Prediction of Gestational Diabetes by Measuring First Trimester Maternal Serum Uric Acid Concentration

M. El-Gharib, A. Mahfouz, M. Morad, M. Farahat
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引用次数: 12

Abstract

Background: Gestational diabetes mellitus (GDM) is a common complication in pregnancy, affecting more than 10% pregnancies worldwide. However, the true underlying causes remain to be fully elucidated. Aim: This study aimed at searching for any relation between first trimester uric acid concentration and the development of GDM. Subjects and Methods: The study was conducted on 250 first trimester pregnant females at risk of diabetes mellitus attending the outpatient clinic of Tanta University Hospital. All cases underwent estimation of first trimester-fasting blood sugar and maternal serum uric acid concentration. Between 24 and 28 weeks' gestation random blood sugar and glucose challenge test were done. Positive cases were confirmed by 3 h glucose tolerance curve. Results: The results demonstrated an association between first trimester maternal serum uric acid concentration obesity and GDM. Approximately, 41.4% (60/145) of non-diabetic women were at first quartile, while 44.8% (47/105) of the diabetic women were at fourth quartile. Conclusion: We concluded that the cut-off level of maternal serum uric acid of 4 mg/dl in the first trimester was associated with developing GDM. Therefore, we suggest that serum uric acid level should be done as routine test during the first antenatal care visit.
通过测定孕早期孕妇血清尿酸浓度预测妊娠糖尿病
背景:妊娠期糖尿病(GDM)是妊娠期常见的并发症,影响全世界10%以上的妊娠。然而,真正的潜在原因仍有待充分阐明。目的:探讨妊娠早期尿酸浓度与GDM发生的关系。对象与方法:选取坦塔大学附属医院门诊就诊的250例有糖尿病危险的妊娠早期孕妇为研究对象。所有病例都进行了妊娠早期空腹血糖和母体血清尿酸浓度的评估。在妊娠24 ~ 28周进行随机血糖和葡萄糖激发试验。3 h葡萄糖耐量曲线证实阳性病例。结果:结果表明孕早期孕妇血清尿酸浓度肥胖与GDM之间存在关联。大约41.4%(60/145)的非糖尿病女性处于第一四分位数,而44.8%(47/105)的糖尿病女性处于第四四分位数。结论:孕早期产妇血清尿酸临界值为4 mg/dl与GDM的发生有关。因此,我们建议在第一次产前检查时将血清尿酸水平作为常规检查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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