Prague medical report最新文献

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Salmonella Paratyphi Infection: Use of Nanopore Sequencing as a Vivid Alternative for the Identification of Invading Bacteria. 副伤寒沙门氏菌感染:使用纳米孔测序作为识别入侵细菌的生动选择。
Prague medical report Pub Date : 2021-01-01 DOI: 10.14712/23362936.2021.10
Martin Chmel, Oldřich Bartoš, Ondřej Beran, Petr Pajer, Jiří Dresler, Martina Čurdová, Michal Holub
{"title":"Salmonella Paratyphi Infection: Use of Nanopore Sequencing as a Vivid Alternative for the Identification of Invading Bacteria.","authors":"Martin Chmel,&nbsp;Oldřich Bartoš,&nbsp;Ondřej Beran,&nbsp;Petr Pajer,&nbsp;Jiří Dresler,&nbsp;Martina Čurdová,&nbsp;Michal Holub","doi":"10.14712/23362936.2021.10","DOIUrl":"https://doi.org/10.14712/23362936.2021.10","url":null,"abstract":"<p><p>In our study we present an overview of the use of Oxford Nanopore Technologies (ONT) sequencing technology on the background of Enteric fever. Unlike traditional methods (e.g., qPCR, serological tests), the nanopore sequencing technology enables virtually real-time data generation and highly accurate pathogen identification and characterization. Blood cultures were obtained from a 48-year-old female patient suffering from a high fever, headache and diarrhea. Nevertheless, both the initial serological tests and stool culture appeared to be negative. Therefore, the bacterial isolate from blood culture was used for nanopore sequencing (ONT). This technique in combination with subsequent bioinformatic analyses allowed for prompt identification of the disease-causative agent as Salmonella enterica subsp. enterica serovar Paratyphi A. The National Reference Laboratory for Salmonella (NIPH) independently reported this isolate also as serovar Paratyphi A on the basis of results of biochemical and agglutination tests. Therefore, our results are in concordance with certified standards. Furthermore, the data enabled us to assess some basic questions concerning the comparative genomics, i.e., to describe whether the isolated strain differs from the formerly published ones or not. Quite surprisingly, these results indicate that we have detected a novel and so far, unknown variety of this bacteria.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39239730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Therapeutic Drug Monitoring of Protein Kinase Inhibitors in Breast Cancer Patients. 乳腺癌患者蛋白激酶抑制剂治疗药物监测。
Prague medical report Pub Date : 2021-01-01 DOI: 10.14712/23362936.2021.22
Jaroslava Roušarová, Martin Šíma, Ondřej Slanař
{"title":"Therapeutic Drug Monitoring of Protein Kinase Inhibitors in Breast Cancer Patients.","authors":"Jaroslava Roušarová,&nbsp;Martin Šíma,&nbsp;Ondřej Slanař","doi":"10.14712/23362936.2021.22","DOIUrl":"https://doi.org/10.14712/23362936.2021.22","url":null,"abstract":"<p><p>Protein kinase inhibitors (PKIs) represent up-to-date therapeutic approach in breast cancer treatment. Although cancer is a rapidly progressive disease, many substances, including PKIs, are usually used at fixed doses without regard to each patient's individuality. Therapeutic drug monitoring (TDM) is a tool that allows individualization of therapy based on drug plasma levels. For TDM conduct, exposure-response relationships of drug substances are required. The pharmacokinetic data and exposure-response evidence supporting the use of TDM for 6 PKIs used in breast cancer treatment, one of the most common female tumour diseases, are discussed in this review.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39614927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Short Review of Liposteroid: A Novel Targeted Glucocorticoid Preparation for Treatment of Autoimmune and Inflammatory Diseases. 脂类固醇:一种治疗自身免疫性和炎症性疾病的新型靶向糖皮质激素制剂。
Prague medical report Pub Date : 2021-01-01 DOI: 10.14712/23362936.2021.23
Biplab K Saha, Nils T Milman
{"title":"Short Review of Liposteroid: A Novel Targeted Glucocorticoid Preparation for Treatment of Autoimmune and Inflammatory Diseases.","authors":"Biplab K Saha,&nbsp;Nils T Milman","doi":"10.14712/23362936.2021.23","DOIUrl":"https://doi.org/10.14712/23362936.2021.23","url":null,"abstract":"<p><p>This paper briefly reviews the safety and efficacy of liposteroid in different inflammatory and non-inflammatory diseases. Corticosteroids (CS) are the first-line therapy in many inflammatory and autoimmune disorders. Although highly efficacious, long-term use of CS is limited due to the occurrence of significant side effects. Liposteroid, which is a liposomal formulation of dexamethasone palmitate, possess more potent anti-inflammatory and immunosuppressive properties compared to dexamethasone sodium phosphate. These two formulations have markedly different lipid solubility, resulting in different pharmacokinetic and pharmacodynamic properties. Liposteroid has been used with success in patients with rheumatoid arthritis, macrophage activation syndrome, and idiopathic pulmonary hemosiderosis. In addition, liposteroid has been used in some non-inflammatory diseases. Moreover, we conceive that liposteroid may have a beneficial effect in patients, who are critically ill due to COVID-19, and suffer from the macrophage activation syndrome.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39850487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Fatal Neutropenic Colitis and Clostridium Septicum Bacteremia in a Breast Cancer Patient. 乳腺癌患者致死性中性粒细胞减少性结肠炎和败血症梭菌血症。
Prague medical report Pub Date : 2021-01-01 DOI: 10.14712/23362936.2021.18
Michal Holub, David Řezáč, Martina Čurdová
{"title":"Fatal Neutropenic Colitis and Clostridium Septicum Bacteremia in a Breast Cancer Patient.","authors":"Michal Holub,&nbsp;David Řezáč,&nbsp;Martina Čurdová","doi":"10.14712/23362936.2021.18","DOIUrl":"https://doi.org/10.14712/23362936.2021.18","url":null,"abstract":"<p><p>A fatal case of 67-year-old female with metastatic breast cancer on chemotherapy complicated with febrile neutropenia, colitis and sepsis due to Clostridium septicum is presented. Important clinical symptoms, laboratory and radiology findings together with therapy and outcome of neuropenic colitis are also discussed.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39483810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Comparison of the Morse Cone Connection with the Internal Hexagon and External Hexagon Connections Based on Microleakage - Review. 基于微泄漏的莫尔斯锥内六边形连接与外六边形连接的比较
Prague medical report Pub Date : 2021-01-01 DOI: 10.14712/23362936.2021.15
Ana Beatriz Bueno Carlini Bittencourt, Clóvis Lamartine de Moraes Melo Neto, Paulo Augusto Penitente, Eduardo Piza Pellizzer, Daniela Micheline Dos Santos, Marcelo Coelho Goiato
{"title":"Comparison of the Morse Cone Connection with the Internal Hexagon and External Hexagon Connections Based on Microleakage - Review.","authors":"Ana Beatriz Bueno Carlini Bittencourt,&nbsp;Clóvis Lamartine de Moraes Melo Neto,&nbsp;Paulo Augusto Penitente,&nbsp;Eduardo Piza Pellizzer,&nbsp;Daniela Micheline Dos Santos,&nbsp;Marcelo Coelho Goiato","doi":"10.14712/23362936.2021.15","DOIUrl":"https://doi.org/10.14712/23362936.2021.15","url":null,"abstract":"<p><p>The gap formed at the abutment-implant interface brings about a bacterial colonization. In addition, a bacterial reservoir can be established within the implant. The build-up of microorganisms around the implant can cause soft tissue infections and bone loss around the implant, which can lead to implant failure. Our literature review aimed to evaluate the infiltration at the implant-abutment interface, comparing the Morse cone connection with the external hexagon and internal hexagon connections. A literature search using the PubMed database was performed on March 24, 2021. The search terms were combinations of \"Morse cone\" or \"Morse taper\" with each of the following terms (individually): \"microleakage\", \"leakage\", \"infiltration\", and \"penetration\". The inclusion criterion was in vitro studies comparing the Morse cone with the external hexagon and/or internal hexagon, based on infiltration at the implant-abutment interface. The exclusion criterion was the evaluation of microleakage at the implant-abutment interface after applying a sealant over this region. The search was expanded as needed. There was no limit on the year of publication, and only articles written in English were included. In addition, references cited in included articles were also included in this review when they were appropriate. This literature review concluded that, in most cases, the microleakage in the Morse cone connection was lower when compared with the external hexagon and internal hexagon connections.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39484321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Testing Positive for SARS-CoV-2 in Two Countries 105 Days Apart. 相隔105天,两个国家的SARS-CoV-2检测呈阳性。
Prague medical report Pub Date : 2021-01-01 DOI: 10.14712/23362936.2021.21
Tshokey Tshokey, Jamyang Choden, Lila Adhikari, Binay Thapa, Sonam Wangchuk
{"title":"Testing Positive for SARS-CoV-2 in Two Countries 105 Days Apart.","authors":"Tshokey Tshokey,&nbsp;Jamyang Choden,&nbsp;Lila Adhikari,&nbsp;Binay Thapa,&nbsp;Sonam Wangchuk","doi":"10.14712/23362936.2021.21","DOIUrl":"https://doi.org/10.14712/23362936.2021.21","url":null,"abstract":"<p><p>Recovered COVID-19 patients may test positive for SARS-CoV-2 for a long time from intermittent shedding of viral fragments. A 36-year-old man who tested positive for SARS-CoV-2 in the Czech Republic and recovered tested positive again in Bhutan, 105 days beyond his first positive test. He experienced minimal symptoms and recovered without complications. Although no virological test was conducted to rule out reinfection, the repeat positive test after initial recovery likely resulted from prolonged shedding of dead viral particles than a reinfection.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39484239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Microscopic Third Ventriculostomy (Lamina Terminalis Fenestration) on Shunt-needed Hydrocephalus in Patients with Aneurysmal Subarachnoid Hemorrhage. 显微第三脑室造瘘术(终末板开窗)治疗动脉瘤性蛛网膜下腔出血患者分流性脑积水的效果。
Prague medical report Pub Date : 2021-01-01 DOI: 10.14712/23362936.2021.2
Alireza Tabibkhooei, Maziar Azar, Morteza Taheri, Hossein Ghalaenovi, Arash Fattahi, Hamed Kheradmand
{"title":"Effect of Microscopic Third Ventriculostomy (Lamina Terminalis Fenestration) on Shunt-needed Hydrocephalus in Patients with Aneurysmal Subarachnoid Hemorrhage.","authors":"Alireza Tabibkhooei,&nbsp;Maziar Azar,&nbsp;Morteza Taheri,&nbsp;Hossein Ghalaenovi,&nbsp;Arash Fattahi,&nbsp;Hamed Kheradmand","doi":"10.14712/23362936.2021.2","DOIUrl":"https://doi.org/10.14712/23362936.2021.2","url":null,"abstract":"<p><p>There are reports that in patients with aSAH (aneurysmal subarachnoid hemorrhage), LTF (lamina terminalis fenestration) reduces the rate of shunt-needed hydrocephalus via facilitation of CSF (cerebrospinal fluid) dynamic, diminished leptomeningeal inflammation, and decreased subarachnoid fibrosis. Regarding the conflicting results, this study was conducted to evaluate the effects of LTF on decreased shunt-needed hydrocephalus in patients with aSAH. A cross-sectional retrospective study was carried out to survey all patients with confirmed aSAH operated from March 2011 to September 2016 in an academic vascular center (Rasool Akram Hospital in Tehran, Iran). Of a total of 151 patients, 72 patients were male and 79 were female. The mean age of the participants was 51 years. A transiently CSF diversion (EVD - external ventricular drainage) was performed (the acute hydrocephalus rate) on 21 patients (13.9%). In 36 patients (23.8%), aneurysm occlusion with LTF and in 115 patients (76.2%) only aneurysm occlusion surgery was performed. In hydrocephalus follow-up after surgery, 13 (12%) patients needed shunt insertion (the rate of shunt-needed hydrocephalus). The statistical analysis demonstrated no significant relation between LTF and shunt-needed hydrocephalus. Confirmation of the hypothesis that LTF may decrease the rate of shunt-needed hydrocephalus can significantly decrease morbidity, mortality, and treatment costs of shunting (that is a simple, but a potentially dangerous procedure). So, it is advised to plan and perform an RCT (randomized controlled trial) that can remove the confounding factors, match the groups, and illustrate the exact effect of LTF on shunt-needed hydrocephalus.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25416834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Appendicitis in a Diabetic Child with Salmonella Infection. 糖尿病儿童急性阑尾炎合并沙门氏菌感染1例。
Prague medical report Pub Date : 2021-01-01 DOI: 10.14712/23362936.2021.4
Stylianos Roupakias, Maria-Ioanna Apostolou, Anastasia Anastasiou
{"title":"Acute Appendicitis in a Diabetic Child with Salmonella Infection.","authors":"Stylianos Roupakias,&nbsp;Maria-Ioanna Apostolou,&nbsp;Anastasia Anastasiou","doi":"10.14712/23362936.2021.4","DOIUrl":"https://doi.org/10.14712/23362936.2021.4","url":null,"abstract":"<p><p>Acute appendicitis is the most frequent and challenging condition requiring emergent intrabdominal surgery in children. The diagnosis of appendicitis becomes more difficult and challenging in children, especially with other medical problems. Computed tomography is the primary tool for diagnosing or excluding appendicitis in cases with atypical presentation. Salmonella infections may present as acute abdominal problems in children. We present a clinical combination that has never been previously reported, of a diabetic girl with non-typhoid Salmonella infection, diagnosed with acute appendicitis. We wonder about the causal correlation of these diseases, versus their simple coexistence.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25416836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Evaluation of the Effect of Radiofrequency Denervation on Quality of Life of Patients with Facet Joint Syndrome by Oswestry Disability Index Score and Visual Analogue Scale Score. 应用Oswestry失能指数评分和视觉模拟评分评价射频去神经对小关节综合征患者生活质量的影响。
Prague medical report Pub Date : 2021-01-01 DOI: 10.14712/23362936.2021.25
Zafer Gündoğdu, Mesut Öterkuş, Ümit Karatepe
{"title":"Evaluation of the Effect of Radiofrequency Denervation on Quality of Life of Patients with Facet Joint Syndrome by Oswestry Disability Index Score and Visual Analogue Scale Score.","authors":"Zafer Gündoğdu,&nbsp;Mesut Öterkuş,&nbsp;Ümit Karatepe","doi":"10.14712/23362936.2021.25","DOIUrl":"https://doi.org/10.14712/23362936.2021.25","url":null,"abstract":"<p><p>In this study, we aimed to investigate the effect of radiofrequency denervation procedure on pain and quality of life of patients with facet joint syndrome. Forty-seven patients who were admitted to our hospital with low back pain and diagnosed with facet joint syndrome between January 2018 and December 2018 were included in our study. The patients underwent denervation with radiofrequency under fluoroscopy in a sterile operating room condition. The pre-procedure and 6th month follow-up VAS (visual analogue scale) and ODI (Oswestry disability index) scores of the patients were recorded. When the demographic data of the patients were analysed, the mean age of the patients was found to be 52. Of the patients, 61.7% were female. In the evaluation of VAS and ODI scores, which we used to measure the efficiency of the procedure, the 6th month values were found to be statistically lower than the pre-procedure values (p&lt;0.05). The first treatment for facet joint syndrome is bed rest and medical treatment. Resistant cases also benefit from physical therapy and intra-articular steroid injection. In patients unresponsive to these treatments, denervation with radiofrequency appears to be an effective method. At least two levels must be performed for the procedure to be successful. Studies have shown that pain decreases in the long term (6-12 months) and quality of life increases. We also obtained similar results in our studies. In conclusion, we think that RF (radiofrequency) can be used as an effective method in cases where other treatments fail.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39850489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Splenic Rupture and Massive Hemoperitoneum Due to Coagulopathy after Atheris Viper Snakebite. 动脉粥样硬化毒蛇咬伤后凝血功能障碍致脾破裂及大量腹膜出血。
Prague medical report Pub Date : 2021-01-01 DOI: 10.14712/23362936.2021.19
Jiří Valenta, Zdeněk Stach, Eva Vagenknechtová, David Hoskovec
{"title":"Splenic Rupture and Massive Hemoperitoneum Due to Coagulopathy after Atheris Viper Snakebite.","authors":"Jiří Valenta,&nbsp;Zdeněk Stach,&nbsp;Eva Vagenknechtová,&nbsp;David Hoskovec","doi":"10.14712/23362936.2021.19","DOIUrl":"https://doi.org/10.14712/23362936.2021.19","url":null,"abstract":"<p><p>Coagulopathy with defibrination is one of symptoms accompanying snakebite envenoming, where life-threatening complications such as massive bleeding and organ hematomas formation can occur. Here, we report a case of hemocoagulation failure due to bite by African Great Lakes bush viper Atheris nitschei with impossibility of specific treatment for absence of antivenom and its life-threatening complication: very rare and unexpected atraumatic splenic rupture with massive hemoperitoneum and necessity of urgent splenectomy.</p>","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39484237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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