Jornal Brasileiro de Patologia e Medicina Laboratorial最新文献_第8页

O valor do jejum no diagnóstico da deficiência de acil-CoA desidrogenase de cadeia média 禁食在诊断中链酰基辅酶a脱氢酶缺乏中的价值

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI: 10.5935/1676-2444.20200011

C. Vargas, Marion Deon, A. Sitta, D. M. Coelho, P. Silva, Larissa Murussi, L. V. Fleith, Luis Pablo Gravina, C. Crespo, Moacir Wajner, M. Sanseverino

引用次数: 0

Vulvar melanocytic nevus: case report 外阴黑色素细胞痣1例

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI: 10.5935/1676-2444.20200045

M. Almeida, Berenice A. Coelho

引用次数: 0

Immunopathological mechanisms involved in SARS-CoV-2 infection SARS-CoV-2感染的免疫病理机制

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI: 10.5935/1676-2444.20200056

S. B. Brito, Isaque Oliveira Braga, M. Moraes, C. Cunha, S. C. Leão, Iukary Takenami

{"title":"Immunopathological mechanisms involved in SARS-CoV-2 infection","authors":"S. B. Brito, Isaque Oliveira Braga, M. Moraes, C. Cunha, S. C. Leão, Iukary Takenami","doi":"10.5935/1676-2444.20200056","DOIUrl":"https://doi.org/10.5935/1676-2444.20200056","url":null,"abstract":"ABSTRACT Introduction: Coronavirus disease 2019 (Covid-19) has become a global health emergency. Although many scientific advances have been achieved over the last few months, the knowledge about how the etiologic agent SARS-CoV-2 interacts with the host's immune system, regulating the pathogenesis and the outcome of the disease, is not yet fully understood. Objective: This is a narrative literature review to discuss the available evidence on modes of transmission and the main immunopathological mechanisms involved in SARS-CoV-2 infection. Material and method: A search in the indexed journals was carried out in the PubMed/MEDLINE database, during the period from January to May 2020. The following descriptors were used in the research: Covid-19, SARS-CoV-2, transmission, immunity, immunopathogenesis, and pathogenesis. Results and discussion: Transmission of SARS-CoV-2 occurs through contact with airway secretions from a symptomatic patient. However, scientific evidence encourages transmission by asymptomatic and/or oligosymptomatic patients. Immunopathological studies suggest that the hypercytokinaemia promotes lung tissue damage and, subsequently, organ and system involvement, leading to decompensation, organ dysfunction and death. Regarding the humoral response, the high titers of B lymphocytes and antibodies, traditionally, correlated with the protection of the host, may be associated with the severity of the disease by SARS-CoV-2. Conclusion: The host's immune response is determinant in the pathogenesis of Covid-19. However, further in vivo and/or in vitro studies are needed to elucidate the pathogenic mechanisms of SARS-CoV-2 and, thus, assist in the development of a vaccine and/or therapeutic target.","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71117503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Performance evaluation of HIV infection diagnostic tests 艾滋病毒感染诊断检测的性能评价

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI: 10.5935/1676-2444.20200024

M. Castejon, Rosemeire Yamashiro, Carmem Aparecida F. Oliveira, E. Mata, L. Brigido, M. Guimarães, M. Veras

{"title":"Performance evaluation of HIV infection diagnostic tests","authors":"M. Castejon, Rosemeire Yamashiro, Carmem Aparecida F. Oliveira, E. Mata, L. Brigido, M. Guimarães, M. Veras","doi":"10.5935/1676-2444.20200024","DOIUrl":"https://doi.org/10.5935/1676-2444.20200024","url":null,"abstract":"Introduction: Many factors can impact the performance of diagnostic assays for the human immunodeficiency virus (HIV) infection, affecting the results of population surveys. Objective: The objective of this study was to evaluate the performance of point-of-care rapid tests (RT) used for HIV diagnosis as compared to conventional tests in blood samples from a population of transvestites and transsexual women. Methods: A total of 1,385 samples with HIV RT results were submitted to Instituto Adolfo Lutz for evaluation by conventional laboratory tests. Results: HIV positivity was confirmed by conventional laboratory tests in 100% of the 240 (17.3%) samples with reactive RT. However, 1,145 (82.7%) samples with non-reactive RT results were evaluated; three (0.3%) tested positive and one (0.1%), indeterminate for HIV. Although a proportion of discordant results were found, the point-of-care RTs showed a high confirmation rate when compared to the serological tests. Conclusion: The data of this study corroborate the importance of adopting effective management tools to ensure quality of HIV infection diagnosis.","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71116214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Interferência da estocagem de sangue contendo os anticoagulantes K 2 EDTA e K 3 EDTA na análise automatizada do hemograma 含k2 EDTA和k3 EDTA抗凝血剂的血液储存对自动血细胞计数分析的干扰

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI: 10.5935/1676-2444.20200037

Vânia Cristina J. Riba, Patrick Gabriel dos Santos Pessini, C. Chagas, Daniel Santos Neves, Thaís Moura Gascón, F. Fonseca, Emerson Barbosa da Silva

引用次数: 0

Hematological and biochemical toxicity analysis of chemotherapy in women diagnosed with cervical cancer 宫颈癌妇女化疗的血液学和生化毒性分析

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI: 10.5935/1676-2444.20200038

D. Araújo, I. D. Cavalcanti, Bruna R. Larrazabal-Hadj-Idris, A. Peres

{"title":"Hematological and biochemical toxicity analysis of chemotherapy in women diagnosed with cervical cancer","authors":"D. Araújo, I. D. Cavalcanti, Bruna R. Larrazabal-Hadj-Idris, A. Peres","doi":"10.5935/1676-2444.20200038","DOIUrl":"https://doi.org/10.5935/1676-2444.20200038","url":null,"abstract":"Introduction and objective: We verified the main hematological and biochemical alterations during the chemotherapy treatment for women with cervical cancer. Material and method: A retrospective, analytical and cross-sectional test was performed. The sample consisted of 39 medical records of women who underwent chemotherapy in the period from January to December 2016. The effects of hematological toxicities were evaluated according to erythrogram, leukogram, and platelet parameters, in relation to biochemical toxicities, using levels of serum marker (urea, creatinine, transaminases). Results: It was evidenced that among the chemotherapy protocols used, cisplatin showed a leukogram and plateletgram of 1.06 and 2.09 chances, respectively, for the development of leucopenia and thrombocytopenia during treatment. Conclusion: It was not possible to identify the degree of toxicity of the adverse effects of the treatment, because when these effects were registered in the medical record, they appeared without description, making it difficult to evaluate the degree of toxicity presented.","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71116617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Tratamento cirúrgico de cementoblastoma: relato de caso 骨母细胞瘤的手术治疗:病例报告

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI: 10.5935/1676-2444.20200042

S. F. Santana, L. M. C. Pimentel, M. Oliveira, M. B. P. Santos, José de Amorim Lisboa Neto, C. M. B. R. G. Panjwani

引用次数: 0

TRH stimulation test in patients with repeatedly elevated TSH and normal FT4 反复升高TSH和FT4正常患者的TRH刺激试验

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI: 10.5935/1676-2444.20200043

P. Rosário

{"title":"TRH stimulation test in patients with repeatedly elevated TSH and normal\u0000 FT4","authors":"P. Rosário","doi":"10.5935/1676-2444.20200043","DOIUrl":"https://doi.org/10.5935/1676-2444.20200043","url":null,"abstract":"Subclinical hypothyroidism (SCH) is defined by elevated thyroid-stimulating hormone (TSH) with normal free thyroxine (FT4). We aimed to evaluate the thyrotropin-releasing hormone (TRH) stimulation test in patients with repeatedly elevated TSH (up to 10 mIU/l) and normal FT4, but without apparent thyroid disease. Women with TSH > 4.5 and ≤ 10 mIU/l (in two measurements) and normal FT4 were selected. Women with a known non-thyroid cause of TSH elevation, those treated with anti-thyroid drugs, amiodarone, lithium, and those with a history of thyroidectomy, neck radiotherapy and 131 I treatment were excluded. Seventy women had negative antithyroperoxidase antibodies. Ultrasonography revealed a eutopic thyroid, usual echogenicity, and a volume ≤ 15 ml, and they underwent the TRH stimulation test during initial evaluation. After stimulation with TRH, TSH > 30 mIU/l was observed in 38 women (expected response), while 32 women had TSH < 20 mIU/l (inadequate response). Age, basal TSH or thyroid volume did not differ between both groups, but FT4 concentrations were significantly lower in the first group. Follow-up was available for 66/70 women. Seven women developed a need for levothyroxine, all of them in the group with an adequate response to TRH [7/36 (19.4%) versus 0/30]. The results suggest that some cases of TSH elevation (even persistent) do not represent the early stage of thyroid insufficiency.","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71117068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brunner’s gland cyst: rare differential diagnosis of dyspeptic symptoms 布伦纳腺囊肿:消化不良症状的罕见鉴别诊断

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI: 10.5935/1676-2444.20200051

F. Ivano, V. K. Ivano, Larissa Miyashiro, D. G. Sakamoto, A. C. Sobral

引用次数: 0

Prevalência de microrganismos em secreção vaginal de gestantes de alto risco de uma maternidade em Caruaru, Pernambuco, Brasil 巴西伯南布哥卡鲁阿鲁妇产医院高危孕妇阴道分泌物中微生物的流行情况

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI: 10.5935/1676-2444.20200048

Leticia Freitas, Larissa Rayanne da Silva Maia Maia, M. R. A. R. D. Deus, S. R. D. Oliveira, Adrya Lúcia Peres

引用次数: 1