[Epidemiological analysis of comorbid diseases determining the prognosis of an elderly patient with type 2 diabetes mellitus.]

Abstract

The article presents a detailed comparative analysis of the medical and demographic indicators of diseases and conditions that determine the prognosis of an elderly patient with type 2 diabetes mellitus (DM2) according to domestic and foreign sources. A systematic review of the results of epidemiological studies on the databases PubMed, Google Scholar, Elibrary, WHO, IDF sites, materials from Rosstat, the Ministry of Health of the Russian Federation and NMRC of Endocrinology for the following keywords: type 2 diabetes mellitus, chronic kidney diseases, heart failure, comorbidity, accompanying pathology, morbidity, prevention, mortality structure, complete epidemiological study, multicenter randomized trial. 51 relevant articles were selected from the 107 sources found according to the criteria of compliance. A quantitative assessment of the differences in the prevalence of comorbid diseases and individual syndromes between samples of elderly people, patients with DM2 and the general population in the Russian Federation and foreign countries was performed, as well as an analysis of the structure of mortality by causes in a cohort of patients with DM2, general trends were identified, and their detailed assessment from the standpoint of pathogenesis was given. It was revealed that the prevalence of CHF, CKD and significant comorbid diseases in the samples of elderly people and patients with DM2 significantly exceeds that in the population in the Russian Federation and foreign countries; in the DM2 cohort, mortality from cardiovascular causes and CKD in the Russian Federation is lower than abroad; concomitant hypertension in an elderly DM2 patient significantly increases the risk of an adverse cardiovascular outcome.