Performance evaluation of HIV infection diagnostic tests

Q4 Medicine

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI:10.5935/1676-2444.20200024

M. Castejon, Rosemeire Yamashiro, Carmem Aparecida F. Oliveira, E. Mata, L. Brigido, M. Guimarães, M. Veras

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引用次数: 3

Abstract

Introduction: Many factors can impact the performance of diagnostic assays for the human immunodeficiency virus (HIV) infection, affecting the results of population surveys. Objective: The objective of this study was to evaluate the performance of point-of-care rapid tests (RT) used for HIV diagnosis as compared to conventional tests in blood samples from a population of transvestites and transsexual women. Methods: A total of 1,385 samples with HIV RT results were submitted to Instituto Adolfo Lutz for evaluation by conventional laboratory tests. Results: HIV positivity was confirmed by conventional laboratory tests in 100% of the 240 (17.3%) samples with reactive RT. However, 1,145 (82.7%) samples with non-reactive RT results were evaluated; three (0.3%) tested positive and one (0.1%), indeterminate for HIV. Although a proportion of discordant results were found, the point-of-care RTs showed a high confirmation rate when compared to the serological tests. Conclusion: The data of this study corroborate the importance of adopting effective management tools to ensure quality of HIV infection diagnosis.

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艾滋病毒感染诊断检测的性能评价

许多因素会影响人类免疫缺陷病毒(HIV)感染诊断分析的性能，从而影响人口调查的结果。目的:本研究的目的是评估点护理快速检测(RT)用于HIV诊断的性能，并将其与传统检测方法在易装癖和变性女性人群的血液样本中进行比较。方法:将1385份HIV RT结果的样本提交给Adolfo Lutz研究所进行常规实验室检测。结果:240例(17.3%)RT阳性样本中，100%通过常规实验室检测证实HIV阳性。然而，对1,145例(82.7%)RT阴性样本进行了评估;3人(0.3%)艾滋病毒检测呈阳性，1人(0.1%)艾滋病毒检测不确定。虽然发现了一部分不一致的结果，但与血清学测试相比，即时治疗RTs显示出较高的确认率。结论:本研究的数据证实了采用有效的管理工具对保证HIV感染诊断质量的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jornal Brasileiro de Patologia e Medicina Laboratorial Health Professions-Medical Laboratory Technology

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： The Jornal Brasileiro de Patologia e Medicina Laboratorial (Brazilian Journal of Pathology and Laboratory Medicine), a continuation of Jornal Brasileiro de Patologia (Brazilian Journal of Pathology), and published quarterly (March, June, September and December) is directed towards the publication of scientific articles that contribute to the development of the area of Laboratory Medicine (Clinical Pathology, Pathology, Cytopathology). It accepts the following categories of articles: original articles, review articles, case reports, short communications, updating articles, letters to editors and reviews.