Prague medical report最新文献_第4页

Raised First Trimester Thyroid Peroxidase Antibodies May Predict First Trimester Miscarriage: A Case Control Study. 怀孕头三个月甲状腺过氧化物酶抗体升高可预测怀孕头三个月流产：病例对照研究。

Prague medical report Pub Date : 2024-01-01 DOI: 10.14712/23362936.2024.3

Boniface Ago, Enya Okpani, Sylvester Abeshi, Lawson Ekpe

{"title":"Raised First Trimester Thyroid Peroxidase Antibodies May Predict First Trimester Miscarriage: A Case Control Study.","authors":"Boniface Ago, Enya Okpani, Sylvester Abeshi, Lawson Ekpe","doi":"10.14712/23362936.2024.3","DOIUrl":"10.14712/23362936.2024.3","url":null,"abstract":"Miscarriages constitute a significant aspect of failed pregnancies and a source of worry for the patient and caregiver. Some of the causes of miscarriages remain unknown. Immunological conditions such as thyroid autoimmunity could play significant roles. Our objective was to determine the relationship between raised thyroid peroxidase antibodies and first trimester miscarriages in a low resource setting. This was a case control study at the Gynaecological Clinic of the University of Calabar Teaching Hospital, Nigeria; from 14th February 2020 to 13th January 2021, involving 145 cases who had first trimester miscarriages, and their matched controls who had apparently normal pregnancies, at same gestational ages. Sera of venous blood from both participants and controls were analysed for thyroid peroxidase antibodies using enzyme-linked immunosorbent assay, and analysed using SPSS version 20, and GraphPad Prism 8.4.3 statistical software. Being a civil servant and low social status had significant odds for first trimester miscarriage. Raised thyroid peroxidase antibodies in the first trimester had 10-fold odds for miscarriage. Odds ratio 10.34, 95% CI: 3.22 to 32.98, P-value = 0.0001. The test had a sensitivity of 89.66% and specificity of 54.41%. The positive predictive value was 17.93%, while the negative predictive value was 97.93% and a likelihood ratio of 1.966. Rising thyroid peroxidase antibodies in early pregnancy could be a predictor for miscarriage. This is so because patients with raised thyroid peroxidase antibodies in the first trimester had a 10-fold risk of having a first trimester miscarriage.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"125 1","pages":"34-46"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Giant Scrotal Neurofibroma in a Child Masquerading as Filariasis: Uncommon Presentation of a Common Disease. 伪装成丝虫病的儿童巨大阴囊神经纤维瘤：一种常见疾病的罕见表现。

Prague medical report Pub Date : 2024-01-01 DOI: 10.14712/23362936.2024.5

Anurag Singh, Gyanendra Singh, Anuragani Verma, Yogendra Narayan Verma

引用次数: 0

Ruptured Liver Abscess Post Severe COVID-19 Infection: A Case Report. 严重 COVID-19 感染后的肝脓肿破裂：病例报告。

Prague medical report Pub Date : 2024-01-01 DOI: 10.14712/23362936.2024.25

Mohd Firdaus Mohd Isa, Faiz Najmuddin Ghazi, Siti Rahmah Hashim Isa Merican, Ahmad Zuraimi Zulkifli, Premjeet Singh

引用次数: 0

Genetic Variations of Angiotensinogen, Angiotensin Converting Enzyme, and Angiotensin Type 1 Receptor with the Risk of Pulmonary Tuberculosis. 血管紧张素原、血管紧张素转换酶和血管紧张素 1 型受体的基因变异与肺结核的风险。

Prague medical report Pub Date : 2024-01-01 DOI: 10.14712/23362936.2024.1

Hamidreza Kouhpayeh, Mohammad Naderi, Zahra Mohammadghasemipour, Gholamreza Bahari, Nastaran Elahian, Mohsen Taheri, Mohammad Hashemi

{"title":"Genetic Variations of Angiotensinogen, Angiotensin Converting Enzyme, and Angiotensin Type 1 Receptor with the Risk of Pulmonary Tuberculosis.","authors":"Hamidreza Kouhpayeh, Mohammad Naderi, Zahra Mohammadghasemipour, Gholamreza Bahari, Nastaran Elahian, Mohsen Taheri, Mohammad Hashemi","doi":"10.14712/23362936.2024.1","DOIUrl":"10.14712/23362936.2024.1","url":null,"abstract":"There is little data regarding the impact of renin-angiotensin system (RAS) gene polymorphisms on tuberculosis. The current study designed to survey the possible association between RAS polymorphisms and the risk of pulmonary tuberculosis (PTB) in a sample of the southeast Iranian population. This case-control study was done on 170 PTB patients and 170 healthy subjects. The AGT rs699 C>T, ACE rs4341 C>G and AT1R rs5186 C>A variants were genotyped using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and ACE rs4646994 (287bp I/D) variant by PCR method. Regarding AT1R rs5186 A>C polymorphism, the findings revealed that AC genotype and C allele significantly decreased the risk of PTB (OR=0.39, 95% CI=0.22-0.67, p=0.001, and OR=0.53, 95% CI=0.25-0.72, p=0.002, C vs. A, respectively). The TC genotype and C allele of AGT rs699 T>C significantly associated with decreased the risk of PTB (OR=0.45, 95% CI=0.28-0.74, p=0.002, TC vs. TT and OR=0.51, 95% CI=0.32-0.80, p=0.005, C vs. T, respectively). The ID genotype of ACE 287bp I/D significantly increased the risk of PTB (OR=1.88, 95% CI=1.12-3.17, p=0.017). Our finding did not support an association between ACE rs4341 C>G variant and the risk of PTB. In summary, the findings revealed an association between AT1R rs5186 A>C, AGT rs699 T>C and ACE 287bp I/D polymorphisms and the risk of PTB in a sample of the southeast Iranian population. Further investigation with higher sample sizes and diverse ethnicities are required to confirm our findings.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"125 1","pages":"5-14"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iatrogenic Chronic Abdominal Pain in a Geriatric Patient: A Case Report. 一名老年患者的先天性慢性腹痛：病例报告。

Prague medical report Pub Date : 2024-01-01 DOI: 10.14712/23362936.2024.9

Apichai Wattanapisit, Natthawan Pankamnerd, Sanhapan Wattanapisit

引用次数: 0

Pharmacokinetic-based Dosing Individualization of Mycophenolate Mofetil in Solid Organ Transplanted Patients. 基于药代动力学对实体器官移植患者进行霉酚酸酯剂量个体化治疗

Prague medical report Pub Date : 2024-01-01 DOI: 10.14712/23362936.2024.18

Sara Merdita, Pavel Ryšánek, Jan Miroslav Hartinger, Ondřej Slanař, Martin Šíma

引用次数: 0

Cocaine-induced Movement Disorder: A Literature Review. 可卡因诱发的运动障碍：文献综述。

Prague medical report Pub Date : 2024-01-01 DOI: 10.14712/23362936.2024.19

Vishnu Vardhan Byroju, Jamir Pitton Rissardo, Ícaro Durante, Ana Letícia Fornari Caprara

{"title":"Cocaine-induced Movement Disorder: A Literature Review.","authors":"Vishnu Vardhan Byroju, Jamir Pitton Rissardo, Ícaro Durante, Ana Letícia Fornari Caprara","doi":"10.14712/23362936.2024.19","DOIUrl":"https://doi.org/10.14712/23362936.2024.19","url":null,"abstract":"This study aims to describe movement disorders secondary to cocaine use. To our knowledge, while these presentations have been previously reported in the literature, a comprehensive review has not been published yet. We searched six databases from 1986 to 2022 without language restriction. Case reports, case series, and literature reviews have been analysed to find associations between cocaine use and movement disorders. The present study encompasses epidemiology, clinical manifestations, pathophysiology, and diagnostic challenges of abnormal movements associated with cocaine use. This review highlights the importance of proper initial evaluation and investigation taking into account the broad spectrum of differential diagnoses and exclusion of primary movement disorders. The role of the dopaminergic system in movement disorders is reviewed. Cocaine use is associated with movement disorders such as dystonia, parkinsonism, akathisia, and tics. The complex interaction of multiple factors, including other neurological conditions, such as Tourette syndrome, and additional substances of abuse is discussed. The presentation of these manifestations is often heterogeneous and does not follow a specific pattern. In this way, future research is needed to improve our understanding of the pathophysiological mechanisms and develop novel drug targets for these disorders. Increased awareness among the general public and policymakers could translate into reduced stigma and improved care.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"125 3","pages":"195-219"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central Pleomorphic Adenoma of Mandible Mimicking Ameloblastoma - A Rare Case Report. 模仿釉母细胞瘤的下颌骨中央多形性腺瘤--罕见病例报告。

Prague medical report Pub Date : 2024-01-01 DOI: 10.14712/23362936.2024.14

Ravindra Manerikar, Amit Mani, Manas Bajpai, Shyam Reddy Karakalla

引用次数: 0

A Rare Case of Breast Carcinoma: An Entity Posing Cytological Challenge. 一例罕见的乳腺癌：一个对细胞学构成挑战的实体。

Prague medical report Pub Date : 2024-01-01 DOI: 10.14712/23362936.2024.31

Ruchi Nagpal, Harshi Dhingra, Nageshwar Rao Suragani, Kshitija Kasturi, Asif Baliyan

引用次数: 0

The Impact of the COVID-19 Pandemic on Dental Education in the Czech Republic: Students' Perception of Hybrid Clinical Education and Psychosocial Impacts, a Retrospective Study. COVID-19大流行对捷克共和国牙科教育的影响：学生对混合临床教育和心理社会影响的看法：一项回顾性研究

Prague medical report Pub Date : 2024-01-01 DOI: 10.14712/23362936.2024.29

Lenka Vavřičková, Jan Schmidt, Radovan Slezák, Eva Čermáková, Christos Micopulos, Bára Malíková, Martin Kapitán

{"title":"The Impact of the COVID-19 Pandemic on Dental Education in the Czech Republic: Students' Perception of Hybrid Clinical Education and Psychosocial Impacts, a Retrospective Study.","authors":"Lenka Vavřičková, Jan Schmidt, Radovan Slezák, Eva Čermáková, Christos Micopulos, Bára Malíková, Martin Kapitán","doi":"10.14712/23362936.2024.29","DOIUrl":"https://doi.org/10.14712/23362936.2024.29","url":null,"abstract":"The COVID-19 pandemic significantly impacted educational methods worldwide, particularly in dental and general medicine education. This study retrospectively analyzes students' perceptions of hybrid theoretical and practical teaching in the Dentistry program during the pandemic at three medical faculties of Charles University in the Czech Republic. A total of 418 students were surveyed regarding their views on hybrid education, concerns about COVID-19, and the pandemic's psychosocial and academic effects. The study revealed notable differences based on faculty location, gender, year of study, language of instruction, and the phase of study affected. Students from smaller faculties (Hradec Kralove and Pilsen) preferred online education and did not report a significant reduction in lectures. Compensatory block teaching post-pandemic was effective but less preferred, especially among women. Men found online communication more challenging than women. Czech-speaking students rated online teaching more effective than those studying in English and compensated for clinical skill gaps by participating in more internships. Future online education methods should address the unique needs of these groups.","PeriodicalId":35490,"journal":{"name":"Prague medical report","volume":"125 4","pages":"324-338"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0