Prague medical report最新文献_第5页

Plastic of Smile: Adhesive Fixed Dental Prosthesis, Fiberglass Post Restoration, and Direct Veneers in Resin Composite. 微笑塑料：粘接固定义齿，玻璃纤维后修复，树脂复合材料直接贴面。

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.36

Cláudio Eufrásio Medeiros Lins, Amina Kadja Martins Cahu, Marlon Ferreira Dias, Glaucia Danielle Ferreira da Silva, Natália Gomes de Oliveira, Luís Felipe Espíndola-Castro

{"title":"Plastic of Smile: Adhesive Fixed Dental Prosthesis, Fiberglass Post Restoration, and Direct Veneers in Resin Composite.","authors":"Cláudio Eufrásio Medeiros Lins, Amina Kadja Martins Cahu, Marlon Ferreira Dias, Glaucia Danielle Ferreira da Silva, Natália Gomes de Oliveira, Luís Felipe Espíndola-Castro","doi":"10.14712/23362936.2025.36","DOIUrl":"10.14712/23362936.2025.36","url":null,"abstract":"Tooth loss, darkened teeth, and disproportionate shape and size of teeth can compromise the way an individual sees themselves and their interpersonal relationships. The present study aims to report a case report of a plastic smile. After initial clinical examinations, it was proposed to perform an adhesive-fixed dental prosthesis, fiberglass post-restoration, and direct veneers in resin composite. For tooth 11, which had extensive coronary damage, a fiberglass post-restoration was performed. The fiberglass post was cemented with dual resin cement and the tooth was sculpted using the indirect resin composite technique. For the tooth loss (13), an adhesive fixed dental prosthesis was made of fiberglass, with wear of the abutment teeth (12 and 14) to support the prosthesis. From teeth 14 to 24, wear to veneers was performed. The veneers were implemented with resin composed by the direct hands-free technique. Treatment was completed with occlusal adjustments, finishing, and polishing. Rehabilitation treatment performed emphasizes the importance of associating adequate planning, dentist dexterity, and the choice of materials and techniques used.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"126 4","pages":"231-237"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development, Implementation, Pharmacokinetic and Safety Evaluation of an Immunotherapeutic Treatment for COVID-19: Double-blind Randomized Placebo-controlled Trial. 新冠肺炎免疫治疗的开发、实施、药代动力学和安全性评价：双盲随机安慰剂对照试验

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.20

Guillermo Alberto Keller, Silvia Miranda, Adolfo Rafael De Roodt, Roxana Salvi, Ivana Colaianni, Elizabeth García, Guillermo Bramuglia, Leandro Calderón, Diego Mazza, Laura Lanari, Oscar Perez, Matias Fingermann, Guillermo Temprano, Guillermo Di Girolamo, Claudio Bonel, José Cristian Dokmetjian

{"title":"Development, Implementation, Pharmacokinetic and Safety Evaluation of an Immunotherapeutic Treatment for COVID-19: Double-blind Randomized Placebo-controlled Trial.","authors":"Guillermo Alberto Keller, Silvia Miranda, Adolfo Rafael De Roodt, Roxana Salvi, Ivana Colaianni, Elizabeth García, Guillermo Bramuglia, Leandro Calderón, Diego Mazza, Laura Lanari, Oscar Perez, Matias Fingermann, Guillermo Temprano, Guillermo Di Girolamo, Claudio Bonel, José Cristian Dokmetjian","doi":"10.14712/23362936.2025.20","DOIUrl":"10.14712/23362936.2025.20","url":null,"abstract":"Passive immunotherapy has been evaluated in many infections. The present study aims to evaluate purified F(ab')2 fraction of equine hyperimmune IgG (anti-SARS-CoV-2) in the treatment of coronavirus lung disease. Patients with coronavirus disease of 2019 (COVID-19) with World Health Organization (WHO) score 3, 4 or 5 up to 72 hours of evolution from the onset of symptoms were included. They were randomly assigned to anti-SARS-CoV-2 or placebo. Follow-up was performed for 28 days to assess efficacy, safety, pharmacokinetics, detection of anti-horse antibodies, circulating cytokines and determination of anti-SARS neutralizing activity. The 20 initial patients (44±14 years) were included. On the third day of treatment there was an improvement (P=0.02) in arterial saturation (95±1.6 vs. 93±2.5%) with increasing differences over time between treatments (day 8: 97±0.1 vs. 94±0.3%). The length of oxygen therapy treatment was 2±0.8 vs. 3±0.9 (0.048) in patients falling within WHO 5 category (no difference to WHO 4). Mean hospitalization was 13±2.5 vs. 14±0.8 days (P=0.095) and time to clinical improvement was 2±0.5 vs. 3±0.9 days (P=0.048) in patients with initial 5 WHO category, with no differences to patients who started with WHO stage 4. The time to nasal swab negativization was 10±2.1 vs. 12±0 day (P=0.015). No adverse reactions or intercurrences were detected. All patients presented heterophile antibodies without clinical correlate. The new treatment shows improvement in arterial saturation (days 3 to 12), and a decrease on detectable viral RNA (days 8 to 11) with good pharmacokinetic and safety profile.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"126 3","pages":"121-138"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intussusception by Colonic Lipoma in a 51-year-old Patient - A Case Report. 51岁结肠脂肪瘤致肠套叠1例报告。

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.24

Marija Zubčić, Florian Stephan Bienenfeld, Alessio Sciacqua, Manuela Montatore, Gianmichele Muscatella, Giuseppe Guglielmi

引用次数: 0

Glucocorticoid Remediable Aldosteronism in a Family with a Strong History of Cerebral Aneurysms and Hypertension. 糖皮质激素可治疗的醛固酮增多症家族与强烈的脑动脉瘤和高血压病史。

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.23

Jan Zeman, Crystal Kamilaris

引用次数: 0

Subacute Sclerosing Encephalitis in an Adult with Congenital HIV Infection - Case Report. 成人先天性HIV感染的亚急性硬化性脑炎病例报告。

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.14

Ihor Hryzhak, Olexandra Pryshlyak, Victoria Gryb, Marianna Prokopovich, Mykola Prokofiev, Olga Matviiuk, Nataliya Diomina, Lilia Hryzhak

{"title":"Subacute Sclerosing Encephalitis in an Adult with Congenital HIV Infection - Case Report.","authors":"Ihor Hryzhak, Olexandra Pryshlyak, Victoria Gryb, Marianna Prokopovich, Mykola Prokofiev, Olga Matviiuk, Nataliya Diomina, Lilia Hryzhak","doi":"10.14712/23362936.2025.14","DOIUrl":"https://doi.org/10.14712/23362936.2025.14","url":null,"abstract":"Subacute sclerosing panencephalitis (SSPE) is the result of a chronic infection of the central nervous system caused by a mutated measles virus. We present a case of SSPE in a 19-year-old female with congenital HIV-infection. The patient has been using antiretroviral therapy regularly since she was 4 years old. At the age of 15, she contracted measles of moderate severity. At the age 17, she had the HIV viral load < 20 copies/ml and the CD4 count 420 cells/μl. Three years after measles, bilateral necrotizing retinitis developed, and five months later, myoclonic seizures of the left limbs. Symptoms progressed gradually, with fever, generalised seizures, and lost consciousness. She was hospitalized in department for treatment patient with HIV-infection. Magnetic resonance imaging of the brain revealed massive areas of the altered signal without clear contours in both hemispheres of the brain, which captured the white and grey matter of the fronto-parietal, temporal-occipital lobes. The electroencephalography showed the flashes of slow-wave paroxysmal activity of the brain in the delta range, mainly in the fronto-parietal area. In the cerebral spinal fluid, anti-measles IgG was detected at a titre of 3738,408 U/ml, and in the blood - 9.4 U/ml. A diagnosis of SSPE was established. Supportive, corticosteroids and anticonvulsant treatment were ineffective. Patient died 10 months after the onset of the disease. Therefore, measles at any age in a person with congenital HIV-infection poses a risk of developing SSPE.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"126 2","pages":"86-91"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term Graft Patency of Saphenous Vein Grafts after Endoscopic Harvest in Aortocoronary Bypass Surgery. 内镜下冠状动脉搭桥术后隐静脉移植物的长期通畅。

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.33

Okaikor Okantey, Tomáš Jonszta, Lubomír Pavliska, Jiří Sieja, Miriam Kende, Radim Brát

{"title":"Long-term Graft Patency of Saphenous Vein Grafts after Endoscopic Harvest in Aortocoronary Bypass Surgery.","authors":"Okaikor Okantey, Tomáš Jonszta, Lubomír Pavliska, Jiří Sieja, Miriam Kende, Radim Brát","doi":"10.14712/23362936.2025.33","DOIUrl":"https://doi.org/10.14712/23362936.2025.33","url":null,"abstract":"Endoscopic vein harvest of the greater saphenous vein for aortocoronary bypass grafting presents a relatively newer and less invasive mode of vein harvest that has become a more popular approach used in the field of cardiac surgery. This study aimed to compare the long-term patency of saphenous vein grafts and clinical outcomes (a minimum of 10 years) after endoscopic harvest with open vein harvest in patients after isolated surgical myocardial revascularization. Fifty patients (25 after endoscopic and 25 after open harvest) who underwent isolated myocardial revascularization between 2009 and 2011 assessed. The study comprised two phases: completion of questionnaires assessing recurring symptoms of ischemic heart disease and visualisation of vein grafts via coronary computed tomography angiography to assess graft patency. The primary outcome showed higher patency rates after open vein harvest (76.1 vs. 68.8%); without significant statistical difference (p=0.873). Differences in clinical outcomes were not statistically significant regarding recurring angina (28% endoscopic group, 32% open group, p=0.519), dyspnea (24 vs. 16%, p=0.817) and myocardial infarctions with catheter-based revascularization of vein grafts (8% endoscopic group, 16% open, p=0.734). Redo surgery was not reported in neither group. Endoscopic and open vein harvest yielded comparable long-term patency rates both angiographically and clinically. That strenghtens endoscopic approach as a non-inferior mode to the traditional approach in patients undergoing surgical myocardial revascularization.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"126 4","pages":"207-214"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiological Analysis of Interhemispheric Fissure: A Comprehensive Study. 半球间裂的放射学分析：一项综合研究。

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.34

Prabhjot Singh, Renu Gupta, Ashish K Nayyar, Surajit Ghatak, Sarbesh Tiwari, Jaskaran Singh Gosal, Kumar Sambhav

{"title":"Radiological Analysis of Interhemispheric Fissure: A Comprehensive Study.","authors":"Prabhjot Singh, Renu Gupta, Ashish K Nayyar, Surajit Ghatak, Sarbesh Tiwari, Jaskaran Singh Gosal, Kumar Sambhav","doi":"10.14712/23362936.2025.34","DOIUrl":"https://doi.org/10.14712/23362936.2025.34","url":null,"abstract":"Interhemispheric fissure is the midline groove present between the cerebral hemispheres. It provides access to corpus callosum, lateral ventricles and third ventricle during interhemispheric approach in neurosurgery. The knowledge and established data about its morphometry are limited. 90 participants who underwent magnetic resonance imaging scans were studied. The data was divided into 4 age groups (25-45, 45-65, 65-85 and >85 years) as well as among males and females. The depth of interhemispheric fissure was measured from 6 predetermined reference points from the superomedial border of cerebral hemisphere to the floor of corpus callosum which is formed by corpus callosum. Mean along with standard deviation and confidence interval were calculated. Unpaired t-test and ANOVA was used to analyse the statistical difference between various age groups. The mean value of depth of interhemispheric fissure from frontal pole to genu is 35.08 ± 3.20 mm, at the level of coronal suture is 35.64 ± 4.27 mm, 1 cm anterior to coronal suture is 35.50 ± 3.27 mm, 1 cm posterior to coronal suture is 34.38 ± 4.95 mm. The depth from superomedial border at the level of parietooccipital sulcus is 43.72 ± 3.63 mm and at the level of calcarine sulcus is 54.13 ± 5.96 mm. This data is useful for neurosurgeons in order to perform interhemispheric approach.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"126 4","pages":"215-222"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Accessory Clavicular Heads of Sternocleidomastoid Stenosing Supraclavicular Fossa in Human: Case Report. 人类双侧副锁骨头锁骨上窝狭窄1例。

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.39

Dibakar Borthakur, Harisha Kusuma, Mohammed Ahmed Ansari

引用次数: 0

Navigating Diagnostic Complexity in Hailey-Hailey Disease: A Case Report with Clinical-histopathological Correlation. 导航诊断复杂性黑利-黑利病：一个病例报告与临床-组织病理学的相关性。

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.27

Parth R Goswami, Gyanendra Singh, Varniraj Patel, Yashdeep Singh Pathania

{"title":"Navigating Diagnostic Complexity in Hailey-Hailey Disease: A Case Report with Clinical-histopathological Correlation.","authors":"Parth R Goswami, Gyanendra Singh, Varniraj Patel, Yashdeep Singh Pathania","doi":"10.14712/23362936.2025.27","DOIUrl":"https://doi.org/10.14712/23362936.2025.27","url":null,"abstract":"Hailey-Hailey disease (HHD), also known as benign familial pemphigus, is a rare autosomal dominant genodermatosis caused by mutations in the ATP2C1 gene. These mutations impair keratinocyte adhesion and disrupt calcium homeostasis, leading to characteristic clinical and histopathological findings. Herein, we present the case of a 50-year-old male with a ten-year history of recurrent, pruritic, erythematous erosions and maceration in the left axilla and groin. Clinical examination revealed no systemic comorbidities or relevant family history. Histopathological analysis of skin biopsy demonstrated hallmark features, including epidermal hyperkeratosis, suprabasal and intraepidermal clefting, and acantholysis with the distinctive \"dilapidated brick wall\" appearance, confirming the diagnosis of HHD. Differential diagnoses, including intertrigo, Darier disease, and pemphigus vegetans, were excluded based on clinical and histological findings. The patient was managed with immunomodulators and topical antibiotics, with follow-up care focused on symptom alleviation and infection prevention. This case underscores the importance of correlating clinical and histopathological findings in diagnosing HHD and differentiating it from other intertriginous dermatoses. Despite its chronic and recurrent nature, timely and accurate diagnosis, coupled with individualized management, significantly enhances patient outcomes. This report also highlights the unique histological feature of acantholysis resembling a \"dilapidated brick wall\", pivotal in distinguishing HHD. Advances in understanding the molecular pathogenesis of ATP2C1 mutations hold promise for the development of targeted therapies, offering hope for more effective management of this challenging condition in the future.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"126 3","pages":"167-170"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orofacial Infection Number Decrease during COVID-19 Pandemic. COVID-19大流行期间口面部感染人数减少。

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.21

Bronislava Dvoranová, Michal Vavro, Martin Selvek, Natália Gurčíková, David Med, Ladislav Czakó

{"title":"Orofacial Infection Number Decrease during COVID-19 Pandemic.","authors":"Bronislava Dvoranová, Michal Vavro, Martin Selvek, Natália Gurčíková, David Med, Ladislav Czakó","doi":"10.14712/23362936.2025.21","DOIUrl":"https://doi.org/10.14712/23362936.2025.21","url":null,"abstract":"This study analyses trends in orofacial infection hospital admissions at a single department, focusing on the impact of the COVID-19 pandemic. Admission counts fluctuated over the study period, but 2020 (n=65) and 2021 (n=56) showed a statistically significant decrease, falling slightly outside the 95% confidence interval of a linear trend established for 2014-2019. In 2022, the number of admitted patients (n=63) remained below average but within the confidence interval, while 2023 saw an increase to 97 patients. A notable shift in treatment methods was observed during the pandemic years. The proportion of patients treated with extraoral revision increased, with the most pronounced disparity in 2020 (n=40:10, 80%:20% extraoral revision-to-local treatment ratio). Statistical analysis (chi-square test, p<0.001) confirmed significant differences across the years. Comparing COVID-19-affected years (2020-2022) with non-COVID years (2014-2019 and 2023), 73% of patients were treated with extraoral revision during the pandemic, compared to 49% in non-COVID years (p<0.001). Additionally, only 44 patients were treated with antibiotics alone, whereas 75 would have been expected in the absence of COVID-19-related disruptions. These findings suggest that the pandemic influenced both the number of orofacial infection admissions and the treatment approach.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"126 3","pages":"139-143"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0