Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo最新文献

{"title":"[The emotional component of the image of well-being in the perceptions of elderly and senile people.]","authors":"I V Vasileva, M V Chumakov","doi":"10.34922/AE.2026.39.2.004","DOIUrl":"https://doi.org/10.34922/AE.2026.39.2.004","url":null,"abstract":"<p><p>Improving people's well-being is one of the most important goals of public policy, as well as one of the tasks of psychology as an applied branch of knowledge. To effectively implement these tasks, it is necessary to clearly understand what the well-being of people of different ages consists of. The study of the well-being of the elderly and senile people is especially relevant due to the entry of society into the phase of super-aging, also due to the fact that psychology goes beyond the ideas of aging as regression and decline. Analysis of the emotional component of the image of well-being in elderly and senile people allows us to identify the most subjectively significant components of well-being. Objective - to identify the features of the emotional component of the image of well-being in the perceptions of elderly and senile people. The study involved 264 elderly and senile people. The data were collected using the method of limited associations using the following instructions: provide 9 associations for the word «well-being» (3 words in the form of a verb, noun, adjective). The resulting associations were examined through the prism of the thesaurus of emotive vocabulary by L.G.Babenko. As a result, the most frequent associations were identified, from which only associates related to emotive vocabulary were subsequently selected. Comparison of older and younger people shows that the most frequent associations of emotive vocabulary are similar. Differences are found in less frequent associations. Semantic groups of associations are unique to elderly and senile people: successful, kindness, cheerful, live, vigorous, communicate. Emotive vocabulary in the thesaurus of elderly and senile people is less represented than in young people, which indicates a lower intensity of needs. The features of the emotional component of the image of well-being, manifested in the associations of elderly and senile people, are described. The emotional component of the image of elderly people is represented mainly by positive emotions. The emotions of the core zone of the image are happiness, joy, calm; the emotions of the middle zone are friendship, love, attraction; the emotions of the peripheral zone of the image are kindness and anxiety.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 2","pages":"199-206"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Senescent dermal fibroblasts: Molecular logistics of the distant and systemic effects of exogenous bioactive compounds in the human body.]","authors":"A Y Prokopov, A O Drobintseva, P N Liubiakina, I M Kvetnoy","doi":"10.34922/AE.2026.39s","DOIUrl":"10.34922/AE.2026.39s","url":null,"abstract":"<p><p>One of the hallmarks of skin aging is the accumulation of senescent cells, which drives the process of inflammaging. The senescence-associated secretory phenotype (SASP), which characterizes senescent cells, can induce dysfunction in both neighboring skin cells and cells of distant organs. In this study, distant negative effects of senescent dermal fibroblasts on target cells (B-lymphocytes, hepatocytes, and alveolar epithelial cells) were demonstrated. The expression of Klotho, Parkin, SIRT6, VDR, Ki-67, CCN1, p16, and p65 proteins was assessed. The effects of an extract from a plant native to Russia, Hippophae rhamnoides (Sea buckthorn, S), extracts from plants of the African ecosystem Aspalathus linearis (Rooibos, R), Moringa oleifera (Moringa, M), Kigelia Africana (Kigelia, Kg), and an injectable hyaluronic acid gel (HA-gel) on the formation of the senescent phenotype in dermal fibroblasts were evaluated. The studied extracts and HA-gel protected cells from the negative processes induced by genotoxic stress. Moreover, extracts R, S, and HA-gel suppressed the adverse distant effects of damaged fibroblasts, normalizing marker expression in recipient cells, suggesting an influence on signaling pathways involved in the senescent transformation of distant cells. These results suggest considering cosmetic products based on the studied extracts and the injectable preparation as potential agents capable of delaying the aging of not only the skin but also the whole organism, which may be a component of the healthy aging concept.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 2 suppl.","pages":"5-35"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147976017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Molecular genetic factors of accelerated vascular aging.]","authors":"S Y Zavalishina, I N Medvedev, N A Starostina","doi":"10.34922/AE.2026.39.1.008","DOIUrl":"10.34922/AE.2026.39.1.008","url":null,"abstract":"<p><p>Aging is recognized as a highly complex process mediated by multiple mechanisms. It affects all body systems, including the cardiovascular system. The severity of age-related changes in the body is often associated with the severity of vascular aging. It remains crucial to analyze current data on vascular aging, tracing the available cause-and-effect relationships of molecular and genetic interactions that are significant for vascular aging. Various studies have confirmed the contribution of various processes and substances to aging, forming a reliable foundation for further gerontological research. Vascular aging is largely associated with the progressive deterioration of endothelial cell function in the vascular intima, leading to impaired production of biologically active substances, causing thrombophilia and increased vascular tone. Endothelial cell aging is largely due to changes in their DNA structure, including telomere shortening and an increase in gene mutations. A comprehensive study of these processes could help us better understand the mechanisms that initiate vascular aging. Furthermore, it is clear that a detailed study of the fundamental intracellular mechanisms underlying vascular aging could help us understand approaches to reducing the incidence of cardiovascular disease with age.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 1","pages":"74-81"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147976077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The experience of clinical and psychological support of the process of formation of readiness for age-related changes in elderly Tuvinians. Part 1.]","authors":"H M-H Kuular, O G Barinova","doi":"10.34922/AE.2026.39.1.004","DOIUrl":"10.34922/AE.2026.39.1.004","url":null,"abstract":"<p><p>The paper presents the experience of practical testing of the program of clinical and psychological support for a comprehensive organization in the process of forming their readiness for: awareness of the natural processes of age-related changes in the body and psyche; tolerant attitude towards them; the formation of productive strategies for age adaptation. The first part of the article shows the relevance and importance of clinical and psychological support for the elderly (Tuvinians) in everyday life in order to maintain and preserve their cognitive reserves; ensure physical and creative activity; and involve them in social interest groups based on a subjective understanding of the «sanctity» of objects of Tuvan culture. The author's program of clinical and psychological support is a short-term group intervention aimed at: stimulating the cognitive sphere; counseling on healthy lifestyle issues; education in the field of gerontological knowledge; emotional support; creative activity; development of adaptive skills in each component of readiness (physiological, social, personality-psychological and professional), and also prevention of possible negative effects of aging. The content of the formative program is presented in the work in the form of successive sessions (meetings) with a brief description of the options for working with elderly Tuvinians. The experience of testing the program was gained on the basis of the existing Center for Communication of the older generation «Soruktuglar», Khandagaity village, Ovyursky district, Republic of Tyva.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 1","pages":"44-54"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147976091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The demand for innovative services by senior citizens of Saint-Petersburg: periods of pandemic and post-pandemic. Part 2.]","authors":"N N Shestakova, M G Djanelidze, M B Skvortsova","doi":"10.34922/AE.2026.39.1.003","DOIUrl":"10.34922/AE.2026.39.1.003","url":null,"abstract":"<p><p>In the article, the authors continue their research into the sector of services for the elderly sector as a segment of the silver economy market. The authors compared two waves of surveys on the demand among elderly citizens of St. Petersburg for innovative services, which were conducted during and after the pandemic. The findings show that basic human needs remain the primary needs at all times (in this case, the delivery of food, essential goods, medicines, etc., as well as assistance in everyday life). In the post-pandemic period, the need to teach older people information technology skills has emerged as a priority in terms of importance (along with the answer «assistance in everyday life and household»). The study highlights the limitations of access to digital social services for older people.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 1","pages":"36-43"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147976056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Outcomes of percutaneous coronary intervention in patients over 90 years with acute coronary syndrome.]","authors":"T R Vildanov, N G Lukyanov, K L Kozlov, V O Polyakova, S V Vlasenko, D A Vorobyevsky, K K Glebov","doi":"10.34922/AE.2026.39.3.012","DOIUrl":"https://doi.org/10.34922/AE.2026.39.3.012","url":null,"abstract":"<p><p>A single-center, retrospective study included 41 patients over 90 years of age who underwent primary percutaneous coronary intervention for the treatment of acute coronary syndrome in the period from 01.2019 to 01.2023. Based on electrocardiography data, patients were divided into 2 groups: Group 1 (n=21) with ST-segment elevation acute coronary syndrome (ST-ACS), Group 2 (n=20) with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Multivessel coronary artery disease was detected in 71% of cases in STE-ACS versus 65% of cases in the NSTE-ACS group (p=0,658). Moreover, simultaneous complete revascularization was predominantly performed in NSTE-ACS (p=0,043). The length of stay in the intensive care unit was comparable (p=0,575), as was the overall length of hospital stay (p=0,463). In-hospital mortality was 35% for NSTE-ACS and 38,1% for STE-ACS (p=0,837). The incidence of hospital-acquired pneumonia, stroke, and bleeding did not differ significantly between the comparison groups. According to the data obtained, patients over 90 years of age with acute coronary syndrome with and without ST-segment elevation can successfully and safely undergo percutaneous coronary intervention.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 3","pages":"421-426"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148593442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The effect of long-term exposure to essential oils on the psychoemotional state and mental performance of elderly people.]","authors":"A M Yarosh, I A Batura, A V Sinitsyn","doi":"10.34922/AE.2026.39.2.016","DOIUrl":"https://doi.org/10.34922/AE.2026.39.2.016","url":null,"abstract":"<p><p>The effect of forty-minute exposure to essential oils (EO) of clove, coriander, lavender, lemon, rosemary, and savory on the psycho-emotional state and mental performance of elderly people (average age over 70 years) was studied when they inhaled air containing vapors of the indicated EOs at a concentration of 1 mg/m3. It was found that all the EO studied reduced anxiety and depression (assessed using the Hospital Anxiety and Depression Scale) and also increased the effectiveness of viewing large image arrays (proofreading test). Lavender, lemon, rosemary, and mountain savory EO improved subjects' self-assessments of their mood, while mountain savory improved subjects' relaxation.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 2","pages":"285-293"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Value orientations of older adults: Comparative analysis of employed and unemployed retirees in the context of active longevity.]","authors":"O A Gizinger, V M Kirsanov, N V Mamylina, A A Semchenko, N A Belousova","doi":"10.34922/AE.2026.39.2.003","DOIUrl":"https://doi.org/10.34922/AE.2026.39.2.003","url":null,"abstract":"<p><p>A comparative analysis of value orientations was conducted among working and non-working retirees within the framework of active longevity. The study involved 120 participants aged 60-70 years (middle age: 66 ± 1years): 60 individuals employed in higher and vocational education and 60 retirees engaged in familial and community activities. The Terminal Values Questionnaire was administered to assess individual priorities. Results indicated that employed retirees scored higher on values related to financial security, creativity, social engagement, and self-development, whereas non-working retirees prioritized achievement and civic involvement. These findings underscore the importance of tailoring psychological support and social interventions to accommodate divergent motivational and value-based profiles, ultimately fostering the sustained well-being and active potential of older adults.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 2","pages":"190-198"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The effect of geroprotectors on life expectancy: Mechanisms of action and clinical potential.]","authors":"A A Petintseva, V V Erdman","doi":"10.34922/AE.2026.39.1.002","DOIUrl":"10.34922/AE.2026.39.1.002","url":null,"abstract":"<p><p>The global increase in life expectancy and the growing proportion of elderly individuals have intensified the challenge of aging and age-related diseases. As the body ages, it accumulates various molecular and cellular damage, often resulting in multiple chronic conditions that complicate treatment and reduce quality of life. One promising approach to addressing these issues is the development of geroprotectors - compounds capable of targeting the fundamental biological mechanisms of aging and extending healthspan. This review provides a comprehensive overview of the major classes of geroprotectors, including senolytics, senostatics, calorie restriction mimetics, antioxidants, and hormetic agents. Each class is characterized by distinct mechanisms of action, yet all are united by their potential to slow down aging processes and reduce the risk of age-associated pathologies. The article summarizes key findings from numerous preclinical studies in animal models, which demonstrate that geroprotective agents can not only increase lifespan but also improve the function of various physiological systems. Special attention is given to the most well-studied and promising compounds, such as the combination of dasatinib and quercetin, rapamycin, metformin, coenzyme Q10, sulforaphane, and curcumin. These substances have shown beneficial effects on cellular senescence, metabolic regulation, oxidative stress, and inflammation. In addition, the review highlights current clinical data on geroprotectors. Although still limited in scope, these studies reveal encouraging results and support the strong therapeutic potential of such compounds in humans. Their growing relevance underscores the importance of continued research aimed at evaluating safety, efficacy, and translational applicability.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 1","pages":"21-35"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147976083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Iba-1-immunopositive cells in rat pineal gland.]","authors":"V S Yakovlev, D A Sufieva, I P Grigorev, V V Guselnikova, D E Korzhevskii","doi":"10.34922/AE.2026.39.3.015","DOIUrl":"https://doi.org/10.34922/AE.2026.39.3.015","url":null,"abstract":"<p><p>The aim of this study was to investigate the morphofunctional organization of microglia and macrophages in the pineal gland of the rat brain using an immunohistochemical reaction to Iba-1. It was found that in the rat pineal gland, Iba-1-immunopositive cells are characterized by a rounded body and short thickened processes. Such morphology indicates their activated state, which is probably associated with the presence of fenestrated capillaries in the pineal gland and the need for more active monitoring and phagocytosis of pathogenic factors. Microglia/macrophages are predominantly localized in the perivascular space around blood vessels and are less commonly found in the parenchyma among pinealocytes. Another distinctive feature of the organization of Iba-1+-cells in the rat pineal gland was the formation of cell clusters. A small but significant decrease in the number of Iba-1+-cells with age was observed, which may be associated with possible dystrophic changes in these cells due to their active interaction with pathogens.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 3","pages":"441-447"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}