[The effect of arterial hypertension on the stimulation of angiogenesis and the severity of systemic inflammation in elderly patients with chronic obstructive lung disease.]

Abstract

Chronic obstructive pulmonary diseases occupy a significant place in the structure of diseases in the elderly and senile and contribute to the diversity and multiplicity of combined pathology, impaired quality of life and causes of mortality in the elderly. One of the leading tasks in the treatment of vascular disorders, which are of particular importance in arterial hypertension combined with COPD in elderly patients, is to improve macrohemodynamics and microcirculation by improving endothelial function, normalizing the relationship between the endothelium and blood cells, reducing the level of markers of chronic inflammation and angiogenesis. The aim of the work: to study the effect of arterial hypertension on the state of angiogenesis inducers in elderly patients with COPD. It has been established that in the development of isolated COPD, the activity of both platelet-derived growth factor AA and tumor necrosis factor α directly depends on age, smoking index and spirometric parameters, in particular, on the forced expiratory volume in first second. The development of concomitant arterial hypertension in elderly patients with COPD promotes stimulation of angiogenesis and an increase in the severity of systemic inflammation.