Prague medical report最新文献_第2页

Intussusception by Colonic Lipoma in a 51-year-old Patient - A Case Report. 51岁结肠脂肪瘤致肠套叠1例报告。

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.24

Marija Zubčić, Florian Stephan Bienenfeld, Alessio Sciacqua, Manuela Montatore, Gianmichele Muscatella, Giuseppe Guglielmi

引用次数: 0

Glucocorticoid Remediable Aldosteronism in a Family with a Strong History of Cerebral Aneurysms and Hypertension. 糖皮质激素可治疗的醛固酮增多症家族与强烈的脑动脉瘤和高血压病史。

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.23

Jan Zeman, Crystal Kamilaris

引用次数: 0

Morphometry of Iliac Bones - A Useful Guide for Harvesting Bone Grafts. 髂骨形态计量学-骨移植收获的有用指南。

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.2

Nidhi Mangla, Surbhi Wadhwa, Sumit Sural, Sabita Mishra, Neelam Vasudeva

{"title":"Morphometry of Iliac Bones - A Useful Guide for Harvesting Bone Grafts.","authors":"Nidhi Mangla, Surbhi Wadhwa, Sumit Sural, Sabita Mishra, Neelam Vasudeva","doi":"10.14712/23362936.2025.2","DOIUrl":"10.14712/23362936.2025.2","url":null,"abstract":"Iliac crest is common site for harvesting bone grafts. Morphometry of iliac crest is of vital importance in orthopedic surgery. Measurements were done on male (n=85) and female (n=85) hip bones. Length of iliac crest, thickness of iliac crest and ilium were measured. Thickness was measured at pre-defined points on crest and ilium 2 cm apart starting from anterior superior iliac spine (ASIS). Ilium was measured at a depth of 2.5 cm from crest. Statistical analysis was done. Iliac crests were longer in male bones. Ventral iliac crest was thickest at 6 cm from ASIS in both sexes. While iliac crest bore minimum thickness at 12 cm and 10 cm from ASIS in male and female bones respectively, however at 2.5 cm below iliac crest surface ilium was thickest at 4 cm from ASIS and at ASIS in male and female bones respectively. In case of male bones, dorsal part of iliac crest was thickest at 2.15 ± 1.29 cm from posterior superior iliac spine (PSIS) while in females it was at 1.78 ± 1.31 cm from PSIS. In dorsal part of ilium, it was observed at 2.31 ± 1.47 cm and 1.9 ± 1.79 cm from PSIS for male and female bones respectively. This study provided detailed variable morphometry and significant sexual dimorphism observed in iliac crest and ilium. Thickest safe zones in both sexes are a useful guide for harvesting appropriate bone grafts.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"126 1","pages":"9-16"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating Diagnostic Complexity in Hailey-Hailey Disease: A Case Report with Clinical-histopathological Correlation. 导航诊断复杂性黑利-黑利病：一个病例报告与临床-组织病理学的相关性。

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.27

Parth R Goswami, Gyanendra Singh, Varniraj Patel, Yashdeep Singh Pathania

{"title":"Navigating Diagnostic Complexity in Hailey-Hailey Disease: A Case Report with Clinical-histopathological Correlation.","authors":"Parth R Goswami, Gyanendra Singh, Varniraj Patel, Yashdeep Singh Pathania","doi":"10.14712/23362936.2025.27","DOIUrl":"https://doi.org/10.14712/23362936.2025.27","url":null,"abstract":"Hailey-Hailey disease (HHD), also known as benign familial pemphigus, is a rare autosomal dominant genodermatosis caused by mutations in the ATP2C1 gene. These mutations impair keratinocyte adhesion and disrupt calcium homeostasis, leading to characteristic clinical and histopathological findings. Herein, we present the case of a 50-year-old male with a ten-year history of recurrent, pruritic, erythematous erosions and maceration in the left axilla and groin. Clinical examination revealed no systemic comorbidities or relevant family history. Histopathological analysis of skin biopsy demonstrated hallmark features, including epidermal hyperkeratosis, suprabasal and intraepidermal clefting, and acantholysis with the distinctive \"dilapidated brick wall\" appearance, confirming the diagnosis of HHD. Differential diagnoses, including intertrigo, Darier disease, and pemphigus vegetans, were excluded based on clinical and histological findings. The patient was managed with immunomodulators and topical antibiotics, with follow-up care focused on symptom alleviation and infection prevention. This case underscores the importance of correlating clinical and histopathological findings in diagnosing HHD and differentiating it from other intertriginous dermatoses. Despite its chronic and recurrent nature, timely and accurate diagnosis, coupled with individualized management, significantly enhances patient outcomes. This report also highlights the unique histological feature of acantholysis resembling a \"dilapidated brick wall\", pivotal in distinguishing HHD. Advances in understanding the molecular pathogenesis of ATP2C1 mutations hold promise for the development of targeted therapies, offering hope for more effective management of this challenging condition in the future.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"126 3","pages":"167-170"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orofacial Infection Number Decrease during COVID-19 Pandemic. COVID-19大流行期间口面部感染人数减少。

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.21

Bronislava Dvoranová, Michal Vavro, Martin Selvek, Natália Gurčíková, David Med, Ladislav Czakó

{"title":"Orofacial Infection Number Decrease during COVID-19 Pandemic.","authors":"Bronislava Dvoranová, Michal Vavro, Martin Selvek, Natália Gurčíková, David Med, Ladislav Czakó","doi":"10.14712/23362936.2025.21","DOIUrl":"https://doi.org/10.14712/23362936.2025.21","url":null,"abstract":"This study analyses trends in orofacial infection hospital admissions at a single department, focusing on the impact of the COVID-19 pandemic. Admission counts fluctuated over the study period, but 2020 (n=65) and 2021 (n=56) showed a statistically significant decrease, falling slightly outside the 95% confidence interval of a linear trend established for 2014-2019. In 2022, the number of admitted patients (n=63) remained below average but within the confidence interval, while 2023 saw an increase to 97 patients. A notable shift in treatment methods was observed during the pandemic years. The proportion of patients treated with extraoral revision increased, with the most pronounced disparity in 2020 (n=40:10, 80%:20% extraoral revision-to-local treatment ratio). Statistical analysis (chi-square test, p<0.001) confirmed significant differences across the years. Comparing COVID-19-affected years (2020-2022) with non-COVID years (2014-2019 and 2023), 73% of patients were treated with extraoral revision during the pandemic, compared to 49% in non-COVID years (p<0.001). Additionally, only 44 patients were treated with antibiotics alone, whereas 75 would have been expected in the absence of COVID-19-related disruptions. These findings suggest that the pandemic influenced both the number of orofacial infection admissions and the treatment approach.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"126 3","pages":"139-143"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eccrine Hidrocystoma of Eyelid Masquerading as Epidermal Inclusion Cyst: A Rare Case Report with Review of Literature. 眼睑汗液囊肿伪装表皮包涵性囊肿1例并文献复习。

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.7

Gyanendra Singh, Mamta Singh, Palak Thakkar, Parth Goswami

引用次数: 0

A Comprehensive Guide to Typhoidal Anemia. 伤寒性贫血综合指南。

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.10

Jayanta Deb, Suddha Sattwa Bandyopadhyay, Sanjit Debnath, Saurabh Gupta

{"title":"A Comprehensive Guide to Typhoidal Anemia.","authors":"Jayanta Deb, Suddha Sattwa Bandyopadhyay, Sanjit Debnath, Saurabh Gupta","doi":"10.14712/23362936.2025.10","DOIUrl":"https://doi.org/10.14712/23362936.2025.10","url":null,"abstract":"Typhoid fever, caused primarily by Salmonella Typhi and Paratyphi, stands as a significant global health concern, with complications extending beyond the typical gastrointestinal manifestations. This review systematically examines the intricate relationship between typhoid fever and hematologic complications, collectively referred to as typhoidal anemia. Hematological abnormalities, including changes in blood profiles and bone marrow responses, are scrutinized, providing a comprehensive understanding of the disease's impact on physiological systems. Specific populations, such as immunocompromised individuals, sickle cell anemia patients, and children in resource-limited settings, reveal varied susceptibilities and outcomes. Complications, such as psoas abscess and secondary hemophagocytic lymphohistiocytosis, are explored, highlighting the multifaceted nature of the disease. The distinct contributions of Salmonella Typhi and Paratyphi to anemia are elucidated, shedding light on the pathophysiological mechanisms involved. Global prevalence and epidemiological variations offer valuable perspectives, underscoring the importance of regional nuances in disease manifestation. Challenges in accurate diagnosis and treatment limitations are acknowledged, emphasizing the need for continued research to enhance diagnostic precision and therapeutic strategies. Insights into long-term effects, prognosis, and the influence of host factors contribute to a holistic understanding of typhoidal anemia. The review concludes by identifying critical gaps in knowledge, advocating for ongoing research initiatives and heightened awareness campaigns. The synthesis of diverse findings provides a comprehensive overview of typhoidal anemia, underscoring the imperative of continued research and awareness for improved patient care and global public health.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"126 2","pages":"55-62"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of Ki-67 Expression with the Stage of Disease in Patients of Colorectal Carcinoma. 结直肠癌患者Ki-67表达与疾病分期的关系

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.12

Ashutosh Nagpal, Poras Chaudhary

{"title":"Correlation of Ki-67 Expression with the Stage of Disease in Patients of Colorectal Carcinoma.","authors":"Ashutosh Nagpal, Poras Chaudhary","doi":"10.14712/23362936.2025.12","DOIUrl":"https://doi.org/10.14712/23362936.2025.12","url":null,"abstract":"Colorectal carcinoma (CRC) is a multifactorial disease process with several factors influencing prognosis. CRC is associated with the expression of multiple cell proliferating markers such as Ki-67/MIB-1. This study was aimed to examine possible correlations between Ki-67 expression and the stage of colorectal carcinoma. This was a single centre prospective study including 93 patients who underwent surgery for colorectal carcinoma. Expression of Ki-67 was assessed by immunohistochemistry on formalin-fixed paraffin-embedded tumour tissue blocks. Categorical variables data were presented as number with corresponding percentage. Continuous data were analysed using parametric tests as applicable and categorical data using nonparametric tests. The level of significance α = 0.05 and P-value < 0.05 was considered statistically significant. The average Ki-67 expression was 77.66% (SD [standard deviation] = 9.68%) with a range of 60 to 90%. Patients with nodal involvement and larger size had a higher Ki-67 expression. To assess statistical significance, the cut-off for Ki-67 expression was set at 70%. Of 66, 48 (72.7%) adenocarcinomas and 12/18 (66.66%) mucinous adenocarcinomas had Ki-67 expression above cut-off as compared to signet ring cell variety. Ki-67 expression in colorectal carcinoma signifies mitotic activity of the tumour. Thus, it could be used as an adjunct to the existing diagnostic arsenal to help overcome its limitation in gauging the functional status of tissues.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"126 2","pages":"75-81"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ormond's Disease - 26 Years of Experience at One Centre. 奥蒙德病-在一个中心26年的经验。

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.1

Miroslav Průcha, Pavel Zdráhal, Radek Kříž, Alena Šnajdrová, Luděk Voska

{"title":"Ormond's Disease - 26 Years of Experience at One Centre.","authors":"Miroslav Průcha, Pavel Zdráhal, Radek Kříž, Alena Šnajdrová, Luděk Voska","doi":"10.14712/23362936.2025.1","DOIUrl":"10.14712/23362936.2025.1","url":null,"abstract":"Ormond's disease is a systemic autoimmune disease with serious complications. We present our retrospective analysis of 83 patients diagnosed with and treated for idiopathic retroperitoneal fibrosis (Ormond's disease) in our department from 1997 to 2023. In this retrospective study, we analysed the diagnostic approaches, the clinical history and surgical and immunosuppressive therapies, and their subsequent effects on our patients. Patients with established disease activity were given immunosuppressive treatment, using corticosteroids alone or in combination with azathioprine, in patients with exacerbation of the disease mycophenolate mofetil. Three patients with Ormond's disease and systemic complications (IgG4-related disease) were treated with rituximab. In the entire cohort, 83 patients received immunosuppressive therapy; the next 5 patients did not receive this treatment because they did not present inflammatory activity from the disease. In these 83 patients, computed tomography showed that immunosuppressive treatment resulted in partial or complete regression of the inflammatory infiltrate. Out of the 83 patients, 10 patients experienced disease exacerbation 7 and 24 months after the immunosuppressive treatment was discontinued. The follow-up ranged from 24 months to 26 years.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"126 1","pages":"3-8"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating the Risks of Dental Aspiration in Older Adults: A Case Study of Prompt Diagnosis and Intervention. 引导老年人误吸牙的风险：及时诊断和干预的案例研究。

Prague medical report Pub Date : 2025-01-01 DOI: 10.14712/23362936.2025.13

Louise Cardoso Fava Ferreira Dos Santos, Marcelo de Queiroz Pereira da Silva, Márcio Luís Duarte

{"title":"Navigating the Risks of Dental Aspiration in Older Adults: A Case Study of Prompt Diagnosis and Intervention.","authors":"Louise Cardoso Fava Ferreira Dos Santos, Marcelo de Queiroz Pereira da Silva, Márcio Luís Duarte","doi":"10.14712/23362936.2025.13","DOIUrl":"https://doi.org/10.14712/23362936.2025.13","url":null,"abstract":"Foreign body aspiration is a significant cause of respiratory distress in geriatric patients, often leading to severe complications if not promptly identified and treated. Dental materials account for approximately 15-20% of foreign body aspirations in adults, with symptoms that can include dyspnea, localized wheezing, and, in some cases, cyanosis and pneumonia. We report the case of a 60-year-old man who aspirated a dental crown, resulting in shortness of breath. A computed tomography scan revealed the crown lodged in the left main bronchus. The patient underwent successful bronchoscopy for foreign body removal and experienced a full recovery without complications. Neurological conditions, such as epilepsy or Parkinson's disease, increase the risk of aspiration, particularly in elderly patients, in which symptoms may be misdiagnosed due to their nonspecific presentation. While the right bronchus is more commonly affected due to anatomical structure, foreign body aspiration in the left bronchus also warrants attention. This case underscores the importance of rapid imaging and bronchoscopy to reduce the risk of morbidity and mortality from aspiration events. Increased awareness and timely intervention are essential for improving patient outcomes in cases of dental and other foreign body aspirations in older populations.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"126 2","pages":"82-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0