Salivary Versus Serum Approaches in Assessment of Biochemical Hyperandrogenemia

M. El-Gharib, SM El‑Din Hazaa
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引用次数: 4

Abstract

Background : Biochemically, hyperandrogenism is established by elevated circulating levels of free or total serum testosterone and an increased free androgen index. Approximately, 60‑80% of women with polycystic ovarian syndrome (PCOS) demonstrate elevated circulating androgen levels. Aim : This prospective observational randomized study was to investigate the likelihood of using the salivary luteinizing hormone (LH), free testosterone (FT) and dehydroepiandrosterone sulfate (DHEAS) levels instead of serum values in diagnosing biochemical hyperandrogenemia in women with PCOS. Subjects and Methods : This study was conducted on 75 women having PCOS in addition to 20 normal fertile women (control group). Venous blood and salivary samples were taken in the 3 rd day of the cycle to measure LH and FT and DHEAS levels. Results : Biochemical hyperandrogenemia prevails in 40% of women with PCOS. Salivary levels of LH, FT and DHEAS correlate with their corresponding serum values, with a higher sensitivity of salivary more than serum approach. Conclusion : Saliva provides a sensitive, simple, reliable, non‑invasive and uncomplicated diagnostic approach for biochemical hyperandrogenemia. Keywords : Biochemical hyperandrogenemia, dehydroepiandrosterone sulfate, luteinizing hormone, polycystic ovarian syndrome, saliva, testosterone
评价生化高雄激素血症的唾液法与血清法
背景:从生化角度看,高雄激素症是由循环游离或总血清睾酮水平升高和游离雄激素指数升高引起的。大约60 - 80%的多囊卵巢综合征(PCOS)女性表现出循环雄激素水平升高。目的:本前瞻性观察性随机研究旨在探讨用唾液促黄体生成素(LH)、游离睾酮(FT)和硫酸脱氢表雄酮(DHEAS)水平代替血清诊断多囊卵巢综合征(PCOS)女性生化高雄激素血症的可能性。对象与方法:本研究选取75名多囊卵巢综合征(PCOS)女性和20名正常生育女性作为对照组。在周期的第3天采集静脉血和唾液样本,测量LH、FT和DHEAS水平。结果:生化性高雄激素血症发生率为40%。唾液LH、FT和DHEAS水平与其相应的血清值相关,且唾液法比血清法敏感性更高。结论:唾液检测是一种灵敏、简便、可靠、无创、简便的生化高雄激素血症诊断方法。关键词:生化高雄激素血症,硫酸脱氢表雄酮,黄体生成素,多囊卵巢综合征,唾液,睾酮
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