Prague medical report最新文献

Actual Problems of Osteoporosis and Osteopenia in Mountainous Regions of the Kyrgyz Republic. 吉尔吉斯共和国山区骨质疏松和骨质减少的实际问题。

Prague medical report Pub Date : 2026-01-01 DOI: 10.14712/23362936.2026.15

Akylbek Shakirov, Tynchtykbek Mamatov, Bakytbek Mamytov, Taalaibek Seiitbekov, Bektur Erkinali Uulu

{"title":"Actual Problems of Osteoporosis and Osteopenia in Mountainous Regions of the Kyrgyz Republic.","authors":"Akylbek Shakirov, Tynchtykbek Mamatov, Bakytbek Mamytov, Taalaibek Seiitbekov, Bektur Erkinali Uulu","doi":"10.14712/23362936.2026.15","DOIUrl":"https://doi.org/10.14712/23362936.2026.15","url":null,"abstract":"The aim of the study was to analyse the incidence of osteoporosis in mountainous regions of Kyrgyzstan, with special emphasis on the study of the influence of altitude on the incidence rate, as well as the identification of factors contributing to its development. For statistical analysis, aimed at assessing the relationship between altitude and the incidence of the disease, the Pearson correlation coefficient was applied. The survey reviewed data from five studies covering regions from altitudes ranging from 779 to 2,420 m above sea level. The incidence varied by region, gender and age group. The results showed no significant association between altitude and incidence of osteoporosis, but a trend towards lower prevalence was observed in high altitude areas, probably due to climatic conditions, physical activity and lifestyle. In addition to altitude, the study looked at other potential factors influencing the development of osteoporosis, including air pollution (PM2.5, NO2, NOX), vitamin D levels and calcium intake. The results of the analysis of osteopenia showed that its incidence and frequency varied depending on age groups and region. In particular, in mountainous areas of Kyrgyzstan, there was a higher prevalence of osteopenia among older people, with the highest rates in urban and foothill regions. The practical significance lies in developing recommendations for osteoporosis prevention in mountainous Kyrgyzstan, improving diagnosis, treatment accessibility, and raising awareness of risk factors.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"127 2","pages":"98-109"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148279046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantification of PDGF-AB and TGF-β1 Proteins in Platelet-rich Plasma Obtained under Different Conditions. 不同条件下富血小板血浆中PDGF-AB和TGF-β1蛋白的定量分析。

Prague medical report Pub Date : 2026-01-01 DOI: 10.14712/23362936.2026.22

Nikoleta Ivanova

{"title":"Quantification of PDGF-AB and TGF-β1 Proteins in Platelet-rich Plasma Obtained under Different Conditions.","authors":"Nikoleta Ivanova","doi":"10.14712/23362936.2026.22","DOIUrl":"https://doi.org/10.14712/23362936.2026.22","url":null,"abstract":"The aim of the study was to determine optimal methods for preparing platelet-rich plasma to maximise the yield of key growth factors, which is essential for standardising clinical applications in regenerative medicine. The study, conducted on 30 healthy volunteers, compared four centrifugation protocols for their effect on protein composition: method 1 (single centrifugation without gel), method 2 (single centrifugation with gel), method 3 (double centrifugation without gel), and method 4 (double centrifugation with gel), followed by activation with calcium gluconate and quantitative analysis. It was found that double centrifugation with a separating gel provided consistently high concentrations of transforming growth factor-β1 (25.17-25.37 ng/ml) without activation, exceeding the values obtained from single centrifugation by 2.4 times. In contrast, single centrifugation with a gel followed by activation resulted in peak concentrations of platelet-derived growth factor-AB (10.59 ± 2.129 ng/ml), which was 44% higher than those achieved with double centrifugation. Statistical analysis confirmed significant differences between the methods (Student's t-test, p<0.05), and correlation analysis revealed an association between average platelet volume (>10.5 fl) and increased yield of platelet-derived growth factor-AB by 22-25%. The findings demonstrate that the maximum bioavailability of TGF-β1 is achieved with double centrifugation using gel, whereas plasma rich in growth factors is obtained by single centrifugation with gel combined with activation. The proposed optimisation enables targeted plasma preparation: double centrifugation with gel without activation for bone regeneration, and single centrifugation with gel with activation for angiogenic procedures, reducing costs by 20% and improving regenerative efficacy.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"127 3","pages":"151-162"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma Cell Vulvitis (Zoon's Vulvitis): A Rare Case Report with Emphasis on Diagnostic Challenge. 浆细胞性外阴炎（Zoon's外阴炎）：罕见病例报告，强调诊断挑战。

Prague medical report Pub Date : 2026-01-01 DOI: 10.14712/23362936.2026.20

Gyanendra Singh, Urmila Sunda, Vishal Tayde, Ridhhi Parmar

引用次数: 0

Liver Transplantation in the Era of Artificial Intelligence: Surgical Innovation, Risk Stratification, and Patient-centred Care. 人工智能时代的肝移植：手术创新、风险分层和以患者为中心的护理。

Prague medical report Pub Date : 2026-01-01 DOI: 10.14712/23362936.2026.11

Aditi Naidu Patti, Vinod Kumar Mugada, Devika Boddu, Benarjee Veera Mani Kishore Boddeda, Srinivasa Rao Yarguntla

{"title":"Liver Transplantation in the Era of Artificial Intelligence: Surgical Innovation, Risk Stratification, and Patient-centred Care.","authors":"Aditi Naidu Patti, Vinod Kumar Mugada, Devika Boddu, Benarjee Veera Mani Kishore Boddeda, Srinivasa Rao Yarguntla","doi":"10.14712/23362936.2026.11","DOIUrl":"https://doi.org/10.14712/23362936.2026.11","url":null,"abstract":"Liver transplantation continues to be the most effective and, in many cases, the only therapeutic recourse for individuals suffering from end-stage liver disease, select hepatocellular malignancies, and uncommon hepatic disorders. Alongside clinical advancements, artificial intelligence (AI) is increasingly being explored for its capacity to support clinical decision-making at all stages of the transplant continuum. In this narrative review, we synthesize recent advancements in liver transplantation and examine the expanding role of AI throughout the process. AI-driven technologies have demonstrated the ability to improve donor-recipient compatibility, evaluate graft function, interpret diagnostic images, and support post-surgical monitoring. Still, obstacles such as limited data availability, bias within algorithms, and unresolved ethical questions continue to pose challenges. At the same time, innovations like machine perfusion, synthetic grafts, and predictive models are helping refine surgical procedures and post-transplant care. Introducing AI into the transplant workflow may boost accuracy, fairness, and healthcare quality. A patient-centred approach that incorporates modern technology, mental health resources, and ethical responsibility will be essential for the future of liver transplantation.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"127 2","pages":"69-80"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148279219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aesthetic Chondrolaryngoplasty in Transgender Women. 变性女性的美学软骨成形术。

Prague medical report Pub Date : 2026-01-01 DOI: 10.14712/23362936.2026.14

Ivo Němec, Michal Mikolaj

引用次数: 0

Using Osstell to Monitor Primary Implant Stability: A Clinical Case Report. 应用Osstell监测初级种植体稳定性：一个临床病例报告。

Prague medical report Pub Date : 2026-01-01 DOI: 10.14712/23362936.2026.19

Giovana Zambuza Silva, Daniela Micheline Dos Santos, João Paulo do Vale Souza, Marcelo Coelho Goiato

引用次数: 0

Evaluation of Glasgow Microenvironment Score in Colorectal Carcinoma and Its Association with Prognostic Markers. 结直肠癌格拉斯哥微环境评分的评价及其与预后标志物的关系。

Prague medical report Pub Date : 2026-01-01 DOI: 10.14712/23362936.2026.2

Adil Aziz Khan, Sana Ahuja, Mukul Singh, Sufian Zaheer

{"title":"Evaluation of Glasgow Microenvironment Score in Colorectal Carcinoma and Its Association with Prognostic Markers.","authors":"Adil Aziz Khan, Sana Ahuja, Mukul Singh, Sufian Zaheer","doi":"10.14712/23362936.2026.2","DOIUrl":"10.14712/23362936.2026.2","url":null,"abstract":"Colorectal carcinoma (CRC) ranks among the most prevalent cancers worldwide, contributing significantly to cancer-related mortality. Despite advancements in understanding CRC's pathophysiology, traditional staging systems like tumour, node, and metastasis (TNM) lack comprehensive prognostic indicators, particularly regarding tumour microenvironment and host-related factors. The Glasgow Microenvironment Score (GMS) integrates inflammatory cell infiltration and stromal percentage, offering a potentially more comprehensive prognostic tool. This study aims to evaluate GMS in CRC and its correlation with established clinicopathological prognostic markers and pathological tumour, node, and metastasis (pTNM) staging. A retrospective study involving 68 CRC patients who underwent curative surgery between January 2022 and March 2024. Haematoxylin and eosin-stained sections were assessed for inflammatory infiltration (Klintrup-Mäkinen score) and tumour stromal percentage, forming the GMS. Statistical analyses evaluated associations between GMS and clinicopathological markers, including lymphovascular invasion (LVI), perineural invasion (PNI), nodal status, and histological grading. The study found significant correlations between GMS and poor prognostic markers. High GMS was associated with increased LVI, PNI, and nodal involvement. GMS showed significant associations with LVI (p<0.0003), PNI (p<0.026), and nodal involvement (p<0.002). GMS serves as a robust prognostic indicator in CRC, correlating with key pathological features that influence patient outcomes. This scoring system could enhance traditional prognostic models, aiding in better stratification of CRC patients for therapeutic interventions.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"127 1","pages":"15-20"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating Adherence to the 2021 Surviving Sepsis Campaign Guidelines for Sepsis and Septic Shock Management in Intensive Care Units: A Prospective Observational Study. 评估2021年脓毒症生存运动指南对重症监护室脓毒症和脓毒性休克管理的依从性：一项前瞻性观察研究

Prague medical report Pub Date : 2026-01-01 DOI: 10.14712/23362936.2026.12

Vinod Kumar Mugada, Greshma Ratna Priyanka Saragadam, Aishwarya Rajana, Ramanjaneyulu Arikitamula

{"title":"Evaluating Adherence to the 2021 Surviving Sepsis Campaign Guidelines for Sepsis and Septic Shock Management in Intensive Care Units: A Prospective Observational Study.","authors":"Vinod Kumar Mugada, Greshma Ratna Priyanka Saragadam, Aishwarya Rajana, Ramanjaneyulu Arikitamula","doi":"10.14712/23362936.2026.12","DOIUrl":"10.14712/23362936.2026.12","url":null,"abstract":"This study evaluated adherence to the 2021 Surviving Sepsis Campaign (SSC) guidelines for managing sepsis and septic shock in a tertiary intensive care unit (ICU), aiming to identify deviations from recommended practices and their clinical implications. A prospective observational study was conducted over six months in the ICU of an academic tertiary-care hospital. Patients aged 50-80 years with sepsis or septic shock were enrolled (n=138). Adherence to 17 SSC 2021 recommendations was assessed using structured case report forms and electronic medical records, and clinical parameters, therapeutic interventions, and outcomes were analysed to determine adherence rates and areas of nonadherence. Adherence was high for foundational resuscitative measures, including early administration of intravenous crystalloids (100%), maintenance of mean arterial pressure (MAP) ≥ 65 mm Hg (100%), and comprehensive medication reconciliation (100%). In contrast, adherence to the recommendation against using the Quick Sequential Organ Failure Assessment as a sole screening tool was 0%. Adherence was suboptimal for low-molecular-weight heparin as the preferred agent for venous thromboembolism prophylaxis (57.1%) and for lung-protective ventilation in acute respiratory distress syndrome (75%). ICU mortality was 16.7%, and the 30-day readmission rate was 23.9%. While adherence to core resuscitative components of the SSC guidelines was robust, important gaps persisted in diagnostic screening practices, thromboprophylaxis choice, and ventilatory strategies, highlighting actionable targets for quality improvement.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"127 2","pages":"81-88"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148279161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Does Capsular Distension Pain Manifest in Patients with Anterior Disc Dislocation with Reduction of Temporomandibular Joint? 前盘脱位伴颞下颌关节复位患者囊膜膨胀性疼痛的表现？

Prague medical report Pub Date : 2026-01-01 DOI: 10.14712/23362936.2026.13

Vladimír Machoň, Michal Beňo, Vasilis Vlachopulos, Martin Bartoš, René Foltán

{"title":"How Does Capsular Distension Pain Manifest in Patients with Anterior Disc Dislocation with Reduction of Temporomandibular Joint?","authors":"Vladimír Machoň, Michal Beňo, Vasilis Vlachopulos, Martin Bartoš, René Foltán","doi":"10.14712/23362936.2026.13","DOIUrl":"https://doi.org/10.14712/23362936.2026.13","url":null,"abstract":"Joint effusion (JE) refers to the presence of a pathological collection of fluid in the joint space, and JE is one of the symptoms of the inflammatory process in the temporomandibular joint (TMJ) and it is associated with the presence of TMJ pain. The authors of this study focused on the ultrasonographic evaluation of TMJ capsular distension, capsular width in patients with unilateral anterior disc dislocation. The cohort included 200 patients, 169 women and 31 men, with a mean age of 34.3 years (range 11-82 years). All patients were diagnosed with disc dislocation with reduction. 102 patients were completely pain free, 98 patients reported pain localized to the TMJ area. 28 patients perceived their pain as persistent in the last week before the examination, 70 patients perceived their pain as irregular. The results showed that capsular distension was demonstrably greater in patients with pain than in patients without pain. The increase in capsular distension is not affected by whether the pain is persistent or irregular. Capsular distension is enhanced in patients with TMJ palpation pain and painful dynamic testing. The authors confirm the use of ultrasonography as an ideal method for diagnosing JE. Also an association between the presence of JE and pain in patients with disc dislocation has been demonstrated. Painful lateral palpation and painful dynamic test are clinical signs of JE and thus signs of an intra articular inflammatory process in patients with TMJ pain.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"127 2","pages":"89-93"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148279201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Copper Tongue Scraper and Toothbrush on Morning Halitosis in Dentistry Students: A Brief Clinical Study. 铜刮舌器和铜牙刷对牙科学生晨间口臭影响的临床研究。

Prague medical report Pub Date : 2026-01-01 DOI: 10.14712/23362936.2026.5

Clóvis Lamartine de Moraes Melo Neto, Marcelo Coelho Goiato, Daniela Micheline Dos Santos, Stefan Fiuza de Carvalho Dekon

{"title":"Influence of Copper Tongue Scraper and Toothbrush on Morning Halitosis in Dentistry Students: A Brief Clinical Study.","authors":"Clóvis Lamartine de Moraes Melo Neto, Marcelo Coelho Goiato, Daniela Micheline Dos Santos, Stefan Fiuza de Carvalho Dekon","doi":"10.14712/23362936.2026.5","DOIUrl":"10.14712/23362936.2026.5","url":null,"abstract":"The objective was to evaluate the influence of two tongue cleaning methods (copper tongue scraper and toothbrush) on morning halitosis in dental students. Thirteen dental students were included. After training, the first participant took the halimeter home and used it for 6 days. On the first three days, halitosis was measured immediately after the participant woke up in the morning. The night before each of these first three days, before going to sleep, the participant cleaned their mouth with dental floss and a soft-bristled toothbrush. The individual's same soft-bristled toothbrush was also used to brush his tongue. Only one halitosis measurement was taken per day and the value was recorded each day (toothbrush group). On the fourth, fifth and sixth day, the same process was carried out, but the night before measuring halitosis, a copper tongue scraper was used to clean the participants' tongue. Only one halitosis measurement was taken per day and the value was recorded each day (tongue scraper group). Subsequently, for each participant, the highest halitosis value of the first three days (toothbrush group) was chosen, as well as the highest halitosis value of the last three days (tongue scraper group). The Wilcoxon test was used to compare the two groups (P<0.05). The halitosis value (median) in the toothbrush group was significantly higher than that in the tongue scraper group. Only the tongue scraper group showed a clinically acceptable halitosis value (imperceptible odour). Therefore, the copper tongue scraper is more recommended for cleaning the tongue.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"127 1","pages":"34-38"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0