[The structure of hypoglycemic therapy in a comorbid elderly patient with type 2 diabetes mellitus according to the outpatient specialized registry.]

Abstract

Objective - a comprehensive clinical assessment of the structure of hypoglycemic therapy in an elderly patient with type 2 diabetes mellitus (DM2) with an emphasis on concomitant manifestations of metabolic syndrome (obesity, hypertension, dyslipidemia). The study was carried out according to a retrospective design; the sample consisted of 462 comorbid elderly patients with DM2, whose primary clinical data were stored and systematized in an outpatient registry using developed digital tools and a specialized formalized protocol. Indicators of clinical and metabolic status and the structure of hypoglycemic therapy were studied. A high prevalence of concomitant diseases (hypertension - 92%, obesity - 63%, dyslipidemia - 86%) was revealed, the pathogenesis of which is closely interrelated with insulin resistance and is associated with age. A significant discrepancy between the average values of key indicators of therapeutic control of diabetes and the target ranges was noted: HbA1c (8,35±2,02%), systolic blood pressure (134,93±9,48 mmHg), LDL (2,60±1,19 mmol/L). A high proportion of prescribing insulins (46,3%), including short-acting ones (22,6%), as well as drugs that stimulate glucose-independent insulin secretion (39,8%), was determined in the structure of sugar-lowering therapy, which indicates that the clinical manifestations of metabolic syndrome are not always taken into account when choosing therapeutic tactics.