biochemical Hyperandrogenemia 评价生化高雄激素血症的唾液法与血清法

Journal of Basic and Clinical Reproductive Sciences Pub Date : 1900-01-01 DOI: 10.4103/2278-960X.129283

M. El-Gharib, SM El‑Din Hazaa

{"title":"Salivary Versus Serum Approaches in Assessment of Biochemical Hyperandrogenemia","authors":"M. El-Gharib, SM El‑Din Hazaa","doi":"10.4103/2278-960X.129283","DOIUrl":"https://doi.org/10.4103/2278-960X.129283","url":null,"abstract":"Background : Biochemically, hyperandrogenism is established by elevated circulating levels of free or total serum testosterone and an increased free androgen index. Approximately, 60‑80% of women with polycystic ovarian syndrome (PCOS) demonstrate elevated circulating androgen levels. Aim : This prospective observational randomized study was to investigate the likelihood of using the salivary luteinizing hormone (LH), free testosterone (FT) and dehydroepiandrosterone sulfate (DHEAS) levels instead of serum values in diagnosing biochemical hyperandrogenemia in women with PCOS. Subjects and Methods : This study was conducted on 75 women having PCOS in addition to 20 normal fertile women (control group). Venous blood and salivary samples were taken in the 3 rd day of the cycle to measure LH and FT and DHEAS levels. Results : Biochemical hyperandrogenemia prevails in 40% of women with PCOS. Salivary levels of LH, FT and DHEAS correlate with their corresponding serum values, with a higher sensitivity of salivary more than serum approach. Conclusion : Saliva provides a sensitive, simple, reliable, non‑invasive and uncomplicated diagnostic approach for biochemical hyperandrogenemia. Keywords : Biochemical hyperandrogenemia, dehydroepiandrosterone sulfate, luteinizing hormone, polycystic ovarian syndrome, saliva, testosterone","PeriodicalId":356195,"journal":{"name":"Journal of Basic and Clinical Reproductive Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132757397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

FNAC Diagnosis of Scar Endometriosis: A Report of 3 Cases with Review of Literature FNAC诊断瘢痕性子宫内膜异位症3例并文献复习

Journal of Basic and Clinical Reproductive Sciences Pub Date : 1900-01-01 DOI: 10.4103/2278-960X.104300

Uma S Andola, S. Andola, Kintan Sanghvi

引用次数: 7

Eribulin mesylate: A new therapeutic option for metastatic breast cancer 甲磺酸埃瑞布林:转移性乳腺癌的新治疗选择

Journal of Basic and Clinical Reproductive Sciences Pub Date : 1900-01-01 DOI: 10.4103/2278-960X.112571

S. Aditya

{"title":"Eribulin mesylate: A new therapeutic option for metastatic breast cancer","authors":"S. Aditya","doi":"10.4103/2278-960X.112571","DOIUrl":"https://doi.org/10.4103/2278-960X.112571","url":null,"abstract":"More than a million women are diagnosed with breast cancer annually worldwide. Death from breast cancer is usually a result of chemotherapyâresistant metastatic disease. Eribulin mesylate is a recent addition to the therapeutic armamentarium for treating locally advanced or metastatic breast cancer (MBC) in patients who have received at least two prior chemotherapy regimens for lateâstage disease. This synthetic analog, derived from a marine sponge macrolide halichondrin B, inhibits microtubule stability by blocking microtubule growth without affecting microtubule shortening. The US Food and Drug Administration has approved eribulin mesylate as a thirdâline treatment for MBC refractory to anthracyclines and taxanes based on a Phase III clinical trial showing significantly increased overall survival compared to treatment of investigator’s. Asthenia, fatigue, neutropenia, alopecia, nausea, anorexia, and neuropathy are the most frequent adverse effects associated with this drug. The aim of this review was to highlight the importance of this drug in the management of breast cancer. Medline, Excerpta Medica database, cochrane database, medscape, Elsevier Scopus, and clinicaltrials.gov were searched using terms “eribulin,” “E7389,” “halichondrin,” “metastatic breast cancer.” Journal articles published from 2007 to 2012 discussing pharmacology and/or clinical trials were screened. The development of this microtubule inhibitor helps to address the need for additional effective regimens for patients progressing after standard treatment with anthracyclineâ and taxaneâcontaining regimens.","PeriodicalId":356195,"journal":{"name":"Journal of Basic and Clinical Reproductive Sciences","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116935063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Editorial: Journal of Basic and Clinical Reproductive Sciences: A New Baby with Enormous Potentials for Scientists in the Developing World 社论:基础和临床生殖科学杂志:发展中国家科学家的一个具有巨大潜力的新生婴儿

Journal of Basic and Clinical Reproductive Sciences Pub Date : 1900-01-01 DOI: 10.4103/2278-960X.104287

U. Nwagha, B. Anyaehie

引用次数: 0

Assessing Folic Acid Awareness and its Usage for the Prevention of Neural Tube Defects Among Pregnant Women in Jos, Nigeria 评估叶酸意识及其在尼日利亚乔斯孕妇神经管缺陷预防中的使用

Journal of Basic and Clinical Reproductive Sciences Pub Date : 1900-01-01 DOI: 10.4103/2278-960X.112574

A. Anzaku

{"title":"Assessing Folic Acid Awareness and its Usage for the Prevention of Neural Tube Defects Among Pregnant Women in Jos, Nigeria","authors":"A. Anzaku","doi":"10.4103/2278-960X.112574","DOIUrl":"https://doi.org/10.4103/2278-960X.112574","url":null,"abstract":"Background: In the precent study, firm evidences indicate that folic acid supplementation during the peri‑conceptional period reduces the risk of having a baby with neural tube defects. Aim: To ascertain the level of awareness about folic acid, its use during peri‑conceptional period and the predictive factors of folic acid awareness among pregnant women in our setting. Subjects and Methods: Confidential, anonymous questionnaires were administered to consecutive 543 pregnant women seeking routine antenatal care at Bingham University Teaching Hospital, Jos between January and June 2012. Questions included enquiry on their demographic features, obstetric history, pregnancy intention, awareness and intake of folic acid during the peri‑conceptional period, and knowledge of its natural sources. Descriptive statistics and multivariate logistic regression to identify predictive factors of folic acid awareness were then performed. Results: Out of 543 pregnant women surveyed, 64.6% (351/543) reported that they were aware of folic acid as a vitamin supplement. However, only 7.4% (26/351) consistently took the vitamin during the protective periconceptional period. The common sources of information about folic acid were health workers (68.5%) and the media (14.6%). Only 26.5% (93/351) of them could correctly identify a natural source of food rich in folic acid. Multivariate logistic regression showed that maternal age >30 years (P=0.01) and higher educational status (P=0.001) were predictive factors for folic acid awareness. Conclusion: Folic acid awareness as a vitamin supplement was relatively high among the women surveyed but its intake during peri‑conceptional period was worryingly low. Antenatal and Population health educational strategies and fortification of staple foods with folic acid may improve its intake among women of child‑bearing age in our setting. Keywords: Awareness in pregnant women, folic acid, neural tube defects, peri‑conceptional usage","PeriodicalId":356195,"journal":{"name":"Journal of Basic and Clinical Reproductive Sciences","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127512795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Abdominal Pregnancy in Usmanu Dan-Fodiyo University Teaching Hospital, Sokoto: A 10-year Review Usmanu Dan-Fodiyo大学教学医院，索科托的腹部妊娠:十年回顾

Journal of Basic and Clinical Reproductive Sciences Pub Date : 1900-01-01 DOI: 10.4103/2278-960X.104294

D. Nnadi, E. Nwobodo, B. Ekele

{"title":"Abdominal Pregnancy in Usmanu Dan-Fodiyo University Teaching Hospital, Sokoto: A 10-year Review","authors":"D. Nnadi, E. Nwobodo, B. Ekele","doi":"10.4103/2278-960X.104294","DOIUrl":"https://doi.org/10.4103/2278-960X.104294","url":null,"abstract":"Background: Abdominal pregnancy, a rare condition with high maternal mortality (up to 50%), and even higher perinatal mortality (40 – 95%), is often associated with diagnostic difficulties. Objectives: To determine the mode of presentation and management of abdominal pregnancy, from cases in the Usmanu Dan-Fodiyo University Teaching Hospital (UDUTH), Sokoto. Materials and Methods: A retrospective review of the case records of all abdominal pregnancies managed in UDUTH, Sokoto, between January 2000 and December 2010. Results: During the 10-year study period, there were eight cases of abdominal pregnancies, 285 extrauterine pregnancies, and 25,506 total deliveries. All the patients were not booked for antenatal care and their ages ranged between 20 and 39 years (mean=28.1±3.4 years). The majority (88%) were grand multipara. The main presenting symptoms were persistent abdominal pain, vaginal bleeding, and prolonged pregnancy. Seven cases (87.5%) were diagnosed accurately by an ultrasound scan. There were seven perinatal deaths (87.5%) and one live birth. There was one maternal death (12.5%), which occurred in the patient whose placenta was left in-situ. Conclusion: Presence of persistent lower abdominal pain, vaginal bleeding, and prolonged pregnancy should raise the suspicion of abdominal pregnancy. Removal of the placenta, where feasible, improves the outcome of maternal health.","PeriodicalId":356195,"journal":{"name":"Journal of Basic and Clinical Reproductive Sciences","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121617461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Case Report: Spontaneous Monochorionic Tetra‑amniotic Quadruplet Pregnancy at Term 病例报告:足月自发性单绒毛膜四胎妊娠

Journal of Basic and Clinical Reproductive Sciences Pub Date : 1900-01-01 DOI: 10.4103/2278-960X.112597

D. Nnadi, A. Ibrahim, E. Nwobodo

引用次数: 10

Prediction of Gestational Diabetes by Measuring First Trimester Maternal Serum Uric Acid Concentration 通过测定孕早期孕妇血清尿酸浓度预测妊娠糖尿病

Journal of Basic and Clinical Reproductive Sciences Pub Date : 1900-01-01 DOI: 10.4103/2278-960X.112582

M. El-Gharib, A. Mahfouz, M. Morad, M. Farahat

{"title":"Prediction of Gestational Diabetes by Measuring First Trimester Maternal Serum Uric Acid Concentration","authors":"M. El-Gharib, A. Mahfouz, M. Morad, M. Farahat","doi":"10.4103/2278-960X.112582","DOIUrl":"https://doi.org/10.4103/2278-960X.112582","url":null,"abstract":"Background: Gestational diabetes mellitus (GDM) is a common complication in pregnancy, affecting more than 10% pregnancies worldwide. However, the true underlying causes remain to be fully elucidated. Aim: This study aimed at searching for any relation between first trimester uric acid concentration and the development of GDM. Subjects and Methods: The study was conducted on 250 first trimester pregnant females at risk of diabetes mellitus attending the outpatient clinic of Tanta University Hospital. All cases underwent estimation of first trimester-fasting blood sugar and maternal serum uric acid concentration. Between 24 and 28 weeks' gestation random blood sugar and glucose challenge test were done. Positive cases were confirmed by 3 h glucose tolerance curve. Results: The results demonstrated an association between first trimester maternal serum uric acid concentration obesity and GDM. Approximately, 41.4% (60/145) of non-diabetic women were at first quartile, while 44.8% (47/105) of the diabetic women were at fourth quartile. Conclusion: We concluded that the cut-off level of maternal serum uric acid of 4 mg/dl in the first trimester was associated with developing GDM. Therefore, we suggest that serum uric acid level should be done as routine test during the first antenatal care visit.","PeriodicalId":356195,"journal":{"name":"Journal of Basic and Clinical Reproductive Sciences","volume":"218 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130327390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Chemosterilization: Spermatogenesis, steroidogenesis, reproductive functions, and behavior; from historical perspective to contemporary practice 化学绝育:精子发生、类固醇发生、生殖功能和行为;从历史视角到当代实践

Journal of Basic and Clinical Reproductive Sciences Pub Date : 1900-01-01 DOI: 10.4103/2278-960X.112568

P. Sengupta

引用次数: 9