Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo最新文献_第8页

[Viral-epigenetic hypothesis of Parkinson's disease etiopathogenesis.] [帕金森病发病机制的病毒-表观遗传假说]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

R N Mustafin

{"title":"[Viral-epigenetic hypothesis of Parkinson's disease etiopathogenesis.]","authors":"R N Mustafin","doi":"","DOIUrl":"","url":null,"abstract":"Data accumulated in scientific literature indicate that Parkinson's disease develops after infections caused by SARS-CoV-2, West Nile, Coxsackie, St. Louis viruses, Japanese encephalitis B, hepatitis B and C, influenza A, HIV, herpes viruses, flaviviruses. Neuroinvasive West Nile viruses and HIV activate expression of alpha-synuclein. Influenza A, SARS-CoV-2, and Coxsackie B3 viruses promote aggregation of alpha-synuclein, which has the biophysical characteristics of antiviral peptides and is required for neuronal interferon-stimulated gene expression. These mechanisms can be triggers of Parkinson's disease, which progression is due to involvement of retroelements activated under their influence, stimulating the interferon response, expression and aggregation of alpha-synuclein in the brain. Direct activation of retroelements of the human genome by the described viral infections has been identified. Additional factors are aging and Parkinson's disease-associated polymorphisms located in intergenic, intronic and regulatory regions where transposon sequences are localized. In addition, the influence of the distribution of retroelements in the genomes of human populations on susceptibility to Parkinson's disease and the role of transposons in monogenic forms of the disease were determined. The effects of pathologically activated retroelements in Parkinson's disease are changes in expression of microRNAs derived from them, which contribute to disruption of epigenetic regulation of genes in the brain and pathology progression. An analysis of the scientific literature made it possible to describe a decrease in the levels of 15 such microRNAs, which can serve as tools for targeted therapy of the disease.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"37 5","pages":"499-507"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Elderly visually disabled: life satisfaction and its predictors.] [视力残疾老人：生活满意度及其预测因素]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

V Z Kantor, N V Nemirova, A B Kolosov

{"title":"[Elderly visually disabled: life satisfaction and its predictors.]","authors":"V Z Kantor, N V Nemirova, A B Kolosov","doi":"","DOIUrl":"","url":null,"abstract":"The article, based on an online survey of 433 blind and visually impaired people aged 65-94 years conducted in 10 regions of the Russian Federation, states that, in general, older visually impaired people are more satisfied with life than dissatisfied. However, the level of satisfaction is mediated by the level that they have and their socio-typological well-being - general, socio-demographic plans, and typical, typhlological ones, in the light of which the corresponding predictors of satisfaction are discovered. In terms of disability, all major categories of life activity are reflected as such outstanding abilities. In the context of the socio-demographic characteristics of elderly visually impaired people, predictors of their satisfaction with life are the stage of old age at which blind or visually impaired people find themselves, involvement in family and household relationships, high educational status, continuation of employment, including in the system of the Association of the Blind, the presence of hobbies and financial situation, and in terms of typhological characteristics - the age period when the disabling impairment of visual functions arose, the preservation of residual vision in case of blindness, as well as the experience of undergoing a rehabilitation course.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"37 4","pages":"352-362"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Aging and clonal hematopoesis.] [衰老与克隆造血]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

A N Bogdanov, S V Voloshin, E O Kunevich, M A Mikhaleva

{"title":"[Aging and clonal hematopoesis.]","authors":"A N Bogdanov, S V Voloshin, E O Kunevich, M A Mikhaleva","doi":"","DOIUrl":"","url":null,"abstract":"The number of somatic mutations among all tissues increases along with age. This process was well-studied in hematopoietic stem cells (HSCs). Some mutations lead to a proliferative advantage and expansion of HSCs to form a dominant clone. Clonal hematopoiesis is general in the elderly population. Clonal hematopoiesis of indeterminate potential (CHIP) is a more common phenomenon in the elderly and is defined as somatic mutations in clonal blood cells without any other hematological malignancies. The development of CHIP is an independent risk factor for hematological malignancies, cardiovascular diseases, and reduced overall survival. CHIP is frequently associated with mutations in DNMT3A and TET2 genes involved in DNA methylation. The epigenetic human body clocks have been developed based on the age-related changes in methylation, making it possible to detect epigenetic aging. The combination of epigenetic aging and CHUP is associated with adverse health outcomes. Further research will reveal the significance of clonal hematopoiesis and CHIP in aging, acquiring various diseases, and determining the feasibility of influencing the mutagenic potential of clones.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"37 3","pages":"266-275"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Comparative assessment of the intensity of caries among dental patients of older age groups in need of removable prosthetics, registered by a phthisiatician and their perception of an artificial ageist situation.] [由一名牙科医师对需要活动义齿的老年牙科患者的龋齿强度及其对人为年龄歧视情况的感知进行比较评估]。

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

A A Kopytov, T N Yushmanova, L V Girko, M B Gneteev

{"title":"[Comparative assessment of the intensity of caries among dental patients of older age groups in need of removable prosthetics, registered by a phthisiatician and their perception of an artificial ageist situation.]","authors":"A A Kopytov, T N Yushmanova, L V Girko, M B Gneteev","doi":"","DOIUrl":"","url":null,"abstract":"Improving the quality of life of older age groups is an urgent problem of medicine, including its components: gerontology, phthisiology and dentistry. The objectives of the study are: to establish the importance of tuberculosis as an infection that causes the intensity of caries among patients of older age groups; assessment using the Palmore scale of gerontological ageism «The ageism survey» and patients' perception of an artificial situation of age inequality. The study involved elderly (n=122) and senile (n=121) persons with partial secondary adentia who needed removable dentures. The control groups of older people included patients who denied being under the supervision of a phthisiologist, and the study groups confirmed this. To solve the first problem, a comparative assessment of the values of the components of the CPI index in the control and study groups was carried out. To solve the second problem, an artificial situation of age inequality was simulated in the process of dental admission. The results of its effects were evaluated based on the response of patients to questions № 9, 10 of the Palmor scale. The absence of a difference in the values of K and N components between the control and study groups indicates the absence of a significant effect of mycobacteria on the development of caries. The large values of component Y in the studied groups may indicate the detrimental effect of mycobacteria on periodontal disease. The absence of an increase in the intensity and stability of the perception of age inequality among patients who are under the influence of an artificially created situation proves the great effectiveness of background age inequality. At the same time, it is impossible to exclude the low sensitivity of the Palmor scale in the process of diagnosing age inequality in Russian society.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"37 3","pages":"230-237"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Comparative analysis of the results of microdiscectomy and minimally invasive transforaminal lumbar interbody fusion in the treatment of adjacent-level intervertebral disc herniations with lumbosacral transitional vertebra in elderly patients.] [显微椎间盘切除术与微创经椎间孔腰椎椎体间融合术治疗老年患者腰骶部过渡椎体邻近水平椎间盘突出症的效果比较分析]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

V A Byvaltsev, A A Kalinin, D V Hozeev, R A Kundubaev, Y Y Pestryakov, M Y Biryuchkov

{"title":"[Comparative analysis of the results of microdiscectomy and minimally invasive transforaminal lumbar interbody fusion in the treatment of adjacent-level intervertebral disc herniations with lumbosacral transitional vertebra in elderly patients.]","authors":"V A Byvaltsev, A A Kalinin, D V Hozeev, R A Kundubaev, Y Y Pestryakov, M Y Biryuchkov","doi":"","DOIUrl":"","url":null,"abstract":"The purpose of the study was a comparative analysis the effectiveness of microsurgical discectomy and minimally invasive transforaminal lumbar interbody fusion in the treatment of disk herniation adjacent to the anomaly of the lumbosacral junction segment in elderly patients. The study included 80 elderly patients (over 60 years old), divided into two groups: the 1st-(n=39) who underwent microsurgical discectomy; the 2nd- patients (n=41) operated on using minimally invasive transforaminal interbody fusion and percutaneous transpedicular stabilization (MI-TLIF). For the comparative analysis, we used gender characteristics (gender, age), constitutional characteristics (BMI), degree of physical status according to ASA, intraoperative parameters of interventions and the specificity of postoperative patient management, clinical data, and the presence of complications. Long-term outcomes were assessed at a minimum follow-up of 3 years. As a result, it was found that the use of MI-TLIF allows achieving better long-term clinical outcomes, fewer major complications in comparison with the microsurgical discectomy technique in the treatment of disc herniation adjacent to the anomaly of the lumbosacral junction segment in elderly patients.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"37 1-2","pages":"50-59"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Computer morphometry of peripheral blood lymphocytes in elderly patients with chronic pyelonephritis.] [慢性肾盂肾炎老年患者外周血淋巴细胞的计算机形态测量]。

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

I L Davydkin, O A Gusyakova, O I Fedorova, N K Ignatova

{"title":"[Computer morphometry of peripheral blood lymphocytes in elderly patients with chronic pyelonephritis.]","authors":"I L Davydkin, O A Gusyakova, O I Fedorova, N K Ignatova","doi":"","DOIUrl":"","url":null,"abstract":"The aim of the study was to investigate the peculiarities of morphometric parameters of peripheral blood lymphocytes in chronic pyelonephritis in elderly patients in comparison with young and middle-aged patients. A total of 81 patients with chronic pyelonephritis in the exacerbation phase were examined. All patients were divided into three age groups according to WHO recommendations: the 1st - 42patients of young age (18-44 years); the 2nd - 17 patients of middle age (45-59 years); the 3rd - 22 elderly patients (60-74 years). Computer morphometry of lymphocytes was performed in all examined patients. In elderly patients with chronic pyelonephritis the size and сytoplasmic-nuclear ratio of lymphocytes increase. This indicates the preservation of lymphocyte defense responses at this age. In male patients with chronic pyelonephritis in the 1st and 2nd age groups the size of lymphocytes increases, and in female patients - decreases. The сytoplasmic-nuclear ratio increases in males of these age groups, while it remains unchanged or decreases in females. Indirect indications of reduced immunity in young and middle-aged women with chronic inflammation in the kidneys have been obtained.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"37 1-2","pages":"40-45"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Older adults with predictors factors of depressive symptoms in the community of Indonesia: a cross sectional study. 印度尼西亚社区老年人抑郁症状的预测因素：一项横断面研究

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

S Susanty, E H Mujahid, J Suyanto, I P Sudayasa, Y-H Chuang

{"title":"Older adults with predictors factors of depressive symptoms in the community of Indonesia: a cross sectional study.","authors":"S Susanty, E H Mujahid, J Suyanto, I P Sudayasa, Y-H Chuang","doi":"","DOIUrl":"","url":null,"abstract":"Depressive symptoms ad depression are common mental health issues that frequently manifest in elderly individuals. Prior research has shown a correlation between depression and diminished quality of life as well as suicidal ideation. Nevertheless, there is limited knowledge regarding the prevalence rate of depressive symptoms among elderly individuals in Indonesia. Thus, the objective of this study was to ascertain the frequency of depressed symptoms among the elderly population in Indonesia and identify the factors associated with it. This study employed a cross-sectional descriptive and correlational research approach. A stratified random sample method was utilized to select 1 381 participants who were 60 years old or older from 15 Community Health Centres. These centres cater to both healthy and unwell senior individuals. Data was collected via questionnaires. Univariate logistic regression was employed to identify the connections between demographic and characteristic data, and depressed symptoms. The researchers employed multivariate logistic regression to identify the factors that predict depression symptoms. The findings of this study indicate that 60.03% of older individuals in Indonesia experience depressive symptoms. The multivariate logistic regression analysis revealed significant associations between depressed symptoms in older persons and variables such as gender, past employment, health condition, and loneliness. Depressive symptoms were highly prevalent among the elderly population in the community of Indonesia. It was a critical health issue that required prompt response from healthcare professionals. The implementation of suitable techniques should be prioritized in the near future.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"37 5","pages":"525-531"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Peculiarities of the time of manifestation of a number of diseases in the periods before and after the COVID-19 pandemic according to the data of municipal polyclinics of Sakhalin region.] [根据库页岛地区市立综合医院数据，新冠肺炎大流行前后若干疾病表现时间的特殊性]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

U R Saginbaev, A S Rukavishnikov, A S Efimov, R T Altynbaev, E V Lupashko, L V Melnikova

{"title":"[Peculiarities of the time of manifestation of a number of diseases in the periods before and after the COVID-19 pandemic according to the data of municipal polyclinics of Sakhalin region.]","authors":"U R Saginbaev, A S Rukavishnikov, A S Efimov, R T Altynbaev, E V Lupashko, L V Melnikova","doi":"","DOIUrl":"","url":null,"abstract":"The topic of the timing of the manifestation of age-associated diseases (as an indirect indicator of accelerated population aging) after the transfer of COVID-19 remains an urgent area in scientific research. Early targeted diagnosis can significantly reduce the consequences of pathology, in connection with which the features of the manifestation of various nosologies in the post-COVID period were studied. The materials were the accounting and statistical data of the municipal polyclinics of the Sakhalin Region for the pre-COVID (2017-2019) and post-COVID (2022-2023) periods. The median age of newly diagnosed patients and the age-specific incidence index were analyzed for the following nosologies: hypertensive diseases, coronary artery disease, type 2 diabetes mellitus, glaucoma, senile cataracts, and Parkinson's disease. There was a «rejuvenation» of the timing of the manifestation of the disease in the post-COVID period. Meanwhile, the decrease in the median age of disease manifestation was uneven: the most pronounced «rejuvenation» was characteristic of hypertensive diseases, type 2 diabetes mellitus, glaucoma and coronary heart disease. The order of manifestation of the considered nosologies was maintained in both observation periods. This circumstance is confirmed by both the median age of patients and the age-specific incidence index.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"37 5","pages":"532-536"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Russian and European experience in implementing the concept of active longevity.] 【俄罗斯和欧洲实施积极长寿理念的经验】

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

E V Vasilyeva

引用次数: 0

[Risk of death from cardiovascular diseases in relation to atrial fibrillation: the 15 year cohort study.] [心血管疾病致死风险与心房颤动的关系：15 年队列研究]。

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

M Y Shapkina, E V Mazdorova, E M Avdeeva, L V Shcherbakova, G I Simonova, A N Ryabikov, S K Malyutina

{"title":"[Risk of death from cardiovascular diseases in relation to atrial fibrillation: the 15 year cohort study.]","authors":"M Y Shapkina, E V Mazdorova, E M Avdeeva, L V Shcherbakova, G I Simonova, A N Ryabikov, S K Malyutina","doi":"","DOIUrl":"","url":null,"abstract":"The aim of this study was to assess the contribution of AF to the risk of death from cardiovascular diseases (CVD) in a population-based cohort of 45-69 years over a 15-year follow-up. The participants (n=9 360) were examined in 2003-2005 and followed during 15 years (HAPIEE Project, Novosibirsk). The presence of AF at baseline was determined by resting ECG. The analysis included 9183 participants, of whom 142 had AF. Documented deaths were collected using CVD and mortality registries and proxy-information from serial examinations. A total of 1 789 all-cause deaths (1 171 CVD deaths) were identified. On the censoring date, the cumulative proportion of survivors among individuals with AF was 51% versus 86% among individuals without AF. The structure of fatal CVD is represented by 56% by chronic ischemic heart disease (I25), 9% by acute ischemic heart disease (I20-I24) and 18% by stroke (I60-I64). The 15-year risk of death from CVD in individuals with AF aged 45-69 was 3 times higher than in respondents with sinus rhythm, regardless of other factors. In men with AF compared with men with sinus rhythm, the risk of CVD death was 3 times higher, regardless of other risk factors. In women with AF, the risk of CVD death was 2 times higher compared with women without AF when adjusted for the main risk factors, but did not reach statistical significance when was adjusted for the main cardiometabolic diseases (DM, hypertension, CVD).","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"37 6","pages":"680-687"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0