Hematological and biochemical toxicity analysis of chemotherapy in women diagnosed with cervical cancer

Q4 Medicine

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI:10.5935/1676-2444.20200038

D. Araújo, I. D. Cavalcanti, Bruna R. Larrazabal-Hadj-Idris, A. Peres

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引用次数: 1

Abstract

Introduction and objective: We verified the main hematological and biochemical alterations during the chemotherapy treatment for women with cervical cancer. Material and method: A retrospective, analytical and cross-sectional test was performed. The sample consisted of 39 medical records of women who underwent chemotherapy in the period from January to December 2016. The effects of hematological toxicities were evaluated according to erythrogram, leukogram, and platelet parameters, in relation to biochemical toxicities, using levels of serum marker (urea, creatinine, transaminases). Results: It was evidenced that among the chemotherapy protocols used, cisplatin showed a leukogram and plateletgram of 1.06 and 2.09 chances, respectively, for the development of leucopenia and thrombocytopenia during treatment. Conclusion: It was not possible to identify the degree of toxicity of the adverse effects of the treatment, because when these effects were registered in the medical record, they appeared without description, making it difficult to evaluate the degree of toxicity presented.

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宫颈癌妇女化疗的血液学和生化毒性分析

简介与目的:我们验证了宫颈癌妇女化疗期间的主要血液学和生化改变。材料和方法:进行回顾性、分析性和横断面试验。样本包括2016年1月至12月期间接受化疗的女性的39份医疗记录。血液学毒性的影响根据红细胞、白细胞和血小板参数进行评估，与生化毒性相关，使用血清标志物(尿素、肌酐、转氨酶)水平。结果:在所采用的化疗方案中，顺铂在治疗期间发生白细胞减少和血小板减少的概率分别为1.06和2.09。结论:无法确定治疗不良反应的毒性程度，因为当这些不良反应在病历中登记时，它们没有出现描述，因此难以评估所呈现的毒性程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jornal Brasileiro de Patologia e Medicina Laboratorial Health Professions-Medical Laboratory Technology

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： The Jornal Brasileiro de Patologia e Medicina Laboratorial (Brazilian Journal of Pathology and Laboratory Medicine), a continuation of Jornal Brasileiro de Patologia (Brazilian Journal of Pathology), and published quarterly (March, June, September and December) is directed towards the publication of scientific articles that contribute to the development of the area of Laboratory Medicine (Clinical Pathology, Pathology, Cytopathology). It accepts the following categories of articles: original articles, review articles, case reports, short communications, updating articles, letters to editors and reviews.