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Prognostic Significance of the Coagulation and Complement Systems in Critical COVID-19 Infection. 凝血和补体系统在COVID-19危重感染中的预后意义
Prague medical report Pub Date : 2023-01-01 DOI: 10.14712/23362936.2023.7
Amitabha Ray, Kristen A K Winter, Dayalu S L Naik, Chuku Okorie
{"title":"Prognostic Significance of the Coagulation and Complement Systems in Critical COVID-19 Infection.","authors":"Amitabha Ray,&nbsp;Kristen A K Winter,&nbsp;Dayalu S L Naik,&nbsp;Chuku Okorie","doi":"10.14712/23362936.2023.7","DOIUrl":"https://doi.org/10.14712/23362936.2023.7","url":null,"abstract":"<p><p>Infection with the SARS-CoV-2 virus (COVID-19 disease) can cause a wide range of clinical situations - from an asymptomatic state to fatal outcomes. In cases of serious clinical manifestations, the underlying mechanisms involve a number of immune cells and stromal cells as well as their products such as pro-inflammatory interleukin-6 and tumour necrosis factor-alpha that ultimately cause the cytokine storm. The situation of overproduction of pro-inflammatory cytokines is somewhat similar to, though in a mild form, health conditions in obesity and related metabolic disorders like type-2 diabetes, which are also considered important risk factors for severe illness in COVID-19. Interestingly, neutrophils perhaps play a significant role in this pathogenesis. On the other hand, it is thought that COVID-19-related critical illness is associated with pathological hyperactivity of the complement system and coagulopathy. Although the precise molecular interactions between the complement and coagulation systems are not clear, we observe an intimate cross-talk between these two systems in critically ill COVID-19 patients. It is believed that both of these biological systems are connected with the cytokine storm in severe COVID-19 disease and actively participate in this vicious cycle. In order to hinder the pathological progression of COVID-19, a number of anticoagulation agents and complement inhibitors have been used with varying success. Among these drugs, low molecular weight heparin enoxaparin, factor Xa inhibitor apixaban, and complement C5 inhibitor eculizumab have been commonly used in patients with COVID-19. Our overall experience might help us in the future to tackle any such conditions.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Therapeutic Drug Monitoring of Protein Kinase Inhibitors in the Treatment of Non-small Cell Lung Cancer. 蛋白激酶抑制剂治疗非小细胞肺癌癌症的药物监测。
Prague medical report Pub Date : 2023-01-01 DOI: 10.14712/23362936.2023.16
Judita Staša, Jana Gregorová, Ondřej Slanař, Martin Šíma
{"title":"Therapeutic Drug Monitoring of Protein Kinase Inhibitors in the Treatment of Non-small Cell Lung Cancer.","authors":"Judita Staša,&nbsp;Jana Gregorová,&nbsp;Ondřej Slanař,&nbsp;Martin Šíma","doi":"10.14712/23362936.2023.16","DOIUrl":"https://doi.org/10.14712/23362936.2023.16","url":null,"abstract":"<p><p>Targeted therapy with protein kinase inhibitors (PKIs) represents one of the important treatment options for non-small cell lung cancer (NSCLC). It has contributed to improve patients' survival and quality of life significantly. These anticancer drugs are administrated orally in flat-fixed doses despite the well-known large interpatient pharmacokinetic variability and the possible need for dose individualization. To optimize and individualize dosing of PKIs, and thereby increasing the effectiveness and safety of the treatment, therapeutic drug monitoring (TDM) is the most frequently mentioned method. Unlike other areas of medicine, TDM has been rather exceptional in oncological practise since there is a little evidence or no data for concentration-effect relationships of PKIs. Therefore, the aim of this review is to summarize the pharmacokinetic characteristics of PKIs and provide the evidence supporting the use of TDM for personalised treatment of patients with NSCLC.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41156272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complete Denture - Border Molding Technique Using a Laboratory Condensation Silicone Putty: Review. 全口义齿 - 使用实验室冷凝硅胶粘合剂的边缘成型技术:回顾。
Prague medical report Pub Date : 2023-01-01 DOI: 10.14712/23362936.2023.28
Clóvis Lamartine de Moraes Melo Neto, Daniela Micheline Dos Santos, Marcelo Coelho Goiato
{"title":"Complete Denture - Border Molding Technique Using a Laboratory Condensation Silicone Putty: Review.","authors":"Clóvis Lamartine de Moraes Melo Neto, Daniela Micheline Dos Santos, Marcelo Coelho Goiato","doi":"10.14712/23362936.2023.28","DOIUrl":"https://doi.org/10.14712/23362936.2023.28","url":null,"abstract":"<p><p>During the fabrication of a complete denture, functional impression is taken. Literature studies show that polydimethylsiloxane (condensation silicone) has not been reported by United States dental schools to perform border molding. Thus, the purpose of this article is to review the functional impression technique when border molding is performed with a laboratory condensation silicone putty.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular Anatomy and Variations of the Anterior Abdominal Wall - Significance in Abdominal Surgery. 血管解剖和前腹壁的变化-在腹部手术中的意义。
Prague medical report Pub Date : 2023-01-01 DOI: 10.14712/23362936.2023.9
Stoyan Kostov, Svetla Dineva, Yavor Kornovski, Stanislav Slavchev, Yonka Ivanova, Angel Yordanov
{"title":"Vascular Anatomy and Variations of the Anterior Abdominal Wall - Significance in Abdominal Surgery.","authors":"Stoyan Kostov,&nbsp;Svetla Dineva,&nbsp;Yavor Kornovski,&nbsp;Stanislav Slavchev,&nbsp;Yonka Ivanova,&nbsp;Angel Yordanov","doi":"10.14712/23362936.2023.9","DOIUrl":"https://doi.org/10.14712/23362936.2023.9","url":null,"abstract":"<p><p>Detailed knowledge of the human anatomy is an integral part of every surgical procedure. The majority of surgery related complications are due to a failure to possess appropriate knowledge of human anatomy. However, surgeons pay less attention of the anatomy of the anterior abdominal wall. It is composed of nine abdominal layers, which are composed of fascias, muscles, nerves, and vessels. Many superficial and deep vessels and their anastomoses supply the anterior abdominal wall. Moreover, anatomical variations of these vessels are often presented. Intraoperative and postoperative complications associated with entry and closure of the anterior abdominal wall could compromise the best surgical procedure. Therefore, sound knowledge of the vascular anatomy of the anterior abdominal wall is fundamental and a prerequisite to having a favourable quality of patient care. The purpose of the present article is to describe and delineate the vascular anatomy and variations of the anterior abdominal wall and its application in abdominal surgery. Consequently, the most types of abdominal incisions and laparoscopic accesses will be discussed. Furthermore, the possibility of vessels injury related to different types of incisions and accesses will be outlined in detail. Morphological characteristics and distribution pattern of the vascular system of the anterior abdominal wall is illustrated by using figures either from open surgery, different types of imaging modalities or embalmed cadaveric dissections. Oblique skin incisions in the upper or lower abdomen such as McBurney, Chevron and Kocher are not the topic of the present article.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Torsion of the Falciform Ligament Diagnosed by Imaging Tests - Case Report of an Unusual Disease. 影像检查诊断镰状韧带扭转1例罕见疾病报告。
Prague medical report Pub Date : 2023-01-01 DOI: 10.14712/23362936.2023.14
Bruna Suda Rodrigues, Daniela Osti Bortolozzo, Maura Harumi Ito, Thaís Nogueira Dantas Gastaldi, Márcio Luís Duarte, Élcio Roberto Duarte
{"title":"Torsion of the Falciform Ligament Diagnosed by Imaging Tests - Case Report of an Unusual Disease.","authors":"Bruna Suda Rodrigues,&nbsp;Daniela Osti Bortolozzo,&nbsp;Maura Harumi Ito,&nbsp;Thaís Nogueira Dantas Gastaldi,&nbsp;Márcio Luís Duarte,&nbsp;Élcio Roberto Duarte","doi":"10.14712/23362936.2023.14","DOIUrl":"https://doi.org/10.14712/23362936.2023.14","url":null,"abstract":"<p><p>The falciform ligament is a peritoneal double layer that anatomically divides the right and left hepatic lobes. Abnormality of the falciform ligament is rare - less than 20 cases of torsion of the falciform ligament have been reported to date in adults. The pathophysiology of these entities is similar to intra-abdominal focal fat infarction. The clinical of the patient with torsion of the falciform ligament is abdominal pain of sudden onset and focal location. Laboratory tests can lead to diagnostic confusion with cholecystitis. Ultrasonography is usually the initial evaluation test, but the gold standard diagnosis is computed tomography. We report the case of a 30-year-old female patient reporting sudden abdominal pain that radiates to the dorsal region associated with nausea and vomiting diagnosed with torsion of the falciform ligament with ultrasonography and confirmed with computed tomography. She was treated conservatively without the need for surgical treatment, being discharged after one week hospitalization.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of a Questionnaire for Evaluation of Surgical Treatment of Masseter Muscle Hypertrophy: A Case Report. 应用调查表评估肥大肌外科治疗:一例报告。
Prague medical report Pub Date : 2023-01-01 DOI: 10.14712/23362936.2023.25
Luiza Roberta Bin, Mateus Diego Pavelski, Ana Carolina Fraga Fernandes, Eleanor Álvaro Garbin
{"title":"Use of a Questionnaire for Evaluation of Surgical Treatment of Masseter Muscle Hypertrophy: A Case Report.","authors":"Luiza Roberta Bin,&nbsp;Mateus Diego Pavelski,&nbsp;Ana Carolina Fraga Fernandes,&nbsp;Eleanor Álvaro Garbin","doi":"10.14712/23362936.2023.25","DOIUrl":"https://doi.org/10.14712/23362936.2023.25","url":null,"abstract":"<p><p>Masseter hypertrophy (MH) is an uncommon natural condition that affects the facial contour. The etiology is debatable, and complaints are usually cosmetic in nature. The diagnosis is essentially clinical and aided by imaging tests. Treatment is still controversial. The literature is relatively scarce in relation to information on MH, particularly in the evaluation of outcomes. Through questionnaires, the progress was observed in the evaluation of the outcomes of aesthetic procedures. Thus, the purpose of this paper is to apply a Facelift Outcome Evaluation (FOE) questionnaire to evaluate the outcomes of surgical treatment in a case of MH. A 23-year-old male presented to the clinic complaining of bullying due to his facial aesthetics. Clinical and imaging evaluation was performed, with the creation of surgical guides. The patient answered the FOE questionnaire pre- and postoperatively, with results of 12.5 and 100.00 respectively. This subjectively shows the success of the treatment. We suggest that a questionnaire applied exclusively to masseter hypertrophy should be developed, as well as studies for the development of muscle volume measurement protocols, aiming at a more specific evaluation of the surgical outcomes.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41152564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rehabilitation of Dentofacial Asymmetry Secondary to Unilateral Temporomandibular Joint Ankylosis with Dual Distraction and Fixed Orthodontics - Stability at Three-year Follow-up. 双牵引和固定正畸治疗单侧颞下颌关节强直继发牙面不对称的康复——三年随访的稳定性。
Prague medical report Pub Date : 2023-01-01 DOI: 10.14712/23362936.2023.21
Harpreet Singh, Sonal Mishra, Dhirendra Srivastava, Poonam Sharma, Lokesh Chandra, Pranav Kapoor, Raj Kumar Maurya
{"title":"Rehabilitation of Dentofacial Asymmetry Secondary to Unilateral Temporomandibular Joint Ankylosis with Dual Distraction and Fixed Orthodontics - Stability at Three-year Follow-up.","authors":"Harpreet Singh,&nbsp;Sonal Mishra,&nbsp;Dhirendra Srivastava,&nbsp;Poonam Sharma,&nbsp;Lokesh Chandra,&nbsp;Pranav Kapoor,&nbsp;Raj Kumar Maurya","doi":"10.14712/23362936.2023.21","DOIUrl":"https://doi.org/10.14712/23362936.2023.21","url":null,"abstract":"<p><p>Optimal rehabilitation of asymmetric dentofacial deformity secondary to unilateral temporomandibular joint (TMJ) ankylosis is often a challenge. The purpose of this case series is to present an insight into esthetic, occlusal and functional rehabilitation of two patients with varying degree of asymmetric Class II dentofacial deformities secondary to long-standing unilateral TMJ ankylosis. The patients were treated with one-stage surgical protocol employing simultaneous dual distraction technique along with interpositional arthroplasty. Dual distraction technique entailed the simultaneous use of two distractors which allowed for proper control of proximal condylar segment during the course of distraction and lowering the risk of ankylosis recurrence. Thereafter, comprehensive fixed orthodontic mechanotherapy involving the use of temporary anchorage devices was instituted to align and level the compensated dentition. Post-treatment records showed significant improvements in skeletal disharmony and functional stability with good functional occlusion. At the three-year follow-up, the morphological and functionally acceptable results were reasonably well-maintained, with no signs of relapse. Through the two cases reported here, we would like to highlight that one-stage concurrent arthroplasty and dual distraction technique is a safe, stable, and reliable approach for surgical and functional rehabilitation of an adult asymmetric dentofacial deformity secondary to unilateral TMJ ankylosis. Meticulously executed comprehensive orthodontic manipulations involving use of acrylic bite-blocks, elastic traction, and temporary skeletal anchorage device play a crucial role in enhancing the final occlusal outcomes.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41158182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paratesticular Dedifferentiated Liposarcoma with Rhabdomyoblastic Differentiation: A Case Report and Review of the Literature. 伴横纹肌母细胞分化的睾丸旁低分化脂肪肉瘤:病例报告和文献综述。
Prague medical report Pub Date : 2023-01-01 DOI: 10.14712/23362936.2023.35
Ahmet Keles, Ozgur Arikan, Ferhat Keser, Ayse Nur Toksoz Yildirim, Asif Yildirim
{"title":"Paratesticular Dedifferentiated Liposarcoma with Rhabdomyoblastic Differentiation: A Case Report and Review of the Literature.","authors":"Ahmet Keles, Ozgur Arikan, Ferhat Keser, Ayse Nur Toksoz Yildirim, Asif Yildirim","doi":"10.14712/23362936.2023.35","DOIUrl":"https://doi.org/10.14712/23362936.2023.35","url":null,"abstract":"<p><p>Liposarcomas of the paratesticular tissue is a rare pathological entity. The symptoms are similar to inguinal hernias or hydroceles. We present the case of an 84-year-old man with a rare paratesticular liposarcoma that manifested as painless right hemiscrotal swelling. Testicular tumour markers were negative. Imaging revealed a heterogeneous mass with a fat component. He underwent a radical orchiectomy on the left side to remove the associated mass. This revealed dedifferentiated liposarcoma (DDLS) with rhabdomyoblastic differentiation and MDM2 amplification. The surgical margins were negative, and the patient had a metastatic workup that included magnetic resonance imaging (MRI) of the abdomen and pelvis. Because of the disease's rarity, there is no clear agreement on radiotherapy and chemotherapy roles.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Removable Partial Denture - Functional Impression Techniques: Review. 可摘局部义齿 - 功能性印模技术:回顾。
Prague medical report Pub Date : 2023-01-01 DOI: 10.14712/23362936.2023.29
Clóvis Lamartine de Moraes Melo Neto, Karina Helga Turcio, Daniela Micheline Dos Santos, Marcelo Coelho Goiato
{"title":"Removable Partial Denture - Functional Impression Techniques: Review.","authors":"Clóvis Lamartine de Moraes Melo Neto, Karina Helga Turcio, Daniela Micheline Dos Santos, Marcelo Coelho Goiato","doi":"10.14712/23362936.2023.29","DOIUrl":"https://doi.org/10.14712/23362936.2023.29","url":null,"abstract":"<p><p>The objective of this article is to concisely review the main clinical techniques used to make the functional impression to manufacture a removable partial denture. Through this review, the dentist can develop his clinical knowledge.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maxillary Sinus Volume and Its Effect on Treated Impacted Canines. 上颌窦容积及其对治疗阻生犬的影响。
Prague medical report Pub Date : 2023-01-01 DOI: 10.14712/23362936.2023.11
Martin Horáček, Taťjana Dostálová, Petra Urbanová, Hana Eliášová, Miloš Špidlen, Petra Hliňáková
{"title":"Maxillary Sinus Volume and Its Effect on Treated Impacted Canines.","authors":"Martin Horáček,&nbsp;Taťjana Dostálová,&nbsp;Petra Urbanová,&nbsp;Hana Eliášová,&nbsp;Miloš Špidlen,&nbsp;Petra Hliňáková","doi":"10.14712/23362936.2023.11","DOIUrl":"https://doi.org/10.14712/23362936.2023.11","url":null,"abstract":"<p><p>The goal of study was to explore the role of 3D CBCT (cone beam computer tomography) in detecting impacted canines and their movement to evaluate the influence of orthodontic therapy parameters on treatment options, and to monitor quality of healing process based on shape and size of sinus maxillae volume. It is known that the volume of maxillary sinus plays an important role in patients with impacted teeth. The prospective study consisted of 26 individuals. For each individual, pre-treatment and post-treatment CBCT data were acquired. Changes of size, and position of impacted canine in 3D CBCT image before and after therapy were prepared using 3D reconstruction. Volumetric measurements of the maxillary sinuses were performed before and after orthodontic therapy of impacted canines, using InVivo6 software. The main effects MANOVA performed on linear measurements showed metric differences between pre-op and post-op images. A paired t-test showed no statistically significant differences between pre-op and post-op values of the sinus volume. Changes of size and position of impacted canine in 3D image before and after therapy were precise and reproducible, using 3D reconstruction in three planes - horizontal, midsagittal, and coronal. The linear measurements showed metric differences between pre-op and post-op images.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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