Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo最新文献

{"title":"[Polymorphism -786T>C (rs2070744) of the NOS3 gene as a potential risk factor for impaired autonomic regulation of the cardiovascular system in the age aspect.]","authors":"I N Bezmenova, I V Averyanova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>According to current understanding, aging is a complex process that is influenced by both genetic and environmental factors. Identifying reliable indicators of healthy aging is a significant challenge for modern science. Previous research has shown that aging is linked to a gradual decrease in HRV (heart rate variability). The aim is to analyze age-related alterations in the autonomic control of the cardiovascular system, taking into consideration different variants of the -786T>C polymorphism in the NOS3 gene, based on heart rate variability characteristics. A cross-sectional study was conducted on a sample of 245 northern men, which were divided into three age groups: group 1 - boys (n=109, average age 18,3±0,3 years), group 2 - mature men (n=97, average age 39,5±0,8 years), and group 3 - elderly men (n=39, average age 65,5±1,5 years). The -786T>C polymorphism (rs 2070744) of the NOS3 gene was genotyped using real-time polymerase chain reaction with commercial SNP-Screen kits («Syntol», Russia). Heart rate variability was recorded using the Varicard complex software («VARICARD-KARDi», Russia), and a number of heart rate variability parameters in the time and frequency range were measured. For all heart rate variability parameters that reflect the activity of the parasympathetic branch of the autonomic nervous system, an age-related decrease was observed. However, the rate of this decline varied depending on the variant of the NOS3 gene polymorphism. The maximum decrease in heart rate variability parameters was seen in individuals with the functionally weaker NOS3*C allele (those with TC+CC genotypes). Given the age-related nature of heart rate variability, its use for prognostic purposes necessitates an understanding of normal ranges in different age groups, including consideration of associations with the -786T>C (rs2070744) polymorphism of NOS3 gene. The presence of the TT genotype has been linked to a more favorable, vagus-mediated heart rate variability profile and can be regarded as a predictor for reduced risk of cardiovascular disease.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 4","pages":"624-632"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Well-being in old age: perspectives from older adults in Iran (a qualitative content analysis study).","authors":"F Joghataei, M Basakha, S Goharinezhad, M Ranjbar, H Rafiey, A Delbari, S H Mohaqeqi Kamal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The growing older adults' population made their well-being as a global concern. Considering the cultural and contextual differences across societies, it is essential to explore the dimensions of well-being within each specific context. This study aims to identify the dimensions of well-being from the perspective of Iranian older adults. This study employed a qualitative approach, conducting 21 in-depth interviews with older adults, selected through purposive sampling across different districts of Tehran. The interviews were analyzed based on directed content analysis. The findings were compared to a framework developed from a prior scoping review. Six dimensions of well-being identifies in the theoretical framework were confirmed through the interviews, though some subcategories differed. Key findings included: independence and autonomy in daily life and the burden of high healthcare expenditures under the Health dimension; warm family relationship and child's well-being in Social Relationships; inadequate income and financial hardship in Economic Status; recreational activities and trips in Environment and Leisure; and the role of education and literacy in Capabilities and Resources. Economic challenges were particularly impactful on the subjective well-being of older adults. Economic difficulties, peaceful family environment and children's well-being emerged as significant factors in the well-being of Iranian older adults compared to previous theoretical framework.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 2","pages":"197-206"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association of age-related viability with systemic inflammation in low-energy fractures.]","authors":"N M Agarkov, A S O Ibiev, T I Yakunchenko, A A Shorokhova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The study of biomarkers of age-related viability (resilience) in gerontology and geriatrics is actively continuing, but it has practically not been considered in patients with low-energy fractures. The aim of the study was to analyze the association of age-related viability with systemic inflammation in low-energy fractures. Among 102 patients after 2,5-3 months of low-energy fractures, stability in the motor and cognitive domains of walking speed, the 6-minute walking test and MMSE, respectively, were studied. A decrease in the motor domain was found in 78,43±3,61% of cases and the cognitive domain in 67,65±3,12% of cases (p<0,01). In patients with a decrease in the motor domain, the content of all pro-inflammatory cytokines is significantly higher compared to representatives with a decrease in the cognitive domain. This is especially true for the level of IL-6, which in patients with decreased motor domain was 30,4±1,5 pg/ml versus 12,1±0,8 pg/ml, TNF-α was 41,2±2,3 and 17,6±0,9 pg/ml, and IL-1b was 24,8±1,6 and 10,6±0,7 pg/ml, respectively. Multiple beta regression coefficients show a negative association with pro-inflammatory cytokines among both patients with low-energy fractures with a decrease in the motor domain and a decrease in the cognitive domain. However, the association with IL-10 is positive and the β coefficient was +1,95 for a decrease in the motor domain and +1,32 for a decrease in the cognitive domain.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 2","pages":"251-255"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Predictors of self-perception of the quality of life of people aged 60 years and older living in the Grodno region.]","authors":"M Y Surmach, P L Korneiko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Approaches to the classification and identification of boundaries of the elderly have been studied, the age structure of the population of the Republic of Belarus and the Grodno region has been calculated, using materials from a database representative of the Grodno region, and an analysis of the quality of life of persons aged 60+ has been carried out. It has been established that, in general, the state of medical and social predictors of self-perception of people 60 years of age and older in the Grodno region can be considered favorable, which is reflected in the maximum values of quality of life in the domains «Microsocial support» and «Social well-being» (95% CI 66,2±0,6%), and also that the integral level of quality of life corresponds to an increased level (64,26±0,52%). A demographically older population with expanded working capacity limits reduces the risk of stigmatization of the elderly. The domain «Physical and psychological well-being» revealed the lowest values (95% CI 61,52±0,55%). The domain has a direct connection with satisfaction with one's own health, with how a person in old age is able to compensate for accumulated disorders and what conditions he has for this. The measures taken in the Republic of Belarus in this direction in the healthcare system receive strong government support.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 1","pages":"156-162"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The effect of arterial hypertension on the stimulation of angiogenesis and the severity of systemic inflammation in elderly patients with chronic obstructive lung disease.]","authors":"T V Tayutina, A V Lysenko, T M Kazaryan, E V Modebadze, M A Kaplunovskaya","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chronic obstructive pulmonary diseases occupy a significant place in the structure of diseases in the elderly and senile and contribute to the diversity and multiplicity of combined pathology, impaired quality of life and causes of mortality in the elderly. One of the leading tasks in the treatment of vascular disorders, which are of particular importance in arterial hypertension combined with COPD in elderly patients, is to improve macrohemodynamics and microcirculation by improving endothelial function, normalizing the relationship between the endothelium and blood cells, reducing the level of markers of chronic inflammation and angiogenesis. The aim of the work: to study the effect of arterial hypertension on the state of angiogenesis inducers in elderly patients with COPD. It has been established that in the development of isolated COPD, the activity of both platelet-derived growth factor AA and tumor necrosis factor α directly depends on age, smoking index and spirometric parameters, in particular, on the forced expiratory volume in first second. The development of concomitant arterial hypertension in elderly patients with COPD promotes stimulation of angiogenesis and an increase in the severity of systemic inflammation.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 1","pages":"150-155"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Anamnesis and examination of an elderly patient.]","authors":"L A Tyultyaeva, T E Lipatova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Based on their own clinical experience and literature data, the authors present the features of collecting anamnesis of the disease and examining elderly and senile patients. Practical methods of interviewing an elderly patient with age-related memory disorders (collecting an anamnesis of the disease at the same time as the anamnesis of life), hearing (being in the patient's field of vision, avoiding high tones in the voice, speaking clearly, slowly, in silence, the doctor's face should be clearly visible to the patient) are proposed. The article presents the features of collecting medical history from a patient with age-related psychological personality traits (rigidity of thinking, increased suggestibility, perception of existing symptoms as natural manifestations of aging). The deontological aspects of the relationship between a doctor and an elderly patient are considered. The age-related features of the physical examination of an elderly patient were noted: gait, speech, voice, anthropometric data, skin (senile keratomas, senile hemangiomas, senile purpura Bateman), senile pulmonary emphysema, senile heart, tense pulse, high pulse pressure, senile aortic stenosis, etc.). The features of interpretation of data from laboratory and instrumental research methods in geriatrics are indicated. Studying the propaedeutic foundations of geriatrics by doctors of various specialties will improve the quality of medical care for the elderly and senile.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 3","pages":"346-351"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145422920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Characteristics of age-related self-esteem, anxiety and quality of life in elderly women with fear of falling.]","authors":"A V Dyomin, A N Ilnitski, A A Spitsina, S M K Shahriar, S V Ovsyannikova, V O Dubsky","doi":"10.34922/AE.2025.38.5.014","DOIUrl":"10.34922/AE.2025.38.5.014","url":null,"abstract":"<p><p>Fear of falling is a common issue among elderly people with postural instability (PI), which negatively impacts the physical and psychological aspects of health-related quality of life (HRQL). Today, there is growing evidence of decreased HRQL in older adults with a fear of falling (FOF). However, in the Russian scientific literature, information on HRQL in elderly people with FOF is minimal and limited. The present study was aimed at determining age-related self-esteem and anxiety, as well as assessing quality of life among elderly people with FOF. A total of 150 women aged 63-74 years with PI, i.e. those who had experienced two or more falls within 12 months, were examined. The study group included women who were found to have FOF. The comparison group included women without the fear. The level of age-related self-esteem (ASE) was defined as the difference between subjective and calendar age. To determine the levels of situational (SA) and personal (PA) anxiety, the method of Charles D. Spielberger and Yuri Khanin was applied. The SF-36 survey was used to assess HRQL. Based on the results of the conducted study, it has been established that the development of a fear of falling in elderly women with PI will indicate an increase in their ASE, SA and PA, as well as a decrease in all scales and grouped components of HRQL. Since we found a significant decrease in HRQL in elderly people with FOF, the data obtained point to serious changes in physical, mental and social functioning in the short term if appropriate treatment and rehabilitation are not provided. Further research is needed to develop measures that will reduce the manifestations and development of the fear of falling syndrome in older people with PI, as well as to improve their HRQL.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 5","pages":"745-752"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Researching happiness and life satisfaction of the older adults: Results from bibliometric network analysis.]","authors":"I A Pavlova","doi":"10.34922/AE.2025.38.5.013","DOIUrl":"10.34922/AE.2025.38.5.013","url":null,"abstract":"<p><p>The senior age group has become a focal point in interdisciplinary studies, with increasing attention on healthy and active aging, including happiness and life satisfaction in later life. This study presents the results of a bibliometric network analysis of scientific literature exploring the happiness of older adults. Relying on R.Veenhoven's concept of overall happiness, the study distinguishes between two strands of literature: happiness and life satisfaction. While these concepts are similar in their theoretical definitions, they yet differ in practical research approaches and empirical implications. This study aims at mapping the knowledge structure for these fields, analyzing keywords and constructing co-occurrence networks, as well as examining the most influential articles and popular publication sources. The results confirm the difference in research topics on happiness and life satisfaction among older people. Studies on happiness related to the senior age group are predominantly associated with the field of psychology, whereas life satisfaction research is more closely linked to aspects of quality of life.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 5","pages":"734-744"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prospects for the development of geriatric rehabilitation: A review of current trends and innovations.]","authors":"D N Bobunov, M D Didur, V I Kartashova, A A Chudina, R A Skorikov, S A Belskaya, A D Erastova, V O Gershenovich, A I Malik, A Y Bartsitskaya","doi":"10.34922/AE.2025.38.5.002","DOIUrl":"10.34922/AE.2025.38.5.002","url":null,"abstract":"<p><p>Medical advances of the 20th-21st centuries have led to an unprecedented increase in life expectancy, giving rise to the phenomenon of global demographic aging. Yet this triumph is overshadowed by a new monumental challenge: ensuring not just long, but high-quality, active, and independent living in old age. Traditional healthcare models, primarily focused on treating acute conditions, prove inadequate in addressing age-related challenges - frailty, sarcopenia, multimorbidity, and cognitive decline - which lead to loss of functional autonomy. In this context, geriatric rehabilitation is undergoing a radical transformation. It is no longer merely a specialized «after-the-fact» service but is emerging as a cornerstone of healthy aging strategies. Its new mission is to sustain physical, cognitive, and social functioning for as long as possible, preventing or delaying dependency. This review examines the key modern trends and cutting-edge innovations shaping the future of geriatric rehabilitation - from digital technologies and personalized approaches to preventive strategies and integrated care systems.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 5","pages":"647-654"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The role of CD31 and endothelial NO synthase in the pathogenesis of atherosclerosis in aging (analytical review).]","authors":"A G Sopromadze, K L Kozlov, V O Polyakova, N G Lukyanov, E I Kechaeva, D S Medvedev","doi":"10.34922/AE.2025.38.6.010","DOIUrl":"10.34922/AE.2025.38.6.010","url":null,"abstract":"<p><p>Cardiovascular diseases remain the leading cause of mortality in the elderly, and atherosclerosis serves as a key morphological basis for these conditions. Aging is recognized as the main non-modifiable risk factor for atherosclerotic lesions, reflecting the accumulation of structural and functional changes in the vascular wall long before the clinical manifestation of the disease. Approximately 40% of deaths in individuals over 65 years of age are associated with atherosclerosis and its complications. Aging is accompanied by endothelial dysfunction and the progression of subclinical vascular changes. In geriatrics, the problem of atherosclerosis is particularly relevant, as increasing life expectancy and population aging mean an increasing number of patients with age-associated vascular pathology. Understanding the specific mechanisms by which aging promotes atherogenesis is essential for developing preventive and therapeutic strategies aimed at prolonging active longevity and reducing cardiovascular risk in older patients. The aim of the study was to analyze literature data on the role of CD31 and eNOS in the pathogenesis of atherosclerosis in aging. The literature search was conducted using the following keywords: CD31, PECAM-1, endothelial NO synthase (eNOS), endothelial dysfunction, vascular aging, oxidative stress, mechanotransduction, inflammation, and atherosclerosis. Leading international scientometric and full-text databases were used, including PubMed, Scopus, Web of Science, ScienceDirect, SpringerLink, and Google Scholar, as well as Russian scientific resources: eLIBRARY.RU, CyberLeninka, websites of peer-reviewed medical journals, and the archives of the National Library of Electronic Library. The search covered the past 10 years (2014 to 2024 inclusive), with a focus on relevant publications reflecting current understanding of the molecular mechanisms of CD31 and eNOS action, age-related changes in the endothelium, and new therapeutic strategies in the context of vascular aging and atherosclerosis.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 6","pages":"870-880"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147949702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}