Journal of Basic and Clinical Reproductive Sciences最新文献

{"title":"Histomorphological effect of zidovudine on the testes of adult male wistar rats (rattus novegicus)","authors":"L. Chris-ozoko, A. A. Charity, V. Ekundina","doi":"10.4103/2278-960X.118642","DOIUrl":"https://doi.org/10.4103/2278-960X.118642","url":null,"abstract":"Background: Zidovudine (ZDV) also referred to as azidothymidine (AZT) was the first approved treatment for human immunodeficiency virus, although, its impact on the reproductive system has not been clearly understood. Aim: The aim is to analyze the effect of dose dependent administration of ZDV (AZT) on the testes of adult Wistar rats was carefully studied. Materials and Methods: The rats ( n =20), with an average weight of 150 g were randomly assigned in to a control group (Group 1) ( n =5) and three treatment groups ( n =5). The control Group 1 received distilled water while the treatment groups divided into Group 2, (subnormal), Group 3 (normal) and Group 4 (excess) were administered 0.3 mg/ml, 1.3 mg/ml and 2.3 mg/ml of AZT respectively (in line with the recommended dose of 600 mg/70 kg) dissolved in distilled water daily for 30 days, using an orogastric cannula. The rats were fed with growers mash and given water liberally. The rats were euthanized under chloroform vapor on the 31 st day of the experiment, and the testes were carefully harvested and fixed in 10% formol saline for histological studies. Results: Histological results of treated group revealed significant changes in testes histoarchitecture (the control showed normal histoarchitecture). Conclusion: ZDV may cause structural abnormalities to testicular tissues.","PeriodicalId":356195,"journal":{"name":"Journal of Basic and Clinical Reproductive Sciences","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121960503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective study of doppler velocimetry in pregnancy-induced hypertension in a rural population of a developing country","authors":"S. Hazra, Kamal Kumar Dash, A. Chaudhuri, M. Ghosh, D. Banerjee, Sarmistha Guha","doi":"10.4103/2278-960X.118658","DOIUrl":"https://doi.org/10.4103/2278-960X.118658","url":null,"abstract":"Background: Pregnancy-induced hypertension (PIH) remains a great challenge to obstetricians. Doppler velocimetry can detect fetal compromise much before other antepartum tests. Aim: The aim of this study is to detect the changes of uterine artery, umbilical artery and middle cerebral artery in PIH by Doppler velocimetry. Subjects and Methods: This prospective study was conducted on hundred subjects with PIH. Doppler studies were carried, and parameters recorded in uterine, umbilical and middle cerebral artery (MCA) were Systolic/Diastolic ratio, Resistance Index, Cerebro Placental Index (CPI). Fetal outcomes were monitored. Statistical analysis was performed using Epi InfoTM software (Version 3.5.1, CDC, Atlanta). Test for significance was done with student’s t-test and Chi-square where applicable. A P- value of<0.05 was considered as significant. Results: Among the 100 subjects, 76 (76%) of fetuses had abnormal and 24% normal umbilical artery Doppler velocimetry; 62% had abnormal and 38% normal MCA Doppler velocimetry; 64% fetuses had abnormal and 36% normal CPI. In 95% of subjects having abnormal umbilical Doppler studies, caesarean section had to be done for acute fetal distress. Incidence of caesarean section was 61% in abnormal MCA group and 63% in abnormal CPI group. Among 14 patients who had abnormal uterine artery Doppler, four developed pre-eclampsia, 2 IUGR. In patients with notches in uterine artery Doppler, 38% developed pre-eclampsia, 38% had IUGR, 13% babies were still born and 25% of newborns required NICU admission. In umbilical artery Doppler, when S/D ratio was abnormal, 60% developed pre-eclampsia, 40% had IUGR and 40% of newborns had to be admitted in NICU. Conclusion: Doppler study for fetal surveillance in pregnancy-induced hypertension is a very useful device and abnormal umbilical artery and uterine artery velocimetry seems to have worse pregnancy outcomes in the present study. Notch as a single parameter is the best indicator with highest sensitivity and positive predicative values. However, combination of parameters is the best indicator.  Keywords: Doppler study, fetomaternal outcome, pregnancy-induced hypertension","PeriodicalId":356195,"journal":{"name":"Journal of Basic and Clinical Reproductive Sciences","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117138509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Testicular Leydig Cell Tumor with Azoospermia; Re-visited","authors":"Sahil I. Panjvani, Minesh B. Gandhi, G. Anandani, Garima Gupta, Ashka H Kodnani","doi":"10.4103/2278-960X.118653","DOIUrl":"https://doi.org/10.4103/2278-960X.118653","url":null,"abstract":"Leydig tumor is relatively a rare testicular tumor but the most common non-germ cell gonadal tumor. It constitutes about 1-3% of all testicular tumors. Clinically, it is usually presented as a testicular mass or with endocrine symptoms, which include gynecomastia, increased sex hormone levels, and other correlated symptoms. Here, we report a case of Leydig cell tumor with azoospermia in a 34-year-old patient.","PeriodicalId":356195,"journal":{"name":"Journal of Basic and Clinical Reproductive Sciences","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123357430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Neonatal Outcome in Relation to Placental Location, Dimensions in Early Pregnancy","authors":"S. Chhabra, Y. Yadav, D. Srujana, S. Tyagi, I. Kutchi","doi":"10.4103/2278-960X.118651","DOIUrl":"https://doi.org/10.4103/2278-960X.118651","url":null,"abstract":"Background: Placenta, which is the vital link between mother and fetus, is critical for maternal neonatal well-being. Its study in early pregnancy may provide information about maternal neonatal disorders. Aim: The study aimed to evaluate the relationship of placental location and dimensions in early pregnancy with maternal neonatal outcomes. Subjects and Methods: Primigravida (801) with singleton pregnancy at 10-weeks gestation and no past/present medical and obstetric disorder had ultrasonography for placental location and dimensions and were followed by ultrasonographic (USG) examination (at 20th week and 30th week), clinically for maternal-neonatal outcome. Statistical analysis was done by Epi 6 software (version 6.0, developed by Centres for Disease Control and Prevention, Atlanta, Georgia, USA) using Chi-square test and Fischer exact test for determining the statistical significance of the observations. P values of 55 cm2 6.8% (13/190), had hypertensive disorders. area 55 cm2 3.7% (7/190) had placental abruption. With thick placenta, 39.2% (58/148), thin, 9.4% (9/96), and normal placenta, 5.2% (29/562) had hypertensive disorders. With thick, 11.5% (17/148), thin 16.7% (16/96), and normal placenta 2.7% (15/562) had placental abruption. With anterior 0.5% (1/200), posterior 14.6% (18/123), fundal placenta 10.55% had preterm births. With anterior 7.5% (15/200), posterior 23.6% (29/123), fundal placenta 18% (58/322) had CS.With placental surface area 55 cm2 14% (28/200) had CS. With thin 27% (25/91), with thick 36.1% (53/148), with normal placenta none had CS for fetal distress. Conclusions: Study of placental location and dimensions in early pregnancy is useful in identifying risks.  Keywords: Dimensions, early pregnancy, location, maternal-neonatal outcome, placenta","PeriodicalId":356195,"journal":{"name":"Journal of Basic and Clinical Reproductive Sciences","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126441800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in the Management of Placental Site Trophoblastic Tumor","authors":"F. Fakor, H. Falah, S. K. Jahromi, P. Porteghali","doi":"10.4103/2278-960X.118652","DOIUrl":"https://doi.org/10.4103/2278-960X.118652","url":null,"abstract":"Placental site trophoblastic tumor (PSTT) is a rare neoplasm of intermediate trophoblastic cells of the placenta. Two cases of PSTT are presented. A 24‑year‑old G2P2 female presented with a flat vaginal ulcerative lesion diagnosed as PTSS 2 years after a term pregnancy. Beta human chorionic gonadotropin (β‑HCG) level was 110 mIU/mL and uterus was diffusely enlarged. Total abdominal hysterectomy was performed and on follow up, her serum β‑HCG level was undetectable. The second case is a 33‑year‑old female with a history of vaginal bleeding referred to hospital. She had myomectomy and the pathology was reported as leiomyosarcoma. We doubted the pathology result. By further pathological investigations and increase in β‑HCG consistent with PSTT, the diagnosis was made. The patient had hysterectomy. For both cases no adjuvant therapy was done and there has not been any sign of recurrence in them. It is thus concluded that complete resection in PSTT, could achieve long‑term remission.","PeriodicalId":356195,"journal":{"name":"Journal of Basic and Clinical Reproductive Sciences","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130031076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Nuchal Cord a Perfect Scapegoat: A Retrospective Analysis from Northwest India?","authors":"Y. Gupta, A. Gupta, Sandesh Ganjoo, Varun Kaul, S. Raina","doi":"10.4103/2278-960X.118656","DOIUrl":"https://doi.org/10.4103/2278-960X.118656","url":null,"abstract":"Background: Entanglement of the umbilical cord around the fetal neck (nuchal cord) is quite a common fi nding at delivery. It is often assumed that nuchal cord causes cord compression and thus low birth weight and intrapartum complications.  Aim: The aim of this article is to study the eff ect of nuchal cord on the mode of delivery, complications and fetal outcome.  Materials and Methods: A retrospective study was carried out on 386 deliveries, 60 of them with nuchal cord, during 1 year from November 2009 through October 2010. Their mode of delivery, complications and fetal outcome were studied and a comparison was established between nuchal cord group and the rest of the deliveries. Nuchal cord group was subdivided into loose nuchal cord (cord could easily be uncoiled before complete delivery of the baby) group and tight nuchal cord (cord was needed to be clamped and cut before delivery of the baby) group. Furthermore, the mode of delivery and fetal outcome were compared between these subgroups. Statistical analyses were performed using SPSS statistical soft ware version 12.0 (Chicago Illinios, USA). The results were expressed as percentages. Test for significance was done using Chi-square, and a P<0.05 was considered as significant. Results: The nuchal cord group did not have any signifi cant diff erence in the mode of delivery or fetal outcome compared with the control group. However, the subgroup having tight cord around the neck had significantly higher proportion of low Apgar scores and meconium staining at birth. Conclusions: Nuchal cord does not increase the chances of cesarean delivery. However, tight cord around the neck may result in low Apgar scores and increased incidence of fetal distress leading to cesarean section.  Keywords: Apgar score, cesarean delivery, meconium staining, north west India, nuchal cord, perinatal outcome","PeriodicalId":356195,"journal":{"name":"Journal of Basic and Clinical Reproductive Sciences","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117157524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Evaluation of the Uterine Scar Thickness after Single Versus Double Layer Closure of Transverse Lower Segment Cesarean Section","authors":"M. El-Gharib, A. M. Awara","doi":"10.4103/2278-960X.112591","DOIUrl":"https://doi.org/10.4103/2278-960X.112591","url":null,"abstract":"Background: The degree of the lower uterine segment (LUS) thinning and the risk of uterine scar defect have been studied. However, the relationship between the methods of closure and the degree of thinning needs further elucidation. Aim: The aim of this study was to determine whether a LUS transverse cesarean section (CS) closure method in one or two layers affects subsequent scar thickness. Subjects and Methods: In this prospective study, 150 women were enrolled and randomly assigned to one‑ or two‑layer closure of the LUS incision. Patients were divided into two groups. Each group included 75 patients, of primigravidae with gestational age from 38 weeks to 40 weeks one group had a single layer closure and the other had a double layer closure. Results: We found an increase in the thickness of LUS‑CS scar in cases with double layer closure of the incision than a single layer closure as depicted by ultrasonography after 2 days and 2 weeks post‑operative. Conclusion: These findings suggest that the number of closing layers of CS directly affect the thickness of the scar. Keywords: Cesarean section, one layer, scar thickness, two layers","PeriodicalId":356195,"journal":{"name":"Journal of Basic and Clinical Reproductive Sciences","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122521273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Parasite Density of Asymptomatic Malaria Parasitemia among Unbooked Paturients at Abakaliki, Nigeria","authors":"N. Igwe, U. O. U. Joannes, Ozumba Benjamin Chukwuma, O. Chukwudi, Ezeonu Paul Oliaemeka, Agwu Uzoma Maryrose, Agboeze Joseph","doi":"10.4103/2278-960X.129279","DOIUrl":"https://doi.org/10.4103/2278-960X.129279","url":null,"abstract":"Background: Malaria in pregnancy has contributed significantly to maternal morbidity and mortality in our environment. Aim: This study was aimed at determining the prevalence, and parasite density of asymptomatic malaria parasitemia among unbooked paturients at Federal Teaching Hospital Abakaliki. Subjects and Methods: This was a prospective cross‑sectional study conducted in the labor ward complex of the Federal Teaching Hospital Abakaliki over a period of three months from March to May 2012. Two hundred and fifty unbooked women presenting in labor at term and willing to participate were consecutively recruited. A structured data collection sheet was administered to each parturient. Thick and thin blood films were prepared for quantification and speciation of parasitemia respectively. Results: A total of 250 unbooked parturients participated in the study. The mean age of the parturients was 28.2 (7.2) years. One hundred and seven 107/250 (42.8%) were primigravid, 111/250 (44.4%) were between para 1‑4 while 32/250 (12.8%) were para 5 and above. Majority of the parturients 236/250 (95.2%) were of low socio‑economic class. The prevalence of asymptomatic malaria parasitemia was 77.6%. Asymptomatic malaria parasitemia was most prevalent among paturients of social class 5 (24/32 (75%) and primigravid paturients (93/107 (86.9%)) and the association of asymptomatic malaria parasitemia with parity (χ2 = 10.8, P = 0.01) and social class (χ2 = 10.88, P = 0.02) was statistically significant. Conclusion: There was high prevalence of asymptomatic malaria parasitemia in the study. Preconceptional care and early antenatal booking are advocated with emphasis on prevention of malaria infestation through health education and effective use of insecticide treated nets and intermittent prophylaxis therapy for malaria during pregnancy.","PeriodicalId":356195,"journal":{"name":"Journal of Basic and Clinical Reproductive Sciences","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128462863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sero-prevalence of Hepatitis B Virus Infection and its Risk factors among Pregnant Women Attending Antenatal Clinic at Aminu Kano Teaching Hospital, Kano, Nigeria","authors":"I. Yakasai, R. Ayyuba, I. Abubakar, S. Ibrahim","doi":"10.4103/2278-960X.104297","DOIUrl":"https://doi.org/10.4103/2278-960X.104297","url":null,"abstract":"Background: Pregnant women infected with hepatitis B virus (HBV) can transmit the infection to their fetuses and newborns. Neonates who contract the HBV have about 90% risk of developing chronic HBsAg carriage (HBsAg: hepatitis B surface antigen) and chronic liver disease. Neonatal immunization interrupts this vertical and perinatal transmission. Objectives: To determine the seroprevalence of HBsAg among pregnant women attending the antenatal clinic at Aminu Kano Teaching Hospital (AKTH) and to identify potential risk factors associated with HBV infection. Materials and Methods: A case control study was conducted involving a total of 303 pregnant women attending the antenatal clinic at AKTH and 303 nonpregnant women of childbearing age. Blood sample was collected from each woman and the serum tested for the presence of HBsAg using latex rapid agglutination slide test kit (Cal-Tech Diagnostic Inc., USA) in the laboratory of the hospital. Reactive samples were stored at -20oC and further confirmed for HBsAg using enzyme-linked immunosorbent assay (ELISA) kits (Bio-Rad, France). HBsAg-positive samples were tested for hepatitis B e antigen (HBeAg) using ELISA kits (Orgenics, Israel). A pretested, structured questionnaire was used for the collection of sociodemographic data and possible risk factors. Results: The prevalence of HBsAg among pregnant women and nonpregnant women were 7.9 and 7.6%, respectively. There was no statistically significant difference in the prevalence of HBsAg in pregnant and nonpregnant women. The presence of HBeAg was statistically significant among both pregnant and nonpregnant women who tested positive for HBsAg. The risk factors associated with HBV infection were blood transfusion, ear piercing, history of an affected sibling with HBV infection, tattooing, and abortion among pregnant women. Conclusion: The prevalence of HBsAg in this study was not statistically different in pregnant and nonpregnant women. There was a high level of HBeAg infection among pregnant women who tested positive for HBsAg. History of an affected sibling with HBV infection, tattoo, and abortion were significant risk factors for HBV infection. Keywords: Africa, hepatitis B, pregnancy, risk factors","PeriodicalId":356195,"journal":{"name":"Journal of Basic and Clinical Reproductive Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129643764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of Vulvovaginal Atrophy‑Related Sexual Dysfunction in Postmenopausal Women","authors":"T. Okeke, C. C. Ezenyeaku, Ikeako Lc, Agu Pu","doi":"10.4103/2278-960X.104288","DOIUrl":"https://doi.org/10.4103/2278-960X.104288","url":null,"abstract":"Menopause and the climacteric period are associated with adverse risk factors for the development of vulvovaginal atrophyrelated sexual dysfunction. Sexual dysfunction is a common problem in postmenopausal women, often underdiagnosed, inadequately treated, frequently overlooked, and most often impairing the quality of life of these women. To provide clinicians with current information on vulvovaginal atrophy‑related sexual dysfunction in postmenopausal women. This study is a literature review on vulvovaginal atrophy‑related sexual dysfunction in postmenopausal women. Relevant publications were identified through a search of PubMed and Medline, selected references, journals, and textbooks on this topic, and were included in the review. The prevalence of female sexual dysfunction increases with age. It is a common multidimensional problem for postmenopausal women that alter the physiological, biochemical, psychological, and sociocultural environment of a woman. Menopause‑related sexual dysfunction may not be reversible without therapy. Estrogen therapy is the most effective option and is the current standard of care for vulvovaginal atrophy‑related sexual dysfunction in postmenopausal women. Sexual dysfunction is a common multidimensional problem for postmenopausal women and often impairs the quality of life of these women. Estrogen preparations are the most effective treatment. Selective estrogen receptor modulators, vaginal dehydroepiandrostenedione, vaginal testosterone, and tissue‑selective estrogen complexes are promising therapies, but further studies are required to confirm their role, efficacy, and safety. Keywords: Estrogen, postmenopausal women, sexual dysfunction, vulvo‑vaginal","PeriodicalId":356195,"journal":{"name":"Journal of Basic and Clinical Reproductive Sciences","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127463746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}